Research Topics
Genomes and Genes | Kurt ZatloukalSummaryAffiliation: Medical University of Graz Country: Austria Publications
| Collaborators
|
Detail Information
Publications
The role of the pathologist in tissue banking: European Consensus Expert Group ReportGeneroso Bevilacqua
Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Medical School, Via Roma 57, 56126 Pisa, Italy
Virchows Arch 456:449-54. 2010....- TAMEE: data management and analysis for tissue microarraysGerhard G Thallinger
Institute for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria
BMC Bioinformatics 8:81. 2007..Robust and scalable applications have to be utilized, which allow secure data access, manipulation and evaluation for researchers from different laboratories... 
The keratin cytoskeleton in liver diseasesKurt Zatloukal
Institute of Pathology, Medical University of Graz, A 8036 Graz, Austria
J Pathol 204:367-76. 2004..The functional relevance of keratins in human diseases has recently been underlined by the identification of mutations in keratin genes in patients with liver cirrhosis...
The role of the hepatocyte cytokeratin network in bile formation and resistance to bile acid challenge and cholestasis in micePeter Fickert
Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria
Hepatology 50:893-9. 2009..However, loss of K8 significantly increased liver injury in response to toxic stress. Conclusion: The intermediate filament network of hepatocytes is not specifically required for proper bile formation in mice...- Clusterin expression in cholestasis, hepatocellular carcinoma and liver fibrosisAriane Aigelsreiter
Institute of Pathology, Medical University of Graz, Graz, Austria
Histopathology 54:561-70. 2009..Its expression is altered in various diseases. The aim was to evaluate the presence and distribution of clusterin in liver diseases associated with cholestasis, in fibrosis and in hepatocellular carcinoma... - Oncosis represents the main type of cell death in mouse models of cholestasisPeter Fickert
Laboratory of Experimental Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University, Auenbruggerplatz 15, A 8036 Graz, Austria
J Hepatol 42:378-85. 2005..Since the mechanisms leading to hepatocyte death in cholestasis are not well defined, we aimed to obtain closer insights into the related pathogenetic principles... - Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosisGernot Zollner
Laboratory of Experimental and Molecular Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
Liver Int 27:920-9. 2007..We therefore investigated expression of genes for bile acid synthesis, detoxification and alternative basolateral export and regulatory nuclear factors in primary biliary cirrhosis (PBC)... - Hepatobiliary transporter expression in intercellular adhesion molecule 1 knockout and Fas receptor-deficient mice after common bile duct ligation is independent of the degree of inflammation and oxidative stressMartin Wagner
Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
Drug Metab Dispos 35:1694-9. 2007..Induction of the adaptive transporter response after CBDL is independent of the degree of the inflammatory response. Rather, retention of biliary constituents may determine transporter expression in CBDL... - Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosisCarolin Lackner
Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, Graz, Austria
J Hepatol 48:821-8. 2008..Ballooning degeneration is considered a hallmark of steatohepatitis, but enlarged hepatocytes may also be observed in a variety of other acute and chronic liver diseases... - Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse modelJohannes Haybaeck
Institute of Pathology, Medical University of Graz, Graz, Austria
Lab Invest 92:857-67. 2012..This stands in contrast to previous work where krt8⁻/⁻ and krt18⁻/⁻ mice on different genetic backgrounds were investigated... - JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissueAndelko Hrzenjak
Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria
J Mol Diagn 7:388-95. 2005..In combination with other established methods, accurate reverse transcriptase-polymerase chain reaction analysis of JAZF1/JJAZ1 gene fusion may be useful in diagnosing difficult or unusual ESS/UES cases... - Cross β-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusionsVineet Mahajan
Institute of Pathology, Medical University of Graz, Graz, Austria
Gastroenterology 141:1080-1090.e1-7. 2011..We investigated the molecular structure of keratin 8 (K8) and 18 (K18), sequestosome 1/p62, and ubiquitin, which are the major constituents of MDBs, to investigate their formation and role in disease pathogenesis... - Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cellsAndelko Hrzenjak
Department of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria
Mol Cancer Ther 5:2203-10. 2006..Our results suggest that HDAC2 might be considered as potential drug target in the therapy of ESS and that HDAC inhibitors should be further evaluated in clinical trials in ESS... - p62 protein is expressed in pancreatic beta cellsCarolin Lackner
Institute of Pathology, Medical University of Graz, Austria
J Pathol 206:402-8. 2005..Further research is necessary to elucidate the role of p62 in beta cell-specific signal transduction... - Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- miceEmina Halilbasic
Laboratory of Experimental and Molecular Hepatology, Department of Gastroenterology and Hepatology, University Clinic of Internal Medicine, Medical University of Graz, Graz, Austria
Hepatology 49:1972-81. 2009..These include the ability to undergo cholehepatic shunting and to directly stimulate cholangiocyte secretion, both resulting in a HCO(3)(-)-rich hypercholeresis that protects the liver from cholestatic injury... - From Mallory to Mallory-Denk bodies: what, how and why?Kurt Zatloukal
Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
Exp Cell Res 313:2033-49. 2007..Although it remains unclear whether MDBs serve a bystander, protective or injury promoting function, they do serve an important role as histological and potential progression markers in several liver diseases... - Cytokeratins as targets for bile acid-induced toxicityPeter Fickert
Department of Medicine, University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
Am J Pathol 160:491-9. 2002..Thus, increased hepatocellular CK expression and phosphorylation in cholestasis may be caused by retention of toxic bile acids and reflect a hepatocellular stress response with potential beneficial effects... - Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNAKatrin Panzitt
Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
Gastroenterology 132:330-42. 2007..We searched the human genome for novel genes including ncRNAs related to hepatocellular carcinoma (HCC)... - Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivoAndelko Hrzenjak
Lore Saldow Research Unit for Molecular Pathology of Gynecologic Tumors, Department of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria
Mol Cancer 9:49. 2010..We analyzed the influence of vorinostat on expression of different HDACs, p21(WAF1) and activation of apoptosis. Finally, we examined the antitumor effects of vorinostat on uterine sarcoma in vivo... - In vitro production of Mallory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62Conny Stumptner
Institute of Pathology, Medical University of Graz, Graz, Austria
Hepatology 46:851-60. 2007.... - Endometrial stromal sarcomas frequently express epidermal growth factor receptor (EGFR, HER-1): potential basis for a new therapeutic approachFarid Moinfar
Institute of Pathology, Medical University Graz, Graz, Austria
Am J Surg Pathol 29:485-9. 2005..This finding may provide the basis for a new therapeutic strategy using monoclonal antibodies against EGFR (such as cetuximab) or small molecule inhibitors of EGFR (such as gefitinib) in patients with endometrial sarcomas... - Hepatobiliary transporter expression and post-operative jaundice in patients undergoing partial hepatectomyGerwin A Bernhardt
Division of General Surgery, Department of Surgery, Medical University of Graz, Graz, Austria
Liver Int 32:119-27. 2012.... - Intermediate filament protein inclusionsKurt Zatloukal
Institute of Pathology, Medical University of Graz, A-8036 Graz, Austria
Methods Cell Biol 78:205-28. 2004 - Interaction of stress proteins with misfolded keratinsElke Janig
Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria
Eur J Cell Biol 84:329-39. 2005..Furthermore, we found clusterin in association with elastic fibers in the extracellular matrix in several chronic liver diseases, including ASH and alpha1-antitrypsin deficiency, implying a possible role of clusterin in liver fibrosis... - Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestineGernot Zollner
Division of Gastroenterology and Hepatology, Department of Medicine, Karl Franzens University, Auenbruggerplatz 15, A 8036 Graz, Austria
J Hepatol 39:480-8. 2003..Whether adaptive changes in ATP-binding cassette (ABC) transporter expression are stimulated by bile acids and their nuclear receptor FXR is unknown... - Human tissue biobanks as instruments for drug discovery and development: impact on personalized medicineKurt Zatloukal
Medical University of Graz, Graz, Austria
Biomark Med 4:895-903. 2010.... - Clusterin associates with altered elastic fibers in human photoaged skin and prevents elastin from ultraviolet-induced aggregation in vitroElke Janig
Institute of Pathology, Medical University of Graz, Graz, Austria
Am J Pathol 171:1474-82. 2007..The interaction of both proteins was further analyzed by electron microscopy, size exclusion chromatography, and mass spectrometry, in which clusterin was found in a stable complex with elastin after UV exposure... - A new technology for stabilization of biomolecules in tissues for combined histological and molecular analysesChristian Viertler
Institute of Pathology, Medical University of Graz, Graz, Austria
J Mol Diagn 14:458-66. 2012.... - Biobanks: transnational, European and global networksMartin Asslaber
Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
Brief Funct Genomic Proteomic 6:193-201. 2007.... - Allelic imbalances in endometrial stromal neoplasms: frequent genetic alterations in the nontumorous normal-appearing endometrial and myometrial tissuesFarid Moinfar
Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
Gynecol Oncol 95:662-71. 2004..The aim of this study was to examine the possibility of loss of heterozygosity (LOH) and microsatellite instability (MIS) in different tissue components of ESS... - Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthasePeter Hasselblatt
Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, A 1030 Vienna, Austria
Proc Natl Acad Sci U S A 104:17105-10. 2007..These findings demonstrate that c-Jun/AP-1 is hepatoprotective during acute hepatitis by regulating nos2/NO expression and thus functionally antagonizes the cell death-promoting functions of JNK... - Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in micePeter Fickert
Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Auenbruggerplatz 15, A-8036 Graz, Austria
Am J Pathol 168:410-22. 2006..Thus, we demonstrate that LCA feeding in mice leads to segmental bile duct obstruction, destructive cholangitis, periductal fibrosis, and an adaptive transporter and metabolic enzyme response... - Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liverGernot Zollner
Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Graz, Austria
Am J Physiol Gastrointest Liver Physiol 289:G798-805. 2005.... - Mallory body--a disease-associated type of sequestosomeCornelia Stumptner
Department of Pathology, School of Medicine, University of Graz, Graz, Austria
Hepatology 35:1053-62. 2002..In conclusion, the constant presence of p62 in MBs suggests that binding of p62 to abnormal keratins may allow hepatocytes to dispose potentially harmful proteins in a biologically inert manner... - p62 Is a common component of cytoplasmic inclusions in protein aggregation diseasesKurt Zatloukal
Department of Pathology, Karl Franzens University, Graz, Austria
Am J Pathol 160:255-63. 2002..The presence of p62 along with other stress proteins and ubiquitin in cytoplasmic inclusions indicates deposition as aggregates as a third line of defense against misfolded proteins in addition to refolding and degradation... - Bile acid-induced Mallory body formation in drug-primed mouse liverPeter Fickert
Department of Medicine, Karl-Franzens University, Auenbruggerplatz 25, A-8036 Graz, Austria
Am J Pathol 161:2019-26. 2002..Furthermore, CBDL and CA feeding resulted in rapid neoformation of MBs in drug-primed mice. It is concluded that MB formation in cholestatic liver diseases may be triggered by the action of potentially toxic bile acids... - CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in miceMartin Wagner
Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University Graz, Auenbruggerplatz 15, A-8036 Graz, Austria
Hepatology 42:420-30. 2005.... - Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratinsPeter Fickert
Department of Medicine, Karl-Franzens University Graz, Auenbruggerplatz 25, A-8036 Graz, Austria
J Hepatol 38:387-94. 2003..CONCLUSIONS: These findings support our concept that IF cytoskeletal alterations and MB formation in cholestatic liver diseases are related to bile acid-induced cell stress... - Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancersBeatrix Vécsey-Semjén
IMP, Research Institute of Molecular Pathology, Vienna, Austria
Oncogene 21:4646-62. 2002.... - Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosisGernot Zollner
Division of Gastroenterology and Hepatology, Department of Medicine, Karl-Franzens University, Auenbruggerplatz 15, A-8036, Graz, Austria
J Hepatol 38:717-27. 2003..CONCLUSIONS: Down-regulation of basolateral uptake systems and maintenance/up-regulation of canalicular and basolateral efflux pumps may represent adaptive mechanisms limiting the accumulation of toxic biliary constituents... - Automated evaluation and normalization of immunohistochemistry on tissue microarrays with a DNA microarray scannerWolfgang Haedicke
Oridis Biomed, Graz, Austria
Biotechniques 35:164-8. 2003..Therefore, DNA microarray scanners and associated image analysis software provide general and efficient analysis of tissue microarray immunostaining, including estimation of specific protein expression levels... - Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated miceMartin Wagner
Department of Medicine, Karl-Franzens University, Graz, Austria
Gastroenterology 125:825-38. 2003..This information is relevant for the potential use of FXR modulators in the treatment of cholestatic liver diseases... - Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosisThomas Muller
Department of Pediatrics, University of Innsbruck, Innsbruck, Austria
Hepatology 39:963-9. 2004..By sequestering potentially harmful misfolded ubiquitinated proteins as inert cytoplasmic inclusion bodies (e.g., as MBs), p62 may be a major player in an important cellular rescue mechanism in oxidative hepatocyte injury... - A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosisPeter Fickert
Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University Graz, Austria
Am J Pathol 171:525-36. 2007..This model may be valuable to investigate the mechanisms of xenobiotic-induced chronic cholangiopathies and its sequels including biliary fibrosis... - Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout micePeter Fickert
Deparment of Medicine, Medical University, Graz, Austria
Gastroenterology 127:261-74. 2004.... - Hepatobiliary transporter expression in human hepatocellular carcinomaGernot Zollner
Division of Gastroenterology and Hepatology, Department of Medicine, Medical University, Auenbruggerplatz 15, A-8036 Graz, Austria
Liver Int 25:367-79. 2005..Since expression of uptake systems is generally reduced in HCC, bile salt-coupled therapeutics may not represent a suitable strategy to overcome insufficient drug enrichment... - Inverse correlation of secreted frizzled-related protein 4 and beta-catenin expression in endometrial stromal sarcomasAndelko Hrzenjak
Department of Pathology, Medical University, Graz, Austria
J Pathol 204:19-27. 2004..SFRP4 may therefore be a putative tumour suppressor involved in deregulation of the Wnt pathway and in the pathogenesis of ESS and UES...