Manuela Baccarini

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. pmc From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity
    Théodora Niault
    Max F Perutz Laboratories, Center for Molecular Biology, University of Vienna, 1030 Vienna, Austria
    J Cell Biol 187:335-42. 2009
  2. pmc Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development
    Gergana Galabova-Kovacs
    Max F Perutz Laboratories, University of Vienna, 1030 Vienna, Austria
    J Cell Biol 180:947-55. 2008
  3. pmc Raf-1 regulates Rho signaling and cell migration
    Karin Ehrenreiter
    Department of Microbiology and Genetics, Max F Perutz Laboratories, University Departments at the Vienna Biocenter, 1030 Vienna, Austria
    J Cell Biol 168:955-64. 2005
  4. pmc Angiogenic sprouting requires the fine tuning of endothelial cell cohesion by the Raf-1/Rok-α complex
    Reiner Wimmer
    Department of Microbiology and Immunobiology, University of Vienna, Max F Perutz Laboratories, Doktor Bohr Gasse 9, 1030 Vienna, Austria
    Dev Cell 22:158-71. 2012
  5. pmc MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance
    Katarina Zmajkovicova
    Department of Microbiology and Immunobiology, Max F Perutz Laboratories, University of Vienna, Vienna, Austria
    Mol Cell 50:43-55. 2013
  6. pmc Ras and Raf pathways in epidermis development and carcinogenesis
    F Kern
    University of Vienna, Center for Molecular Biology, Max F Perutz Laboratories, Doktor Bohr Gasse 9, A 1030 Vienna, Austria
    Br J Cancer 104:229-34. 2011
  7. pmc EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers
    Eszter Doma
    Max F Perutz Laboratories, Department of Microbiology, Immunology and Genetics, University of Vienna, Doktor Bohr Gasse 9, 1030 Vienna, Austria
    Int J Mol Sci 14:19361-84. 2013
  8. ncbi request reprint Second nature: biological functions of the Raf-1 "kinase"
    Manuela Baccarini
    Max F Perutz Laboratories, Department of Microbiology and Immunobiology, The University of Vienna, Vienna Biocenter, Dr Bohr Gasse 9, 1030 Vienna, Austria
    FEBS Lett 579:3271-7. 2005
  9. pmc Essential role of B-Raf in ERK activation during extraembryonic development
    Gergana Galabova-Kovacs
    Max F Perutz Laboratories, Vienna Biocenter, Dr Bohr Gasse 9, 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 103:1325-30. 2006
  10. ncbi request reprint Raf-1 addiction in Ras-induced skin carcinogenesis
    Karin Ehrenreiter
    Max F Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria
    Cancer Cell 16:149-60. 2009

Collaborators

  • Veronika Jesenberger
  • Oliviero Carugo
  • Dietmar Abraham
  • F Kern
  • Ruth Herbst
  • Christian Baumgartner
  • Klaus Podar
  • Lucia Kucerova
  • Ingrid Walter
  • Andrea Kolbus
  • Maria Sibilia
  • Walter Kolch
  • Gergana Galabova-Kovacs
  • Daniela Piazzolla
  • Katrin Meissl
  • Eszter Doma
  • Karin Ehrenreiter
  • Reiner Wimmer
  • Federica Catalanotti
  • Cristina Rubiolo
  • Dana Matzen
  • Katarina Zmajkovicova
  • Christian Rupp
  • Eric O'Neill
  • Gloria Reyes
  • Théodora S Niault
  • Théodora Niault
  • Dilek Telci
  • Karen L Edelblum
  • David Matallanas
  • Vanishree Velamoor
  • Alcino Silva
  • Izabela Sobczak
  • Thomas Leung
  • Osamu Yamaguchi
  • Markus Kubicek
  • Bettina Riegler
  • Andrea Varga
  • Karina Scherrer
  • Barbara Maier
  • Botond Cseh
  • Matthias Hamerl
  • Tony Ng
  • Ricardo de Matos Simoes
  • Ismail Moarefi
  • Gabriele Maurer
  • Gregory Weitsman
  • Elisabetta A M Verderio
  • Martin J Humphries
  • M Kay Washington
  • Sylvie Robine
  • Tatsuki Koyama
  • Gloria X Reyes
  • Martin Griffin
  • Jürgen Zezula
  • Zhuo Wang
  • Huveyda Basaga
  • D Brent Polk
  • Xiaoling Li
  • J Keith Vass
  • Karen Yee
  • David Romano
  • Tatiana Plyushch
  • Katharina Steinitz
  • Hartmut Beug
  • Adele P Chen
  • Johannes C Huber
  • Junji Takeda
  • J Victor Small
  • Chiharu Sadamitsu
  • Linda Rushworth
  • Yasushi Matsumura
  • Masayuki Taniike
  • Kazuhiko Nishida
  • Michio Asahi
  • Masatsugu Hori
  • Kinya Otsu
  • Kenneth R Chien
  • Atsushi Matsuzawa
  • Yoshiharu Higuchi
  • Tetsuya Watanabe
  • Atsuko Nakai
  • Shungo Hikoso
  • Ikuko Tsujimoto
  • Jun ichi Miyazaki
  • Hidenori Ichijo
  • Shinichi Hirotani
  • Toshihiro Takeda
  • Kazunori Kashiwase
  • Manfred Eulitz

Detail Information

Publications26

  1. pmc From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity
    Théodora Niault
    Max F Perutz Laboratories, Center for Molecular Biology, University of Vienna, 1030 Vienna, Austria
    J Cell Biol 187:335-42. 2009
    ..Downstream of Ras and Rho, the Raf-1-Rok-alpha interaction represents a novel paradigm of pathway cross talk that contributes to tumorigenesis and cell motility...
  2. pmc Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development
    Gergana Galabova-Kovacs
    Max F Perutz Laboratories, University of Vienna, 1030 Vienna, Austria
    J Cell Biol 180:947-55. 2008
    ..These data define B-Raf as the rate-limiting MEK/ERK activator in oligodendrocyte differentiation and myelination and have implications for the design and use of Raf inhibitors...
  3. pmc Raf-1 regulates Rho signaling and cell migration
    Karin Ehrenreiter
    Department of Microbiology and Genetics, Max F Perutz Laboratories, University Departments at the Vienna Biocenter, 1030 Vienna, Austria
    J Cell Biol 168:955-64. 2005
    ..Thus, Raf-1 plays an essential, kinase-independent function as a spatial regulator of Rho downstream signaling during migration...
  4. pmc Angiogenic sprouting requires the fine tuning of endothelial cell cohesion by the Raf-1/Rok-α complex
    Reiner Wimmer
    Department of Microbiology and Immunobiology, University of Vienna, Max F Perutz Laboratories, Doktor Bohr Gasse 9, 1030 Vienna, Austria
    Dev Cell 22:158-71. 2012
    ..This Raf-1-mediated fine tuning of Rok-α signaling allows the activation of junctional myosin and the timely maturation of AJ essential for maintaining cell cohesion during sprouting angiogenesis...
  5. pmc MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance
    Katarina Zmajkovicova
    Department of Microbiology and Immunobiology, Max F Perutz Laboratories, University of Vienna, Vienna, Austria
    Mol Cell 50:43-55. 2013
    ....
  6. pmc Ras and Raf pathways in epidermis development and carcinogenesis
    F Kern
    University of Vienna, Center for Molecular Biology, Max F Perutz Laboratories, Doktor Bohr Gasse 9, A 1030 Vienna, Austria
    Br J Cancer 104:229-34. 2011
    ..In particular, we will focus on the recently established role of Raf-1 as the decisive element that, by restraining keratinocyte differentiation, allows the development and maintenance of Ras-driven tumours...
  7. pmc EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers
    Eszter Doma
    Max F Perutz Laboratories, Department of Microbiology, Immunology and Genetics, University of Vienna, Doktor Bohr Gasse 9, 1030 Vienna, Austria
    Int J Mol Sci 14:19361-84. 2013
    ..In this review, we briefly discuss the properties of the epidermal stem cells and review the role of EGFR-Ras-Raf signaling in keratinocyte stem cells during homeostatic and pathological conditions. ..
  8. ncbi request reprint Second nature: biological functions of the Raf-1 "kinase"
    Manuela Baccarini
    Max F Perutz Laboratories, Department of Microbiology and Immunobiology, The University of Vienna, Vienna Biocenter, Dr Bohr Gasse 9, 1030 Vienna, Austria
    FEBS Lett 579:3271-7. 2005
    ..Do they still hold surprises? Recent gene targeting studies indicate that they do. This review focuses on the regulation and biology of the best-studied Raf isoform, Raf-1, in the context of its kinase-independent functions...
  9. pmc Essential role of B-Raf in ERK activation during extraembryonic development
    Gergana Galabova-Kovacs
    Max F Perutz Laboratories, Vienna Biocenter, Dr Bohr Gasse 9, 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 103:1325-30. 2006
    ..The data demonstrate that B-Raf plays a nonredundant role in ERK activation during extraembyronic mammalian development in vivo...
  10. ncbi request reprint Raf-1 addiction in Ras-induced skin carcinogenesis
    Karin Ehrenreiter
    Max F Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria
    Cancer Cell 16:149-60. 2009
    ..These data link the Raf-1:Rok-alpha complex to STAT3/Myc activation and delineate a pathway crucial for cell fate decision in Ras-induced tumorigenesis...
  11. ncbi request reprint ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts
    Gergana Galabova-Kovacs
    Max F Perutz Laboratories, University of Vienna, Vienna, Austria
    Cell Cycle 5:1514-8. 2006
    ..Here, we discuss some of the surprises yielded by the analysis of the role of B-Raf and Raf-1 and of their downstream effectors...
  12. ncbi request reprint A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation
    Cristina Rubiolo
    Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria
    Blood 108:152-9. 2006
    ..These results identify Raf-1 and Fas as the key molecules whose expression finely tunes erythropoiesis and the extent of ERK activation as the switch that tips the balance between them...
  13. ncbi request reprint A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal
    Federica Catalanotti
    Max F Perutz Laboratories, University of Vienna, Doktor Bohr Gasse 9, 1030 Vienna, Austria
    Nat Struct Mol Biol 16:294-303. 2009
    ..Our data establish Mek1 as the crucial modulator of Mek and Erk signaling and have potential implications for the role of Mek1 and Mek2 in tumorigenesis...
  14. ncbi request reprint Skin tumorigenesis stimulated by Raf inhibitors relies upon Raf functions that are dependent and independent of ERK
    Eszter Doma
    Authors Affiliation Department of Microbiology, Immunobiology and Genetics, University of Vienna, Max F Perutz Laboratories, Vienna, Austria
    Cancer Res 73:6926-37. 2013
    ..Taken together, our findings suggest that combination therapies targeting ERK-dependent and -independent functions of Raf may be more efficient but also safer for cancer treatment...
  15. ncbi request reprint Dephosphorylation of Ser-259 regulates Raf-1 membrane association
    Markus Kubicek
    Department of Cell Biology and Microbiology, Institute of Microbiology and Genetics, Vienna Biocenter, Dr Bohr Gasse 9, 1030 Vienna, Austria
    J Biol Chem 277:7913-9. 2002
    ....
  16. doi request reprint Deciphering signaling pathways in vivo: the Ras/Raf/MEK/ERK cascade
    Gergana Galabova-Kovacs
    Max F Perutz Laboratories, Center for Molecular Biology of the University of Vienna, Vienna, Austria
    Methods Mol Biol 661:421-31. 2010
    ....
  17. doi request reprint Targets of Raf in tumorigenesis
    Théodora S Niault
    Center for Molecular Biology, Max F Perutz Laboratories, University of Vienna, Doktor Bohr Gasse 9, 1030 Vienna, Austria
    Carcinogenesis 31:1165-74. 2010
    ..This review focuses on old and new targets of Raf in tumorigenesis...
  18. pmc Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling
    Daniela Piazzolla
    Max F Perutz Laboratories, Department of Microbiology and Immunobiology, Campus Vienna Biocenter, 1030 Vienna, Austria
    J Cell Biol 171:1013-22. 2005
    ..Thus, Raf-1 has an essential function in regulating Fas expression and setting the threshold of Fas sensitivity during embryonic life...
  19. pmc Raf-1 antagonizes erythroid differentiation by restraining caspase activation
    Andrea Kolbus
    Research Institute of Molecular Pathology, Institute of Microbiology and Genetics, Vienna Biocenter, 1030 Vienna, Austria
    J Exp Med 196:1347-53. 2002
    ..These results reveal an essential function of Raf-1 in erythropoiesis and demonstrate that the ability of Raf-1 to restrict caspase activation is biologically relevant in a context distinct from apoptosis...
  20. doi request reprint Partner exchange: protein-protein interactions in the Raf pathway
    Reiner Wimmer
    University of Vienna, Center for Molecular Biology, Max F Perutz Laboratories, Doktor Bohr Gasse 9, A 1030 Vienna, Austria
    Trends Biochem Sci 35:660-8. 2010
    ..Given the roles of these interactions in tumorigenesis, their study will provide new opportunities for molecule-based therapies that target the pathway...
  21. ncbi request reprint An old kinase on a new path: Raf and apoptosis
    Manuela Baccarini
    Institute of Microbiology and Genetics, Vienna Biocenter, Dr Bohr Gasse 9, 1030 Vienna, Austria
    Cell Death Differ 9:783-5. 2002
  22. pmc Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis
    Osamu Yamaguchi
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Clin Invest 114:937-43. 2004
    ..The ablation of ASK1 rescued heart dysfunction and dilatation as well as cardiac fibrosis. These results indicate that Raf-1 promotes cardiomyocyte survival through a MEK/ERK-independent mechanism...
  23. ncbi request reprint Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1
    Eric O'Neill
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Science 306:2267-70. 2004
    ..Conversely, depletion of Raf-1 from Raf-1+/+ mouse or human cells led to MST2 activation and apoptosis. The concomitant depletion of both Raf-1 and MST2 prevented apoptosis...
  24. pmc Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB
    Karen L Edelblum
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA
    Gastroenterology 135:539-51. 2008
    ..This study addresses the role of Raf in epithelial cell survival in response to dextran sulfate sodium (DSS)-induced injury and inflammation...
  25. pmc RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein
    David Matallanas
    Signaling and Proteomics Laboratory, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Mol Cell 27:962-75. 2007
    ..Our results describe an MST2-dependent effector pathway for RASSF1A proapoptotic signaling and indicate that silencing of RASSF1A in tumors removes a proapoptotic signal emanating from p73...
  26. pmc Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling
    Dilek Telci
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom
    J Biol Chem 283:20937-47. 2008
    ....