Thomas M Stulnig

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. ncbi LAT displacement from lipid rafts as a molecular mechanism for the inhibition of T cell signaling by polyunsaturated fatty acids
    Maximilian Zeyda
    Department of Internal Medicine III and the Institute of Immunology, University of Vienna, A 1090 Vienna, Austria
    J Biol Chem 277:28418-23. 2002
  2. ncbi Polyunsaturated fatty acids block dendritic cell activation and function independently of NF-kappaB activation
    Maximilian Zeyda
    Clinical Divisions of Endocrinology and Metabolism, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Biol Chem 280:14293-301. 2005
  3. pmc The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function
    Bernhard M Kirsch
    Department of Internal Medicine III Clinical Division of Nephrology, Medical University of Vienna, Vienna, Austria
    Arthritis Res Ther 7:R694-703. 2005
  4. ncbi Osteopontin expression in human and murine obesity: extensive local up-regulation in adipose tissue but minimal systemic alterations
    Florian W Kiefer
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Endocrinology 149:1350-7. 2008
  5. doi Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men
    Martin Clodi
    Dept of Medicine III, Medical Univ of Vienna, Waehringer Guertel 18 20, A 1090, Vienna, Austria
    Am J Physiol Endocrinol Metab 295:E686-91. 2008
  6. doi An accelerated mouse model for atherosclerosis and adipose tissue inflammation
    Angelika Neuhofer
    Christian Doppler Laboratory for Cardio Metabolic Immunotherapy and Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Cardiovasc Diabetol 13:23. 2014
  7. pmc Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice
    F W Kiefer
    Department of Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Diabetologia 54:2132-42. 2011
  8. ncbi Immunomodulation by polyunsaturated fatty acids: impact on T-cell signaling
    Thomas M Stulnig
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Lipids 39:1171-5. 2004
  9. doi Osteopontin is an activator of human adipose tissue macrophages and directly affects adipocyte function
    Maximilian Zeyda
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Endocrinology 152:2219-27. 2011
  10. ncbi Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation
    Maximilian Zeyda
    Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Leukoc Biol 81:319-27. 2007

Collaborators

Detail Information

Publications48

  1. ncbi LAT displacement from lipid rafts as a molecular mechanism for the inhibition of T cell signaling by polyunsaturated fatty acids
    Maximilian Zeyda
    Department of Internal Medicine III and the Institute of Immunology, University of Vienna, A 1090 Vienna, Austria
    J Biol Chem 277:28418-23. 2002
    ..These data reveal LAT displacement from lipid rafts as a molecular mechanism by which PUFAs inhibit T cell signaling and underline the predominant importance of LAT localization in rafts for efficient T cell activation...
  2. ncbi Polyunsaturated fatty acids block dendritic cell activation and function independently of NF-kappaB activation
    Maximilian Zeyda
    Clinical Divisions of Endocrinology and Metabolism, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Biol Chem 280:14293-301. 2005
    ..These data demonstrate a unique interference with DC activation and function that could significantly contribute to the well known anti-inflammatory effects of PUFAs...
  3. pmc The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function
    Bernhard M Kirsch
    Department of Internal Medicine III Clinical Division of Nephrology, Medical University of Vienna, Vienna, Austria
    Arthritis Res Ther 7:R694-703. 2005
    ..These data indicate that interference with several aspects of DC function could significantly contribute to the beneficial effects of leflunomide in inflammatory diseases, including RA...
  4. ncbi Osteopontin expression in human and murine obesity: extensive local up-regulation in adipose tissue but minimal systemic alterations
    Florian W Kiefer
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Endocrinology 149:1350-7. 2008
    ..In conclusion, our data point toward a specific local role of OPN in obese AT. Therefore, OPN could be a critical regulator in obesity induced AT inflammation and insulin resistance...
  5. doi Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men
    Martin Clodi
    Dept of Medicine III, Medical Univ of Vienna, Waehringer Guertel 18 20, A 1090, Vienna, Austria
    Am J Physiol Endocrinol Metab 295:E686-91. 2008
    ..Oxytocin might be a candidate for the therapy of inflammatory diseases and conditions associated with high cytokine and VEGF levels...
  6. doi An accelerated mouse model for atherosclerosis and adipose tissue inflammation
    Angelika Neuhofer
    Christian Doppler Laboratory for Cardio Metabolic Immunotherapy and Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Cardiovasc Diabetol 13:23. 2014
    ....
  7. pmc Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice
    F W Kiefer
    Department of Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Diabetologia 54:2132-42. 2011
    ..Accumulating evidence links OPN to the pathogenesis of NAFLD. Here we aimed to identify the role of OPN in obesity-associated hepatic steatosis and impaired hepatic glucose metabolism...
  8. ncbi Immunomodulation by polyunsaturated fatty acids: impact on T-cell signaling
    Thomas M Stulnig
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Lipids 39:1171-5. 2004
    ..These recent results add considerably to the understanding of mechanisms of PUFA actions, but their relevance in the in vivo situation must still be elucidated...
  9. doi Osteopontin is an activator of human adipose tissue macrophages and directly affects adipocyte function
    Maximilian Zeyda
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Endocrinology 152:2219-27. 2011
    ..In conclusion, OPN activates ATM and interferes with adipocyte function. Thus these data underline the potential of OPN as a therapeutic target for obesity-induced complications...
  10. ncbi Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation
    Maximilian Zeyda
    Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Leukoc Biol 81:319-27. 2007
    ..Furthermore, these data imply novel functions of calcineurin and NF-kappaB for successful IS maturation...
  11. ncbi Inhibition of human dendritic cell maturation and function by the novel immunosuppressant FK778
    Maximilian Zeyda
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Transplantation 80:1105-11. 2005
    ....
  12. ncbi Antithymocyte globulin impairs T-cell/antigen-presenting cell interaction: disruption of immunological synapse and conjugate formation
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Transplantation 84:117-21. 2007
    ..In conclusion, ATG impairs T-cell/APC conjugate formation, a mechanism that may help to understand the functional inactivation of peripheral blood T-cells that have escaped cellular depletion after ATG treatment...
  13. pmc Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance
    Florian W Kiefer
    Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Diabetes 59:935-46. 2010
    ..Here, we studied OPN effects in obesity-induced inflammation and insulin resistance by targeting OPN action in vivo...
  14. ncbi Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation
    Maximilian Zeyda
    Medical University of Vienna, Vienna, Austria
    Arthritis Rheum 52:2730-9. 2005
    ..In this study, we evaluated the impact of the active leflunomide metabolite teriflunomide on T cell integrin activation, evolution of the IS, and antigen-specific formation of stable T cell/APC conjugates...
  15. ncbi Selective inhibition of T cell activation via CD147 through novel modulation of lipid rafts
    Gunther Staffler
    Institute of Immunology, University of Vienna, Vienna, Austria
    J Immunol 171:1707-14. 2003
    ..These results indicate that negative regulating signals can modulate microdomains and suggest a general mechanism for inhibition of receptor signaling...
  16. ncbi Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin
    Rene Geyeregger
    Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Austria
    Blood 109:4288-95. 2007
    ..Due to the central position of DCs in immunity, LXRalpha could be a potential novel target for immunomodulation...
  17. ncbi Polyunsaturated fatty acids interfere with formation of the immunological synapse
    Rene Geyeregger
    Department of Internal Medicine, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Leukoc Biol 77:680-8. 2005
    ....
  18. pmc Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation
    Angelika Neuhofer
    Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Diabetes 62:1945-56. 2013
    ....
  19. doi The TSC-mTOR signaling pathway regulates the innate inflammatory response
    Thomas Weichhart
    Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    Immunity 29:565-77. 2008
    ..These data identify the TSC2-mTOR pathway as a key regulator of innate immune homeostasis with broad clinical implications for infectious and autoimmune diseases, vaccination, cancer, and transplantation...
  20. doi CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity
    Joakim Huber
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    J Clin Endocrinol Metab 93:3215-21. 2008
    ..Obesity is associated with a low-grade inflammation, insulin resistance, and macrophage infiltration of adipose tissue. The role of CC chemokines and their respective receptors in human adipose tissue inflammation remains to be determined...
  21. doi Coenzyme Q10 does not enhance preadipocyte viability in an in vitro lipotransfer model
    Maike Keck
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University Vienna, Währingergürtel 18 20, 1090, Vienna, Austria
    Aesthetic Plast Surg 36:453-7. 2012
    ..The aim of this study was to evaluate the effect of Q10 on preadipocyte viability with special regard to impairment after lidocaine treatment...
  22. doi Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes
    Rene Geyeregger
    Department of Internal Medicine III, Medical University of Vienna, A 1090 Vienna, Austria
    J Leukoc Biol 86:1039-48. 2009
    ..This novel LXR action could find clinical application in immunosuppressive and antileukemic therapies...
  23. doi Obesity, inflammation, and insulin resistance--a mini-review
    Maximilian Zeyda
    Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Gerontology 55:379-86. 2009
    ..Moreover, novel approaches for treatment and prevention of insulin resistance and type 2 diabetes by targeting obesity-induced inflammatory processes are discussed here...
  24. ncbi Lipid raft-associated GTPase signaling controls morphology and CD8+ T cell stimulatory capacity of human dendritic cells
    Silvia Jaksits
    Center of Molecular Medicine of the Austrian Academy of Sciences, and Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Austria
    J Immunol 173:1628-39. 2004
    ..We conclude that Cdc42 and Rac1 signaling controls DC morphology and conditions DCs for efficient CD8(+) T cell stimulation...
  25. pmc Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    J Clin Invest 115:468-75. 2005
    ..These data show that THP is a regulatory factor of innate and adaptive immunity and therefore could have significant impact on host immunity in the urinary tract...
  26. ncbi Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154
    Marcus D Saemann
    Institute of Immunology, Vienna, Austria
    Transplantation 75:1864-72. 2003
    ..Recent evidence, however, indicates a critical role for JAK3 in signaling linked to the T-cell antigen receptor...
  27. pmc Treatment with n-3 polyunsaturated fatty acids overcomes the inverse association of vitamin D deficiency with inflammation in severely obese patients: a randomized controlled trial
    Bianca K Itariu
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    PLoS ONE 8:e54634. 2013
    ..However, abrogation of the inverse association of 25(OH)D concentration with inflammatory markers indicated that n-3 PUFA treatment could compensate for some detrimental consequences of vitamin D deficiency...
  28. ncbi Suppression of T cell signaling by polyunsaturated fatty acids: selectivity in inhibition of mitogen-activated protein kinase and nuclear factor activation
    Maximilian Zeyda
    Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism and Institute of Immunology, University of Vienna Medical School, Vienna, Austria
    J Immunol 170:6033-9. 2003
    ..In conclusion, PUFA treatment of T cells inhibits selectively c-Jun NH(2)-terminal kinase and NF-AT activation, resulting in diminished production of IL-2 and IL-13...
  29. doi Long-chain n-3 PUFAs reduce adipose tissue and systemic inflammation in severely obese nondiabetic patients: a randomized controlled trial
    Bianca K Itariu
    Department of Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria
    Am J Clin Nutr 96:1137-49. 2012
    ..Long-chain n-3 PUFAs reduce cardiovascular events and exert well-established antiinflammatory effects, but their effects on human adipose tissue inflammation are unknown...
  30. doi Increased bone resorption and impaired bone microarchitecture in short-term and extended high-fat diet-induced obesity
    Janina M Patsch
    Division of Cellular and Molecular Pathophysiology, Department of Pathophysiology, Center of Physiology, Pathophysiology and Immunology, Medical University Vienna, A 1090 Vienna, Austria
    Metabolism 60:243-9. 2011
    ..Trabecular and cortical thickness remained unaffected. Short-term and extended high-fat diet-induced obesity caused significant bone loss in male C57BL/6J mice mainly because of resorptive changes in trabecular architecture...
  31. doi Inflammation correlates with markers of T-cell subsets including regulatory T cells in adipose tissue from obese patients
    Maximilian Zeyda
    Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University Vienna, Vienna, Austria
    Obesity (Silver Spring) 19:743-8. 2011
    ....
  32. ncbi Adipose tissue macrophages
    Maximilian Zeyda
    Department of Internal Medicine III, Clin Div Endocrinology and Metabolism, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Immunol Lett 112:61-7. 2007
    ..Strategies to interfere with ATM recruitment and adverse activation could give rise to novel options for treatment and prevention of insulin resistance and type 2 diabetes mellitus...
  33. pmc CTX (crosslaps) rather than osteopontin is associated with disturbed glucose metabolism in gestational diabetes
    Yvonne Winhofer
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    PLoS ONE 7:e40947. 2012
    ..Here, we aimed to investigate the role of the bone resorption marker CTX and osteopontin (OPN), a key molecule in subclinical inflammation underlying insulin resistance, in gestational diabetes...
  34. ncbi Janus kinase-3 (JAK3) inhibition: a novel immunosuppressive option for allogeneic transplantation
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Transpl Int 17:481-9. 2004
    ..The potential clinical application of JAK3 inhibitors in organ transplantations is discussed in the light of a recent series of successful kidney transplantations in non-human primates immunosuppressed solely with a novel JAK3 inhibitor...
  35. doi Local anesthetics have a major impact on viability of preadipocytes and their differentiation into adipocytes
    Maike Keck
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria
    Plast Reconstr Surg 126:1500-5. 2010
    ..The aim of this study was to investigate the influence of different local anesthetics frequently used in clinical practice on the viability of preadipocytes and their ability to differentiate into adipocytes...
  36. ncbi Immunomodulation by polyunsaturated fatty acids: mechanisms and effects
    Thomas M Stulnig
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, and Center of Molecular Medicine, Austrian Academy of Sciences, Vienna, Austria
    Int Arch Allergy Immunol 132:310-21. 2003
    ..In addition, the effects of PUFAs on the immune system in general are summarized, as are clinical effects in rheumatoid arthritis, inflammatory bowel disease and sepsis...
  37. ncbi Lipid Rafts & Co.: an integrated model of membrane organization in T cell activation
    Maximilan Zeyda
    Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria
    Prog Lipid Res 45:187-202. 2006
    ..Further research has to elucidate the relative contribution and interrelation of different modes of membrane organization in productive T cell activation...
  38. ncbi Blood glucose-lowering nuclear receptor agonists only partially normalize hepatic gene expression in db/db mice
    Michael Loffler
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University Vienna, Austria
    J Pharmacol Exp Ther 316:797-804. 2006
    ..These results suggest that diabetes-induced gene expression is minimally reversed by potent blood glucose-lowering nuclear receptor agonists...
  39. doi Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis
    Nikolaus B Binder
    Division of Rheumatology, Medical University Vienna, Vienna, Austria
    Nat Med 15:417-24. 2009
    ..These data reveal a previously undescribed pathway by which RANK, osteoclasts and bone homeostasis are regulated in health and disease...
  40. pmc Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression
    Jong Bae Seo
    School of Biological Sciences Marine Biotechnology Laboratory, School of Earth and Environmental Sciences, Seoul National University, Seoul 151 742, Korea
    Mol Cell Biol 24:3430-44. 2004
    ..Taken together, these results suggest that LXR plays a role in the execution of adipocyte differentiation by regulation of lipogenesis and adipocyte-specific gene expression...
  41. ncbi SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients
    Silvia Sanzone
    Centro Ricerche Parco Scientifico E Menni, Ospedale Poliambulanza, Brescia 25124, Italy
    J Biol Chem 278:29593-9. 2003
    ..Moreover, these data provide evidence that SAP functions as an essential integrator in early TCR signal transduction...
  42. ncbi Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively
    Knut R Steffensen
    Department of Biosciences, Karolinska Institutet at NOVUM, Huddinge, Sweden
    Biochem Biophys Res Commun 310:589-93. 2003
    ..These results indicate a role of LXR in early developmental stages of adipose tissue...
  43. ncbi Glucocorticoids alter the lipid and protein composition of membrane rafts of a murine T cell hybridoma
    Francois Van Laethem
    Laboratoire de Physiologie Animale, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    J Immunol 170:2932-9. 2003
    ....
  44. ncbi Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors
    J Christopher Corton
    Toxicogenomics, Chapel Hill, North Carolina 27514, USA
    J Biol Chem 279:46204-12. 2004
    ..These results demonstrate that PPARalpha mediates some of the effects of CR and indicate that a pharmacological approach to mimicking many of the beneficial effects of CR may be possible...
  45. ncbi Early nutrition and immunity - progress and perspectives
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 96:774-90. 2006
    ..This report summarizes the content of the lectures and the subsequent discussions...
  46. ncbi Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver
    Steven P Anderson
    Investigative Toxicology and Pathology Group, Safety Assessment, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, USA
    Mol Pharmacol 66:1440-52. 2004
    ....
  47. ncbi Liver X receptors regulate adrenal steroidogenesis and hypothalamic-pituitary-adrenal feedback
    Maria Nilsson
    Department of Biosciences and Nutrition, Karolinska Institutet, S 14157 Huddinge, Sweden
    Mol Endocrinol 21:126-37. 2007
    ..In conclusion, LXRs independently interfere with the hypothalamic-pituitary-adrenal axis regulation at the level of the pituitary and the adrenal gland...
  48. ncbi Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue
    Thomas M Stulnig
    Department of Medical Nutrition and Biosciences, Karolinska Institutet, Huddinge, Sweden
    Mol Pharmacol 62:1299-305. 2002
    ....