Karin Stiasny

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. ncbi Age affects quantity but not quality of antibody responses after vaccination with an inactivated flavivirus vaccine against tick-borne encephalitis
    Karin Stiasny
    Department of Virology, Medical University of Vienna, Vienna, Austria
    PLoS ONE 7:e34145. 2012
  2. ncbi Quantitative determination of IgM antibodies reduces the pitfalls in the serodiagnosis of tick-borne encephalitis
    K Stiasny
    Department of Virology, Medical University of Vienna, Vienna, Austria
    J Clin Virol 54:115-20. 2012
  3. ncbi Characteristics of antibody responses in tick-borne encephalitis vaccination breakthroughs
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, AT 1095, Vienna, Austria
    Vaccine 27:7021-6. 2009
  4. ncbi Effect of membrane curvature-modifying lipids on membrane fusion by tick-borne encephalitis virus
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, A 1095 Vienna, Austria
    J Virol 78:8536-42. 2004
  5. ncbi Differences in the postfusion conformations of full-length and truncated class II fusion protein E of tick-borne encephalitis virus
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, A 1095 Vienna, Austria
    J Virol 79:6511-5. 2005
  6. ncbi Probing the flavivirus membrane fusion mechanism by using monoclonal antibodies
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, AT 1095, Vienna, Austria
    J Virol 81:11526-31. 2007
  7. ncbi Molecular mechanisms of flavivirus membrane fusion
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, AT, Austria
    Amino Acids 41:1159-63. 2011
  8. ncbi Involvement of lipids in different steps of the flavivirus fusion mechanism
    Karin Stiasny
    Institute of Virology, University of Vienna, Kinderspitalgasse 15, A 1095 Vienna, Austria
    J Virol 77:7856-62. 2003
  9. ncbi Characterization of a structural intermediate of flavivirus membrane fusion
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, Vienna, Austria
    PLoS Pathog 3:e20. 2007
  10. ncbi Impact of quaternary organization on the antigenic structure of the tick-borne encephalitis virus envelope glycoprotein E
    Stefan Kiermayr
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, A 1095 Vienna, Austria
    J Virol 83:8482-91. 2009

Collaborators

Detail Information

Publications23

  1. ncbi Age affects quantity but not quality of antibody responses after vaccination with an inactivated flavivirus vaccine against tick-borne encephalitis
    Karin Stiasny
    Department of Virology, Medical University of Vienna, Vienna, Austria
    PLoS ONE 7:e34145. 2012
    ..Our work indicates that healthy elderly people are able to produce antibodies in response to vaccination with similar avidity and functional activity as young individuals, albeit at lower titers...
  2. ncbi Quantitative determination of IgM antibodies reduces the pitfalls in the serodiagnosis of tick-borne encephalitis
    K Stiasny
    Department of Virology, Medical University of Vienna, Vienna, Austria
    J Clin Virol 54:115-20. 2012
    ....
  3. ncbi Characteristics of antibody responses in tick-borne encephalitis vaccination breakthroughs
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, AT 1095, Vienna, Austria
    Vaccine 27:7021-6. 2009
    ..The antibody profile of these patients therefore had the characteristics of an anamnestic immune response. In the VBTs analyzed, immunological priming and memory were apparently not sufficient or fast enough to prevent the disease...
  4. ncbi Effect of membrane curvature-modifying lipids on membrane fusion by tick-borne encephalitis virus
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, A 1095 Vienna, Austria
    J Virol 78:8536-42. 2004
    ..These data emphasize, however, the importance of the composition of the target membrane in its interactions with the fusion peptide that are crucial for the initiation of fusion...
  5. ncbi Differences in the postfusion conformations of full-length and truncated class II fusion protein E of tick-borne encephalitis virus
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, A 1095 Vienna, Austria
    J Virol 79:6511-5. 2005
    ..These data provide experimental evidence to support the model of a fusion process that leads to the interaction of the stem-anchor region with the fusion peptide loop in the postfusion trimer...
  6. ncbi Probing the flavivirus membrane fusion mechanism by using monoclonal antibodies
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, AT 1095, Vienna, Austria
    J Virol 81:11526-31. 2007
    ..These data provide new insights into the mechanisms of flavivirus fusion inhibition by antibodies and their possible contribution to virus neutralization...
  7. ncbi Molecular mechanisms of flavivirus membrane fusion
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, AT, Austria
    Amino Acids 41:1159-63. 2011
    ..This includes the identification of a conserved histidine as being part of the pH sensor in the fusion protein that responds to the acidic pH and thus initiates the structural transitions driving fusion...
  8. ncbi Involvement of lipids in different steps of the flavivirus fusion mechanism
    Karin Stiasny
    Institute of Virology, University of Vienna, Kinderspitalgasse 15, A 1095 Vienna, Austria
    J Virol 77:7856-62. 2003
    ....
  9. ncbi Characterization of a structural intermediate of flavivirus membrane fusion
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, Vienna, Austria
    PLoS Pathog 3:e20. 2007
    ..This sequence of events provides important new insights for understanding the dynamic process of viral membrane fusion...
  10. ncbi Impact of quaternary organization on the antigenic structure of the tick-borne encephalitis virus envelope glycoprotein E
    Stefan Kiermayr
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, A 1095 Vienna, Austria
    J Virol 83:8482-91. 2009
    ..We have thus identified several important factors that influence the antigenicity of the flavivirus E protein and have an impact on the interaction with neutralizing antibodies...
  11. ncbi Identification of specific histidines as pH sensors in flavivirus membrane fusion
    Richard Fritz
    Institute of Virology, Medical University of Vienna, 1095 Vienna, Austria
    J Cell Biol 183:353-61. 2008
    ..Conserved histidines located outside this critical interface were found to be completely dispensable for triggering fusion...
  12. ncbi Characterization of a membrane-associated trimeric low-pH-induced Form of the class II viral fusion protein E from tick-borne encephalitis virus and its crystallization
    Karin Stiasny
    Institute of Virology, University of Vienna, A1095 Vienna, Austria
    J Virol 78:3178-83. 2004
    ..sE trimers, solubilized with nonionic detergents, yielded three-dimensional crystals suitable for X-ray diffraction analysis...
  13. ncbi Entry functions and antigenic structure of flavivirus envelope proteins
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, A1095 Vienna, Austria
    Novartis Found Symp 277:57-65; discussion 65-73, 251-3. 2006
    ..Broadly flavivirus cross-reactive antibodies, however, primarily recognize a site involving residues of the highly conserved fusion peptide loop which is cryptic and largely inaccessible on the surface of native infectious virions...
  14. ncbi Membrane interactions of the tick-borne encephalitis virus fusion protein E at low pH
    Karin Stiasny
    Institute of Virology, University of Vienna, A 1095 Vienna, Austria
    J Virol 76:3784-90. 2002
    ..Its stability is apparently maintained by contacts between the ectodomains only and is not dependent on sequence elements in the stem-anchor region as previously assumed...
  15. ncbi Cryptic properties of a cluster of dominant flavivirus cross-reactive antigenic sites
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, A-1095 Vienna, Austria
    J Virol 80:9557-68. 2006
    ....
  16. ncbi Flaviviruses and flavivirus vaccines
    Franz X Heinz
    Department of Virology, Medical University of Vienna, Kinderspitalgasse 15, 1095 Vienna, Austria
    Vaccine 30:4301-6. 2012
    ..Currently, several kinds of dengue vaccines are in development, but only one of these candidates (a chimeric dengue-yellow fever live attenuated vaccine) has reached the stage of phase 3 clinical trials...
  17. ncbi The unique transmembrane hairpin of flavivirus fusion protein E is essential for membrane fusion
    Richard Fritz
    Department of Virology, Medical University of Vienna, Kinderspitalgasse 15, 1095, Vienna, Austria
    J Virol 85:4377-85. 2011
    ..Our data provide evidence for both intratrimer and intertrimer interactions mediated by the TMDs of E and thus extend the existing models of flavivirus membrane fusion...
  18. ncbi Flavivirus membrane fusion
    Karin Stiasny
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, A1095 Vienna, Austria
    J Gen Virol 87:2755-66. 2006
    ....
  19. ncbi Mutational analysis of the zippering reaction during flavivirus membrane fusion
    Karen Pangerl
    Department of Virology, Medical University of Vienna, Kinderspitalgasse 15, 1095 Vienna, Austria
    J Virol 85:8495-501. 2011
    ....
  20. ncbi Immunodominance and functional activities of antibody responses to inactivated West Nile virus and recombinant subunit vaccines in mice
    Juergen Zlatkovic
    Department of Virology, Medical University of Vienna, A 1095 Vienna, Austria
    J Virol 85:1994-2003. 2011
    ..Despite its low potency for priming, DIII was an excellent boosting antigen, suggesting novel vaccination strategies that strengthen and focus the antibody response to critical neutralizing sites in DIII...
  21. ncbi Tick-borne encephalitis from eating goat cheese in a mountain region of Austria
    Heidemarie Holzmann
    Clinical Institute of Virology, Medical University of Vienna, Vienna, Austria
    Emerg Infect Dis 15:1671-3. 2009
    ..This outbreak indicates the emergence of ticks and TBEV at increasing altitudes in central Europe and the efficiency of oral transmission of TBEV...
  22. ncbi Flaviviruses and their antigenic structure
    F X Heinz
    Department of Virology, Medical University of Vienna, Kinderspitalgasse 15, A 1095 Vienna, Austria Electronic address
    J Clin Virol 55:289-95. 2012
    ....
  23. ncbi Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation
    Stéphane Bressanelli
    Virologie Moléculaire and Structurale, CNRS UMR 2472 INRA UMR 1157, IFR 115 Gif sur Yvette, France
    EMBO J 23:728-38. 2004
    ....