Walther H Wernsdorfer

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. doi request reprint In vitro drug sensitivity testing in Plasmodium vivax
    Walther H Wernsdorfer
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University of Vienna, Austria
    Wien Klin Wochenschr 120:30-3. 2008
  2. doi request reprint Global challenges of changing epidemiological patterns of malaria
    Walther H Wernsdorfer
    Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Wien, Austria
    Acta Trop 121:158-65. 2012
  3. doi request reprint Activity of Eurycoma longifolia root extract against Plasmodium falciparum in vitro
    Walther H Wernsdorfer
    Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 121:23-6. 2009
  4. ncbi request reprint Susceptibility to chloroquine, mefloquine and artemisinin of Plasmodium vivax in northwestern Thailand
    Birgit Woitsch
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Thailand
    Wien Klin Wochenschr 119:76-82. 2007
  5. ncbi request reprint Specific pharmacokinetic interaction between lumefantrine and monodesbutyl-benflumetol in Plasmodium falciparum
    Peter Starzengruber
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 119:60-6. 2007
  6. ncbi request reprint In vitro interaction between artemisinin and chloroquine as well as desbutyl-benflumetol in Plasmodium vivax
    Leila Kyavar
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University Vienna, Vienna, Austria
    Wien Klin Wochenschr 118:62-9. 2006
  7. doi request reprint Pharmacodynamic interaction between monodesbutyl-benflumetol and artemisinin as well as proguanil in Plasmodium falciparum in vitro
    Jens Raffelsberger
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University of Vienna, Austria
    Wien Klin Wochenschr 120:90-4. 2008
  8. ncbi request reprint Synergistic interaction between monodesbutyl-benflumetol and retinol in Plasmodium falciparum
    Maria Parizek
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 119:53-9. 2007
  9. ncbi request reprint Pharmacodynamic interaction between atovaquone and other antimalarial compounds against Plasmodium falciparum in vitro
    Carola Lütgendorf
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 118:70-6. 2006
  10. ncbi request reprint In vitro activity of artemisinin alone and in combination with retinol against Plasmodium falciparum
    Kamala Thriemer
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University Vienna, Vienna, Austria
    Wien Klin Wochenschr 117:45-8. 2005

Collaborators

Detail Information

Publications31

  1. doi request reprint In vitro drug sensitivity testing in Plasmodium vivax
    Walther H Wernsdorfer
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University of Vienna, Austria
    Wien Klin Wochenschr 120:30-3. 2008
    ..The population-based test procedure would also permit the identification of any stage-specific impact of antimalarial agents...
  2. doi request reprint Global challenges of changing epidemiological patterns of malaria
    Walther H Wernsdorfer
    Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Wien, Austria
    Acta Trop 121:158-65. 2012
    ..Similarly, the reasons for failing the declared goal of eliminating malaria sets the new scene for the global challenges ahead of us in the endeavour of future attempts at eliminating malaria...
  3. doi request reprint Activity of Eurycoma longifolia root extract against Plasmodium falciparum in vitro
    Walther H Wernsdorfer
    Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 121:23-6. 2009
    ..The inhibitory activity of the E. longifolia extract was higher than that expected from the three quassinoids isolated from the plant, suggesting synergism between the quassinoids or the presence of other unidentified compounds...
  4. ncbi request reprint Susceptibility to chloroquine, mefloquine and artemisinin of Plasmodium vivax in northwestern Thailand
    Birgit Woitsch
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Thailand
    Wien Klin Wochenschr 119:76-82. 2007
    ..0 nM. For artemisinin the EC(50) and EC(90) values were 8.7 nM and 105.2 nM, respectively, the GMCOC was 310.5 nM. As compared to 2002, the sensitivity of P. vivax to artemisinin has shown a slight but not significant increase...
  5. ncbi request reprint Specific pharmacokinetic interaction between lumefantrine and monodesbutyl-benflumetol in Plasmodium falciparum
    Peter Starzengruber
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 119:60-6. 2007
    ..Correlation analysis indicates that DBB is the leading determinant for the activity of the combination...
  6. ncbi request reprint In vitro interaction between artemisinin and chloroquine as well as desbutyl-benflumetol in Plasmodium vivax
    Leila Kyavar
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University Vienna, Vienna, Austria
    Wien Klin Wochenschr 118:62-9. 2006
    ..0300, and synergism at the therapeutically most important EC(99) with a mean SigmaFIC of 0.5990...
  7. doi request reprint Pharmacodynamic interaction between monodesbutyl-benflumetol and artemisinin as well as proguanil in Plasmodium falciparum in vitro
    Jens Raffelsberger
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University of Vienna, Austria
    Wien Klin Wochenschr 120:90-4. 2008
    ..The SFIC values indicated moderate synergism between DBB and proguanil that could be an advantage in an eventual therapeutic and prophylactic use of DBB...
  8. ncbi request reprint Synergistic interaction between monodesbutyl-benflumetol and retinol in Plasmodium falciparum
    Maria Parizek
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 119:53-9. 2007
    ..00 nM and 13.74 nM, respectively, indicating significant synergistic interaction between DBB and retinol. The degree of synergism increases with the retinol concentration in the combination and is highest at the EC(99) level for DBB...
  9. ncbi request reprint Pharmacodynamic interaction between atovaquone and other antimalarial compounds against Plasmodium falciparum in vitro
    Carola Lütgendorf
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 118:70-6. 2006
    ..g. artesunate...
  10. ncbi request reprint In vitro activity of artemisinin alone and in combination with retinol against Plasmodium falciparum
    Kamala Thriemer
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University Vienna, Vienna, Austria
    Wien Klin Wochenschr 117:45-8. 2005
    ..71 nM and 13.37 nM, respectively. The combination showed synergistic activity. Retinol appears to be a promising partner for the antimalarial therapy with artemisinins...
  11. doi request reprint Interaction between lumefantrine and monodesbutyl-benflumetol in Plasmodium falciparum in vitro
    Peter Starzengruber
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University of Vienna, Austria
    Wien Klin Wochenschr 120:85-9. 2008
    ....
  12. doi request reprint Synergism between monodesbutyl-benflumetol and artemisinin in Plasmodium falciparum in vitro
    Gernot Müller
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University of Vienna, Austria
    Wien Klin Wochenschr 120:80-4. 2008
    ..Positive specific pharmacodynamic interaction was therefore most marked in isolates with reduced sensitivity against artemisinin and DBB...
  13. ncbi request reprint Synergism of desbutyl-benflumetol and retinol against Plasmodium falciparum in vitro
    Doris Samal
    Department of Neurology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 117:39-44. 2005
    ..It is well known that retinol levels are significantly decreased in acute falciparum malaria. Supplementation with retinol during malaria treatment may improve the therapeutic results of blood schizontocides of the fluorene class...
  14. ncbi request reprint In-vitro sensitivity testing of Plasmodium vivax: response to lumefantrine and chloroquine in northwestern Thailand
    Daniela Lux
    Department of Specific Prophylaxis and Tropical Medicine, Institute of Pathophysiology, University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 115:50-4. 2003
    ..The EC50 and EC90 for chloroquine were 16 nM and 511 nM, respectively. One of the isolates, from Myanmar, showed low sensitivity to chloroquine...
  15. doi request reprint Synergism between mefloquine and artemisinin and its enhancement by retinol in Plasmodium falciparum in vitro
    Gerwald Kerschbaumer
    Centre for Pathophysiology, Infectiology and Immunology, Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 122:57-60. 2010
    ..In the combinations with artemisinin and retinol moderate synergism was observed at the IC(50), but synergism increased strongly at the IC(90) and the IC(99)...
  16. ncbi request reprint Comparative study on the in vitro activity of lumefantrine and desbutyl-benflumetol in fresh isolates of Plasmodium vivax from Thailand
    Daniela K Pirker-Krassnig
    Division of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Austria
    Wien Klin Wochenschr 116:47-52. 2004
    ..0. The activity of desbutyl-benflumetol in P. vivax exceeds that of lumefantrine by one order of magnitude, suggesting a high, hitherto unexploited therapeutic potential of desbutyl-benflumetol...
  17. doi request reprint Activity of selected phytochemicals against Plasmodium falciparum
    Florian Astelbauer
    Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Austria
    Acta Trop 123:96-100. 2012
    ..38. Analogues of rocaglamid and aglafoline merit further exploration of their anti-plasmodial activity...
  18. doi request reprint Pharmacodynamic interaction between lumefantrine and desbutyl-benflumetol in Plasmodium falciparum in vitro
    Alexander Leeb
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 122:61-5. 2010
    ..The geometric mean of the sums of the FIC(50) is 0.73, of the FIC(90) it is 0.37 and of the FIC(99) it is 0.25...
  19. ncbi request reprint Synergistic interaction between atovaquone and retinol in Plasmodium falciparum in vitro
    Bettina Exner
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 119:45-52. 2007
    ....
  20. doi request reprint Sensitivity of Plasmodium vivax to chloroquine, mefloquine, artemisinin and atovaquone in north-western Thailand
    Moritz Treiber
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Pathophysiology, Immunology and Infectiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 123:20-5. 2011
    ..High prevalence of mefloquine resistance precludes its alternative use. However, atovaquone, in combination with proguanil, may be a possible alternative...
  21. ncbi request reprint Drug sensitivity of Plasmodium falciparum along the Thai-Myanmar border using the new field-deployable HRP2 in vitro assay
    Bernhard Attlmayr
    Department of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 117:35-8. 2005
    ..The HRP2 field test was found to be highly sensitive and simple enough to be entirely performed in the field...
  22. doi request reprint Pharmacodynamic interaction between mefloquine and retinol in Plasmodium falciparum in vitro
    Maria Gruber
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 121:27-31. 2009
    ..29, 1.15 and 3.48 microM, and those for mefloquine + retinol "high" 0.20, 0.85 and 2.70 microM. Evidence for strong synergism between mefloquine and retinol in P. falciparum was highly significant...
  23. doi request reprint Sensitivity to artemisinin, mefloquine and quinine of Plasmodium falciparum in northwestern Thailand
    Felix Hüttinger
    Centre for Pathophysiology, Infectiology and Immunology, Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 122:52-6. 2010
    ..All tested drugs showed a significant reduction in the effectiveness, compared with the results of former years. This suggests a further rise of resistance of local P. falciparum, which is alarming especially for artemisinin and quinine...
  24. doi request reprint Synergism between pyronaridine and retinol in Plasmodium vivax in vitro
    Julia Riedl
    Center for Pathophysiology, Infectiology and Immunology, Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 122:66-70. 2010
    ..5, 313.7 and 58891.4 nM and for the combination with retinol "high" they were 0.2, 96.7 and 16754.3 nM. These results suggest strong synergism between the two substances...
  25. ncbi request reprint Comparative study of the in vitro sensitivity of Plasmodium falciparum to artemisinin in two border areas of Thailand
    Birgit Woitsch
    Division of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 116:35-40. 2004
    ..Furthermore, the lower sensitivity of Plasmodium falciparum to mefloquine in Mae Sot may play a minor (but amplifying) role, as the activities of artemisinin and mefloquine show a significant correlation...
  26. ncbi request reprint Development of a pharmacodynamic screening model with Entamoeba histolytica
    Oumaporn Tasanor
    Institute for Specific Prophylaxis und Tropical Medicine, Center for Physiology und Pathophysiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 119:88-95. 2007
    ..1325, followed by leaf extract from Stemona tuberosa with an IC(99) of 638 ng/ml and a slope S of 1.5648. All seven extracts showed full activity at concentrations <4000 ng/ml and qualified for further investigation...
  27. ncbi request reprint Malaria drug-susceptibility testing. HRP2-based assays: current data, future perspectives
    Harald Noedl
    Department of Specific Prophylaxis and Tropical Medicine, Institute of Pathophysiology, University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 115:23-7. 2003
    ..It has proved to be a valuable tool for a wide range of applications, from epidemiological field studies to the screening of new drugs, and may therefore have the potential to replace traditional in-vitro drug-sensitivity techniques...
  28. ncbi request reprint Comparison of the in-vitro activity of amodiaquine and its main metabolite, monodesethyl-amodiaquine, in Plasmodium falciparum
    Ulrich Gerstner
    Department of Specific Prophylaxis and Tropical Medicine, Institute of Pathophysiology, University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 115:33-8. 2003
    ..Both compounds showed highly significant activity correlation. These findings suggest that the sensitivity of Plasmodium falciparum to amodiaquine closely reflects its sensitivity to monodesethyl-amodiaquine...
  29. ncbi request reprint Development of a pharmacodynamic screening model with Crithidia fasciculata
    Oumaporn Tasanor
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University of Vienna, Austria
    Wien Klin Wochenschr 118:42-9. 2006
    ..Encouraging results were obtained with extracts from Aglaia odorata leaves, A. elaeagnoidea stem bark and A. edulis leaves, with EC(90) values of 1213 ng/ml, 1606 ng/ml, and 1462 ng/ml, respectively...
  30. ncbi request reprint Malaria drug-sensitivity testing: new assays, new perspectives
    Harald Noedl
    Dept of Specific Prophylaxis and Tropical Medicine, Institute of Pathophysiology, University of Vienna, Kinderspitalgasse 15, A 1095, Vienna, Austria
    Trends Parasitol 19:175-81. 2003
    ..This review examines the various new approaches to the in vitro assessment of malaria drug sensitivity and their limitations...
  31. doi request reprint Clinical and molecular characterization of a near fatal case of human babesiosis in Austria
    Michael Ramharter
    Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria
    J Travel Med 17:416-8. 2010
    ..However, upon reevaluation Babesia microti infection was suspected and molecular characterization by polymerase chain reaction and sequence analysis was performed...