Reinhold Schmidt

Summary

Affiliation: Medical University of Graz
Country: Austria

Publications

  1. ncbi [Dementia with Lewy Bodies and its differentiation from Alzheimer's disease]
    Gerhard Ransmayr
    Neurologische Universitätsklinik Graz, Medizinische Universitat Graz
    Neuropsychiatr 21:63-74. 2007
  2. ncbi Progression of leukoaraiosis and cognition
    Reinhold Schmidt
    Department of Neurology, Medical University of Graz, Graz, Austria
    Stroke 38:2619-25. 2007
  3. pmc Longitudinal multimodal imaging in mild to moderate Alzheimer disease: a pilot study with memantine
    R Schmidt
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Neurosurg Psychiatry 79:1312-7. 2008
  4. ncbi [Therapy of Alzheimer's disease: current status and future development]
    Reinhold Schmidt
    Universitätsklinik für Neurologie, Medizinische Universitat Graz
    Neuropsychiatr 22:153-71. 2008
  5. ncbi White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study
    Reinhold Schmidt
    Department of Neurology, Medical University Graz, Austria
    Ann Neurol 58:610-6. 2005
  6. doi MRI in dementia
    Reinhold Schmidt
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Neurol Clin 27:221-36, ix. 2009
  7. ncbi [Memantine for treatment of behavioural disturbances and psychotic symptoms in moderate to moderately severe Alzheimer dementia: a naturalistic study in outpatient services in Austria]
    Reinhold Schmidt
    Universitätsklinik für Neurologie, Medizinische Universitat Graz
    Neuropsychiatr 24:125-31. 2010
  8. ncbi [Transdermal rivastigmine patch in outpatient services in Austria: a naturalistic study in 103 patients with Alzheimer dementia]
    Reinhold Schmidt
    Universitätsklinik für Neurologie, Medizinische Universitat Graz
    Neuropsychiatr 23:58-63. 2009
  9. ncbi C-reactive protein, carotid atherosclerosis, and cerebral small-vessel disease: results of the Austrian Stroke Prevention Study
    Reinhold Schmidt
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria
    Stroke 37:2910-6. 2006
  10. ncbi Subcortical vascular cognitive impairment: similarities and differences with multiple sclerosis
    Reinhold Schmidt
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 245:3-7. 2006

Detail Information

Publications99

  1. ncbi [Dementia with Lewy Bodies and its differentiation from Alzheimer's disease]
    Gerhard Ransmayr
    Neurologische Universitätsklinik Graz, Medizinische Universitat Graz
    Neuropsychiatr 21:63-74. 2007
    ..We also guide in the management of DLB as pharmacological treatment can pose difficult dilemmas for the treating clinician...
  2. ncbi Progression of leukoaraiosis and cognition
    Reinhold Schmidt
    Department of Neurology, Medical University of Graz, Graz, Austria
    Stroke 38:2619-25. 2007
    ..Progression of leukoaraiosis relates to cognitive decline, but this association is complex and modulated by other morphological factors like brain atrophy...
  3. pmc Longitudinal multimodal imaging in mild to moderate Alzheimer disease: a pilot study with memantine
    R Schmidt
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Neurosurg Psychiatry 79:1312-7. 2008
    ....
  4. ncbi [Therapy of Alzheimer's disease: current status and future development]
    Reinhold Schmidt
    Universitätsklinik für Neurologie, Medizinische Universitat Graz
    Neuropsychiatr 22:153-71. 2008
    ..A disease-modifying therapy which delays the onset of Alzheimer disease by 5 years, will probably reduce the number of patients by nearly 50% during the next 50 years...
  5. ncbi White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study
    Reinhold Schmidt
    Department of Neurology, Medical University Graz, Austria
    Ann Neurol 58:610-6. 2005
    ....
  6. doi MRI in dementia
    Reinhold Schmidt
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Neurol Clin 27:221-36, ix. 2009
    ..In addition, we explore the usefulness of such techniques as surrogate markers of these diseases...
  7. ncbi [Memantine for treatment of behavioural disturbances and psychotic symptoms in moderate to moderately severe Alzheimer dementia: a naturalistic study in outpatient services in Austria]
    Reinhold Schmidt
    Universitätsklinik für Neurologie, Medizinische Universitat Graz
    Neuropsychiatr 24:125-31. 2010
    ..Controlled clinical trials which have behavioral disturbances and psychotic symptoms as primary endpoint are needed to define the true potential of memantine in mild dementia stages...
  8. ncbi [Transdermal rivastigmine patch in outpatient services in Austria: a naturalistic study in 103 patients with Alzheimer dementia]
    Reinhold Schmidt
    Universitätsklinik für Neurologie, Medizinische Universitat Graz
    Neuropsychiatr 23:58-63. 2009
    ..Patients and their caregivers should receive detailed information about skin reactions to omit unnecessary drop outs to treatment...
  9. ncbi C-reactive protein, carotid atherosclerosis, and cerebral small-vessel disease: results of the Austrian Stroke Prevention Study
    Reinhold Schmidt
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria
    Stroke 37:2910-6. 2006
    ..We examined the associations between CRP, carotid atherosclerosis, white matter lesions, and lacunes as manifestations of cerebral large- and small-vessel disease...
  10. ncbi Subcortical vascular cognitive impairment: similarities and differences with multiple sclerosis
    Reinhold Schmidt
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 245:3-7. 2006
    ..Involvement of these common functional anatomical structures and their modulatory transmitter systems has now led to common interventional approaches such as the use of cholinesterase inhibitors...
  11. ncbi White matter lesion progression: a surrogate endpoint for trials in cerebral small-vessel disease
    R Schmidt
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Neurology 63:139-44. 2004
    ..Like any other MRI metric, the change in white matter lesion volume cannot be considered preferable to clinical outcomes unless it has been demonstrated that it matters to the patient in terms of function...
  12. ncbi [Sex differences in Alzheimer's disease]
    Reinhold Schmidt
    Univ Klinik für Neurologie, Medizinische Universitat Graz
    Neuropsychiatr 22:1-15. 2008
    ..Care takes place in 80% by the families and is provided by women in 78%. The rate of female care-givers in partly institutionalized care units in 91% in nursing homes it is 84%...
  13. doi Cognition, gender, and functional abilities in Alzheimer's disease: how are they related?
    Thomas Benke
    Department of Neurology, Medical University, Innsbruck, Austria
    J Alzheimers Dis 35:247-52. 2013
    ..Few studies have investigated in detail which factors influence activities of daily (ADL) in Alzheimer's disease (AD). Objective: To assess the influence of cognitive, gender, and other factors on ADL in patients with mild to moderate AD...
  14. doi Levodopa changes brain motor network function during ankle movements in Parkinson's disease
    Petra Schwingenschuh
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria
    J Neural Transm 120:423-33. 2013
    ....
  15. doi MRI-detected white matter lesions: do they really matter?
    Reinhold Schmidt
    Division of Special Neurology, Department of Neurology, Medical University of Graz, Graz, Austria
    J Neural Transm 118:673-81. 2011
    ....
  16. pmc Driving cessation and dementia: results of the prospective registry on dementia in Austria (PRODEM)
    Stephan Seiler
    Department of Neurology, Division of Neurogeriatrics, Medical University of Graz, Graz, Austria
    PLoS ONE 7:e52710. 2012
    ..To assess the influence of cognitive, functional and behavioral factors, co-morbidities as well as caregiver characteristics on driving cessation in dementia patients...
  17. ncbi White matter lesion progression in LADIS: frequency, clinical effects, and sample size calculations
    Reinhold Schmidt
    Department of Neurology, Statistics and Documentation Medical University Graz, Austria
    Stroke 43:2643-7. 2012
    ....
  18. doi Vascular risk factors, white matter hyperintensities and hippocampal volume in normal elderly individuals
    Thomas Gattringer
    Department of Neurology, Medical University of Graz, Graz, Austria
    Dement Geriatr Cogn Disord 33:29-34. 2012
    ..To what extent vascular risk factors and white matter hyperintensities (WMH) affect hippocampal volume (HV) in asymptomatic elderly subjects and thus may impact such a predictive capacity is controversial...
  19. ncbi Lesion probability maps of white matter hyperintensities in elderly individuals: results of the Austrian stroke prevention study
    Christian Enzinger
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, 8036 Graz, Austria
    J Neurol 253:1064-70. 2006
    ..While this increase in extension is frequently seen as evidence for a continuum of changes, histological data and clinical follow-up suggest differences in underlying pathology and their progression...
  20. ncbi Progression of cerebral white matter lesions -- clinical and radiological considerations
    Christian Enzinger
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 257:5-10. 2007
    ..Power calculations based on quantitative data of the Austrian Stroke Prevention Study (ASPS) suggest that such studies would be feasible...
  21. doi Vascular dementia and Alzheimer's disease - are we in a dead-end road?
    Margherita Cavalieri
    Division of Special Neurology, Department of Neurology, Medical University of Graz, Graz, Austria
    Neurodegener Dis 7:122-6. 2010
    ..Most importantly, vascular lesions, even if subtle, exert significant effects on the patients' cognitive functioning if they coexist with AD pathology...
  22. ncbi The impact of our genes: consequences of the apolipoprotein E polymorphism in Alzheimer disease and multiple sclerosis
    Franz Fazekas
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 245:35-9. 2006
    ..In summary we presently may assume only subtle effects of the apoE polymorphism on the course of MS. These effects are probably further modulated by other genes and need further investigation...
  23. ncbi [Consensus statement "Dementia 2010" of the Austrian Alzheimer Society]
    Reinhold Schmidt
    Universitätsklinik für Neurologie, Medizinische Universitat Graz
    Neuropsychiatr 24:67-87. 2010
    ..The purpose of these guidelines is the rational and cost-effective use of diagnostic and therapeutic measures in dementing illnesses. Users are physicians and all other providers of care for patients with dementia in Austria...
  24. doi Diffusion-weighted imaging and cognition in the leukoariosis and disability in the elderly study
    Reinhold Schmidt
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria
    Stroke 41:e402-8. 2010
    ..We hypothesized that ultrastructural abnormalities of the normal-appearing brain tissue (NABT) assessed by diffusion-weighted imaging played a major and independent role...
  25. pmc Microstructural tissue damage in normal appearing brain tissue accumulates with Framingham Stroke Risk Profile Score: magnetization transfer imaging results of the Austrian Stroke Prevention Study
    Nina Homayoon
    Department of Neurology, Division of Special Neurology, Medical University of Graz, Graz, Austria
    Clin Neurol Neurosurg 115:1317-21. 2013
    ....
  26. doi B vitamins and magnetic resonance imaging-detected ischemic brain lesions in patients with recent transient ischemic attack or stroke: the VITAmins TO Prevent Stroke (VITATOPS) MRI-substudy
    Margherita Cavalieri
    Medical University of Graz, Department of Neurology, Division of Neurogeriatrics, Auenbruggerplatz 22, 8036 Graz, Austria
    Stroke 43:3266-70. 2012
    ..In a substudy of the VITAmins TO Prevent Stroke (VITATOPS) trial, we assessed the hypothesis that the addition of once-daily supplements of B vitamins would reduce the progression of CSVD-related brain lesions...
  27. ncbi MTI of white matter hyperintensities
    Franz Fazekas
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Brain 128:2926-32. 2005
    ..We conclude that MTR measurements can serve to quantify WMH associated tissue damage. It is predominantly focal, relatively mild, increases with lesion size and may have remote effects on the frontal white matter...
  28. ncbi [Dementia and pain]
    Reinhold Schmidt
    Universitätsklinik für Neurologie, Medizinische Universitat Graz
    Neuropsychiatr 24:1-13. 2010
    ..Multimodal pain therapy is superior to one-dimensional approaches. A discussion of the effects and interactions of the analgesics presently available for geriatric care forms an integral part of this review...
  29. doi Transient global amnesia: diffusion-weighted imaging lesions and cerebrovascular disease
    Christian Enzinger
    Department of Neurology and Section of Neuroradiology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Stroke 39:2219-25. 2008
    ....
  30. pmc Abnormalities of resting state functional connectivity are related to sustained attention deficits in MS
    Marisa Loitfelder
    Medical University of Graz, Department of Neurology, Graz, Austria
    PLoS ONE 7:e42862. 2012
    ....
  31. doi White matter hyperintensities alter functional organization of the motor system
    Patricia Linortner
    Department of Neurology, Medical University of Graz, Graz, Austria
    Neurobiol Aging 33:197.e1-9. 2012
    ..This suggests compensatory activation related to disturbance of frontosubcortical circuits...
  32. doi Altered functional organization of the motor system related to ankle movements in Parkinson's disease: insights from functional MRI
    Petra Katschnig
    Department of Neurology, Division of Special Neurology, Medical University of Graz, Graz, Austria
    J Neural Transm 118:783-93. 2011
    ..The missing correlation with behavioural variables and lack of differences with the passive paradigm suggests that this excess activation is not exclusively compensatory and also not hard-wired...
  33. ncbi Lower levels of N-acetylaspartate in multiple sclerosis patients with the apolipoprotein E epsilon4 allele
    Christian Enzinger
    Department of Neurology, Karl Franzens University, Graz, Austria
    Arch Neurol 60:65-70. 2003
    ..In multiple sclerosis (MS), the epsilon4 allele of apolipoprotein E (APOE epsilon4) has been associated with more rapid clinical worsening and more severe tissue damage on magnetic resonance imaging...
  34. pmc Metabolic syndrome, brain magnetic resonance imaging, and cognition
    Margherita Cavalieri
    Division of Special Neurology, Department of Neurology, Medical University of Graz, Graz, Austria
    Diabetes Care 33:2489-95. 2010
    ..We explored cognitive impairment in metabolic syndrome in relation to brain magnetic resonance imaging (MRI) findings...
  35. ncbi The natural course of MRI white matter hyperintensities
    Reinhold Schmidt
    Department of Neurology, Karl Franzens University, Auenbruggerplatz 22, A 8036, Graz, Austria
    J Neurol Sci 203:253-7. 2002
    ..The Austrian Stroke Prevention Study did not find an association between the evolution of WMH and cognitive functioning but the statistical power of this analysis was small and the relationship needs to be further explored...
  36. pmc Genetics of subcortical vascular dementia
    Helena Schmidt
    Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Harrachgasse 21, A 8010 Graz, Austria
    Exp Gerontol 47:873-7. 2012
    ..The recent genomegenome wide association study on white matter lesions identified a novel locus on chromosome 17q25 harboring several genes such as TRIM65 and TRIM47 which pinpoints to possible novel mechanisms leading to these lesions...
  37. pmc Genetic variants of the NOTCH3 gene in the elderly and magnetic resonance imaging correlates of age-related cerebral small vessel disease
    Helena Schmidt
    Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria
    Brain 134:3384-97. 2011
    ..Additional investigations are required to explore the biological mechanisms underlying the observed association...
  38. ncbi Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study
    Reinhold Schmidt
    Department of Neurology, Karl Franzens University, Graz, Austria
    Ann Neurol 52:168-74. 2002
    ..These data support the view that inflammatory markers may reflect not only peripheral disease, but also cerebral disease mechanisms related to dementia, and that these processes are measurable long before clinical symptoms appear...
  39. ncbi Evolution of white matter lesions
    Reinhold Schmidt
    Department of Neurology, Karl Franzens University, Graz, Austria
    Cerebrovasc Dis 13:16-20. 2002
    ..Lesion progression had no influence on the course of neuropsychologic test performance over the observational period, but the statistical power of this analysis was low...
  40. doi High-grade internal carotid artery stenosis and chronic brain damage: a volumetric magnetic resonance imaging study
    Christian Enzinger
    Department of Neurology, Medical University of Graz, Graz, Austria
    Cerebrovasc Dis 30:540-6. 2010
    ..Experimental data suggest that high-grade vascular stenosis may induce chronic cerebral tissue damage...
  41. doi Heterogeneity in age-related white matter changes
    Reinhold Schmidt
    Division of Special Neurology, Department of Neurology, Medical University of Graz, Austria
    Acta Neuropathol 122:171-85. 2011
    ..There is a need for additional pre- and postmortem studies in humans, including these new imaging techniques...
  42. ncbi Slow progression of white-matter changes
    Reinhold Schmidt
    Department of Neurology, Karl Franzens University, Graz, Austria
    Int Psychogeriatr 15:173-6. 2003
    ..Lesion progression had no influence on the course of neuropsychologic test performance over the observational period, but the statistical power of this analysis was low...
  43. doi Association between higher plasma lutein, zeaxanthin, and vitamin C concentrations and longer telomere length: results of the austrian stroke prevention study
    Abhijit Sen
    Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria
    J Am Geriatr Soc 62:222-9. 2014
    ..To examine the association between plasma concentrations of antioxidative micronutrients and leukocyte telomere length (LTL) in elderly adults...
  44. doi Vascular cognitive impairment - an ill-defined concept with the need to define its vascular component
    Stephan Seiler
    Division of Special Neurology, Department of Neurology, Medical University of Graz, Austria
    J Neurol Sci 322:11-6. 2012
    ....
  45. doi Association of cardiorespiratory fitness and morphological brain changes in the elderly: results of the Austrian Stroke Prevention Study
    Abhijit Sen
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria
    Neurodegener Dis 10:135-7. 2012
    ..Physical activity and cardiorespiratory fitness relate to better cognitive performance. Little is known about the effects of fitness on structural brain abnormalities in the elderly...
  46. doi Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) study
    Stefan Ropele
    Department of Neurology, Medical University of Graz, Austria
    J Magn Reson Imaging 29:268-74. 2009
    ..To explore the value of diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) for the improved detection and quantification of cerebral tissue changes associated with ageing and white matter hyperintensities (WMH)...
  47. pmc Genetics of age-related white matter lesions from linkage to genome wide association studies
    Paul Freudenberger
    Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, A 8010 Graz, Harrachgasse 21, Austria
    J Neurol Sci 322:82-6. 2012
    ..The recent genome wide association study by the CHARGE consortium identified a novel locus on chromosome 17q25 harboring several genes such as TRIM65 and TRIM47 which pinpoint to possible novel mechanisms leading to white matter lesions...
  48. doi Structural MRI in normal aging and Alzheimer's disease: white and black spots
    Margherita Cavalieri
    Division of Special Neurology, Department of Neurology, Medical University of Graz, Graz, Austria
    Neurodegener Dis 10:253-6. 2012
    ..White matter changes (WMC) and microbleeds (MBs) are common in the elderly and in patients with Alzheimer's disease (AD)...
  49. ncbi Progression of cerebral white matter lesions: 6-year results of the Austrian Stroke Prevention Study
    Reinhold Schmidt
    Department of Neurology, Karl Franzens University Graz, A 8036, Graz, Austria
    Lancet 361:2046-8. 2003
    ..0001). Punctate white matter lesions are not progressive and are thus benign, whereas early confluent and confluent white matter abnormalities are progressive, and thus malignant...
  50. ncbi Qualitative MRI: evidence of usual aging in the brain
    Peter Kapeller
    Department of Neurology, Medical University Graz, Graz, Austria
    Top Magn Reson Imaging 15:343-7. 2004
    ..Furthermore the meaning of darkening of the basal ganglia will be discussed and, in more general terms, the occurrence of virchow robin spaces and changes in cerebral metabolites assessable by proton magnetic resonance spectroscopy...
  51. ncbi Apolipoprotein E epsilon 4 is associated with rapid progression of multiple sclerosis
    F Fazekas
    Department of Neurology, Karl Franzens University, Graz, Austria
    Neurology 57:853-7. 2001
    ..Previous findings concerning a possible modulation of the clinical course of MS have been inconsistent, however...
  52. ncbi Angiotensinogen gene promoter haplotype and microangiopathy-related cerebral damage: results of the Austrian Stroke Prevention Study
    H Schmidt
    Institute of Medical Biochemistry and Medical Molecular Biology, Karl Franzens University, Graz, Austria
    Stroke 32:405-12. 2001
    ..Arterial hypertension and age are the most important risk factors. We assessed the association between MARCD and sequence alterations in the promoter region of the angiotensinogen (AGT) gene...
  53. ncbi Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects
    C Enzinger
    Department of Neurology, Medical University Graz, Graz, Austria
    Neurology 64:1704-11. 2005
    ....
  54. doi Reorganization in cognitive networks with progression of multiple sclerosis: insights from fMRI
    M Loitfelder
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Neurology 76:526-33. 2011
    ..We attempted to assess the concept of functional reorganization concerning cognition using a simple "Go/No-go" fMRI paradigm...
  55. ncbi Lack of association of lobar intracerebral hemorrhage with apolipoprotein E genotype in an unselected population
    T Seifert
    Department of Neurology, Medical University Graz, Graz, Austria
    Cerebrovasc Dis 21:266-70. 2006
    ..These studies were performed primarily on the North American population and investigated in partly selected patient cohorts...
  56. doi MRI for iron mapping in Alzheimer's disease
    Christian Langkammer
    Department of Neurology, Medical University of Graz, Graz, Austria
    Neurodegener Dis 13:189-91. 2014
    ..2013 S. Karger AG, Basel. ..
  57. pmc Moving toward "laboratory-supported" criteria for psychogenic tremor
    Petra Schwingenschuh
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom
    Mov Disord 26:2509-15. 2011
    ..Our data suggest such a battery that, if supported in a prospective study, may form the basis of laboratory-supported criteria for the diagnosis of psychogenic tremor...
  58. ncbi Secondary prevention after cryptogenic cerebrovascular events in patients with patent foramen ovale
    Herwig Walter Schuchlenz
    Medical Department II, LKH Graz West, Graz, Austria
    Int J Cardiol 101:77-82. 2005
    ..Patients with patent foramen ovale and cryptogenic stroke are at risk of recurrence, but there are few data on strategies to prevent this...
  59. doi New development in diagnosis of vascular cognitive impairment
    Margherita Cavalieri
    Division of Special Neurology, Department of Neurology, Medical University Graz, Austria
    J Neurol Sci 299:11-4. 2010
    ..Such data are the pre-requisite to further develop the currently vague concept of VCI to a clearly defined diagnostic entity...
  60. ncbi MRI cerebral white matter lesions and paraoxonase PON1 polymorphisms : three-year follow-up of the austrian stroke prevention study
    R Schmidt
    Department of Neurology, Karl Franzens University, Graz, Austria
    Arterioscler Thromb Vasc Biol 20:1811-6. 2000
    ..05/mm Hg), and LL paraoxonase genotype (odds ratio, 2. 65) to be significant predictors of WML progression. These data suggest that the LL PON1 genotype at position 54 influences the extent and progression of WMLs in elderly subjects...
  61. ncbi Human paraoxonase 1 gene polymorphisms and the risk of coronary heart disease: a community-based study
    N Watzinger
    Department of Medicine, Karl Franzens University, Graz, Austria
    Cardiology 98:116-22. 2002
    ..86), HDL cholesterol (odds ratio 0.94/mg/dl) and the paraoxonase LL genotype (odds ratio 2.25) to be significant predictors of CHD. These data suggest that the paraoxonase LL genotype at position 55 may present a risk factor for CHD...
  62. ncbi Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study
    Reinhold Schmidt
    Department of Neurology, Medical University Graz, Graz, Austria
    Diabetes 53:687-92. 2004
    ..Cognitive and pathological data are needed to determine the clinical significance of these findings as well as to understand the mechanisms underlying these associations...
  63. ncbi Angiotensinogen promoter B-haplotype associated with cerebral small vessel disease enhances basal transcriptional activity
    Helena Schmidt
    Institute of Medical Molecular Biology and Biochemistry, Medical University of Graz, Harrachgasse 21, 8010 Graz, Austria
    Stroke 35:2592-7. 2004
    ....
  64. ncbi Rivastigmine in outpatient services: experience of 114 neurologists in Austria
    R Schmidt
    Department of Neurology, Karl Franzens University Graz, Austria
    Int Clin Psychopharmacol 17:81-5. 2002
    ..This study suggests that, in daily clinical practice, titration of rivastigmine deviates from the prescribing information. Under routine conditions, the safety profile of the drug is favourable, as is the response to treatment...
  65. doi The impact of sex and vascular risk factors on brain tissue changes with aging: magnetization transfer imaging results of the Austrian stroke prevention study
    Stefan Ropele
    Department of Neurology, Medical University of Graz, Graz, Austria
    AJNR Am J Neuroradiol 31:1297-301. 2010
    ..To what extent sex and cerebrovascular risk factors impact these changes is largely unknown. We attempted to study these risk factors in the context of the community-based ASPS...
  66. ncbi Visual rating of age-related white matter changes on magnetic resonance imaging: scale comparison, interrater agreement, and correlations with quantitative measurements
    P Kapeller
    Department of Neurology, Karl Franzens University, Graz, Austria
    Stroke 34:441-5. 2003
    ..Furthermore, the correlation between visual ratings and quantitative volumetric measurement was assessed...
  67. doi Cerebellar learning distinguishes inflammatory neuropathy with and without tremor
    Petra Schwingenschuh
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK
    Neurology 80:1867-73. 2013
    ..This study aims to investigate if patients with inflammatory neuropathies and tremor have evidence of dysfunction in the cerebellum and interactions in sensorimotor cortex compared to nontremulous patients and healthy controls...
  68. ncbi MRI white matter hyperintensities: three-year follow-up of the Austrian Stroke Prevention Study
    R Schmidt
    Department of Neurology, Institute of Medical Biochemistry, Karl Franzens University, Graz, Austria
    Neurology 53:132-9. 1999
    ..To determine the rate, clinical predictors, and cognitive consequences of MRI white matter hyperintensity evolution over 3 years...
  69. ncbi Angiotensinogen polymorphism M235T, carotid atherosclerosis, and small-vessel disease-related cerebral abnormalities
    R Schmidt
    Department of Neurology, MRI Center, Karl Franzens University, Graz, Austria
    Hypertension 38:110-5. 2001
    ..These data suggest that the angiotensinogen T/T genotype at position 235 is a genetic marker for brain lesions from and progression of small vessel disease but not for extracranial carotid atherosclerosis...
  70. ncbi [Vascular dementia]
    R Schmidt
    Neurologische Universitatsklinik, Auenbruggerplatz 22, A 8036 Graz
    Wien Med Wochenschr 152:85-91. 2002
    ..Lately, this concept is tested by several studies on the efficacy of acetylcholinesterase inhibitors in vascular dementia...
  71. pmc Apolipoprotein E genotype related differences in brain lesions of multiple sclerosis
    F Fazekas
    Department of Neurology, Karl Franzens University, Graz, Austria
    J Neurol Neurosurg Psychiatry 69:25-8. 2000
    ..As this could be reflected by differences in the severity of tissue damage MRI was used to obtain further support for a disease modifying effect of the apoE genotype...
  72. ncbi Apolipoprotein E polymorphism and silent microangiopathy-related cerebral damage. Results of the Austrian Stroke Prevention Study
    R Schmidt
    Department of Neurology, Karl Franzens University Graz, Austria
    Stroke 28:951-6. 1997
    ..The risk factors of such brain abnormalities are not fully determined. The goal of this study was to determine whether the genetic heterogeneity of apolipoprotein E (apoE) contributes to the occurrence of MARCD...
  73. ncbi Beta-fibrinogen gene polymorphism (C148-->T) is associated with carotid atherosclerosis: results of the Austrian Stroke Prevention Study
    H Schmidt
    Institute for Medical Biochemistry, Karl Franzens University, Graz, Austria
    Arterioscler Thromb Vasc Biol 18:487-92. 1998
    ..05/10 mg/dL), and cardiac disease (OR, 1.80). These data suggest that the beta-fibrinogen promoter T/T148 genotype represents a genetic risk factor for carotid atherosclerosis in the middle-aged to elderly...
  74. ncbi Paraoxonase PON1 polymorphism leu-Met54 is associated with carotid atherosclerosis: results of the Austrian Stroke Prevention Study
    H Schmidt
    Institute for Medical Biochemistry, Karl Franz University, Graz, Austria
    Stroke 29:2043-8. 1998
    ..This is the first study to determine the effect of these polymorphisms on carotid atherosclerosis...
  75. ncbi Vascular risk factors in dementia
    R Schmidt
    Department of Neurology, Karl Franzens University Graz, Austria
    J Neurol 247:81-7. 2000
    ..A modulatory effect of vascular risk factors in the development of primary degenerative dementia may extend treatment options...
  76. ncbi Pathophysiologic mechanisms in the development of age-related white matter changes of the brain
    F Fazekas
    Department of Neurology, Karl Franzens University, Graz, Austria
    Dement Geriatr Cogn Disord 9:2-5. 1998
    ..Early confluent and confluent hyperintensities, however, indicate more extensive ischemic damage consistent with advanced microangiopathy...
  77. ncbi The prevalence of cerebral damage varies with migraine type: a MRI study
    F Fazekas
    Department of Neurology, Karl-Franzens University, Graz, Austria
    Headache 32:287-91. 1992
    ..Our findings confirm a higher prevalence of MRI lesions in a mixed group of migraineurs than in headache free individuals. Signal abnormalities are most often non-specific, however their occurrence relates to the type of migraine...
  78. ncbi [Mild cognitive impairment]
    Reinhold Schmidt
    Wien Klin Wochenschr 117:617-9. 2005
  79. ncbi Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study
    Elisabeth C W van Straaten
    Department of Neurology and Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands
    Stroke 37:836-40. 2006
    ..Associations may depend on the method used for measuring WMH. We investigated the ability of different WMH scoring methods to detect differences in WMH load between groups with and without symptoms...
  80. ncbi Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Am Geriatr Soc 54:1095-101. 2006
    ..To determine whether leukoaraiosis severity is independently associated with differences in global functioning in nondisabled elderly patients...
  81. doi Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study
    Alida A Gouw
    Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Stroke 39:1414-20. 2008
    ..We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development...
  82. ncbi Cerebral changes on MRI and cognitive function: the CASCADE study
    Hedvig Söderlund
    The Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Canada, and Department of Psychology, Stockholm University, Stockholm, Sweden
    Neurobiol Aging 27:16-23. 2006
    ..The findings are consistent with findings from lesion and functional neuroimaging studies...
  83. ncbi Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study
    Wiesje M van der Flier
    Alzheimer Center, Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 36:2116-20. 2005
    ..We investigated the independent contribution of WMH and lacunes to general cognitive function in a group of independently living elderly with varying degrees of small vessel disease...
  84. ncbi Comparison of the Alzheimer's Disease Assessment Scale Cognitive Subscale and the Vascular Dementia Assessment Scale in differentiating elderly individuals with different degrees of white matter changes. The LADIS Study
    Raija Ylikoski
    Memory Research Unit, Department of Neurology, University of Helsinki, Helsinki, Finland
    Dement Geriatr Cogn Disord 24:73-81. 2007
    ..The objective of this study was to compare the results of the two scales among subjects with various degrees of white matter hyperintensities (WMHs)...
  85. doi Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression
    A A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Cerebrovasc Dis 25:247-53. 2008
    ..However, the most suitable method for measuring WMH progression has not been established yet. We compared the reliability and sensitivity of cross-sectional and longitudinal visual scales with volumetry for measuring WMH progression...
  86. ncbi Treatment strategies in Alzheimer's disease with a focus on early pharmacological interventions
    Josef Marksteiner
    Department of Psychiatry, Medical University Innsbruck, Innsbruck, Austria
    Drugs Aging 21:415-26. 2004
    ..No disease-modifying strategy can presently be offered to patients; however, given the pace of recent research there is optimism that slowing progression of Alzheimer's disease will soon be possible...
  87. doi On the etiology of incident brain lacunes: longitudinal observations from the LADIS study
    Alida A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 39:3083-5. 2008
    ..We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period...
  88. pmc Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age-related white matter hyperintensities: the LADIS Study
    Hanna Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    J Neurol Neurosurg Psychiatry 78:491-6. 2007
    ..Previous research has indicated that corpus callosum atrophy is associated with global cognitive decline in neurodegenerative diseases, but few studies have investigated specific cognitive functions...
  89. ncbi Visual rating scales for age-related white matter changes (leukoaraiosis): can the heterogeneity be reduced?
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Stroke 33:2827-33. 2002
    ..We aimed to compare 6 widely used rating scales for leukoaraiosis and to calculate conversion coefficients of the score of 1 scale in the score of a second scale...
  90. ncbi Markers of endothelial and hemostatic activation and progression of cerebral white matter hyperintensities: longitudinal results of the Austrian Stroke Prevention Study
    Hugh S Markus
    Clinical Neuroscience, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Stroke 36:1410-4. 2005
    ..In a prospective study, we determined whether circulating markers of endothelial activation predicted progression of WMH...
  91. doi Association of gait and balance disorders with age-related white matter changes: the LADIS study
    H Baezner
    Mannheim University Hospital, University of Heidelberg, Department of Neurology, Theodor Kutzer Ufer, D 68135 Mannheim, Germany
    Neurology 70:935-42. 2008
    ..We aimed at determining the influence of ARWMC on different objective measures of gait and balance...
  92. ncbi Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis
    Matthias Griese
    Children s Hospital, University of Munich, Munich, Germany
    Am J Respir Crit Care Med 170:1000-5. 2004
    ....
  93. ncbi Surfactant abnormalities after single lung transplantation in dogs: impact of bronchoscopic surfactant administration
    Andreas Gunther
    Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    J Thorac Cardiovasc Surg 127:344-54. 2004
    ..The aim of this study was to evaluate the influence of exogenous surfactant administration on surfactant properties in a model of single lung transplantation...
  94. pmc Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients
    Matthias Griese
    Children s Hospital, University of Munich, Lindwurmstr 4, 80337 München, Germany
    Respir Res 6:133. 2005
    ..So far, longitudinal measurements of surfactant function in CF patients are lacking and it remains unclear how these alterations relate to the progression of airway inflammation as well as decline in pulmonary function over time...
  95. ncbi Operational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study
    Elisabeth C W van Straaten
    Department of Neurology and Alzheimer Center, VU Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, Netherlands
    Stroke 34:1907-12. 2003
    ..The purposes of our study were to operationalize the radiological part of the NINDS-AIREN criteria and to assess the effect of this operationalization on interobserver agreement...
  96. doi Segmentation of age-related white matter changes in a clinical multi-center study
    Tim B Dyrby
    Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark
    Neuroimage 41:335-45. 2008
    ..Expert knowledge not available to the neural networks was a minor source of discrepancy, while variation in MR scan quality constituted the largest source of error...
  97. ncbi The association between blood pressure, hypertension, and cerebral white matter lesions: cardiovascular determinants of dementia study
    Ewoud J van Dijk
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Hypertension 44:625-30. 2004
    ..Successful treatment of hypertension may reduce this risk; however, a potential negative effect of decreasing diastolic blood pressure level on the occurrence of severe periventricular white matter lesions should be taken into account...
  98. ncbi Secondary prevention of stroke in patients with atrial fibrillation: factors influencing the prescription of oral anticoagulation at discharge
    Dominique Deplanque
    Department of Pharmacology, University of Lille II, Lille, France, and Department of Neurosciences and Mental Health, Hospital Santa Maria, Lisbon, Portugal
    Cerebrovasc Dis 21:372-9. 2006
    ..However, OAC is still underused, even at discharge from neurological centers. The objective of this study was to identify the reasons underlying the prescription of OAC at discharge after an ischemic stroke in patients with NVAF...
  99. pmc Stroke prevention and atrial fibrillation: reasons leading to an inappropriate management. Main results of the SAFE II study
    Dominique Deplanque
    Department of Pharmacology, University of Lille, France
    Br J Clin Pharmacol 57:798-806. 2004
    ..The aim of the Stroke and Atrial Fibrillation Ensemble (SAFE) II study was to identify the reasons underlying the under-utilization of oral anticoagulation (OAC) in patients with nonvalvular atrial fibrillation (NVAF)...