Herbert Schöchl

Summary

Country: Austria

Publications

  1. doi request reprint [Perioperative coagulation management in multiple trauma patients based on viscoelastic test results]
    H Schöchl
    AUVA Unfallkrankenhaus, Akademisches Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität Salzburg, Franz Rehrl Platz 5, 5020, Salzburg, Osterreich
    Unfallchirurg 117:111-7. 2014
  2. doi request reprint The role of fibrinogen in trauma-induced coagulopathy
    C J Schlimp
    Herbert Schöchl, Assoc Prof, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Centre Vienna, Tel 43 1 33 11 04 62, Fax 43 1 33 11 04 60, E mail
    Hamostaseologie 34:29-39. 2014
  3. pmc Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/- fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study
    Christoph J Schlimp
    Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, AUVA Research Centre, Vienna, Austria
    Scand J Trauma Resusc Emerg Med 21:74. 2013
  4. doi request reprint Management of hemorrhage in trauma
    Herbert Schöchl
    Department of Anaesthesiology and Intensive Care Medicine, AUVA Trauma Centre, Salzburg, Austria
    J Cardiothorac Vasc Anesth 27:S35-43. 2013
  5. ncbi request reprint Potential value of pharmacological protocols in trauma
    Herbert Schöchl
    Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Salzburg, Austria
    Curr Opin Anaesthesiol 26:221-9. 2013
  6. doi request reprint Hyperfibrinolysis is common in out-of-hospital cardiac arrest: results from a prospective observational thromboelastometry study
    H Schöchl
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Resuscitation 84:454-9. 2013
  7. pmc Early and individualized goal-directed therapy for trauma-induced coagulopathy
    Herbert Schöchl
    Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Vienna, Austria
    Scand J Trauma Resusc Emerg Med 20:15. 2012
  8. pmc In vitro impairment of whole blood coagulation and platelet function by hypertonic saline hydroxyethyl starch
    Alexander A Hanke
    Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Germany
    Scand J Trauma Resusc Emerg Med 19:12. 2011
  9. pmc Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate
    Herbert Schöchl
    Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Dr Franz Rehrl Platz 5, Salzburg, Austria
    Crit Care 14:R55. 2010
  10. ncbi request reprint [Coagulation management in major trauma]
    H Schöchl
    Abteilung für Anästhesiologie und Intensivmedizin, AUVA Unfallkrankenhaus Salzburg, Dr Franz Rehrl Platz 5, 5020 Salzburg, Austria
    Hamostaseologie 26:S52-5. 2006

Collaborators

Detail Information

Publications32

  1. doi request reprint [Perioperative coagulation management in multiple trauma patients based on viscoelastic test results]
    H Schöchl
    AUVA Unfallkrankenhaus, Akademisches Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität Salzburg, Franz Rehrl Platz 5, 5020, Salzburg, Osterreich
    Unfallchirurg 117:111-7. 2014
    ..Thrombin generation is initially less compromised and can be improved by the administration of plasma, prothrombin complex concentrate, or with restrictiveness by recombinant activated factor VII. ..
  2. doi request reprint The role of fibrinogen in trauma-induced coagulopathy
    C J Schlimp
    Herbert Schöchl, Assoc Prof, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Centre Vienna, Tel 43 1 33 11 04 62, Fax 43 1 33 11 04 60, E mail
    Hamostaseologie 34:29-39. 2014
    ..Recent guidelines recommend maintaining plasma fibrinogen concentration at 1.5-2 g/l in coagulopathic patients. It has been shown that early fibrinogen substitution is associated with improved outcome. ..
  3. pmc Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/- fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study
    Christoph J Schlimp
    Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, AUVA Research Centre, Vienna, Austria
    Scand J Trauma Resusc Emerg Med 21:74. 2013
    ..Low plasma fibrinogen concentration is a predictor of poor outcome in major trauma patients. The role of fibrinogen concentrate for rapidly increasing fibrinogen plasma levels in severe trauma is not well defined...
  4. doi request reprint Management of hemorrhage in trauma
    Herbert Schöchl
    Department of Anaesthesiology and Intensive Care Medicine, AUVA Trauma Centre, Salzburg, Austria
    J Cardiothorac Vasc Anesth 27:S35-43. 2013
    ..However, there is increased awareness that coagulation factor concentrate could be beneficial in the treatment of trauma-induced coagulopathy. ..
  5. ncbi request reprint Potential value of pharmacological protocols in trauma
    Herbert Schöchl
    Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Salzburg, Austria
    Curr Opin Anaesthesiol 26:221-9. 2013
    ..We summarize the concept of individualized, goal-directed coagulation management using coagulation factor concentrates...
  6. doi request reprint Hyperfibrinolysis is common in out-of-hospital cardiac arrest: results from a prospective observational thromboelastometry study
    H Schöchl
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Resuscitation 84:454-9. 2013
    ..Until now, no studies have used whole-blood viscoelastic tests to characterize coagulation and the impact of fibrinolysis in out-of-hospital cardiac arrest (OHCA)...
  7. pmc Early and individualized goal-directed therapy for trauma-induced coagulopathy
    Herbert Schöchl
    Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Vienna, Austria
    Scand J Trauma Resusc Emerg Med 20:15. 2012
    ..The concept of early, individualized and goal-directed therapy is explored in this review and the AUVA Trauma Hospital algorithm for managing trauma-induced coagulopathy is presented...
  8. pmc In vitro impairment of whole blood coagulation and platelet function by hypertonic saline hydroxyethyl starch
    Alexander A Hanke
    Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Germany
    Scand J Trauma Resusc Emerg Med 19:12. 2011
    ..Furthermore 7.2% hypertonic saline, 6% hydroxyethylstarch (as ingredients of HH), and 0.9% saline solution (as control) were tested in comparable dilutions to estimate specific component effects of HH on coagulation...
  9. pmc Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate
    Herbert Schöchl
    Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Dr Franz Rehrl Platz 5, Salzburg, Austria
    Crit Care 14:R55. 2010
    ..The appropriate strategy for trauma-induced coagulopathy management is under debate. We report the treatment of major trauma using mainly coagulation factor concentrates...
  10. ncbi request reprint [Coagulation management in major trauma]
    H Schöchl
    Abteilung für Anästhesiologie und Intensivmedizin, AUVA Unfallkrankenhaus Salzburg, Dr Franz Rehrl Platz 5, 5020 Salzburg, Austria
    Hamostaseologie 26:S52-5. 2006
    ..Raising inhibitors of coagulation (antithrombin) simultaneously to antihaemorragic therapy is being discussed, but seems not reasonable in the acute phase of a life-threatening haemorrage...
  11. doi request reprint Thromboelastometric (ROTEM) findings in patients suffering from isolated severe traumatic brain injury
    Herbert Schöchl
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and AUVA Research Centre, Vienna, Austria
    J Neurotrauma 28:2033-41. 2011
    ..ROTEM testing appeared to offer an early signal of severe life-threatening sTBI. Further studies are warranted to confirm these results and to investigate the role of ROTEM in guiding coagulation therapy...
  12. doi request reprint The effectiveness of different functional fibrinogen polymerization assays in eliminating platelet contribution to clot strength in thromboelastometry
    Christoph J Schlimp
    From the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and AUVA Research Centre, Vienna Department of Anesthesiology and Intensive Care, Salzburger Landeskliniken SALK, Salzburg, Austria CSL Behring, Marburg, Germany Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy and Department of Anesthesiology and Intensive Care, AUVA Trauma Hospital of Salzburg, Salzburg, Austria
    Anesth Analg 118:269-76. 2014
    ..Incomplete platelet inhibition influences maximum clot firmness (MCF) of FFPAs. We compared the ability of existing and newly developed FFPAs to eliminate the platelet contribution to clot strength...
  13. doi request reprint FIBTEM PLUS provides an improved thromboelastometry test for measurement of fibrin-based clot quality in cardiac surgery patients
    Cristina Solomon
    From the Department of Anesthesiology and Intensive Care, Salzburger Landeskliniken SALK, Salzburg, Austria CSL Behring, Marburg, Germany Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy Haemostasis Research, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and AUVA Research Centre, Vienna, Austria Department of Anesthesiology and Intensive Care, AUVA Trauma Hospital of Salzburg, Salzburg, Austria and Laboratory Medicine, Unilabs Coagulation Laboratory, Zurich, Switzerland
    Anesth Analg 117:1054-62. 2013
    ..Inhibition of platelet function is a necessary precondition for these tests to work. We investigated a novel test for measuring fibrin-based clotting, FIBTEM PLUS, in cardiac surgery and compared it with FF and FIBTEM...
  14. ncbi request reprint Recovery of fibrinogen concentrate after intraosseous application is equivalent to the intravenous route in a porcine model of hemodilution
    Christoph J Schlimp
    From the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology C J S, C S, C K, J Z, W O, H R, H S, AUVA Research Centre, Vienna and Bernhard Gottlieb University of Dentistry S N, Vienna and Department of Traumatology S N, Medical University of Vienna and AUVA Trauma Hospital of Salzburg H S, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria and CSL Behring C S, Marburg, Germany
    J Trauma Acute Care Surg 76:1235-42. 2014
    ..Studies of intraosseous infusion of coagulation factor concentrates are limited. We investigated in vivo recovery following intraosseous administration of fibrinogen concentrate and compared the results with intravenous administration...
  15. ncbi request reprint A comparison of fibrinogen measurement methods with fibrin clot elasticity assessed by thromboelastometry, before and after administration of fibrinogen concentrate in cardiac surgery patients
    Cristina Solomon
    Department of Anaesthesiology and Intensive Care and the Institute of Medical and Chemical Laboratory Diagnostics, Salzburger Landeskliniken SALK, Salzburg, Austria
    Transfusion 51:1695-706. 2011
    ....
  16. pmc Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy
    Herbert Schöchl
    Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Crit Care 15:R83. 2011
    ....
  17. ncbi request reprint Severe pediatric blunt trauma--successful ROTEM-guided hemostatic therapy with fibrinogen concentrate and no administration of fresh frozen plasma or platelets
    Bernhard Ziegler
    Department of Anaesthesiology, Perioperative Medicine and General Intensive Care, SALK University Hospital, Salzburg, Austria
    Clin Appl Thromb Hemost 19:453-9. 2013
    ..This case shows the potential for hemostatic treatment with coagulation factor concentrates to be applied to pediatric trauma. ..
  18. pmc Effect of haematocrit on fibrin-based clot firmness in the FIBTEM test
    Cristina Solomon
    Department of Anaesthesiology and Intensive Care, Salzburger Landeskliniken SALK, Salzburg, Austria
    Blood Transfus 11:412-8. 2013
    ..We investigated the relationships between FIBTEM maximum clot firmness (MCF), whole blood fibrinogen concentration and plasma fibrinogen concentration to determine the impact of haematocrit on these parameters during cardiac surgery...
  19. doi request reprint Thromboelastometric maximum clot firmness in platelet-free plasma is influenced by the assay used
    Christoph J Schlimp
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Centre, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Anesth Analg 117:23-9. 2013
    ..There are no reports on whether components of the FFPAs have any effects on fibrin polymerization, aside from the effects of platelet inhibition...
  20. doi request reprint High-dose fibrinogen concentrate for haemostatic therapy of a major trauma patient with recent clopidogrel and aspirin intake
    Herbert Schöchl
    AUVA Research Centre for Traumatology, Vienna, Austria
    Scand J Clin Lab Invest 70:453-7. 2010
    ..We report on a severely injured trauma patient who suffered a high velocity motorcycle accident. The patient was receiving dual antiplatelet therapy with aspirin and clopidogrel...
  21. doi request reprint Platelet function following trauma. A multiple electrode aggregometry study
    Cristina Solomon
    Department of Anaesthesiology and Intensive Care Medicine, AUVA Trauma Centre, Salzburg, Austria
    Thromb Haemost 106:322-30. 2011
    ..Further studies are warranted to confirm these results and investigate the role of platelet function in trauma haemostatic management...
  22. doi request reprint Comparison of whole blood fibrin-based clot tests in thrombelastography and thromboelastometry
    Cristina Solomon
    Department of Anaesthesiology and Intensive Care, Salzburger Landeskliniken SALK, 48 Müllner Hauptstrasse, 5020 Salzburg, Austria
    Anesth Analg 114:721-30. 2012
    ..Our objective was to compare clot firmness parameters through standard (FF on a thrombelastography device [TEG®]; FIBTEM on a thromboelastometry device [ROTEM®]) and crossover (FF on ROTEM®; FIBTEM on TEG®) analyses...
  23. doi request reprint Similarities in thromboelastometric (ROTEM®) findings between humans and baboons
    Herbert Schöchl
    Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Vienna, Austria
    Thromb Res 130:e107-12. 2012
    ..Interest in visco-elastic testing in different clinical scenarios has increased but few data are available on thromboelastometric findings in primates...
  24. doi request reprint Haemostatic therapy in coronary artery bypass graft patients with decreased platelet function: comparison of fibrinogen concentrate with allogeneic blood products
    Cristina Solomon
    Department of Anaesthesiology and Intensive Care Medicine, SALK University Hospital, Salzburg, Austria
    Scand J Clin Lab Invest 72:121-8. 2012
    ..We compared patient outcomes following fibrinogen concentrate administration or transfusion of allogeneics in CABG patients with decreased platelet function...
  25. pmc Thromboelastometry (TEM) findings in disseminated intravascular coagulation in a pig model of endotoxinemia
    Herbert Schöchl
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Mol Med 17:266-72. 2011
    ..Further investigations are necessary to establish the clinical relevance of these findings...
  26. doi request reprint Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry
    Herbert Schöchl
    Department of Anesthesiology and Intensive Care, AUVA Trauma Hospital, Salzburg, Austria
    J Trauma 67:125-31. 2009
    ..Furthermore, routine laboratory based and the rotational thrombelastometry analyzer (ROTEM)-derived variables were also correlated with survival...
  27. pmc The effect of fibrinogen concentrate and factor XIII on thromboelastometry in 33% diluted blood with albumin, gelatine, hydroxyethyl starch or saline in vitro
    Christoph Johannes Schlimp
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Workers Compensation Board AUVA Research Centre, Vienna, Austria
    Blood Transfus 11:510-7. 2013
    ..Fluid replacement results in dilutional coagulopathy. We investigated the potential role of fibrinogen, factor XIII and a combination of both to reverse dilutional coagulopathy, assessed by thromboelastometry (ROTEM(®))...
  28. doi request reprint Xylazine-/diazepam-ketamine and isoflurane differentially affect hemodynamics and organ injury under hemorrhagic/traumatic shock and resuscitation in rats
    Soheyl Bahrami
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Research Center of AUVA, Vienna, Austria
    Shock 35:573-8. 2011
    ..Anesthetics differentially affect HTS-induced hemodynamic alterations and organ injury. Thus, when interpreting data from HTS models, the individual effect of anesthetics should be considered...
  29. ncbi request reprint Tranexamic acid, fibrinogen concentrate, and prothrombin complex concentrate: data to support prehospital use?
    Herbert Schöchl
    AUVA Trauma Centre Salzburg, Academic Teaching Hospital of the Paracelsus Medical University Salzburg, Salzburg and Ludwig Boltzmann Institute for Experimental and Clinical and Traumatology, AUVA Research Centre, Vienna, Austria and Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Cologne, Germany
    Shock 41:44-6. 2014
    ..Beyond emergency reversal of vitamin K antagonists, safety data on prothrombin complex concentrate use in trauma are lacking. ..
  30. doi request reprint Vasopressin for hemorrhagic shock management: revisiting the potential value in civilian and combat casualty care
    Wolfgang G Voelckel
    Department of Anesthesiology and Critical Care Medicine, AUVA Trauma Center Salzburg, Salzburg, Austria
    J Trauma 69:S69-74. 2010
    ..However, the significance of AVP as a rescue medication for life-threatening hemorrhage has yet to be proven...
  31. ncbi request reprint An update on the coagulopathy of trauma
    Marc Maegele
    Department of Traumatology, Orthopedic Surgery and Sportsmedicine, Cologne Merheim Medical Center, and Institute for Research in Operative Medicine, University of Witten Herdecke, Cologne, Germany Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna and Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Salzburg, Austria and Department of Surgery, University of California San Francisco, San Francisco, California
    Shock 41:21-5. 2014
    ..The present article summarizes an update on the principal mechanisms and triggers of the coagulopathy of trauma including traumatic brain injury. ..
  32. doi request reprint Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate
    H Schöchl
    Department of Anaesthesiology and Critical Care Medicine, AUVA Trauma Centre, Salzburg, Austria
    Anaesthesia 65:199-203. 2010
    ..This case shows the potential success of treatment using both fibrinogen concentrate and prothrombin complex concentrate, not only in restoring haemostasis but also in minimising requirement for transfusion of allogeneic blood products...