Alexander Zimprich

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. doi Genetics of Parkinson's disease and essential tremor
    Alexander Zimprich
    Department of Neurology, Medizinische Universität Wien, Vienna, Austria
    Curr Opin Neurol 24:318-23. 2011
  2. doi Phenocopies in families with essential tremor and restless legs syndrome challenge Mendelian laws. Epigenetics might provide answers
    Alexander Zimprich
    Department of Clinical Neurology, Medical University of Vienna, Vienna, Austria
    Parkinsonism Relat Disord 18:711-6. 2012
  3. pmc A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease
    Alexander Zimprich
    Department of Neurology, Medizinische Universität Wien, Vienna, Austria
    Am J Hum Genet 89:168-75. 2011
  4. doi Sequence analysis of the complete SLITRK1 gene in Austrian patients with Tourette's disorder
    Alexander Zimprich
    Department of Neurology, Medical University of Vienna, Austria
    Psychiatr Genet 18:308-9. 2008
  5. doi PARK11 gene (GIGYF2) variants Asn56Ser and Asn457Thr are not pathogenic for Parkinson's disease
    Alexander Zimprich
    Department of Clinical Neurology, Medical University of Vienna, Vienna, Austria
    Parkinsonism Relat Disord 15:532-4. 2009
  6. pmc Role of LINGO1 polymorphisms in Parkinson's disease
    Dietrich Haubenberger
    Department of Neurology, Medical University of Vienna, Vienna, Austria
    Mov Disord 24:2404-7. 2009
  7. doi Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease
    Dietrich Haubenberger
    Department of Neurology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Neurobiol Aging 32:302-7. 2011
  8. doi Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients
    Mascha C Schmied
    Department of Neurology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Neurogenetics 13:181-7. 2012
  9. ncbi Lack of association between a GABA receptor 1 gene polymorphism and temporal lobe epilepsy
    Elisabeth Stogmann
    Department of Clinical Neurology, Core Unit of Medical Statistics and Informatics, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Epilepsia 47:437-9. 2006
  10. doi A novel mutation in the VCP gene (G157R) in a German family with inclusion-body myopathy with Paget disease of bone and frontotemporal dementia
    Atbin Djamshidian
    Department of Neurology, Medical University of Vienna Währinger Gürtel 18 20, Vienna A 1097, Austria
    Muscle Nerve 39:389-91. 2009

Collaborators

Detail Information

Publications17

  1. doi Genetics of Parkinson's disease and essential tremor
    Alexander Zimprich
    Department of Neurology, Medizinische Universität Wien, Vienna, Austria
    Curr Opin Neurol 24:318-23. 2011
    ..This review summarizes some key findings of the past few years on the genetics of the two common movement disorders Parkinson's disease and essential tremor...
  2. doi Phenocopies in families with essential tremor and restless legs syndrome challenge Mendelian laws. Epigenetics might provide answers
    Alexander Zimprich
    Department of Clinical Neurology, Medical University of Vienna, Vienna, Austria
    Parkinsonism Relat Disord 18:711-6. 2012
    ..Inheritance of epigenetic mutations along with paramutational events have the potential to explain the non-mendelian features in the genetics of both diseases...
  3. pmc A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease
    Alexander Zimprich
    Department of Neurology, Medizinische Universität Wien, Vienna, Austria
    Am J Hum Genet 89:168-75. 2011
    ..VPS35 is a component of the retromer complex and mediates retrograde transport between endosomes and the trans-Golgi network, and it has recently been found to be involved in Alzheimer disease...
  4. doi Sequence analysis of the complete SLITRK1 gene in Austrian patients with Tourette's disorder
    Alexander Zimprich
    Department of Neurology, Medical University of Vienna, Austria
    Psychiatr Genet 18:308-9. 2008
    ..In conclusion, our results provide no evidence for SLITRK1 playing a major role in TD...
  5. doi PARK11 gene (GIGYF2) variants Asn56Ser and Asn457Thr are not pathogenic for Parkinson's disease
    Alexander Zimprich
    Department of Clinical Neurology, Medical University of Vienna, Vienna, Austria
    Parkinsonism Relat Disord 15:532-4. 2009
    ..This variant was not found in 50 control individuals from Egypt. We conclude that neither of these two variants plays a major role in the pathogenesis of PD in our study population...
  6. pmc Role of LINGO1 polymorphisms in Parkinson's disease
    Dietrich Haubenberger
    Department of Neurology, Medical University of Vienna, Vienna, Austria
    Mov Disord 24:2404-7. 2009
    ..Neither did a subgroup analysis in tremor-dominant patients with PD reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD...
  7. doi Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease
    Dietrich Haubenberger
    Department of Neurology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Neurobiol Aging 32:302-7. 2011
    ....
  8. doi Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients
    Mascha C Schmied
    Department of Neurology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Neurogenetics 13:181-7. 2012
    ..01), rs7090530 (IL2RA, p < 0.026) and rs1841770 (ZIC1, p < 0.017) with a younger age at MS onset and of rs12044852 (CD58, p < 0.035) with shorter time to reach EDSS6...
  9. ncbi Lack of association between a GABA receptor 1 gene polymorphism and temporal lobe epilepsy
    Elisabeth Stogmann
    Department of Clinical Neurology, Core Unit of Medical Statistics and Informatics, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Epilepsia 47:437-9. 2006
    ..To clarify the role of this polymorphism in TLE, we attempted to replicate this study...
  10. doi A novel mutation in the VCP gene (G157R) in a German family with inclusion-body myopathy with Paget disease of bone and frontotemporal dementia
    Atbin Djamshidian
    Department of Neurology, Medical University of Vienna Währinger Gürtel 18 20, Vienna A 1097, Austria
    Muscle Nerve 39:389-91. 2009
    ..Two family members also showed signs of early hearing impairment, which was confirmed to be sensorineural in one person, a symptom not yet described in the context of IBMPFD...
  11. ncbi A novel LRRK2 mutation in an Austrian cohort of patients with Parkinson's disease
    Dietrich Haubenberger
    Department of Neurology, Medical University of Vienna, and SMZ Ost Donauspital, Vienna, Austria
    Mov Disord 22:1640-3. 2007
    ..While the most common mutation G2019S and the risk variant G2385R were not found in our samples, we detected a novel missense mutation (S973N) in a patient with familial, late-onset and dopa-responsive PD...
  12. doi Lack of association between ABCC2 gene variants and treatment response in epilepsy
    Eva Hilger
    Department of Clinical Neurology, Medical University of Vienna, Vienna, Austria
    Pharmacogenomics 13:185-90. 2012
    ..The aim of this study was to replicate a previously reported association between drug resistance in epilepsy patients and the 24C>T variant of the ABCC2 gene that codes for the drug efflux transporter MRP2...
  13. doi Autosomal recessive cortical myoclonic tremor and epilepsy: association with a mutation in the potassium channel associated gene CNTN2
    Elisabeth Stogmann
    Department of Clinical Neurology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Brain 136:1155-60. 2013
    ..Given the severity of the mutation and the proposed function of the gene, we consider this mutation as the most likely cause for cortical myoclonic tremor and epilepsy in this family...
  14. ncbi VPS35 Parkinson's disease phenotype resembles the sporadic disease
    Walter Struhal
    Department of Neurology, Allgemeines Krankenhaus Linz AKHL, Krankenhausstr 9, 4020, Linz, Upper Austria, Austria
    J Neural Transm 121:755-9. 2014
    ..However, we were unable to identify a specific clinical maker of VPS35 patients, who otherwise resemble sporadic PD patients. ..
  15. doi Association of the chromosome 11q13.5 variant with atopic dermatitis in Austrian patients
    Elli K Greisenegger
    Department of Dermatology, DIAID, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Waehringer Guertel 18 20 1090 Vienna, Austria
    Eur J Dermatol 23:142-5. 2013
    ..5 and rs877776 within the region of the hornerin gene, were identified as novel susceptibility variants for atopic dermatitis in the first genome wide association study in atopic dermatitis...
  16. pmc A genetic polymorphism of the endogenous opioid dynorphin modulates monetary reward anticipation in the corticostriatal loop
    Mikhail Votinov
    Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna, Austria
    PLoS ONE 9:e89954. 2014
    ....
  17. ncbi A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy
    Elisabeth Stogmann
    Department of Neurology, University Hospital of Vienna, Vienna, Austria
    Ann Neurol 51:260-3. 2002
    ..Irrespective of the familial background, L-homozygotes display a higher risk for secondarily generalized seizures and status epilepticus...