Kurt Zatloukal

Summary

Affiliation: Medical University of Graz
Country: Austria

Publications

  1. pmc The role of the pathologist in tissue banking: European Consensus Expert Group Report
    Generoso Bevilacqua
    Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Medical School, Via Roma 57, 56126 Pisa, Italy
    Virchows Arch 456:449-54. 2010
  2. pmc TAMEE: data management and analysis for tissue microarrays
    Gerhard G Thallinger
    Institute for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria
    BMC Bioinformatics 8:81. 2007
  3. ncbi The keratin cytoskeleton in liver diseases
    Kurt Zatloukal
    Institute of Pathology, Medical University of Graz, A 8036 Graz, Austria
    J Pathol 204:367-76. 2004
  4. doi The role of the hepatocyte cytokeratin network in bile formation and resistance to bile acid challenge and cholestasis in mice
    Peter Fickert
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria
    Hepatology 50:893-9. 2009
  5. doi Clusterin expression in cholestasis, hepatocellular carcinoma and liver fibrosis
    Ariane Aigelsreiter
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Histopathology 54:561-70. 2009
  6. ncbi Oncosis represents the main type of cell death in mouse models of cholestasis
    Peter Fickert
    Laboratory of Experimental Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Hepatol 42:378-85. 2005
  7. ncbi Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis
    Gernot Zollner
    Laboratory of Experimental and Molecular Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    Liver Int 27:920-9. 2007
  8. doi Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis
    Carolin Lackner
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, Graz, Austria
    J Hepatol 48:821-8. 2008
  9. ncbi Hepatobiliary transporter expression in intercellular adhesion molecule 1 knockout and Fas receptor-deficient mice after common bile duct ligation is independent of the degree of inflammation and oxidative stress
    Martin Wagner
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Drug Metab Dispos 35:1694-9. 2007
  10. doi Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model
    Johannes Haybaeck
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Lab Invest 92:857-67. 2012

Collaborators

Detail Information

Publications49

  1. pmc The role of the pathologist in tissue banking: European Consensus Expert Group Report
    Generoso Bevilacqua
    Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Medical School, Via Roma 57, 56126 Pisa, Italy
    Virchows Arch 456:449-54. 2010
    ....
  2. pmc TAMEE: data management and analysis for tissue microarrays
    Gerhard G Thallinger
    Institute for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria
    BMC Bioinformatics 8:81. 2007
    ..Robust and scalable applications have to be utilized, which allow secure data access, manipulation and evaluation for researchers from different laboratories...
  3. ncbi The keratin cytoskeleton in liver diseases
    Kurt Zatloukal
    Institute of Pathology, Medical University of Graz, A 8036 Graz, Austria
    J Pathol 204:367-76. 2004
    ..The functional relevance of keratins in human diseases has recently been underlined by the identification of mutations in keratin genes in patients with liver cirrhosis...
  4. doi The role of the hepatocyte cytokeratin network in bile formation and resistance to bile acid challenge and cholestasis in mice
    Peter Fickert
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria
    Hepatology 50:893-9. 2009
    ..However, loss of K8 significantly increased liver injury in response to toxic stress. Conclusion: The intermediate filament network of hepatocytes is not specifically required for proper bile formation in mice...
  5. doi Clusterin expression in cholestasis, hepatocellular carcinoma and liver fibrosis
    Ariane Aigelsreiter
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Histopathology 54:561-70. 2009
    ..Its expression is altered in various diseases. The aim was to evaluate the presence and distribution of clusterin in liver diseases associated with cholestasis, in fibrosis and in hepatocellular carcinoma...
  6. ncbi Oncosis represents the main type of cell death in mouse models of cholestasis
    Peter Fickert
    Laboratory of Experimental Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Hepatol 42:378-85. 2005
    ..Since the mechanisms leading to hepatocyte death in cholestasis are not well defined, we aimed to obtain closer insights into the related pathogenetic principles...
  7. ncbi Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis
    Gernot Zollner
    Laboratory of Experimental and Molecular Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    Liver Int 27:920-9. 2007
    ..We therefore investigated expression of genes for bile acid synthesis, detoxification and alternative basolateral export and regulatory nuclear factors in primary biliary cirrhosis (PBC)...
  8. doi Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis
    Carolin Lackner
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, Graz, Austria
    J Hepatol 48:821-8. 2008
    ..Ballooning degeneration is considered a hallmark of steatohepatitis, but enlarged hepatocytes may also be observed in a variety of other acute and chronic liver diseases...
  9. ncbi Hepatobiliary transporter expression in intercellular adhesion molecule 1 knockout and Fas receptor-deficient mice after common bile duct ligation is independent of the degree of inflammation and oxidative stress
    Martin Wagner
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Drug Metab Dispos 35:1694-9. 2007
    ..Induction of the adaptive transporter response after CBDL is independent of the degree of the inflammatory response. Rather, retention of biliary constituents may determine transporter expression in CBDL...
  10. doi Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model
    Johannes Haybaeck
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Lab Invest 92:857-67. 2012
    ..This stands in contrast to previous work where krt8⁻/⁻ and krt18⁻/⁻ mice on different genetic backgrounds were investigated...
  11. pmc JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue
    Andelko Hrzenjak
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria
    J Mol Diagn 7:388-95. 2005
    ..In combination with other established methods, accurate reverse transcriptase-polymerase chain reaction analysis of JAZF1/JJAZ1 gene fusion may be useful in diagnosing difficult or unusual ESS/UES cases...
  12. ncbi Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells
    Andelko Hrzenjak
    Department of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria
    Mol Cancer Ther 5:2203-10. 2006
    ..Our results suggest that HDAC2 might be considered as potential drug target in the therapy of ESS and that HDAC inhibitors should be further evaluated in clinical trials in ESS...
  13. doi Cross β-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusions
    Vineet Mahajan
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Gastroenterology 141:1080-1090.e1-7. 2011
    ..We investigated the molecular structure of keratin 8 (K8) and 18 (K18), sequestosome 1/p62, and ubiquitin, which are the major constituents of MDBs, to investigate their formation and role in disease pathogenesis...
  14. ncbi p62 protein is expressed in pancreatic beta cells
    Carolin Lackner
    Institute of Pathology, Medical University of Graz, Austria
    J Pathol 206:402-8. 2005
    ..Further research is necessary to elucidate the role of p62 in beta cell-specific signal transduction...
  15. pmc Cytokeratins as targets for bile acid-induced toxicity
    Peter Fickert
    Department of Medicine, University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Am J Pathol 160:491-9. 2002
    ..Thus, increased hepatocellular CK expression and phosphorylation in cholestasis may be caused by retention of toxic bile acids and reflect a hepatocellular stress response with potential beneficial effects...
  16. pmc Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice
    Emina Halilbasic
    Laboratory of Experimental and Molecular Hepatology, Department of Gastroenterology and Hepatology, University Clinic of Internal Medicine, Medical University of Graz, Graz, Austria
    Hepatology 49:1972-81. 2009
    ..These include the ability to undergo cholehepatic shunting and to directly stimulate cholangiocyte secretion, both resulting in a HCO(3)(-)-rich hypercholeresis that protects the liver from cholestatic injury...
  17. ncbi From Mallory to Mallory-Denk bodies: what, how and why?
    Kurt Zatloukal
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Exp Cell Res 313:2033-49. 2007
    ..Although it remains unclear whether MDBs serve a bystander, protective or injury promoting function, they do serve an important role as histological and potential progression markers in several liver diseases...
  18. ncbi In vitro production of Mallory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62
    Conny Stumptner
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Hepatology 46:851-60. 2007
    ....
  19. ncbi Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA
    Katrin Panzitt
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Gastroenterology 132:330-42. 2007
    ..We searched the human genome for novel genes including ncRNAs related to hepatocellular carcinoma (HCC)...
  20. pmc Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo
    Andelko Hrzenjak
    Lore Saldow Research Unit for Molecular Pathology of Gynecologic Tumors, Department of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria
    Mol Cancer 9:49. 2010
    ..We analyzed the influence of vorinostat on expression of different HDACs, p21(WAF1) and activation of apoptosis. Finally, we examined the antitumor effects of vorinostat on uterine sarcoma in vivo...
  21. ncbi Endometrial stromal sarcomas frequently express epidermal growth factor receptor (EGFR, HER-1): potential basis for a new therapeutic approach
    Farid Moinfar
    Institute of Pathology, Medical University Graz, Graz, Austria
    Am J Surg Pathol 29:485-9. 2005
    ..This finding may provide the basis for a new therapeutic strategy using monoclonal antibodies against EGFR (such as cetuximab) or small molecule inhibitors of EGFR (such as gefitinib) in patients with endometrial sarcomas...
  22. doi Hepatobiliary transporter expression and post-operative jaundice in patients undergoing partial hepatectomy
    Gerwin A Bernhardt
    Division of General Surgery, Department of Surgery, Medical University of Graz, Graz, Austria
    Liver Int 32:119-27. 2012
    ....
  23. ncbi Intermediate filament protein inclusions
    Kurt Zatloukal
    Institute of Pathology, Medical University of Graz, A 8036 Graz, Austria
    Methods Cell Biol 78:205-28. 2004
  24. ncbi Interaction of stress proteins with misfolded keratins
    Elke Janig
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Eur J Cell Biol 84:329-39. 2005
    ..Furthermore, we found clusterin in association with elastic fibers in the extracellular matrix in several chronic liver diseases, including ASH and alpha1-antitrypsin deficiency, implying a possible role of clusterin in liver fibrosis...
  25. pmc Quality control of RNA preservation and extraction from paraffin-embedded tissue: implications for rt-PCR and microarray analysis
    Karl Kashofer
    Institute of Pathology, Medical University of Graz, Graz, Austria
    PLoS ONE 8:e70714. 2013
    ....
  26. ncbi Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine
    Gernot Zollner
    Division of Gastroenterology and Hepatology, Department of Medicine, Karl Franzens University, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Hepatol 39:480-8. 2003
    ..Whether adaptive changes in ATP-binding cassette (ABC) transporter expression are stimulated by bile acids and their nuclear receptor FXR is unknown...
  27. pmc Transition between acute and chronic hepatotoxicity in mice is associated with impaired energy metabolism and induction of mitochondrial heme oxygenase-1
    Aniket Nikam
    Institute of Pathology, Medical University of Graz, Graz, Austria
    PLoS ONE 8:e66094. 2013
    ..Our observations clearly demonstrate principally different mechanisms for acute and chronic toxic damage...
  28. doi Human tissue biobanks as instruments for drug discovery and development: impact on personalized medicine
    Kurt Zatloukal
    Medical University of Graz, Graz, Austria
    Biomark Med 4:895-903. 2010
    ....
  29. pmc Clusterin associates with altered elastic fibers in human photoaged skin and prevents elastin from ultraviolet-induced aggregation in vitro
    Elke Janig
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Am J Pathol 171:1474-82. 2007
    ..The interaction of both proteins was further analyzed by electron microscopy, size exclusion chromatography, and mass spectrometry, in which clusterin was found in a stable complex with elastin after UV exposure...
  30. doi A new technology for stabilization of biomolecules in tissues for combined histological and molecular analyses
    Christian Viertler
    Institute of Pathology, Medical University of Graz, Graz, Austria
    J Mol Diagn 14:458-66. 2012
    ....
  31. ncbi Allelic imbalances in endometrial stromal neoplasms: frequent genetic alterations in the nontumorous normal-appearing endometrial and myometrial tissues
    Farid Moinfar
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Gynecol Oncol 95:662-71. 2004
    ..The aim of this study was to examine the possibility of loss of heterozygosity (LOH) and microsatellite instability (MIS) in different tissue components of ESS...
  32. ncbi Biobanks: transnational, European and global networks
    Martin Asslaber
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Brief Funct Genomic Proteomic 6:193-201. 2007
    ....
  33. ncbi Mallory body--a disease-associated type of sequestosome
    Cornelia Stumptner
    Department of Pathology, School of Medicine, University of Graz, Graz, Austria
    Hepatology 35:1053-62. 2002
    ..In conclusion, the constant presence of p62 in MBs suggests that binding of p62 to abnormal keratins may allow hepatocytes to dispose potentially harmful proteins in a biologically inert manner...
  34. pmc Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase
    Peter Hasselblatt
    Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 104:17105-10. 2007
    ..These findings demonstrate that c-Jun/AP-1 is hepatoprotective during acute hepatitis by regulating nos2/NO expression and thus functionally antagonizes the cell death-promoting functions of JNK...
  35. pmc Bile acid-induced Mallory body formation in drug-primed mouse liver
    Peter Fickert
    Department of Medicine, Karl Franzens University, Auenbruggerplatz 25, A 8036 Graz, Austria
    Am J Pathol 161:2019-26. 2002
    ..Furthermore, CBDL and CA feeding resulted in rapid neoformation of MBs in drug-primed mice. It is concluded that MB formation in cholestatic liver diseases may be triggered by the action of potentially toxic bile acids...
  36. ncbi Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver
    Gernot Zollner
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Graz, Austria
    Am J Physiol Gastrointest Liver Physiol 289:G798-805. 2005
    ....
  37. pmc Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice
    Peter Fickert
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Am J Pathol 168:410-22. 2006
    ..Thus, we demonstrate that LCA feeding in mice leads to segmental bile duct obstruction, destructive cholangitis, periductal fibrosis, and an adaptive transporter and metabolic enzyme response...
  38. pmc p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases
    Kurt Zatloukal
    Department of Pathology, Karl Franzens University, Graz, Austria
    Am J Pathol 160:255-63. 2002
    ..The presence of p62 along with other stress proteins and ubiquitin in cytoplasmic inclusions indicates deposition as aggregates as a third line of defense against misfolded proteins in addition to refolding and degradation...
  39. ncbi Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis
    Gernot Zollner
    Division of Gastroenterology and Hepatology, Department of Medicine, Karl Franzens University, Auenbruggerplatz 15, A 8036, Graz, Austria
    J Hepatol 38:717-27. 2003
    ....
  40. pmc A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis
    Peter Fickert
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University Graz, Austria
    Am J Pathol 171:525-36. 2007
    ..This model may be valuable to investigate the mechanisms of xenobiotic-induced chronic cholangiopathies and its sequels including biliary fibrosis...
  41. ncbi Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins
    Peter Fickert
    Department of Medicine, Karl Franzens University Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    J Hepatol 38:387-94. 2003
    ....
  42. ncbi Automated evaluation and normalization of immunohistochemistry on tissue microarrays with a DNA microarray scanner
    Wolfgang Haedicke
    Oridis Biomed, Graz, Austria
    Biotechniques 35:164-8. 2003
    ..Therefore, DNA microarray scanners and associated image analysis software provide general and efficient analysis of tissue microarray immunostaining, including estimation of specific protein expression levels...
  43. ncbi Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice
    Martin Wagner
    Department of Medicine, Karl Franzens University, Graz, Austria
    Gastroenterology 125:825-38. 2003
    ..We aimed to investigate the role of the nuclear bile acid receptor (farnesoid X receptor [FXR]) in mediating changes in ABC transporter expression and in determining liver injury...
  44. ncbi Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis
    Thomas Muller
    Department of Pediatrics, University of Innsbruck, Innsbruck, Austria
    Hepatology 39:963-9. 2004
    ..By sequestering potentially harmful misfolded ubiquitinated proteins as inert cytoplasmic inclusion bodies (e.g., as MBs), p62 may be a major player in an important cellular rescue mechanism in oxidative hepatocyte injury...
  45. ncbi Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
    Peter Fickert
    Deparment of Medicine, Medical University, Graz, Austria
    Gastroenterology 127:261-74. 2004
    ....
  46. ncbi Inverse correlation of secreted frizzled-related protein 4 and beta-catenin expression in endometrial stromal sarcomas
    Andelko Hrzenjak
    Department of Pathology, Medical University, Graz, Austria
    J Pathol 204:19-27. 2004
    ..SFRP4 may therefore be a putative tumour suppressor involved in deregulation of the Wnt pathway and in the pathogenesis of ESS and UES...
  47. ncbi CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice
    Martin Wagner
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Hepatology 42:420-30. 2005
    ....
  48. ncbi Hepatobiliary transporter expression in human hepatocellular carcinoma
    Gernot Zollner
    Division of Gastroenterology and Hepatology, Department of Medicine, Medical University, Auenbruggerplatz 15, A 8036 Graz, Austria
    Liver Int 25:367-79. 2005
    ..Furthermore, we investigated expression of the major bile salt uptake system Na(+)/taurocholate cotransporter NTCP (SLC10A1), since bile salt-coupled chemotherapeutics were proposed to increase therapeutic drug enrichment in HCC...
  49. ncbi Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers
    Beatrix Vécsey-Semjén
    IMP, Research Institute of Molecular Pathology, Vienna, Austria
    Oncogene 21:4646-62. 2002
    ....