Rotraud Wieser

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. ncbi request reprint [Cystic fibrosis--the most frequent life-shortening autosomal recessive disease]
    Rotraud Wieser
    Abteilung für Humangenetik, Klinisches Institut für Medizinische und Chemische Labordiagnostik, Medizinische Universität Wien, Wien, Osterreich
    Wien Med Wochenschr 155:268-72. 2005
  2. doi request reprint microRNAs in acute myeloid leukemia: expression patterns, correlations with genetic and clinical parameters, and prognostic significance
    Rotraud Wieser
    Clinic of Medicine I, Medical University of Vienna, Vienna, Austria
    Genes Chromosomes Cancer 49:193-203. 2010
  3. ncbi request reprint The oncogene and developmental regulator EVI1: expression, biochemical properties, and biological functions
    Rotraud Wieser
    Department of Medical Genetics, Medical University of Vienna, Währingerstr, 10, A 1090 Wien, Austria
    Gene 396:346-57. 2007
  4. ncbi request reprint Novel rearrangement of chromosome band 22q11.2 causing 22q11 microdeletion syndrome-like phenotype and rhabdoid tumor of the kidney
    R Wieser
    Abteilung für Humangenetik, Klinisches Institut für Medizinische und Chemische Labordiagnostik, Medizinische Universität Wien, Wien, Austria
    Hum Mutat 26:78-83. 2005
  5. pmc Overexpression of primary microRNA 221/222 in acute myeloid leukemia
    Anna Rommer
    Department of Medicine I, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    BMC Cancer 13:364. 2013
  6. pmc Zinc finger transcription factor ecotropic viral integration site 1 is induced by all-trans retinoic acid (ATRA) and acts as a dual modulator of the ATRA response
    Sonja C Bingemann
    Department of Medical Genetics, Medical University of Vienna, Vienna, Austria
    FEBS J 276:6810-22. 2009
  7. ncbi request reprint Regulation of the expression of the oncogene EVI1 through the use of alternative mRNA 5'-ends
    Metin Aytekin
    KIMCL, Abteilung fuer Humangenetik, Medizinische Universitaet Wien, Waehringerstr 10, A 1090 Wien, Austria
    Gene 356:160-8. 2005
  8. pmc EVI1 and MDS1/EVI1 expression during primary human hematopoietic progenitor cell differentiation into various myeloid lineages
    Katarina Steinleitner
    Department of Medicine I, Medical University Vienna, Wahringer Gurtel 18 20, 1090 Wien, Austria
    Anticancer Res 32:4883-9. 2012
  9. doi request reprint Expression and prognostic significance of different mRNA 5'-end variants of the oncogene EVI1 in 266 patients with de novo AML: EVI1 and MDS1/EVI1 overexpression both predict short remission duration
    Katja Haas
    Department of Medical Genetics, Medical University of Vienna, Vienna, Austria
    Genes Chromosomes Cancer 47:288-98. 2008
  10. ncbi request reprint Quantitative comparison of the expression of EVI1 and its presumptive antagonist, MDS1/EVI1, in patients with myeloid leukemia
    Ursula Vinatzer
    Institut für Medizinische Biologie der Universitaet Wien, Vienna, Austria
    Genes Chromosomes Cancer 36:80-9. 2003

Collaborators

Detail Information

Publications23

  1. ncbi request reprint [Cystic fibrosis--the most frequent life-shortening autosomal recessive disease]
    Rotraud Wieser
    Abteilung für Humangenetik, Klinisches Institut für Medizinische und Chemische Labordiagnostik, Medizinische Universität Wien, Wien, Osterreich
    Wien Med Wochenschr 155:268-72. 2005
    ..Since 4% of white Europeans and North Americans are healthy heterozygous carriers of CF, the molecular diagnosis of this disease, offered in the context of genetic counselling by a specialist in human genetics, is of great importance...
  2. doi request reprint microRNAs in acute myeloid leukemia: expression patterns, correlations with genetic and clinical parameters, and prognostic significance
    Rotraud Wieser
    Clinic of Medicine I, Medical University of Vienna, Vienna, Austria
    Genes Chromosomes Cancer 49:193-203. 2010
    ..Interestingly, the results of these analyses showed only very limited congruence. This review summarizes published reports on the expression patterns of miRNAs in AML, and discusses possible reasons for the differences in their results...
  3. ncbi request reprint The oncogene and developmental regulator EVI1: expression, biochemical properties, and biological functions
    Rotraud Wieser
    Department of Medical Genetics, Medical University of Vienna, Währingerstr, 10, A 1090 Wien, Austria
    Gene 396:346-57. 2007
    ..This review summarizes the currently available experimental evidence for the proposed biochemical and biological functions of this important oncogene...
  4. ncbi request reprint Novel rearrangement of chromosome band 22q11.2 causing 22q11 microdeletion syndrome-like phenotype and rhabdoid tumor of the kidney
    R Wieser
    Abteilung für Humangenetik, Klinisches Institut für Medizinische und Chemische Labordiagnostik, Medizinische Universität Wien, Wien, Austria
    Hum Mutat 26:78-83. 2005
    ..Two nonallelic homologous recombination events between low-copy repeats (LCRs) could explain the emergence of this novel and complex mutation associated with the phenotype of 22q11 microdeletion syndrome...
  5. pmc Overexpression of primary microRNA 221/222 in acute myeloid leukemia
    Anna Rommer
    Department of Medicine I, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    BMC Cancer 13:364. 2013
    ..In this context, leukemia-associated misexpression of microRNAs (miRNAs) has been studied, but no coherent picture has emerged yet, thus warranting further investigations...
  6. pmc Zinc finger transcription factor ecotropic viral integration site 1 is induced by all-trans retinoic acid (ATRA) and acts as a dual modulator of the ATRA response
    Sonja C Bingemann
    Department of Medical Genetics, Medical University of Vienna, Vienna, Austria
    FEBS J 276:6810-22. 2009
    ..Thus, we have established EVI1 as a novel type of modulator of the retinoic acid response, which can both enhance and repress induction by this agent in a promoter-specific manner...
  7. ncbi request reprint Regulation of the expression of the oncogene EVI1 through the use of alternative mRNA 5'-ends
    Metin Aytekin
    KIMCL, Abteilung fuer Humangenetik, Medizinische Universitaet Wien, Waehringerstr 10, A 1090 Wien, Austria
    Gene 356:160-8. 2005
    ..This induction required transcriptional activity of RNA polymerase, but was also associated with a substantial increase in the stability of these mRNA variants...
  8. pmc EVI1 and MDS1/EVI1 expression during primary human hematopoietic progenitor cell differentiation into various myeloid lineages
    Katarina Steinleitner
    Department of Medicine I, Medical University Vienna, Wahringer Gurtel 18 20, 1090 Wien, Austria
    Anticancer Res 32:4883-9. 2012
    ..We therefore studied its expression and function in cluster of differentiation 34-positive (CD34(+)) primary human hematopoietic progenitor cells...
  9. doi request reprint Expression and prognostic significance of different mRNA 5'-end variants of the oncogene EVI1 in 266 patients with de novo AML: EVI1 and MDS1/EVI1 overexpression both predict short remission duration
    Katja Haas
    Department of Medical Genetics, Medical University of Vienna, Vienna, Austria
    Genes Chromosomes Cancer 47:288-98. 2008
    ..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat...
  10. ncbi request reprint Quantitative comparison of the expression of EVI1 and its presumptive antagonist, MDS1/EVI1, in patients with myeloid leukemia
    Ursula Vinatzer
    Institut für Medizinische Biologie der Universitaet Wien, Vienna, Austria
    Genes Chromosomes Cancer 36:80-9. 2003
    ..We further provide preliminary evidence that the RTQ-RT-PCR assay may be useful for disease monitoring in patients overexpressing EVI1...
  11. pmc Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes
    Torsten A Konrad
    Department of Medical Genetics, Medical University of Vienna, A 1090 Vienna, Austria
    J Leukoc Biol 86:813-22. 2009
    ..In summary, these data show that inducible expression of EVI1 in U937 cells causes phenotypes that may be relevant for its role in MDS and provides a basis for further investigation of its contribution to this fatal disease...
  12. pmc EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells
    Anna Rommer
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    PLoS ONE 8:e56308. 2013
    ..Indeed, overexpression of CDKN1A in U937 cells mimicked the phenotype of EVI1 overexpression, similarly conferring partial resistance to antileukemic drugs...
  13. ncbi request reprint Disruption of exonic splicing enhancer elements is the principal cause of exon skipping associated with seven nonsense or missense alleles of NF1
    Andrea Zatkova
    Institut für Medizinische Biologie, Medizinische Universität Wien, Vienn, Austria
    Hum Mutat 24:491-501. 2004
    ....
  14. doi request reprint Update on genetic and molecular markers associated with myelodysplastic syndromes
    Peter Valent
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Leuk Lymphoma 50:341-8. 2009
    ..The present article provides a summary of our current knowledge about molecular and genetic markers in MDS, with special reference to their potential prognostic and therapeutic implications...
  15. ncbi request reprint Rearrangements of chromosome band 3q21 in myeloid leukemia
    Rotraud Wieser
    Institut für Medizinische Biologie der Universitaet Wien, Vienna, Austria
    Leuk Lymphoma 43:59-65. 2002
    ..Several additional candidate genes have been identified in or near the 3q21 breakpoint region, but their possible contribution to the characteristics of leukemias with 3q21 rearrangements remains to be explored...
  16. doi request reprint Clinical significance of genetic aberrations in secondary acute myeloid leukemia
    Jelena D Milosevic
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
    Am J Hematol 87:1010-6. 2012
    ..Somatic mutations in TP53 are the only independent adverse prognostic factor in sAML. Patients with dnAML and complex karyotype show genetic features associated with sAML and myeloproliferative neoplasms...
  17. ncbi request reprint Both IGH translocations and chromosome 13q deletions are early events in monoclonal gammopathy of undetermined significance and do not evolve during transition to multiple myeloma
    H Kaufmann
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    Leukemia 18:1879-82. 2004
    ..IgH translocations and del(13q) are early genetic events in monoclonal gammopathies, suggesting that additional events are required for the transition from stable MGUS to progressive MM...
  18. ncbi request reprint Bortezomib in relapsed multiple myeloma: response rates and duration of response are independent of a chromosome 13q-deletion
    V Sagaster
    Department of Internal Medicine I, Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria
    Leukemia 21:164-8. 2007
    ..Patients who do not respond to bortezomib and consecutively have short time to treatment failure and overall survival can be identified by low serum albumin in addition to del(13q14) and should be considered for bortezomib combinations...
  19. ncbi request reprint Transcription factor GATA-2 gene is located near 3q21 breakpoints in myeloid leukemia
    R Wieser
    Institut für Medizinische Biologie der Universität Wien, Währingerstrasse 10, Vienna, A 1090, Austria
    Biochem Biophys Res Commun 273:239-45. 2000
    ....
  20. ncbi request reprint Comparative expression analysis of the antagonistic transcription factors EVI1 and MDS1-EVI1 in murine tissues and during in vitro hematopoietic differentiation
    K Wimmer
    Institut für Medizinische Biologie der Universität Wien, Währingerstrasse 10, Wien, A 1090, Austria
    Biochem Biophys Res Commun 252:691-6. 1998
    ..Our data underscore the biological importance of both EVI1 and MDS1-EVI1 and provide the basis for further studies of their function in the mouse model system...
  21. ncbi request reprint Interphase fluorescence in situ hybridization assay for the detection of 3q21 rearrangements in myeloid malignancies
    R Wieser
    Institut für Medizinische Biologie, Universitat Wien, Wien, Austria
    Genes Chromosomes Cancer 32:373-80. 2001
    ..These findings may contribute to the understanding of the molecular basis of the clinical features associated with 3q21 rearrangements...
  22. ncbi request reprint Deletion of sequences telomeric of the EVI1 gene in 3q26 associated with a novel pericentric inv(3)(p25q26) in a patient with acute myelogenous leukemia
    Rotraud Wieser
    Haematologica 88:1427-9. 2003
  23. ncbi request reprint Interphase fluorescence in situ hybridization assay for the detection of rearrangements of the EVI-1 locus in chromosome band 3q26 in myeloid malignancies
    Rotraud Wieser
    Institut für Medizinische Biologie der Universitaet Wien, Austria
    Haematologica 88:25-30. 2003
    ..To aid the diagnosis of such aberrations, and possibly disease monitoring, we established an interphase fluorescence in situ hybridization (FISH) assay for the affected breakpoint region...