Sabine Strehl

Summary

Country: Austria

Publications

  1. Denk D, Bradtke J, König M, Strehl S. PAX5 fusion genes in t(7;9)(q11.2;p13) leukemia: a case report and review of the literature. Mol Cytogenet. 2014;7:13 pubmed publisher
    ..2;p13) or der(9)t(7;9)(q11.2;p13), which cannot be distinguished cytogenetically and whose discrimination requires molecular analysis. ..
  2. Husa A, Strobl M, Strajeriu A, Wieser M, Strehl S, Fortschegger K. Generation of CD34 fluorescent reporter human induced pluripotent stem cells for monitoring hematopoietic differentiation. Stem Cells Dev. 2018;: pubmed publisher
    ..In summary, we have generated functional CD34 GFP reporter hiPSCs, which not only permit label free separation of HSPCs but also tracing of the emergence and fate of CD34+ progenitors at the single cell level. ..
  3. Strehl S, Nebral K, König M, Harbott J, Strobl H, Ratei R, et al. ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations. Clin Cancer Res. 2008;14:977-83 pubmed publisher
    ..The ETV6-NCOA2 fusion may define a novel subgroup of acute leukemia with T-lymphoid and myeloid features, which is associated with a high prevalence of NOTCH1 mutations. ..
  4. Nebral K, Denk D, Attarbaschi A, Konig M, Mann G, Haas O, et al. Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia. Leukemia. 2009;23:134-43 pubmed publisher
    ..Our data show that these not only comprise transcription factors but also structural proteins and genes involved in signal transduction, which at least in part have not been implicated in tumorigenesis. ..
  5. Fortschegger K, Anderl S, Denk D, Strehl S. Functional heterogeneity of PAX5 chimeras reveals insight for leukemia development. Mol Cancer Res. 2014;12:595-606 pubmed publisher
    ..This comparative study of multiple PAX5 fusion proteins demonstrates both common and unique properties, which likely dictate their function and impact on leukemia development. ..