Barbara Kofler

Summary

Affiliation: Paracelsus Private Medical University
Country: Austria

Publications

  1. pmc Mitochondrial haplogroups and control region polymorphisms in age-related macular degeneration: a case-control study
    Edith E Mueller
    Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
    PLoS ONE 7:e30874. 2012
  2. pmc Functional differences between mitochondrial haplogroup T and haplogroup H in HEK293 cybrid cells
    Edith E Mueller
    Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
    PLoS ONE 7:e52367. 2012
  3. pmc Mitochondrial haplogroups, control region polymorphisms and malignant melanoma: a study in middle European Caucasians
    Sabine Ebner
    Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
    PLoS ONE 6:e27192. 2011
  4. pmc The mitochondrial T16189C polymorphism is associated with coronary artery disease in Middle European populations
    Edith E Mueller
    Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
    PLoS ONE 6:e16455. 2011
  5. pmc Mitochondrial DNA mutations in renal cell carcinomas revealed no general impact on energy metabolism
    D Meierhofer
    Department of Paediatrics, Paracelsus Private Medical University Salzburg, Muellner Hauptstr 48, A 5020 Salzburg, Austria
    Br J Cancer 94:268-74. 2006
  6. pmc Lack of complex I is associated with oncocytic thyroid tumours
    F A Zimmermann
    Department of Paediatrics, University Hospital Salzburg, Paracelsus Medical University, Muellner Hauptstrasse 48, A 5020 Salzburg, Austria
    Br J Cancer 100:1434-7. 2009
  7. pmc Mitochondrial DNA haplogroup T is associated with coronary artery disease and diabetic retinopathy: a case control study
    Barbara Kofler
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
    BMC Med Genet 10:35. 2009
  8. pmc Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma
    Rene G Feichtinger
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
    BMC Cancer 10:149. 2010
  9. ncbi request reprint Galanin and galanin receptors in human gliomas
    Alexandra Berger
    Department of Pediatrics, General Hospital, Muellner Hauptstrasse 48, 5020, Salzburg, Austria
    Acta Neuropathol 105:555-60. 2003
  10. ncbi request reprint Loss of mitochondria in ganglioneuromas
    Rene G Feichtinger
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
    Front Biosci (Elite Ed) 3:179-86. 2011

Collaborators

Detail Information

Publications42

  1. pmc Mitochondrial haplogroups and control region polymorphisms in age-related macular degeneration: a case-control study
    Edith E Mueller
    Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
    PLoS ONE 7:e30874. 2012
    ..Previous studies from Australia and the United States detected associations of mitochondrial haplogroups with AMD. The aim of the present study was to test these associations in Middle European Caucasians...
  2. pmc Functional differences between mitochondrial haplogroup T and haplogroup H in HEK293 cybrid cells
    Edith E Mueller
    Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
    PLoS ONE 7:e52367. 2012
    ..However, justifications for the assumption that haplogroups are functionally distinct are rare. Therefore, we attempted to compare differences in mitochondrial function between haplogroup H and T cybrids...
  3. pmc Mitochondrial haplogroups, control region polymorphisms and malignant melanoma: a study in middle European Caucasians
    Sabine Ebner
    Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
    PLoS ONE 6:e27192. 2011
    ....
  4. pmc The mitochondrial T16189C polymorphism is associated with coronary artery disease in Middle European populations
    Edith E Mueller
    Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
    PLoS ONE 6:e16455. 2011
    ....
  5. pmc Mitochondrial DNA mutations in renal cell carcinomas revealed no general impact on energy metabolism
    D Meierhofer
    Department of Paediatrics, Paracelsus Private Medical University Salzburg, Muellner Hauptstr 48, A 5020 Salzburg, Austria
    Br J Cancer 94:268-74. 2006
    ....
  6. pmc Lack of complex I is associated with oncocytic thyroid tumours
    F A Zimmermann
    Department of Paediatrics, University Hospital Salzburg, Paracelsus Medical University, Muellner Hauptstrasse 48, A 5020 Salzburg, Austria
    Br J Cancer 100:1434-7. 2009
    ..A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrounding non-cancerous tissue...
  7. pmc Mitochondrial DNA haplogroup T is associated with coronary artery disease and diabetic retinopathy: a case control study
    Barbara Kofler
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
    BMC Med Genet 10:35. 2009
    ..We therefore examined the association between mtDNA haplogroups and coronary artery disease (CAD) as well as diabetic retinopathy...
  8. pmc Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma
    Rene G Feichtinger
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
    BMC Cancer 10:149. 2010
    ..Succinate dehydrogenase (SDH) has been associated with carcinogenesis in pheochromocytoma and paraganglioma. In the present study we investigated components of the oxidative phosphorylation system in human neuroblastoma tissue samples...
  9. ncbi request reprint Galanin and galanin receptors in human gliomas
    Alexandra Berger
    Department of Pediatrics, General Hospital, Muellner Hauptstrasse 48, 5020, Salzburg, Austria
    Acta Neuropathol 105:555-60. 2003
    ..No correlation could be found between GAL-LI, the level of GAL binding and proliferative activity as determined by immunostaining with the cell proliferation marker Ki-67...
  10. ncbi request reprint Loss of mitochondria in ganglioneuromas
    Rene G Feichtinger
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
    Front Biosci (Elite Ed) 3:179-86. 2011
    ..Knowledge of the mechanism by which tumor cells achieve the Warburg effect will provide a starting point for functional studies aimed at restoring aerobic energy metabolism as a potential new therapeutic strategy to treat malignancies...
  11. pmc Alarin is a vasoactive peptide
    Radmila Santic
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria
    Proc Natl Acad Sci U S A 104:10217-22. 2007
    ..Alarin adds another facet to the surprisingly high-functional redundancy of the galanin family of peptides...
  12. ncbi request reprint Respiratory chain complex I is a mitochondrial tumor suppressor of oncocytic tumors
    Franz A Zimmermann
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
    Front Biosci (Elite Ed) 3:315-25. 2011
    ..Therefore, complex I of the respiratory chain has to be added to the growing list of mitochondrial tumor suppressors...
  13. ncbi request reprint Alterations of respiratory chain complexes in sporadic pheochromocytoma
    Rene G Feichtinger
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
    Front Biosci (Elite Ed) 3:194-200. 2011
    ..Strikingly, one of the nine PCs showed specific loss of complex I and a compensatory up-regulation of complexes II-V, which is a phenotype usually characteristic of oncocytic tumors...
  14. ncbi request reprint Multiplex primer extension analysis for rapid detection of major European mitochondrial haplogroups
    Martina Wiesbauer
    Department of Paediatrics, Paracelsus Private Medical University Salzburg, Salzburg, Austria
    Electrophoresis 27:3864-8. 2006
    ..Our method may be suitable for mitochondrial genotyping of samples from large-scale epidemiology studies and for identifying markers of genetic susceptibility...
  15. ncbi request reprint Galanin and galanin receptors in human cancers
    Alexandra Berger
    Department of Pediatrics, Paracelsus Private Medical University, Salzburg, Muellner Hauptstrasse 48, A 5020 Salzburg, Austria
    Neuropeptides 39:353-9. 2005
    ..The co-expression of galanin and its receptors supports a role for galanin in tumor cell pathology via autocrine/paracrine mechanisms...
  16. doi request reprint Reduction of nuclear encoded enzymes of mitochondrial energy metabolism in cells devoid of mitochondrial DNA
    Edith E Mueller
    Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Salzburg, Austria
    Biochem Biophys Res Commun 417:1052-7. 2012
    ..This finding indicates the existence of a feedback mechanism in ρ(0) cells that downregulates the expression of entirely nuclear encoded components of mitochondrial energy metabolism...
  17. doi request reprint Evidence that the modulatory effect of galanin on inflammatory edema formation is mediated by the galanin receptor 3 in the murine microvasculature
    Sabine M Schmidhuber
    Department of Pediatrics, Paracelsus Medical University Salzburg, Muellner Hauptstrasse 48, 5020, Salzburg, Austria
    J Mol Neurosci 37:177-81. 2009
    ..Thus, we were able to show that SNAP 37889 selectively antagonized galanin in the periphery and suggest that GalR3 is the receptor subtype mediating galanin's effects on the dermal microvasculature...
  18. doi request reprint Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma
    Johannes A Mayr
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
    Clin Cancer Res 14:2270-5. 2008
    ....
  19. ncbi request reprint Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma
    David Meierhofer
    Department of Pediatrics, Paracelsus Private Medical University Salzburg, Muellner Hauptstr 48, A 5020 Salzburg, Austria
    Carcinogenesis 25:1005-10. 2004
    ....
  20. ncbi request reprint Rapid screening of the entire mitochondrial DNA for low-level heteroplasmic mutations
    David Meierhofer
    Department of Paediatrics, Paracelsus Private Medical University Salzburg, Muellner Hauptstr 48, A 5020 Salzburg, Austria
    Mitochondrion 5:282-96. 2005
    ..In order to demonstrate that the method has diagnostic value, we analyzed and confirmed known mtDNA mutations in patient samples...
  21. ncbi request reprint The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease
    Roland Lang
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria
    Pharmacol Ther 115:177-207. 2007
    ....
  22. ncbi request reprint Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene
    Radmila Santic
    Department of Pediatrics, Paracelsus Private Medical University Salzburg, A 5020 Salzburg, Austria
    J Mol Neurosci 29:145-52. 2006
    ..Our findings indicate that alarin expression is a feature of ganglionic differentiation in neuroblastic tumor tissues...
  23. pmc Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians
    Edith E Mueller
    Department of Pediatrics, Paracelsus Medical University Salzburg, Salzburg, Austria
    PLoS ONE 4:e6370. 2009
    ....
  24. ncbi request reprint Galanin receptor subtype GalR2 mediates apoptosis in SH-SY5Y neuroblastoma cells
    Alexandra Berger
    Department of Pediatrics, General Hospital Salzburg, Muellner Hauptstrasse 48, A 5020 Salzburg, Austria
    Endocrinology 145:500-7. 2004
    ....
  25. ncbi request reprint Severe depletion of mitochondrial DNA in spinal muscular atrophy
    Alexandra Berger
    Department of Pediatrics, General Hospital Salzburg, Muellner Hauptstrasse 48, Austria
    Acta Neuropathol 105:245-51. 2003
    ....
  26. ncbi request reprint Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists
    Roland Lang
    Department of Pediatrics, Paracelsus Private Medical University Salzburg, Muellner Hauptstrasse 48, 5020 Salzburg, Austria
    Neuropeptides 39:179-84. 2005
    ..Furthermore it might be a useful tool to study the affinity of GALP to galanin receptors and to search for specific GALP receptors...
  27. ncbi request reprint The interobserver reliability in diagnosing osseous lesions after first-time anterior shoulder dislocation comparing plain radiographs with computed tomography scans
    Alexander Auffarth
    Department of Traumatology and Sports Injuries, Paracelsus Medical University, Salzburg, Austria Electronic address
    J Shoulder Elbow Surg 22:1507-13. 2013
    ..We evaluated the interobserver reliability of radiologic diagnoses after first-time traumatic shoulder dislocation based on radiographs and computed tomography (CT) images...
  28. ncbi request reprint Heterogeneity of mitochondrial energy metabolism in classical triphasic Wilms' tumor
    Rene G Feichtinger
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
    Front Biosci (Elite Ed) 3:187-93. 2011
    ..Interestingly, our studies show that, even within a specific tumor entity, cell-type-specific alterations of aerobic energy metabolism can occur, although all cell types showed a clear tendency toward a reduced aerobic energy metabolism...
  29. ncbi request reprint Targeted disruption of the galanin gene attenuates inflammatory responses in murine skin
    Sabine M Schmidhuber
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University Salzburg, Muellner Hauptstrasse 48, 5020 Salzburg, Austria
    J Mol Neurosci 34:149-55. 2008
    ..These data indicate that Gal KO mice demonstrate abnormal neurogenic inflammatory responses in murine skin compared to strain-matched wild-type mice...
  30. ncbi request reprint 125I-labeled galanin binding sites in congenital innervation defects of the distal colon
    Alexandra Berger
    Department of Pediatrics, General Hospital, Muellner Hauptstrasse 48, 5020 Salzburg, Austria
    Acta Neuropathol 105:43-8. 2003
    ..The presence of GAL binding sites in different cellular structures suggests an involvement of GAL in various physiological functions of the gastrointestinal tract...
  31. pmc Galanin message-associated peptide suppresses growth and the budded-to-hyphal-form transition of Candida albicans
    Isabella Rauch
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Mullner Hauptstr 48, A 5020 Salzburg, Austria
    Antimicrob Agents Chemother 51:4167-70. 2007
    ..GMAP has growth-inhibiting activity against C. albicans and inhibits the budded-to-hyphal-form transition, establishing GMAP as a possible new component of the innate immune system...
  32. pmc Distribution of alarin immunoreactivity in the mouse brain
    Nicole Eberhard
    Department of Pediatrics, Laura Bassi Centre of Expertise THERAPEP, Research Program for Receptor Biochemistry and Tumormetabolism, Paracelsus Medical University, Salzburg, 5020, Austria
    J Mol Neurosci 46:18-32. 2012
    ..The distinct expression pattern of alarin in the adult mouse brain suggests potential functions in reproduction and metabolism...
  33. doi request reprint The galanin peptide family in inflammation
    Roland Lang
    Department of Dermatology, Paracelsus Medical University Salzburg, Muellner Hauptstrasse 48, A 5020 Salzburg, Austria
    Neuropeptides 45:1-8. 2011
    ..We also highlight the effects of galanin and other members of the galanin peptide family on experimentally induced inflammation and discuss these data in light of an anti-inflammatory role for this family of peptides...
  34. doi request reprint Distribution of the regulatory peptide alarin in the eye of various species
    Falk Schrödl
    Dept of Ophthalmology, Paracelsus Medical University, SALK, Muellner Hauptstrasse 48, 5020 Salzburg, Austria Dept of Anatomy, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria
    Exp Eye Res 106:74-81. 2013
    ..Since alarin is found widely distributed in the eyes of species investigated, we were able to establish the basis for further functional experiments...
  35. doi request reprint Effects of galanin message-associated peptide and neuropeptide Y against various non-albicans Candida strains
    Barbara S Holub
    Department of Pediatrics, Laura Bassi Centre of Expertise THERAPEP, Paracelsus Medical University, A 5020 Salzburg, Austria
    Int J Antimicrob Agents 38:76-80. 2011
    ..This study also confirms the research on neuropeptides as potential fungicides, which are still in the early stages. The results also suggest that testing of strain-specific susceptibility is mandatory...
  36. doi request reprint Alterations of oxidative phosphorylation complexes in astrocytomas
    René Günther Feichtinger
    Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
    Glia 62:514-25. 2014
    ..OXPHOS defects were present not only in the cell bodies of tumor cells but also in the pilem structures, indicating that the ramifications/protuberances (tumorpil) in general originate from tumor cells...
  37. ncbi request reprint Galanin-like peptides exert potent vasoactive functions in vivo
    Sabine M Schmidhuber
    Department of Pediatrics, Paracelsus Private Medical University Salzburg, Salzburg, Austria
    J Invest Dermatol 127:716-21. 2007
    ..These results indicate functional activity of GALP in the periphery in vivo and suggest a potential role as an inflammatory modulator...
  38. ncbi request reprint The galanin system in cancer
    I Rauch
    Department of Pediatrics, SALK and Paracelsus Medical University, Mullner Hauptstrasse 48, 5020 Salzburg, Austria
    EXS 102:223-41. 2010
    ..Therefore, galanin and its receptors are promising targets for diagnosis and treatment of several types of tumours...
  39. pmc GAL3 receptor KO mice exhibit an anxiety-like phenotype
    Susanne M Brunner
    Laura Bassi Centre of Expertise Therapeutic Application of Neuropeptides THERAPEP, Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, and
    Proc Natl Acad Sci U S A 111:7138-43. 2014
    ..In conclusion, our data suggest involvement of GAL3 receptors in GAL-mediated effects on mood, anxiety, and behavior, making it a possible target for alternative treatment strategies for mood disorders. ..
  40. ncbi request reprint Elevated expression of galanin receptors in childhood neuroblastic tumors
    Alexandra Berger
    Department of Pediatrics, General Hospital Salzburg, Salzburg, Austria
    Neuroendocrinology 75:130-8. 2002
    ..021) in this limited analysis of neuroblastic tumor samples. These results raise the possibility that the expression of GAL binding sites may play a role in neuroblastic tumor biology and behavior...
  41. doi request reprint Expression of alarin in ependymoma and choroid plexus tumors
    Nicole Eberhard
    Department of Pediatrics, Laura Bassi Centre of Expertise THERAPEP, Paracelsus Medical University, Müllner Hauptstraße 48, Salzburg, Austria
    J Neurooncol 114:165-71. 2013
    ..The high specificity (83 %) of alarin-LI suggests that it might be used as a diagnostic marker for ependymoma in differentiating them from other gliomas such as astrocytomas and oligodendrogliomas...
  42. ncbi request reprint The J-bone graft for anatomical glenoid reconstruction in recurrent posttraumatic anterior shoulder dislocation
    Alexander Auffarth
    Department of Traumatology, General Hospital Salzburg of the Paracelsus Medical University, Salzburg, Austria
    Am J Sports Med 36:638-47. 2008
    ..For glenoid rim defects exceeding a certain size, several investigators recommend bone grafting. Few reports on anatomical glenoid reconstruction addressing this problem are published...