Johannes Tauscher

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics
    Johannes Tauscher
    University of Toronto Department of Psychiatry, Schizophrenia Program
    Am J Psychiatry 161:1620-5. 2004
  2. ncbi request reprint Reduced serotonin-1A receptor binding in social anxiety disorder
    Rupert R Lanzenberger
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Biol Psychiatry 61:1081-9. 2007
  3. ncbi request reprint Binding kinetics of 123I[ADAM] in healthy controls: a selective SERT radioligand
    Julia Sacher
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Int J Neuropsychopharmacol 10:211-8. 2007
  4. ncbi request reprint Significant dissociation of brain and plasma kinetics with antipsychotics
    Johannes Tauscher
    Schizophrenia PET program, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Mol Psychiatry 7:317-21. 2002
  5. ncbi request reprint Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study
    Nikolas Klein
    Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Psychopharmacology (Berl) 191:333-9. 2007
  6. ncbi request reprint Striatal D(2) receptor occupancy in bipolar patients treated with olanzapine
    Trawat Attarbaschi
    Department of General Psychiatry, Medical University Vienna, Vienna, Austria
    Eur Neuropsychopharmacol 17:102-7. 2007
  7. ncbi request reprint Volumetric MRI measurement of caudate nuclei in antipsychotic-naive patients suffering from a first episode of psychosis
    Sitra Tauscher-Wisniewski
    Department of Neuropsychiatry for Children and Adolescents, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Psychiatr Res 39:365-70. 2005
  8. pmc Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents
    Garth Terry
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
    Neuroimage 41:690-8. 2008
  9. ncbi request reprint Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacology
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    World J Biol Psychiatry 3:133-46. 2002
  10. ncbi request reprint Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade
    Sitra Tauscher-Wisniewski
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
    J Clin Psychiatry 63:992-7. 2002

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics
    Johannes Tauscher
    University of Toronto Department of Psychiatry, Schizophrenia Program
    Am J Psychiatry 161:1620-5. 2004
    ....
  2. ncbi request reprint Reduced serotonin-1A receptor binding in social anxiety disorder
    Rupert R Lanzenberger
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Biol Psychiatry 61:1081-9. 2007
    ..The objective of this study was to investigate 5-HT1A receptor binding potential (BP) in social anxiety disorder (SAD)...
  3. ncbi request reprint Binding kinetics of 123I[ADAM] in healthy controls: a selective SERT radioligand
    Julia Sacher
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Int J Neuropsychopharmacol 10:211-8. 2007
    ..Our data suggest that the acquisition time for the SPECT scan is optimally, under pseudo-equilibrium conditions, between 205-320 min post-bolus injection of the tracer...
  4. ncbi request reprint Significant dissociation of brain and plasma kinetics with antipsychotics
    Johannes Tauscher
    Schizophrenia PET program, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Mol Psychiatry 7:317-21. 2002
    ..Our results question the current reliance on plasma kinetics as the main basis for dosing regimens of antipsychotics. Studies of brain kinetics may provide a sounder basis for determining dosing schedules of psychotropic medications...
  5. ncbi request reprint Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study
    Nikolas Klein
    Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Psychopharmacology (Berl) 191:333-9. 2007
    ..In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioligand [(123)I]ADAM and single photon emission computed tomography (SPECT)...
  6. ncbi request reprint Striatal D(2) receptor occupancy in bipolar patients treated with olanzapine
    Trawat Attarbaschi
    Department of General Psychiatry, Medical University Vienna, Vienna, Austria
    Eur Neuropsychopharmacol 17:102-7. 2007
    ..Although we did not find an increased vulnerability for acute EPS in bipolar patients receiving olanzapine at clinical relevant doses, this needs to be replicated with larger sample sizes...
  7. ncbi request reprint Volumetric MRI measurement of caudate nuclei in antipsychotic-naive patients suffering from a first episode of psychosis
    Sitra Tauscher-Wisniewski
    Department of Neuropsychiatry for Children and Adolescents, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Psychiatr Res 39:365-70. 2005
    ..441). In contrast to previous studies in patients treated with typical neuroleptics, this cross-sectional MRI study did not find significant differences in CNV of neuroleptic-naive first-episode patients compared to healthy controls...
  8. pmc Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents
    Garth Terry
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
    Neuroimage 41:690-8. 2008
    ..Radiometabolites of [11C]MePPEP in brain caused distribution volume to be overestimated by approximately 13%...
  9. ncbi request reprint Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacology
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    World J Biol Psychiatry 3:133-46. 2002
    ..Our data provide insight into the pathophysiology of neuropsychiatric disorders and may guide future psychopharmacological drug developments...
  10. ncbi request reprint Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade
    Sitra Tauscher-Wisniewski
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
    J Clin Psychiatry 63:992-7. 2002
    ..We treated patients experiencing their first episode of schizophrenia with a single daily dose of quetiapine to achieve a transient daily peak of D(2) receptor blockade, to determine if this would lead to an antipsychotic response...
  11. ncbi request reprint Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635
    Johannes Tauscher
    PET Centre, Toronto, Ontario
    Arch Gen Psychiatry 59:514-20. 2002
    ....
  12. ncbi request reprint Striatal dopamine-2 receptor occupancy as measured with [123I]iodobenzamide and SPECT predicted the occurrence of EPS in patients treated with atypical antipsychotics and haloperidol
    Johannes Tauscher
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Psychopharmacology (Berl) 162:42-9. 2002
    ..Extrapyramidal symptoms (EPS) are common with conventional antipsychotics. Clozapine and other novel antipsychotic substances with lower in vitro affinity for dopamine-2 (D(2)) receptors have a lower propensity to induce EPS...
  13. ncbi request reprint Relationship between power spectra of the awake EEG and psychomotor activity patterns measured by short-term actigraphy
    Dietmar Winkler
    Department of General Psychiatry, University Hospital for Psychiatry, Vienna, Austria
    Neuropsychobiology 48:176-81. 2003
    ..Our results, while preliminary, suggest that short-term actigraphy may be apt to reflect central nervous system arousal...
  14. ncbi request reprint Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S,S)-[18F]FMeNER-D2: a human whole-body PET study
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 35:630-6. 2008
    ..The aim of this study was to provide dosimetry estimates for (S,S)-[(18)F]FMeNER-D(2) based on human whole-body PET measurements...
  15. ncbi request reprint The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain
    Fumihiko Yasuno
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
    Neuropsychopharmacology 33:259-69. 2008
    ..These promising results in monkey justify studying this radioligand in human subjects...
  16. ncbi request reprint Caudate volume changes in first episode psychosis parallel the effects of normal aging: a 5-year follow-up study
    Sitra Tauscher-Wisniewski
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 58:185-8. 2002
    ..Both groups demonstrated a significant 9% decline in caudate volume. We were unable to replicate previous reports of caudate enlargement in patients receiving antipsychotic treatment...
  17. ncbi request reprint Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2
    Nicholas Seneca
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176, Stockholm, Sweden
    Psychopharmacology (Berl) 188:119-27. 2006
    ..Previous positron emission tomography (PET) studies had failed to demonstrate the feasibility of measuring a dose-dependent and saturable NET occupancy in human brain using [11C]MeNER...
  18. ncbi request reprint Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder
    Dietmar Winkler
    Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Eur Neuropsychopharmacol 13:129-34. 2003
    ..Due to methodological limitations our results need to be replicated in controlled double-blind randomized clinical trials...
  19. ncbi request reprint Therapy of treatment resistant depression: focus on the management of TRD with atypical antipsychotics
    Nikolas Klein
    Department of General Psychiatry, Medical University of Vienna, A 1090 Vienna, Austria
    CNS Spectr 9:823-32. 2004
    ..This review especially focuses on the augmentation of the antidepressant therapy with atypical antipsychotics...