Research Topics
Genomes and Genes | Günter SteinerSummaryAffiliation: Medical University of Vienna Country: Austria Publications
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Publications
Auto-antibodies and autoreactive T-cells in rheumatoid arthritis: pathogenetic players and diagnostic toolsGünter Steiner
Department of Rheumatology, Internal Medicine III, Medical University of Vienna, Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna and Ludwig Boltzmann Institute for Rheumatology, Vienna, Austria
Clin Rev Allergy Immunol 32:23-36. 2007..This has made possible the development of novel therapeutic concepts that may allow to treat the disease more effectively in its early stages where the chances are highest to interrupt the deleterious processes...- Aberrant expression of the autoantigen heterogeneous nuclear ribonucleoprotein-A2 (RA33) and spontaneous formation of rheumatoid arthritis-associated anti-RA33 autoantibodies in TNF-alpha transgenic miceSilvia Hayer
Department of Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria
J Immunol 175:8327-36. 2005..These findings suggest that overproduction of TNF-alpha leads to aberrant expression of hnRNP-A2 in the rheumatoid joint and subsequently to autoimmune reactions, which may enhance the inflammatory and destructive process... 
JNK1 is not essential for TNF-mediated joint diseaseMarcus Koller
Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Austria
Arthritis Res Ther 7:R166-73. 2005..Thus, JNK1 activation does not seem to be essential for TNF-mediated arthritis...- Endothelial progenitor cells in active rheumatoid arthritis: effects of tumour necrosis factor and glucocorticoid therapyJohannes Grisar
Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Ann Rheum Dis 66:1284-8. 2007.... 
Immunodominant T-cell epitopes of hnRNP-A2 associated with disease activity in patients with rheumatoid arthritisSylvie Trembleau
Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
Eur J Immunol 40:1795-808. 2010..These data suggest involvement of hnRNP-A2 specific cellular autoimmune responses in RA pathogenesis...- The rheumatoid arthritis-associated autoantigen hnRNP-A2 (RA33) is a major stimulator of autoimmunity in rats with pristane-induced arthritisMarkus H Hoffmann
Department of Rheumatology, Medical University of Vienna, Vienna, Austria
J Immunol 179:7568-76. 2007..Taken together, these data suggest hnRNP-A2 to be among the primary inducers of autoimmunity in PIA. Therefore, this Ag might play a pivotal role in the pathogenesis of PIA and possibly also human RA... - Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destructionJochen Zwerina
University of Vienna, Vienna, Austria
Arthritis Rheum 50:277-90. 2004..To investigate the efficacy of single and combined blockade of tumor necrosis factor (TNF), interleukin-1 (IL-1), and RANKL pathways on synovial inflammation, bone erosion, and cartilage destruction in a TNF-driven arthritis model... - Phenotypic and functional deficiencies of monocyte-derived dendritic cells in systemic lupus erythematosus (SLE) patientsMarcus Koller
Department of Rheumatology, Internal Medicine III, Medical University of Vienna, General Hospital of Vienna, Währingergürtel 18 20, A 1090 Vienna, Austria
Int Immunol 16:1595-604. 2004..Our data imply a crucial role of APC in the immunological imbalance in SLE for foreign and self-antigen reactivity... - The spliceosomal autoantigen heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) is a major T cell autoantigen in patients with systemic lupus erythematosusRuth Fritsch-Stork
Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria
Arthritis Res Ther 8:R118. 2006..Taken together, the pronounced peripheral T cell reactivity to hnRNP-A2 observed in the majority of SLE patients and the distinct phenotype of patient-derived CD8+ TCCs suggest a role for these T cells in the pathogenesis of SLE... - CD44 is a determinant of inflammatory bone lossSilvia Hayer
Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, A 1090 Vienna, Austria
J Exp Med 201:903-14. 2005..These data identify CD44 as a critical inhibitor of TNF-driven joint destruction and inflammatory bone loss... - Pro-inflammatory cytokines in rheumatoid arthritis: pathogenetic and therapeutic aspectsJosef S Smolen
Division of Rheumatology, Internal Medicine III, Medical University of Vienna, Austria
Clin Rev Allergy Immunol 28:239-48. 2005.... - Effects of short-term infliximab therapy on autoantibodies in systemic lupus erythematosusMartin Aringer
Medical University of Vienna, Vienna, Austria
Arthritis Rheum 56:274-9. 2007..To analyze changes in autoantibodies occurring in patients with systemic lupus erythematosus (SLE) treated with 4 infusions of the chimeric anti-tumor necrosis factor alpha (TNFalpha) antibody infliximab... - Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label studyMartin Aringer
Internal Medicine III, Medical University of Vienna, Vienna, Austria
Arthritis Rheum 50:3161-9. 2004..This finding, coupled with the clinical improvement in the inflammatory manifestations of the disease, indicates that further study in larger controlled trials is warranted... - Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formationBirgit Görtz
Division of Rheumatology, Department of Internal Medicine III, University of Vienna, Vienna, Austria
J Bone Miner Res 19:990-8. 2004..Bone marrow next to arthritic lesions exhibits B-lymphocyte-rich infiltrates, which express BMPs and stimulate endosteal bone formation. Thus, bone marrow actively participates in the arthritic process... - Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signalingPamina Pflegerl
Institute of Clinical Pathology, Department of Internal Medicine III, Medical University of Vienna, Währingergürtel 18 20, A 1090 Vienna, Austria
Proc Natl Acad Sci U S A 106:20423-8. 2009..Thus, keratinocyte-induced IL-6 secretion can cause SLE and systemic autoimmunity. Our results support trials to use alpha-IL-6 receptor antibody therapy for treatment of SLE... - The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?Josef S Smolen
Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Arthritis Res Ther 10:208. 2008..The analysis suggests the search for better markers to predict outcomes and therapeutic responsiveness in rheumatoid arthritis needs to be intensified... - Activation of the interferon-gamma signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cellsThomas Karonitsch
Department of Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria
Arthritis Rheum 60:1463-71. 2009.... - Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritisKurt Redlich
Department of Internal Medicine III, University of Vienna, Vienna, Austria
Am J Pathol 164:543-55. 2004.... - Interferon signals and monocytic sensitization of the interferon-γ signaling pathway in the peripheral blood of patients with rheumatoid arthritisThomas Karonitsch
Division of Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria
Arthritis Rheum 64:400-8. 2012..The aim of this study was to determine the systemic activity of the IFN/STAT-1 signaling pathway in the peripheral blood cells of patients with RA... - Does mixed connective tissue disease exist? YesMartin Aringer
Department of Rheumatology, Internal Medicine III, Medical University of Vienna, AKH, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Rheum Dis Clin North Am 31:411-20, v. 2005..The authors believe that the concept is useful in daily practice and accurate in the idea that MCTD constitutes a disease entity of its own... - Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic miceGeorg Schett
Department of Internal Medicine III, Division of Rheumatology, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
Arthritis Rheum 48:2042-51. 2003..To investigate the role of tumor necrosis factor (TNF) in systemic bone loss of chronic inflammatory conditions, such as rheumatoid arthritis (RA), and to address the therapeutic potential of osteoclast blockade... - Gait changes precede overt arthritis and strongly correlate with symptoms and histopathological events in pristane-induced arthritisMarkus H Hoffmann
Division of Rheumatology, Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Arthritis Res Ther 12:R41. 2010..To investigate this issue a detailed analysis of the pathologic changes occurring during the prodromal and early stages of PIA was performed... - Nucleic acid-associated autoantigens: pathogenic involvement and therapeutic potentialMarkus H Hoffmann
Division of Rheumatology, Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
J Autoimmun 34:J178-206. 2010..Furthermore, recent advances in immunotherapy such as antigen-specific approaches targeted at nucleic acid-binding antigens are discussed... - Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerinKurt Redlich
University of Vienna, Vienna, Austria
Arthritis Rheum 46:785-92. 2002.... - Cell death and cytokine production induced by autoimmunogenic hydrocarbon oilsSonja Herman
Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Autoimmunity 45:602-11. 2012..The higher serum IL-1β levels in pristane-injected animals might be caused by both inflammasome-dependent and -independent mechanisms, such as passive release from dying-cells and probably extracellular maturation of pro-IL-1β... - Osteoclasts are essential for TNF-alpha-mediated joint destructionKurt Redlich
Department of Internal Medicine III, Division of Rheumatology, University of Vienna, Vienna, Austria
J Clin Invest 110:1419-27. 2002..Therefore, in addition to the use of anti-inflammatory therapies, osteoclast inhibition could be beneficial for the treatment of rheumatoid arthritis... - Expression patterns of CD44 and CD44 splice variants in patients with rheumatoid arthritisJ Grisar
Divison of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria
Clin Exp Rheumatol 30:64-72. 2012..We therefore studied the expression of various CD44 splicevariants in the circulation and synovial tissue of patients with RA and correlated expression with clinical features... - Depletion of endothelial progenitor cells in the peripheral blood of patients with rheumatoid arthritisJohannes Grisar
Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Circulation 111:204-11. 2005..Because the quantity of endothelial progenitor cells (EPCs) in the peripheral blood is correlated inversely with cardiovascular risk, we studied whether such abnormalities could also be observed in patients with RA... - RNA chaperone activity of protein components of human Ro RNPsAurélia Belisova
Department of Medical Biochemistry, Medical University of Vienna, Vienna Biocenter, Dr Bohrgasse 9, A 1030 Vienna, Austria
RNA 11:1084-94. 2005.... - Therapeutic strategies for rheumatoid arthritisJosef S Smolen
Division of Rheumatology, Department of Internal Medicine III, University of Vienna, Austria
Nat Rev Drug Discov 2:473-88. 2003.... - Rheumatoid arthritis therapy after tumor necrosis factor and interleukin-1 blockadeKurt Redlich
University of Vienna, Vienna, Austria
Arthritis Rheum 48:3308-19. 2003 - Characterization of autoreactive T cells to the autoantigens heterogeneous nuclear ribonucleoprotein A2 (RA33) and filaggrin in patients with rheumatoid arthritisRuth Fritsch
Division of Rheumatology, Department of Internal Medicine III, University of Vienna, Vienna, Austria
J Immunol 169:1068-76. 2002..Taken together, the presence of autoreactive Th1-like cells in RA patients in conjunction with synovial overexpression of A2/RA33 may indicate potential involvement of this autoantigen in the pathogenesis of RA... - Autoantibodies in rheumatoid arthritis and their clinical significanceGünter Steiner
Vienna General Hospital, University of Vienna, and Ludwig Boltzmann Institute for Rheumatology, Vienna, Austria
Arthritis Res 4:S1-5. 2002..These autoantibodies are reviewed and the potential role of the autoantibodies in the pathogenesis of RA is briefly discussed...