Research Topics
Genomes and GenesSpecies | Thomas BergerSummaryAffiliation: University of Innsbruck Country: Austria Publications
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Publications
Multiple sclerosisThomas Berger
Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria
Autoimmunity 37:321-4. 2004- Biomarkers in multiple sclerosis: role of antibodiesThomas Berger
Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Dis Markers 22:207-12. 2006..The present review summarizes the presentation on the potential role of antibodies as biomarkers for diagnosis, disease activity, classification and prediction of clinical courses in multiple sclerosis... - Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating eventThomas Berger
Department of Neurology, University of Innsbruck, Innsbruck, Austria
N Engl J Med 349:139-45. 2003.... - Increased serum levels of soluble CD14 indicate stable multiple sclerosisAndreas Lutterotti
Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
J Neuroimmunol 181:145-9. 2006..An increased expression of sCD14 was also detected after treatment with interferon-beta. In summary, we report evidence that serum sCD14 levels are increased in MS and correlate inversely with disease activity in relapsing MS patients... - Epitope specificity of serum antibodies directed against the extracellular domain of myelin oligodendrocyte glycoprotein: Influence of relapses and immunomodulatory treatmentsMichael Khalil
Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
J Neuroimmunol 174:147-56. 2006..Recently experienced relapses intensified the anti-MOG peptide antibody response. Immunomodulatory treatment with interferon-beta or glatiramer-acetate had no major impact on the anti-MOG peptide immunoreactivity after 1 year of therapy... 
Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disordersSimone Mader
Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
J Neuroinflammation 8:184. 2011....
Elevated γ-glutamyltransferase in implantable cardioverter defibrillator patientsWolfgang Dichtl
Clinic for Internal Medicine III, Cardiology, Medical University Innsbruck, Innsbruck, Austria
Wien Klin Wochenschr 124:18-24. 2012..Elevated γ-glutamyltransferase (GGT) is a new risk factor for cardiovascular diseases, but its impact on ventricular tachyarrhythmia occurrence and survival in patients with an implantable cardioverter defibrillator (ICD) is unknown...- Features of intrathecal immunoglobulins in patients with multiple sclerosisFranziska Di Pauli
Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
J Neurol Sci 288:147-50. 2010..Finally, intrathecal IgG production (IgG1 and IgG3) correlated with the presence of mature B cells and plasma blasts... - Persistency of neutralizing antibodies depends on titer and interferon-beta preparationHarald Hegen
Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Mult Scler 18:610-5. 2012..Neutralizing antibodies (NAbs) affect the efficacy of interferon-beta (IFNβ) treatment in multiple sclerosis (MS) patients, particularly if NAbs persist. Persistency depends on NAb titers, which differ between IFNβ preparations... - B cells and antibodies in MSMarkus Reindl
Neuroimmunological and Multiple Sclerosis Clinic and Research Unit, Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
Results Probl Cell Differ 51:99-113. 2010..This chapter therefore aims to summarize the present knowledge and to outline future directions about the role of B cells and antibodies in research and therapy of MS and NMO... - Temporal dynamics of anti-MOG antibodies in CNS demyelinating diseasesFranziska Di Pauli
Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Clin Immunol 138:247-54. 2011.... - Antibodies as biological markers for pathophysiological processes in MSMarkus Reindl
Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
J Neuroimmunol 180:50-62. 2006..We believe that antibodies serving as biomarkers will help to establish a differential therapeutic concept in MS, which will allow to treat individuals selectively according to their pathogenetic subtype and disease status... - Cerebrospinal fluid B cells correlate with early brain inflammation in multiple sclerosisBettina Kuenz
Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
PLoS ONE 3:e2559. 2008..There is accumulating evidence from immunological, pathological and therapeutic studies that B cells are key components in the pathophysiology of multiple sclerosis (MS)... - Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patientsMascha C Schmied
Department of Neurology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
Neurogenetics 13:181-7. 2012..01), rs7090530 (IL2RA, p < 0.026) and rs1841770 (ZIC1, p < 0.017) with a younger age at MS onset and of rs12044852 (CD58, p < 0.035) with shorter time to reach EDSS6... - Serum and cerebrospinal fluid antibodies to Nogo-A in patients with multiple sclerosis and acute neurological disordersMarkus Reindl
Department of Neurology, University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria
J Neuroimmunol 145:139-47. 2003..We finally demonstrate that human anti-Nogo-A antibodies recognize native Nogo-A in brain extracts, oligodendrocytes and cells expressing human Nogo-A... - Influence of interferon-beta therapy switching on neutralizing antibody titres: results from the Austrian Switch StudyClaudia Gneiss
Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Mult Scler 15:1481-8. 2009..Baseline and final neutralizing antibody titres correlated significantly. In conclusion, neither switching nor continuous therapy with any subcutaneous interferon-beta preparation significantly changed neutralizing antibody titres... - Plasma levels of soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin are associated with relapsing-remitting disease course of multiple sclerosisBettina Kuenz
Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
J Neuroimmunol 167:143-9. 2005..These findings indicate that sPECAM-1, sP-selectin and sE-selectin might be implemented as paraclinical markers of disease activity in MS with restriction to the clinical course of the disease... - Antibodies to myelin oligodendrocyte glycoprotein in HIV-1 associated neurocognitive disorder: a cross-sectional cohort studyPeter Lackner
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
J Neuroinflammation 7:79. 2010..This cross-sectional cohort study explores the potential role of antibodies to myelin oligodendrocyte glycoprotein (MOG), a putative autoantigen in multiple sclerosis, in the pathogenesis of HAND... - Impact of human myelin on the maturation and function of human monocyte-derived dendritic cellsViktoria Gredler
Clinical Department of Neurology, Innsbruck Medical University, Austria
Clin Immunol 134:296-304. 2010..We hypothesize that myelin influences DC activation and plays a pivotal role in balancing immunity and tolerance... - Fibrinogen is not elevated in the cerebrospinal fluid of patients with multiple sclerosisRainer Ehling
Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Fluids Barriers CNS 8:25. 2011..abstract:.. - Natalizumab treatment reduces endothelial activity in MS patientsAlban Millonig
Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
J Neuroimmunol 227:190-4. 2010..Correspondingly Natalizumab diminished VLA-4 on leukocyte subsets. Our findings indicate that Natalizumab reduces transmigration not only by blocking VLA-4 but also by down-regulating VCAM-1... - Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis opticaSimone Mader
Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
PLoS ONE 5:e10455. 2010..Serum NMO-IgG autoantibodies (Abs), a specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as a long (M-1) or a short (M-23) isoform... - Biological markers for multiple sclerosisAndreas Lutterotti
Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
Curr Med Chem 14:1956-65. 2007.... - Intrathecal anti-alphaB-crystallin IgG antibody responses: potential inflammatory markers in Guillain-Barré syndromeJulia Wanschitz
Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
J Neurol 255:917-24. 2008..To address the role of alphaBC in Guillain-Barré syndrome (GBS) we analyzed humoral responses against alphaBC in relation to clinical, electrophysiological and CSF features in GBS... - Antibody response to myelin oligodendrocyte glycoprotein and myelin basic protein depend on familial background and are partially associated with human leukocyte antigen alleles in multiplex families and sporadic multiple sclerosisAndreas Lutterotti
Department of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria
J Neuroimmunol 131:201-7. 2002..We conclude that antibody responses to MOG and MBP depend on familial background. Moreover, the humoral immune reactivity against MOG is partially under control of certain HLA class II alleles... - Epitope specificity of neutralizing antibodies against IFN-betaClaudia Gneiss
Department of Neurology, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
J Interferon Cytokine Res 24:283-90. 2004..Our results indicate a qualitative and quantitative difference between NAb and NNAb, with special emphasis on the recognition of different epitopes... - Anti-myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritisKevin Rostasy
Division of Pediatric Neurology and Inherited Metabolic Disorders, Department of Pediatrics IV, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
Arch Neurol 69:752-6. 2012..To study the humoral immune response directed at myelin oligodendrocyte glycoprotein (MOG)in pediatric patients with isolated and recurrent optic neuritis(ON)... - Current therapeutic recommendations in multiple sclerosisThomas Berger
Neuroimmunological and Multiple Sclerosis Clinic and Research Unit, Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
J Neurol Sci 287:S37-45. 2009.... - Multiple sclerosis - established and novel therapeutic approachesRainer Ehling
Clinical Department of Neurology, Innsbruck Medical University, Austria
Cent Nerv Syst Agents Med Chem 10:3-15. 2010..This will pave the way for an optimized treatment approach, which will likely need both to target inflammation and to focus on promotion of neuroprotection and repair... - Is there a rationale for therapeutic immunoadsorption in multiple sclerosis?Thomas Berger
Innsbruck Medical University, Innsbruck, Austria
Eur J Clin Invest 35:467-8. 2005 - Duration of the A(H)-A(Md) interval predicts occurrence of AV-block after radiofrequency ablation of the slow pathwayMarkus C Stühlinger
Department of Internal Medicine III Cardiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria
J Interv Card Electrophysiol 31:207-15. 2011..We sought to evaluate the predictive value of the A(H)-A(Md) interval-the electrical delay between atrial signals on the His- and the ablation-catheter-upon development of AVB during SP ablation... - Multiple sclerosis: disease biomarkers as indicated by pathophysiologyThomas Berger
Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
J Neurol Sci 259:21-6. 2007..Antibodies (and other molecules) serving as biomarkers will help to establish a differential therapeutic concept in MS, which should allow to treat individuals selectively according to their pathogenetic subtype and disease status... - Single-beat noninvasive imaging of cardiac electrophysiology of ventricular pre-excitationThomas Berger
Department of Internal Medicine, Division of Cardiology, Medical University Innsbruck, Innsbruck, Austria
J Am Coll Cardiol 48:2045-52. 2006.... - The influence of high versus normal impedance ventricular leads on pacemaker generator longevityThomas Berger
Department of Internal Medicine, Division of Cardiology, University Hospital Innsbruck, Leopold Franzens University Innsbruck, Austria
Pacing Clin Electrophysiol 26:2116-20. 2003..3 +/- 8.5 vs 97.6 +/- 9.0 months; P = 0.02). In conclusion, implantation of a high impedance lead for ventricular pacing results in a clinically relevant extension of generator longevity... - The effect of nabilone on neuropsychological functions related to driving ability: an extended case seriesIlsemarie Kurzthaler
Department of Biological Psychiatry, Innsbruck University Clinics, Austria
Hum Psychopharmacol 20:291-3. 2005..No indication was found of a deterioration of any of the five investigated neuropsychological functions during the 4-week treatment period with nabilone... - Daytime sleepiness is not increased in mild to moderate multiple sclerosis: a pupillographic studyBirgit Frauscher
Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
Sleep Med 6:543-7. 2005..CONCLUSION: In a general sample of MS patients with mild to moderate disease, there was no evidence for overall increased daytime sleepiness compared to healthy controls... - Long-term results of high vs. normal impedance ventricular leads on actual (Real-Life) pacemaker generator longevityKakhaber Etsadashvili
Clinical Department of Cardiology, Medical University Innsbruck Anichstrasse, Innsbruck, Austria
Europace 11:200-5. 2009..The long-term effects of high impedance vs. standard impedance pacing leads on actual generator longevity were studied... - Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : a double-blind placebo-controlled cross-over trialJorg Wissel
Department of Neurology, University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
J Neurol 253:1337-41. 2006..Nabilone 1 mg per day proved to be a safe and easily applicable option in the care of patients with chronic UMNS and spasticity-related pain otherwise not controllable... - Serial contrast-enhanced magnetic resonance imaging and spectroscopic imaging of acute multiple sclerosis lesions under high-dose methylprednisolone therapyMichael F H Schocke
Department of Radiology, the University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
Neuroimage 20:1253-63. 2003..We believe that combined contrast-enhanced MRI and 1H MRSI may help to further investigate inflammatory processes within active MS lesions and should be employed more frequently to the research on therapy effects in MS... - Appropriate therapy but not inappropriate shocks predict survival in implantable cardioverter defibrillator patientsWolfgang Dichtl
Clinic for Internal Medicine III Cardiology, Medical University Innsbruck, Innsbruck, Austria
Clin Cardiol 34:433-6. 2011..Inappropriate implantable cardioverter defibrillator (ICD) shocks have been linked to a worse clinical outcome due to direct myocardial injury... - Clinical ECG mapping and imaging of cardiac electrical excitationBernhard Tilg
Institute for Medical Signal Processing and Imaging, University for Health Informatics and Technology Tyrol, Innsbruck, Austria
J Electrocardiol 35:81-7. 2002..For focal arrhythmias, this model-based imaging approach might allow the guidance and evaluation of antiarrhythmic interventions, for instance, in case of catheter ablation or drug therapy... - Lack of association between antimyelin antibodies and progression to multiple sclerosisThomas Berger
N Engl J Med 356:1888-9; author reply 1888-9. 2007 - Antimyelin antibodies in clinically isolated syndromes correlate with inflammation in MRI and CSFJens Kuhle
Department of Neurology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
J Neurol 254:160-8. 2007.... - A new paraclinical CSF marker for hypoxia-like tissue damage in multiple sclerosis lesionsHans Lassmann
Division of Neuroimmunology, Brain Research Institute, University of Vienna, Austria
Brain 126:1347-57. 2003..The respective epitope is liberated into the CSF and, thus, may become a useful diagnostic tool to identify clinically a defined multiple sclerosis subtype... - Antimyelin antibodies with no progression to multiple sclerosisRaul Pelayo
N Engl J Med 356:426-8. 2007 - De novo aphasic status epilepticus as presenting symptom of multiple sclerosisEugen Trinka
J Neurol 249:782-3. 2002 - [Tolerability and efficacy of a herbal combination preparation in children and adolescents with recurrent infections of the upper respiratory tract]Thomas Berger
, Frankfurt
MMW Fortschr Med 150:85-90. 2008 - Model-based imaging of cardiac electrical excitation in humansBernhard Tilg
Institute of Biomedical Engineering, Graz University of Technology
IEEE Trans Med Imaging 21:1031-9. 2002..The reconstructed sinus rhythm sequence was in good qualitative agreement with the pattern previously published for the isolated Langendorff-perfused human heart... - Neonatal kyphectomy in the patient with myelomeningoceleAlvin H Crawford
Department of Pediatric Orthopaedic Surgery, Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
Spine (Phila Pa 1976) 28:260-6. 2003..A retrospective cohort study was used to investigate a group of neonates with myelomeningocele who had a kyphectomy performed in conjunction with dural sac closure during the first few days of life... - Atrial noninvasive activation mapping of paced rhythm dataRobert Modre
Institute for Medical Signal Processing and Imaging, University for Health Informatics and Technology Tyrol, Innrain 98, 6020 Innsbruck, Austria
J Cardiovasc Electrophysiol 14:712-9. 2003..Noninvasive imaging of electrical function in humans may be useful for computer-aided diagnosis and treatment of cardiac arrhythmias, which can be accomplished by the fusion of data from ECG mapping and magnetic resonance imaging (MRI)... - Progressive multifocal leukoencephalopathy, natalizumab, and multiple sclerosisThomas Berger
N Engl J Med 353:1744-6; author reply 1744-6. 2005 - Costs and quality of life of multiple sclerosis in AustriaGisela Kobelt
Lund University, Lund, Sweden
Eur J Health Econ 7:S14-23. 2006..This loss increases to approximately 0.4 for patients over 60 years of age with an average EDSS score of 6.0-6.5. Patients with a recent relapse had lower utility (-0.1) and higher costs (+ euro 4.750)... - Clinical predictors of health-related quality of life after pacemaker implantationWerner Benzer
Department of Interventional Cardiology, Academic Hospital, Feldkirch, Austria
Wien Klin Wochenschr 118:739-43. 2006..The purpose of this study was to investigate the influence of clinical symptoms and ECG diagnoses as predictors of improved HRQL in patients referred for PMI... - Global P wave duration on the 65-lead ECG: single-site and dual-site pacing in the structurally normal human atriumStefan Gozolits
Department of Clinical Cardiology, University Hospital Innsbruck, Austria
J Cardiovasc Electrophysiol 13:1240-5. 2002..The fact that high septal pacing results in the shortest PWD may have implications for preventive pacing in patients with atrial fibrillation...