Gottfried Baier

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi PKCdelta is involved in signal attenuation in CD3+ T cells
    Thomas Gruber
    Department of Medical Biology and Human Genetics, Innsbruck Medical University, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    Immunol Lett 96:291-3. 2005
  2. ncbi PKC isotype functions in T lymphocytes
    G Baier
    Department for Medical Gentics and Molecular and Chemical Pharmacology, Medical University of Innsbruck, Schoepfstrasse 41, 6020 Innsbruck, Austria
    Ernst Schering Found Symp Proc . 2007
  3. pmc Molecular genetics and structural genomics of the human protein kinase C gene module
    Kurt Kofler
    Institute for Medical Biology and Human Genetics, University of Innsbruck, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    Genome Biol 3:RESEARCH0014. 2002
  4. ncbi The PKC gene module: molecular biosystematics to resolve its T cell functions
    Gottfried Baier
    Institute of Medical Biology and Human Genetics, University of Innsbruck, Austria
    Immunol Rev 192:64-79. 2003
  5. doi PKCtheta and Itk functionally interact during primary mouse CD3+ T cell activation
    Nikolaus Thuille
    Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria
    Immunol Lett 126:54-9. 2009
  6. ncbi PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes
    Thomas Gruber
    Department for Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    Mol Immunol 45:117-26. 2008
  7. pmc PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes
    Nikolaus Thuille
    Department of Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria
    PLoS ONE 8:e53709. 2013
  8. ncbi PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes
    Natascha Hermann-Kleiter
    Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schoepfstr 41, A 6020 Innsbruck, Austria
    Blood 107:4841-8. 2006
  9. pmc The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses
    Marlies Meisel
    Department for Pharmacology and Genetics, Division of Translational Cell Genetics, Medical University of Innsbruck, Innsbruck 6020, Austria
    Immunity 38:41-52. 2013
  10. pmc Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells
    Christa Pfeifhofer
    Institute of Medical Biology and Human Genetics, University of Innsbruck, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    J Exp Med 197:1525-35. 2003

Collaborators

Detail Information

Publications41

  1. ncbi PKCdelta is involved in signal attenuation in CD3+ T cells
    Thomas Gruber
    Department of Medical Biology and Human Genetics, Innsbruck Medical University, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    Immunol Lett 96:291-3. 2005
    ..These findings suggest that PKCdelta serves a so far unrecognized role in TCR-induced negative regulation of IL-2 cytokine production and T cell proliferation...
  2. ncbi PKC isotype functions in T lymphocytes
    G Baier
    Department for Medical Gentics and Molecular and Chemical Pharmacology, Medical University of Innsbruck, Schoepfstrasse 41, 6020 Innsbruck, Austria
    Ernst Schering Found Symp Proc . 2007
    ..This review describes the current knowledge of the physiological and non-redundant functions of the PKC gene products in T cells...
  3. pmc Molecular genetics and structural genomics of the human protein kinase C gene module
    Kurt Kofler
    Institute for Medical Biology and Human Genetics, University of Innsbruck, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    Genome Biol 3:RESEARCH0014. 2002
    ..In this study we systematically address the genomic locations and gene structures of the human PKC gene module...
  4. ncbi The PKC gene module: molecular biosystematics to resolve its T cell functions
    Gottfried Baier
    Institute of Medical Biology and Human Genetics, University of Innsbruck, Austria
    Immunol Rev 192:64-79. 2003
    ....
  5. doi PKCtheta and Itk functionally interact during primary mouse CD3+ T cell activation
    Nikolaus Thuille
    Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria
    Immunol Lett 126:54-9. 2009
    ..Taken together, this provides evidence for a more complex functional crosstalk between Itk and PKCtheta during T cell receptor signalling then previously anticipated...
  6. ncbi PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes
    Thomas Gruber
    Department for Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    Mol Immunol 45:117-26. 2008
    ..Together, these data demonstrate that atypical PKCzeta/iota isotypes serve as direct downstream targets of PKCtheta in the signalling pathway leading to NF-kappaB activation in T lymphocytes...
  7. pmc PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes
    Nikolaus Thuille
    Department of Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria
    PLoS ONE 8:e53709. 2013
    ..Taken together, our study establishes CYLD as a new and critical PKCθ interactor in T cells and reveals that antagonistic PKCθ/β-CYLD crosstalk is crucial for the adjustment of immune thresholds in primary mouse CD3(+) T cells...
  8. ncbi PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes
    Natascha Hermann-Kleiter
    Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schoepfstr 41, A 6020 Innsbruck, Austria
    Blood 107:4841-8. 2006
    ..Taken together, this opposite effect between the positive PKCtheta and the negative cAMP/PKA signaling pathways appears rate limiting for NF-AT transactivation and IL-2 secretion responses of CD3(+) T lymphocytes...
  9. pmc The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses
    Marlies Meisel
    Department for Pharmacology and Genetics, Division of Translational Cell Genetics, Medical University of Innsbruck, Innsbruck 6020, Austria
    Immunity 38:41-52. 2013
    ..Consistently, Prkca(-/-) cells failed to mount appropriate IL-17A, but not IL-17F, responses in vitro and were resistant to induction of Th17-cell-dependent experimental autoimmune encephalomyelitis in vivo...
  10. pmc Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells
    Christa Pfeifhofer
    Institute of Medical Biology and Human Genetics, University of Innsbruck, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    J Exp Med 197:1525-35. 2003
    ..Our finding suggests that PKCtheta plays a critical and nonredundant role in T cell receptor-induced NFAT activation...
  11. ncbi Protein kinase C beta is dispensable for TCR-signaling
    Nikolaus Thuille
    Department for Medical Biology and Human Genetics, Innsbruck Medical University, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    Mol Immunol 41:385-90. 2004
    ..Thus, PKCbeta-deficient T cells had similar physiological thresholds for activation in vitro. These findings suggest that PKCbeta plays a redundant role in TCR-induced regulation of IL-2 cytokine production and T cell proliferation...
  12. pmc The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity
    Natascha Hermann-Kleiter
    Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University Innsbruck, 6020 Innsbruck, Austria
    Immunity 29:205-16. 2008
    ..Our study establishes NR2F6 as a transcriptional repressor of IL-17 expression in Th17-differentiated CD4(+) T cells in vitro and in vivo...
  13. doi PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation
    Thomas Gruber
    Department of Medical Genetics, Clinical and Molecular Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria
    Sci Signal 2:ra30. 2009
    ..Thus, our data establish a nonredundant antagonism between PKC-theta and Cbl-b that regulates T cell activation responses...
  14. pmc PKCtheta is necessary for efficient activation of NFkappaB, NFAT, and AP-1 during positive selection of thymocytes
    Thomas Gruber
    Department of Medical Genetics, Clinical and Molecular Pharmacology, Medical University of Innsbruck, Schopfstrasse 41, A 6020 Innsbruck, Austria
    Immunol Lett 132:6-11. 2010
    ..Together, these results reveal a crucial role of PKCtheta in positive selection of thymocytes in a pathway leading to the activation of ERK, AP-1, NFAT, and NFkappaB...
  15. ncbi Protein kinase Cepsilon is dispensable for TCR/CD3-signaling
    Thomas Gruber
    Department for Medical Biology and Human Genetics, Medical University of Innsbruck, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    Mol Immunol 42:305-10. 2005
    ..Thus, PKCepsilon-deficient T-cells had similar physiological thresholds for activation in vitro. This finding suggests that PKCepsilon plays a redundant role in TCR-induced regulation of T-cell proliferation...
  16. ncbi Defective IgG2a/2b class switching in PKC alpha-/- mice
    Christa Pfeifhofer
    Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    J Immunol 176:6004-11. 2006
    ..Our genetic data, thus, define PKCalpha as the physiological and nonredundant PKC isotype in signaling pathways that are necessary for T cell-dependent IFN-gamma production and IgG2a/2b Ab responses...
  17. doi Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells
    Thomas Gruber
    Department for Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria
    J Mol Cell Biol 5:358-68. 2013
    ..These results demonstrate an essential and non-redundant role for Cbl-b in controlling TGFβR signaling by directly targeting SMAD7 for degradation during T cell responses in vitro and in vivo. ..
  18. pmc Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter
    Natascha Hermann-Kleiter
    Department for Pharmacology and Genetics, Medical University Innsbruck, Peter Mayr Str 1a, A 6020 Innsbruck, Austria
    J Autoimmun 39:428-40. 2012
    ..Taken together, our findings uncover an example of antagonistic regulation of Il17a transcription through the direct reciprocal actions of NR2F6 versus NFAT and RORγt...
  19. pmc The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance
    Natascha Hermann-Kleiter
    Translational Cell Genetics, Department for Pharmacology and Genetics, Medical University of Innsbruck, 6020 Innsbruck, Austria Electronic address
    Cell Rep 12:2072-85. 2015
    ..Altogether, this defines NR2F6 as an intracellular immune checkpoint in effector T cells, governing the amplitude of anti-cancer immunity...
  20. ncbi AKT1/PKBalpha is recruited to lipid rafts and activated downstream of PKC isotypes in CD3-induced T cell signaling
    Birgit Bauer
    Department of Medical Biology and Human Genetics, University of Innsbruck, Austria
    FEBS Lett 541:155-62. 2003
    ....
  21. doi Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells
    Sandra Kaminski
    Experimental Cell Genetics, Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Austria
    J Autoimmun 37:198-208. 2011
    ..Taken together, these data provide experimental evidence of a non-redundant role of Coro1A in the regulation of Th17 CD4(+) cell effector functions and, subsequently, in the development of autoimmunity...
  22. pmc Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells
    Katarzyna Wachowicz
    Translational Cell Genetics, Department of Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria
    PLoS ONE 9:e96401. 2014
    ..Taken together, our data provide genetic evidence that PKCθ is critical for stabilizing Th17 cell phenotype by selective suppression of the STAT4/IFN-γ/T-bet axis at the onset of differentiation. ..
  23. pmc LAMTOR2-mediated modulation of NGF/MAPK activation kinetics during differentiation of PC12 cells
    Bettina Thauerer
    Division of Neurobiochemistry, CCB Biocenter, Medical University of Innsbruck, Innsbruck, Austria
    PLoS ONE 9:e95863. 2014
    ..These results suggest a modulatory role of the MEK1 adapter protein LAMTOR2 in NGF-mediated MAPK activation required for induction of neurite outgrowth in PC12 cells. ..
  24. pmc Releasing the brake: targeting Cbl-b to enhance lymphocyte effector functions
    Stephanie Wallner
    Department of Internal Medicine V Hematology and Oncology, Medical University Innsbruck, 6020 Innsbruck, Austria
    Clin Dev Immunol 2012:692639. 2012
    ..This paper summarizes the current knowledge about the negative regulatory role of Cbl-b in T-cell activation and its potential therapeutic implications for cancer immunotherapy...
  25. doi Beyond CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy
    Victoria Klepsch
    Translational Cell Genetics, Department for Pharmacology and Genetics, Medical University of Innsbruck, Peter Mayr Str 1a, A 6020 Innsbruck, Austria
    Immunol Lett 178:31-6. 2016
    ..Based on our study, an approach shall be initiated to identify low molecular weight compounds that selectively interfere with NR2F6 function in the clinic. ..
  26. ncbi The immunological synapse: kinases in T cell signalling as potential drug targets
    Gottfried Baier
    Medical University of Innsbruck, Austria
    Immunol Lett 105:3-5. 2006
    ..g. asthma, rheumatoid arthritis, multiple sclerosis and transplant rejection)...
  27. ncbi Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP)
    Christina Lutz
    Institute for Medical Biology and Human Genetics, the Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria A6020
    J Biol Chem 277:43143-51. 2002
    ..Taken together, we here demonstrate that sIgG-LRP protein sequesters activated JNK into the plasma membrane compartment in intact cells, inhibiting nuclear activation of the JNK-dependent transcription factors Elk-1 and cJun...
  28. pmc cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation
    Sana Khalid
    Daniel Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria
    Sci Rep 6:20930. 2016
    ..Finally, the low ROS phenotype of JNK1/2 knockout MEFs was reversed by the phosphomimetic p66ShcS36E mutant. Inhibiting JNK1/2-regulated p66Shc activation may thus provide a therapeutic approach for the prevention of oxidative damage...
  29. doi Protein kinase Cθ: the pleiotropic T-cell signalling intermediate
    Katarzyna Wachowicz
    Translational Cell Genetics, Department of Pharmacology and Genetics, Medical University of Innsbruck, Peter Mayr Strasse 1a, A 6020 Innsbruck, Austria
    Biochem Soc Trans 42:1512-8. 2014
    ....
  30. pmc Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions
    Natascha Hermann-Kleiter
    Department for Pharmacology and Genetics, Translational Cell Genetics, Medical University of Innsbruck, Peter Mayr Str, 1a, A 6020, Innsbruck, Austria
    Cell Commun Signal 12:38. 2014
    ..Investigating these signaling pathway(s) will enable a greater knowledge of the genetic, immune, and environmental mechanisms that lead to chronic inflammation and of certain autoimmune disorders in a given individual. ..
  31. ncbi Critical role of protein kinase C alpha and calcium in growth factor induced activation of the Na(+)/H(+) exchanger NHE1
    Karl Maly
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    FEBS Lett 521:205-10. 2002
    ....
  32. ncbi Protein kinase C and AKT/protein kinase B in CD4+ T-lymphocytes: new partners in TCR/CD28 signal integration
    Birgit Bauer
    Institute for Medical Biology and Human Genetics, University of Innsbruck, Schoepfstr 41, A 6020 Innsbruck, Austria
    Mol Immunol 38:1087-99. 2002
    ..Here, we attempt to summarize the regulation as well as downstream signaling pathways of PKC and AKT/PKB isotypes, that may act additive in TCR/CD28 induced proliferation and survival of peripheral CD4+ T-lymphocytes...
  33. pmc Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C
    Martin Villalba
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Cell Biol 157:253-63. 2002
    ..These results provide evidence that a nonconventional PI3-K- and Vav-dependent pathway mediates the selective membrane recruitment and, possibly, activation of PKCtheta in T cells...
  34. ncbi Protein kinase C (PKC) alpha and PKC theta are the major PKC isotypes involved in TCR down-regulation
    Marina von Essen
    Institute of Medical Microbiology and Immunology, University of Copenhagen, Denmark
    J Immunol 176:7502-10. 2006
    ..Finally, we found that PKCtheta was mainly implicated in down-regulation of directly engaged TCR, whereas PKCalpha was involved in down-regulation of nonengaged TCR...
  35. ncbi Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation"
    Thomas Gruber
    Department for Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Austria
    Science 312:55; author reply 55. 2006
    ..Reports, 1 April 2005, p. 114) that the Thr-538 phosphorylation of PKC is regulated by T cell receptor activation. Other mechanisms, such as autophosphorylation of Thr-219, might orchestrate the cellular function of PKC in T cells...
  36. pmc Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes
    Nikolaus Thuille
    Department for Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    EMBO J 24:3869-80. 2005
    ..We conclude that autophosphorylation of PKCtheta at Thr-219 plays an important role in the correct targeting and cellular function of PKCtheta upon antigen receptor ligation...
  37. ncbi The MAGUK family protein CARD11 is essential for lymphocyte activation
    Hiromitsu Hara
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Immunity 18:763-75. 2003
    ..Our results show that the same family of molecules are critical regulators of neuronal synapses and immune receptor signaling...
  38. pmc Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation
    Konstantina Nika
    Program of Inflammation, Infectious and Inflammatory Disease Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Mol Cell Biol 26:1806-16. 2006
    ..This represents a novel mechanism for the active immune synapse recruitment and activation of a phosphatase in TCR signaling...
  39. ncbi Loss of PKC-delta alters cardiac metabolism
    Manuel Mayr
    Department of Cardiac and Vascular Sciences, St George s Hospital Medical School, London SW17 0RE, UK
    Am J Physiol Heart Circ Physiol 287:H937-45. 2004
    ..The consequences of these metabolic alterations on sensitivity to myocardial ischemia are further explored in the accompanyingpaper (20)...
  40. ncbi 7,8-Dihydroneopterin induces apoptosis of Jurkat T-lymphocytes via a Bcl-2-sensitive pathway
    Christiane Enzinger
    Institute for Medical Chemistry and Biochemistry, Innsbruck, Austria
    Eur J Cell Biol 81:197-202. 2002
    ..Results suggest that 7,8-dihydroneopterin-induced apoptosis of T-lymphocytes is mediated by a Bcl-2-sensitive pathway...