Research Topics
| Johannes TauscherSummaryAffiliation: Medical University of Vienna Country: Austria Publications
| Collaborators
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Detail Information
Publications
Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychoticsJohannes Tauscher
University of Toronto Department of Psychiatry, Schizophrenia Program
Am J Psychiatry 161:1620-5. 2004....- Reduced serotonin-1A receptor binding in social anxiety disorderRupert R Lanzenberger
Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
Biol Psychiatry 61:1081-9. 2007..The objective of this study was to investigate 5-HT1A receptor binding potential (BP) in social anxiety disorder (SAD)... - Binding kinetics of 123I[ADAM] in healthy controls: a selective SERT radioligandJulia Sacher
Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
Int J Neuropsychopharmacol 10:211-8. 2007..Our data suggest that the acquisition time for the SPECT scan is optimally, under pseudo-equilibrium conditions, between 205-320 min post-bolus injection of the tracer... - Significant dissociation of brain and plasma kinetics with antipsychoticsJohannes Tauscher
Schizophrenia PET program, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Mol Psychiatry 7:317-21. 2002..Our results question the current reliance on plasma kinetics as the main basis for dosing regimens of antipsychotics. Studies of brain kinetics may provide a sounder basis for determining dosing schedules of psychotropic medications... - Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT studyNikolas Klein
Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
Psychopharmacology (Berl) 191:333-9. 2007..In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioligand [(123)I]ADAM and single photon emission computed tomography (SPECT)... - Striatal D(2) receptor occupancy in bipolar patients treated with olanzapineTrawat Attarbaschi
Department of General Psychiatry, Medical University Vienna, Vienna, Austria
Eur Neuropsychopharmacol 17:102-7. 2007..Although we did not find an increased vulnerability for acute EPS in bipolar patients receiving olanzapine at clinical relevant doses, this needs to be replicated with larger sample sizes... - Volumetric MRI measurement of caudate nuclei in antipsychotic-naive patients suffering from a first episode of psychosisSitra Tauscher-Wisniewski
Department of Neuropsychiatry for Children and Adolescents, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
J Psychiatr Res 39:365-70. 2005..441). In contrast to previous studies in patients treated with typical neuroleptics, this cross-sectional MRI study did not find significant differences in CNV of neuroleptic-naive first-episode patients compared to healthy controls... 
Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodentsGarth Terry
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
Neuroimage 41:690-8. 2008..Radiometabolites of [11C]MePPEP in brain caused distribution volume to be overestimated by approximately 13%...- Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacologySiegfried Kasper
Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
World J Biol Psychiatry 3:133-46. 2002..Our data provide insight into the pathophysiology of neuropsychiatric disorders and may guide future psychopharmacological drug developments... - Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockadeSitra Tauscher-Wisniewski
Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
J Clin Psychiatry 63:992-7. 2002..Future studies aimed at evaluating the relative merits of "transiently high" versus "continuously high" D(2) occupancy are warranted... - Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635Johannes Tauscher
PET Centre, Toronto, Ontario
Arch Gen Psychiatry 59:514-20. 2002.... - Striatal dopamine-2 receptor occupancy as measured with [123I]iodobenzamide and SPECT predicted the occurrence of EPS in patients treated with atypical antipsychotics and haloperidolJohannes Tauscher
Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
Psychopharmacology (Berl) 162:42-9. 2002..Extrapyramidal symptoms (EPS) are common with conventional antipsychotics. Clozapine and other novel antipsychotic substances with lower in vitro affinity for dopamine-2 (D(2)) receptors have a lower propensity to induce EPS... - Relationship between power spectra of the awake EEG and psychomotor activity patterns measured by short-term actigraphyDietmar Winkler
Department of General Psychiatry, University Hospital for Psychiatry, Vienna, Austria
Neuropsychobiology 48:176-81. 2003..Our results, while preliminary, suggest that short-term actigraphy may be apt to reflect central nervous system arousal... - Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S,S)-[18F]FMeNER-D2: a human whole-body PET studyAkihiro Takano
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden
Eur J Nucl Med Mol Imaging 35:630-6. 2008..The aim of this study was to provide dosimetry estimates for (S,S)-[(18)F]FMeNER-D(2) based on human whole-body PET measurements... - The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brainFumihiko Yasuno
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
Neuropsychopharmacology 33:259-69. 2008..These promising results in monkey justify studying this radioligand in human subjects... - Caudate volume changes in first episode psychosis parallel the effects of normal aging: a 5-year follow-up studySitra Tauscher-Wisniewski
Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Toronto, Canada
Schizophr Res 58:185-8. 2002..Both groups demonstrated a significant 9% decline in caudate volume. We were unable to replicate previous reports of caudate enlargement in patients receiving antipsychotic treatment... - Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2Nicholas Seneca
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176, Stockholm, Sweden
Psychopharmacology (Berl) 188:119-27. 2006..Previous positron emission tomography (PET) studies had failed to demonstrate the feasibility of measuring a dose-dependent and saturable NET occupancy in human brain using [11C]MeNER... - Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorderDietmar Winkler
Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
Eur Neuropsychopharmacol 13:129-34. 2003..Due to methodological limitations our results need to be replicated in controlled double-blind randomized clinical trials... - Therapy of treatment resistant depression: focus on the management of TRD with atypical antipsychoticsNikolas Klein
Department of General Psychiatry, Medical University of Vienna, A 1090 Vienna, Austria
CNS Spectr 9:823-32. 2004..This review especially focuses on the augmentation of the antidepressant therapy with atypical antipsychotics...