Eva Untersmayr

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. pmc The role of protein digestibility and antacids on food allergy outcomes
    Eva Untersmayr
    Department of Pathophysiology, Center of Physiology, Pathophysiology, and Immunology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 121:1301-8; quiz 1309-10. 2008
  2. pmc The high affinity IgE receptor Fc epsilonRI is expressed by human intestinal epithelial cells
    Eva Untersmayr
    Department of Pathophysiology, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Vienna, Austria
    PLoS ONE 5:e9023. 2010
  3. pmc Nitration of the egg-allergen ovalbumin enhances protein allergenicity but reduces the risk for oral sensitization in a murine model of food allergy
    Eva Untersmayr
    Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
    PLoS ONE 5:e14210. 2010
  4. ncbi request reprint Mucosal targeting of allergen-loaded microspheres by Aleuria aurantia lectin
    Franziska Roth-Walter
    Department of Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Vaccine 23:2703-10. 2005
  5. ncbi request reprint Mimotopes identify conformational epitopes on parvalbumin, the major fish allergen
    Eva Untersmayr
    Center of Physiology and Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Mol Immunol 43:1454-61. 2006
  6. ncbi request reprint Characterization of intrinsic and extrinsic risk factors for celery allergy in immunosenescence
    Eva Untersmayr
    Department of Pathophysiology, Center of Physiology, Pathophysiology and Immunology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Mech Ageing Dev 129:120-8. 2008
  7. ncbi request reprint M cell targeting with Aleuria aurantia lectin as a novel approach for oral allergen immunotherapy
    Franziska Roth-Walter
    Department of Pathophysiology, Medical University of Vienna, Austria
    J Allergy Clin Immunol 114:1362-8. 2004
  8. ncbi request reprint Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients
    Eva Untersmayr
    Center of Physiology and Pathophysiology, Medical University Vienna, Vienna, Austria
    FASEB J 19:656-8. 2005
  9. ncbi request reprint Internal images: human anti-idiotypic Fab antibodies mimic the IgE epitopes of grass pollen allergen Phl p 5a
    Brigitte Hantusch
    Center of Physiology and Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Mol Immunol 43:2180-7. 2006
  10. ncbi request reprint Targeting antigens to murine and human M-cells with Aleuria aurantia lectin-functionalized microparticles
    Franziska Roth-Walter
    Center of Physiology and Pathophysiology, Medical University of Vienna, AKH 3Q, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Immunol Lett 100:182-8. 2005

Collaborators

Detail Information

Publications29

  1. pmc The role of protein digestibility and antacids on food allergy outcomes
    Eva Untersmayr
    Department of Pathophysiology, Center of Physiology, Pathophysiology, and Immunology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 121:1301-8; quiz 1309-10. 2008
    ..Thus antiulcer agents impeding gastric protein digestion have a major effect on the sensitization and effector phase of food allergy...
  2. pmc The high affinity IgE receptor Fc epsilonRI is expressed by human intestinal epithelial cells
    Eva Untersmayr
    Department of Pathophysiology, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Vienna, Austria
    PLoS ONE 5:e9023. 2010
    ..To gain insights in IgE-mediated pathophysiology of the gut, we investigated the expression of the high affinity IgE receptor Fc epsilonRI in human intestinal epithelium...
  3. pmc Nitration of the egg-allergen ovalbumin enhances protein allergenicity but reduces the risk for oral sensitization in a murine model of food allergy
    Eva Untersmayr
    Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
    PLoS ONE 5:e14210. 2010
    ..In the current study we have analyzed the impact of protein nitration on sensitization via the oral route...
  4. ncbi request reprint Mucosal targeting of allergen-loaded microspheres by Aleuria aurantia lectin
    Franziska Roth-Walter
    Department of Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Vaccine 23:2703-10. 2005
    ....
  5. ncbi request reprint Mimotopes identify conformational epitopes on parvalbumin, the major fish allergen
    Eva Untersmayr
    Center of Physiology and Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Mol Immunol 43:1454-61. 2006
    ..We suggest that these mimotopes are suitable candidates for an epitope-specific immunotherapy of fish-allergic patients...
  6. ncbi request reprint Characterization of intrinsic and extrinsic risk factors for celery allergy in immunosenescence
    Eva Untersmayr
    Department of Pathophysiology, Center of Physiology, Pathophysiology and Immunology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Mech Ageing Dev 129:120-8. 2008
    ..Thus, in the geriatric murine model, celery allergy was induced only if gastric digestion was hindered. Accordingly, gastric proteolysis decreased in vitro and in vivo IgE-reactivity against celery proteins in aged allergic patients...
  7. ncbi request reprint M cell targeting with Aleuria aurantia lectin as a novel approach for oral allergen immunotherapy
    Franziska Roth-Walter
    Department of Pathophysiology, Medical University of Vienna, Austria
    J Allergy Clin Immunol 114:1362-8. 2004
    ..The extent and quality of the immune response to orally applied allergens may critically depend on the precise site of uptake at the intestinal mucosa...
  8. ncbi request reprint Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients
    Eva Untersmayr
    Center of Physiology and Pathophysiology, Medical University Vienna, Vienna, Austria
    FASEB J 19:656-8. 2005
    ..In line with our previous animal experiments, our data strongly suggest that anti-ulcer treatment primes the development of IgE toward dietary compounds in long-term acid-suppressed patients...
  9. ncbi request reprint Internal images: human anti-idiotypic Fab antibodies mimic the IgE epitopes of grass pollen allergen Phl p 5a
    Brigitte Hantusch
    Center of Physiology and Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Mol Immunol 43:2180-7. 2006
    ..Here, we describe the selection of anti-idiotypic antibodies against Phl p 5a-specific IgE directly from the B-cell repertoire of a grass pollen allergic individual...
  10. ncbi request reprint Targeting antigens to murine and human M-cells with Aleuria aurantia lectin-functionalized microparticles
    Franziska Roth-Walter
    Center of Physiology and Pathophysiology, Medical University of Vienna, AKH 3Q, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Immunol Lett 100:182-8. 2005
    ..We conclude that AAL-coated microparticles may have the potential to target entrapped antigens to human M-cells for oral vaccination...
  11. ncbi request reprint Immunization with mimotopes prevents growth of carcinoembryonic antigen positive tumors in BALB/c mice
    Kira H Brämswig
    Department of Pathophysiology, Medical University Vienna, Vienna, Austria
    Clin Cancer Res 13:6501-8. 2007
    ..At present, anti-CEA antibodies are being tested in clinical studies as passive immunotherapeutics. This study aims to establish an active immunotherapy for the poorly immunogenic CEA glycoprotein by generating antigen surrogates...
  12. pmc Use of lectin-functionalized particles for oral immunotherapy
    Susanne C Diesner
    Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Immunology and Infectiology, Medical University of Vienna, Vienna, Austria
    Ther Deliv 3:277-90. 2012
    ..Thus, enhanced uptake and presentation of the encapsulated antigen by antigen-presenting cells favor strong systemic, but also local, mucosal immune responses...
  13. pmc Incomplete digestion of codfish represents a risk factor for anaphylaxis in patients with allergy
    Eva Untersmayr
    Center of Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 119:711-7. 2007
    ..Fish represents one of the most important allergenic foods causing severe allergic reactions. Nevertheless, it has been shown that gastric digestion significantly reduces its allergenic capacity...
  14. doi request reprint Perspectives on immunomodulation early in life
    Susanne C Diesner
    Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Pediatr Allergy Immunol 23:210-23. 2012
    ..Therefore, they can potentially modulate and balance immune responses, which might be in particular beneficial for the immaturity of the immune response early in life...
  15. pmc Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a mouse model of food allergy
    Susanne C Diesner
    Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Immunol Lett 141:210-9. 2012
    ..Further, S1P was proposed to play a major role in the induction and promotion of allergic diseases. However, to date only limited information is available on the role of S1P in food allergy...
  16. ncbi request reprint Antacid medication inhibits digestion of dietary proteins and causes food allergy: a fish allergy model in BALB/c mice
    Eva Untersmayr
    Department of Pathophysiology, University of Vienna, AKH 3Q, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Allergy Clin Immunol 112:616-23. 2003
    ..Approximately 10% of the adult population uses antacids for the treatment of dyspeptic disorders, drugs that hinder peptic digestion. In these patients, proteins that are normally degradable might act as food allergens...
  17. ncbi request reprint The effect of gastric digestion on food allergy
    Eva Untersmayr
    Center of Physiology and Pathophysiology, Medical University Vienna, Vienna, Austria
    Curr Opin Allergy Clin Immunol 6:214-9. 2006
    ..This review analyses the role of gastric digestion in food allergy...
  18. ncbi request reprint Functionalisation of allergen-loaded microspheres with wheat germ agglutinin for targeting enterocytes
    Franziska Walter
    Department of Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna A 1090, Austria
    Biochem Biophys Res Commun 315:281-7. 2004
    ..Thus, we conclude that WGA-microspheres are suitable vehicles for oral delivery and mucosal targeting due to lectin-mediated bioadhesion...
  19. ncbi request reprint Antiulcer drugs promote oral sensitization and hypersensitivity to hazelnut allergens in BALB/c mice and humans
    Isabella Schöll
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Am J Clin Nutr 81:154-60. 2005
    ..However, severe allergic reactions after ingestion of hazelnuts without associated pollen allergy have been reported. In these cases, oral sensitization by hazelnut ingestion is plausible...
  20. ncbi request reprint Active induction of tumor-specific IgE antibodies by oral mimotope vaccination
    Angelika B Riemer
    Departments of Pathophysiology, Dermatology, and Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Cancer Res 67:3406-11. 2007
    ..We conclude that directed and epitope-specific induction of IgE against tumor antigens is feasible with an oral mimotope vaccination regimen, and that these antibodies mediate anticancer effects...
  21. pmc Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring
    Isabella Schöll
    Department of Pathophysiology, Medical University of Vienna, Währinger Gürtel1090 Vienna, Austria
    FASEB J 21:1264-70. 2007
    ..From these results we propose that anti-acid treatment during pregnancy could be responsible for the increasing number of sensitizations against food allergens in young infants...
  22. ncbi request reprint Mechanisms of type I food allergy
    Eva Untersmayr
    Center of Physiology and Pathophysiology, Medical University Vienna, Waehringer Guertel 18 20, E3Q, 1090 Vienna, Austria
    Pharmacol Ther 112:787-98. 2006
    ..Therefore, the available models are critically analyzed in this review...
  23. ncbi request reprint Eosinophils accumulate in the gastric mucosa of food-allergic mice
    Eva Untersmayr
    Department of Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, AT 1090 Vienna, Austria
    Int Arch Allergy Immunol 135:1-2. 2004
  24. ncbi request reprint Mapping of conformational IgE epitopes on Phl p 5a by using mimotopes from a phage display library
    Brigitte Hantusch
    Department of Patophysiology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 114:1294-300. 2004
    ..Phl p 5 represents a major allergen of timothy grass pollen (Phleum pratense). Detailed knowledge about the structures responsible for IgE binding would allow the design of a novel generation of allergy vaccines...
  25. ncbi request reprint The effects of gastric digestion on codfish allergenicity
    Eva Untersmayr
    Center of Physiology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 115:377-82. 2005
    ..In a recent murine study, we showed that impaired gastric digestion supports the induction of fish allergy by protecting the digestion-sensitive major allergen parvalbumin and thus enhancing its sensitizing properties...
  26. ncbi request reprint Exercise with latex sport bands represents a risk for latex allergic patients
    Eva Untersmayr
    Department of Pathophysiology, Center of Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
    Immunol Lett 115:98-104. 2008
    ..Even though latex is labeled on products, it is important that patients as well as athletic trainers and physical therapists recognize the risk of adverse reactions with these bands...
  27. doi request reprint Food allergy: only a pediatric disease?
    Susanne C Diesner
    Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria
    Gerontology 57:28-32. 2011
    ..Previous reports have already suggested that allergies are underdiagnosed among the elderly. Based on our own recent study conducted in a geriatric nursing home, we also suggest that food allergies may be underestimated...
  28. ncbi request reprint Food safety: in vitro digestion tests are non-predictive for allergenic potential of food in stomach insufficiency
    Erika Jensen-Jarolim
    Immunol Lett 102:118-9. 2006
    ....
  29. ncbi request reprint Risk assessment in elderly for sensitization to food and respiratory allergens
    Noemi Bakos
    Department of Dermatology, Hetenyi Geza Hospital, Szolnok, Hungary
    Immunol Lett 107:15-21. 2006
    ..001). The risk factors for sensitization in elderly to respiratory allergens were chronic damage of respiratory epithelia due to smoking, and for sensitization to food allergens chronic alcohol consumption...