Research Topics
Genomes and Genes | Barbara KoflerSummaryAffiliation: Paracelsus Private Medical University Country: Austria Publications
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Detail Information
Publications
Distribution of alarin immunoreactivity in the mouse brainNicole Eberhard
Department of Pediatrics, Laura Bassi Centre of Expertise THERAPEP, Research Program for Receptor Biochemistry and Tumormetabolism, Paracelsus Medical University, Salzburg, 5020, Austria
J Mol Neurosci 46:18-32. 2012..The distinct expression pattern of alarin in the adult mouse brain suggests potential functions in reproduction and metabolism...- Mitochondrial DNA haplogroup T is associated with coronary artery disease and diabetic retinopathy: a case control studyBarbara Kofler
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
BMC Med Genet 10:35. 2009..We therefore examined the association between mtDNA haplogroups and coronary artery disease (CAD) as well as diabetic retinopathy... 
Galanin and galanin receptors in human gliomasAlexandra Berger
Department of Pediatrics, General Hospital, Muellner Hauptstrasse 48, 5020, Salzburg, Austria
Acta Neuropathol (Berl) 105:555-60. 2003..No correlation could be found between GAL-LI, the level of GAL binding and proliferative activity as determined by immunostaining with the cell proliferation marker Ki-67...- Loss of mitochondria in ganglioneuromasRene G Feichtinger
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
Front Biosci (Elite Ed) 3:179-86. 2011..Knowledge of the mechanism by which tumor cells achieve the Warburg effect will provide a starting point for functional studies aimed at restoring aerobic energy metabolism as a potential new therapeutic strategy to treat malignancies... - Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastomaRene G Feichtinger
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
BMC Cancer 10:149. 2010..Succinate dehydrogenase (SDH) has been associated with carcinogenesis in pheochromocytoma and paraganglioma. In the present study we investigated components of the oxidative phosphorylation system in human neuroblastoma tissue samples... - Alarin is a vasoactive peptideRadmila Santic
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria
Proc Natl Acad Sci U S A 104:10217-22. 2007..Alarin adds another facet to the surprisingly high-functional redundancy of the galanin family of peptides... - Galanin and galanin receptors in human cancersAlexandra Berger
Department of Pediatrics, Paracelsus Private Medical University, Salzburg, Muellner Hauptstrasse 48, A 5020 Salzburg, Austria
Neuropeptides 39:353-9. 2005..The co-expression of galanin and its receptors supports a role for galanin in tumor cell pathology via autocrine/paracrine mechanisms... 
Reduction of nuclear encoded enzymes of mitochondrial energy metabolism in cells devoid of mitochondrial DNAEdith E Mueller
Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Salzburg, Austria
Biochem Biophys Res Commun 417:1052-7. 2012..This finding indicates the existence of a feedback mechanism in ρ(0) cells that downregulates the expression of entirely nuclear encoded components of mitochondrial energy metabolism...- Mitochondrial haplogroups, control region polymorphisms and malignant melanoma: a study in middle European CaucasiansSabine Ebner
Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
PLoS ONE 6:e27192. 2011.... - Respiratory chain complex I is a mitochondrial tumor suppressor of oncocytic tumorsFranz A Zimmermann
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
Front Biosci (Elite Ed) 3:315-25. 2011..Therefore, complex I of the respiratory chain has to be added to the growing list of mitochondrial tumor suppressors... - Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinomaDavid Meierhofer
Department of Pediatrics, Paracelsus Private Medical University Salzburg, Muellner Hauptstr. 48, A-5020 Salzburg, Austria
Carcinogenesis 25:1005-10. 2004.... - Alterations of respiratory chain complexes in sporadic pheochromocytomaRene G Feichtinger
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
Front Biosci (Elite Ed) 3:194-200. 2011..Strikingly, one of the nine PCs showed specific loss of complex I and a compensatory up-regulation of complexes II-V, which is a phenotype usually characteristic of oncocytic tumors... - Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide geneRadmila Santic
Department of Pediatrics, Paracelsus Private Medical University Salzburg, A 5020 Salzburg, Austria
J Mol Neurosci 29:145-52. 2006..Our findings indicate that alarin expression is a feature of ganglionic differentiation in neuroblastic tumor tissues... - The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and diseaseRoland Lang
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria
Pharmacol Ther 115:177-207. 2007.... - Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European CaucasiansEdith E Mueller
Department of Pediatrics, Paracelsus Medical University Salzburg, Salzburg, Austria
PLoS ONE 4:e6370. 2009.... - Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonistsRoland Lang
Department of Pediatrics, Paracelsus Private Medical University Salzburg, Muellner-Hauptstrasse 48, 5020 Salzburg, Austria
Neuropeptides 39:179-84. 2005..Furthermore it might be a useful tool to study the affinity of GALP to galanin receptors and to search for specific GALP receptors... - Severe depletion of mitochondrial DNA in spinal muscular atrophyAlexandra Berger
Department of Pediatrics, General Hospital Salzburg, Muellner Hauptstrasse 48, Austria
Acta Neuropathol (Berl) 105:245-51. 2003.... - Mitochondrial haplogroups and control region polymorphisms in age-related macular degeneration: a case-control studyEdith E Mueller
Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
PLoS ONE 7:e30874. 2012..Previous studies from Australia and the United States detected associations of mitochondrial haplogroups with AMD. The aim of the present study was to test these associations in Middle European Caucasians... - 125I-labeled galanin binding sites in congenital innervation defects of the distal colonAlexandra Berger
Department of Pediatrics, General Hospital, Muellner Hauptstrasse 48, 5020 Salzburg, Austria
Acta Neuropathol 105:43-8. 2003..The presence of GAL binding sites in different cellular structures suggests an involvement of GAL in various physiological functions of the gastrointestinal tract... - Galanin receptor subtype GalR2 mediates apoptosis in SH-SY5Y neuroblastoma cellsAlexandra Berger
Department of Pediatrics, General Hospital Salzburg, Muellner Hauptstrasse 48, A 5020 Salzburg, Austria
Endocrinology 145:500-7. 2004.... - Functional differences between mitochondrial haplogroup T and haplogroup H in HEK293 cybrid cellsEdith E Mueller
Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
PLoS ONE 7:e52367. 2012..However, justifications for the assumption that haplogroups are functionally distinct are rare. Therefore, we attempted to compare differences in mitochondrial function between haplogroup H and T cybrids... - Evidence that the modulatory effect of galanin on inflammatory edema formation is mediated by the galanin receptor 3 in the murine microvasculatureSabine M Schmidhuber
Department of Pediatrics, Paracelsus Medical University Salzburg, Muellner Hauptstrasse 48, 5020, Salzburg, Austria
J Mol Neurosci 37:177-81. 2009..Thus, we were able to show that SNAP 37889 selectively antagonized galanin in the periphery and suggest that GalR3 is the receptor subtype mediating galanin's effects on the dermal microvasculature... - The mitochondrial T16189C polymorphism is associated with coronary artery disease in Middle European populationsEdith E Mueller
Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
PLoS ONE 6:e16455. 2011.... - Heterogeneity of mitochondrial energy metabolism in classical triphasic Wilms' tumorRene G Feichtinger
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
Front Biosci (Elite Ed) 3:187-93. 2011..Interestingly, our studies show that, even within a specific tumor entity, cell-type-specific alterations of aerobic energy metabolism can occur, although all cell types showed a clear tendency toward a reduced aerobic energy metabolism... - Loss of complex I due to mitochondrial DNA mutations in renal oncocytomaJohannes A Mayr
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
Clin Cancer Res 14:2270-5. 2008.... - Multiplex primer extension analysis for rapid detection of major European mitochondrial haplogroupsMartina Wiesbauer
Department of Paediatrics, Paracelsus Private Medical University Salzburg, Salzburg, Austria
Electrophoresis 27:3864-8. 2006..Our method may be suitable for mitochondrial genotyping of samples from large-scale epidemiology studies and for identifying markers of genetic susceptibility... - Effects of galanin message-associated peptide and neuropeptide Y against various non-albicans Candida strainsBarbara S Holub
Department of Pediatrics, Laura Bassi Centre of Expertise THERAPEP, Paracelsus Medical University, A 5020 Salzburg, Austria
Int J Antimicrob Agents 38:76-80. 2011..This study also confirms the research on neuropeptides as potential fungicides, which are still in the early stages. The results also suggest that testing of strain-specific susceptibility is mandatory... - Galanin-like peptides exert potent vasoactive functions in vivoSabine M Schmidhuber
Department of Pediatrics, Paracelsus Private Medical University Salzburg, Salzburg, Austria
J Invest Dermatol 127:716-21. 2007..These results indicate functional activity of GALP in the periphery in vivo and suggest a potential role as an inflammatory modulator... - Elevated expression of galanin receptors in childhood neuroblastic tumorsAlexandra Berger
Department of Pediatrics, General Hospital Salzburg, Salzburg, Austria
Neuroendocrinology 75:130-8. 2002..021) in this limited analysis of neuroblastic tumor samples. These results raise the possibility that the expression of GAL binding sites may play a role in neuroblastic tumor biology and behavior... - Distribution of the regulatory peptide alarin in the eye of various speciesFalk Schrödl
Dept of Ophthalmology, Paracelsus Medical University, SALK, Muellner Hauptstrasse 48, 5020 Salzburg, Austria Dept of Anatomy, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria
Exp Eye Res 106:74-81. 2013..Since alarin is found widely distributed in the eyes of species investigated, we were able to establish the basis for further functional experiments... - The galanin system in cancerI Rauch
Department of Pediatrics, SALK and Paracelsus Medical University, Mullner Hauptstrasse 48, 5020 Salzburg, Austria
EXS 102:223-41. 2010..Therefore, galanin and its receptors are promising targets for diagnosis and treatment of several types of tumours... - Targeted disruption of the galanin gene attenuates inflammatory responses in murine skinSabine M Schmidhuber
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University Salzburg, Muellner Hauptstrasse 48, 5020 Salzburg, Austria
J Mol Neurosci 34:149-55. 2008..These data indicate that Gal KO mice demonstrate abnormal neurogenic inflammatory responses in murine skin compared to strain-matched wild-type mice... - Galanin message-associated peptide suppresses growth and the budded-to-hyphal-form transition of Candida albicansIsabella Rauch
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Mullner Hauptstr 48, A 5020 Salzburg, Austria
Antimicrob Agents Chemother 51:4167-70. 2007..GMAP has growth-inhibiting activity against C. albicans and inhibits the budded-to-hyphal-form transition, establishing GMAP as a possible new component of the innate immune system... - The J-bone graft for anatomical glenoid reconstruction in recurrent posttraumatic anterior shoulder dislocationAlexander Auffarth
Department of Traumatology, General Hospital Salzburg of the Paracelsus Medical University, Salzburg, Austria
Am J Sports Med 36:638-47. 2008..For glenoid rim defects exceeding a certain size, several investigators recommend bone grafting. Few reports on anatomical glenoid reconstruction addressing this problem are published...