Marcus D Saemann

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. doi request reprint The versatility of HDL: a crucial anti-inflammatory regulator
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Wahringer Gurtel, Vienna, Austria
    Eur J Clin Invest 40:1131-43. 2010
  2. pmc Blood volume-monitored regulation of ultrafiltration in fluid-overloaded hemodialysis patients: study protocol for a randomized controlled trial
    Manfred Hecking
    Department of Internal Medicine III, Nephrology and Dialysis, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna 1090, Austria
    Trials 13:79. 2012
  3. doi request reprint Fluid overload in hemodialysis patients: a cross-sectional study to determine its association with cardiac biomarkers and nutritional status
    Marlies Antlanger
    Department of Internal Medicine III Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna Austria
    BMC Nephrol 14:266. 2013
  4. ncbi request reprint Janus kinase-3 (JAK3) inhibition: a novel immunosuppressive option for allogeneic transplantation
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Transpl Int 17:481-9. 2004
  5. doi request reprint Maintenance immunosuppressive therapy in adult renal transplantation: a single center analysis
    Marcus D Saemann
    Department of Medicine III, Medical University of Vienna, Austria
    Transpl Immunol 20:14-20. 2008
  6. ncbi request reprint Uncovering host defences in the urinary tract: cathelicidin and beyond
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Nephrol Dial Transplant 22:347-9. 2007
  7. ncbi request reprint [Causes of recurrent urinary tract infections: new insights]
    M D Säemann
    Innere Medizin III, Abteilung für Nephrologie und Dialyse, Medizinische Universität Wien, Osterreich
    Dtsch Med Wochenschr 130:2031-4. 2005
  8. doi request reprint The multifunctional role of mTOR in innate immunity: implications for transplant immunity
    M D Säemann
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria
    Am J Transplant 9:2655-61. 2009
  9. ncbi request reprint Tamm-Horsfall protein: a multilayered defence molecule against urinary tract infection
    M D Säemann
    Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 35:227-35. 2005
  10. ncbi request reprint Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154
    Marcus D Saemann
    Institute of Immunology, Vienna, Austria
    Transplantation 75:1864-72. 2003

Detail Information

Publications52

  1. doi request reprint The versatility of HDL: a crucial anti-inflammatory regulator
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Wahringer Gurtel, Vienna, Austria
    Eur J Clin Invest 40:1131-43. 2010
    ..However, the current evidence that raising HDL per se will reduce atherosclerosis and thereby cardiovascular events still remains controversial...
  2. pmc Blood volume-monitored regulation of ultrafiltration in fluid-overloaded hemodialysis patients: study protocol for a randomized controlled trial
    Manfred Hecking
    Department of Internal Medicine III, Nephrology and Dialysis, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna 1090, Austria
    Trials 13:79. 2012
    ....
  3. doi request reprint Fluid overload in hemodialysis patients: a cross-sectional study to determine its association with cardiac biomarkers and nutritional status
    Marlies Antlanger
    Department of Internal Medicine III Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna Austria
    BMC Nephrol 14:266. 2013
    ..In addition, we aimed to confirm whether volume status correlates with nutritional status...
  4. ncbi request reprint Janus kinase-3 (JAK3) inhibition: a novel immunosuppressive option for allogeneic transplantation
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Transpl Int 17:481-9. 2004
    ..The potential clinical application of JAK3 inhibitors in organ transplantations is discussed in the light of a recent series of successful kidney transplantations in non-human primates immunosuppressed solely with a novel JAK3 inhibitor...
  5. doi request reprint Maintenance immunosuppressive therapy in adult renal transplantation: a single center analysis
    Marcus D Saemann
    Department of Medicine III, Medical University of Vienna, Austria
    Transpl Immunol 20:14-20. 2008
    ....
  6. ncbi request reprint Uncovering host defences in the urinary tract: cathelicidin and beyond
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Nephrol Dial Transplant 22:347-9. 2007
  7. ncbi request reprint [Causes of recurrent urinary tract infections: new insights]
    M D Säemann
    Innere Medizin III, Abteilung für Nephrologie und Dialyse, Medizinische Universität Wien, Osterreich
    Dtsch Med Wochenschr 130:2031-4. 2005
  8. doi request reprint The multifunctional role of mTOR in innate immunity: implications for transplant immunity
    M D Säemann
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria
    Am J Transplant 9:2655-61. 2009
    ....
  9. ncbi request reprint Tamm-Horsfall protein: a multilayered defence molecule against urinary tract infection
    M D Säemann
    Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 35:227-35. 2005
    ....
  10. ncbi request reprint Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154
    Marcus D Saemann
    Institute of Immunology, Vienna, Austria
    Transplantation 75:1864-72. 2003
    ..Recent evidence, however, indicates a critical role for JAK3 in signaling linked to the T-cell antigen receptor...
  11. ncbi request reprint Inhibition of human dendritic cell maturation and function by the novel immunosuppressant FK778
    Maximilian Zeyda
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Transplantation 80:1105-11. 2005
    ....
  12. ncbi request reprint Suppression of T cell signaling by polyunsaturated fatty acids: selectivity in inhibition of mitogen-activated protein kinase and nuclear factor activation
    Maximilian Zeyda
    Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism and Institute of Immunology, University of Vienna Medical School, Vienna, Austria
    J Immunol 170:6033-9. 2003
    ..In conclusion, PUFA treatment of T cells inhibits selectively c-Jun NH(2)-terminal kinase and NF-AT activation, resulting in diminished production of IL-2 and IL-13...
  13. doi request reprint A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    J Immunol 185:3919-31. 2010
    ....
  14. ncbi request reprint Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3
    Marcus D Saemann
    Institute of Immunology, University of Vienna, Vienna, Austria
    Am J Transplant 3:1341-9. 2003
    ..This property of JAK3 inhibitors therefore represents a further level of interference, which together with the well-established suppression of cgamma signaling could be responsible for their clinical efficacy...
  15. ncbi request reprint Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation
    Maximilian Zeyda
    Medical University of Vienna, Vienna, Austria
    Arthritis Rheum 52:2730-9. 2005
    ..In this study, we evaluated the impact of the active leflunomide metabolite teriflunomide on T cell integrin activation, evolution of the IS, and antigen-specific formation of stable T cell/APC conjugates...
  16. ncbi request reprint Alemtuzumab (Campath-1H) induction therapy and dendritic cells: Impact on peripheral dendritic cell repertoire in renal allograft recipients
    Bernhard M Kirsch
    Department of Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Austria
    Transpl Immunol 16:254-7. 2006
    ..Further studies are warranted to further elucidate the functional significance of these finding in the setting of allogeneic organ transplantation...
  17. ncbi request reprint Polyunsaturated fatty acids block dendritic cell activation and function independently of NF-kappaB activation
    Maximilian Zeyda
    Clinical Divisions of Endocrinology and Metabolism, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Biol Chem 280:14293-301. 2005
    ..These data demonstrate a unique interference with DC activation and function that could significantly contribute to the well known anti-inflammatory effects of PUFAs...
  18. doi request reprint Vildagliptin and pioglitazone in patients with impaired glucose tolerance after kidney transplantation: a randomized, placebo-controlled clinical trial
    Johannes Werzowa
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Transplantation 95:456-62. 2013
    ..Currently, no guidelines exist for the management of renal transplant patients with impaired glucose tolerance (IGT), a risk factor for the development of NODAT and an independent predictor of death...
  19. doi request reprint The TSC-mTOR signaling pathway regulates the innate inflammatory response
    Thomas Weichhart
    Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    Immunity 29:565-77. 2008
    ..These data identify the TSC2-mTOR pathway as a key regulator of innate immune homeostasis with broad clinical implications for infectious and autoimmune diseases, vaccination, cancer, and transplantation...
  20. doi request reprint Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells
    Thomas Weichhart
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    Blood 117:4273-83. 2011
    ....
  21. ncbi request reprint Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation
    Maximilian Zeyda
    Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Leukoc Biol 81:319-27. 2007
    ..Furthermore, these data imply novel functions of calcineurin and NF-kappaB for successful IS maturation...
  22. ncbi request reprint Sirolimus in renal transplant recipients with tuberous sclerosis complex: clinical effectiveness and implications for innate immunity
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Transpl Int 23:777-85. 2010
    ..Larger studies are warranted to further examine the relationship between clinical parameters and the molecular response to mTOR-inhibition in TSC patients after renal transplantation...
  23. pmc Glucose metabolism after renal transplantation
    Manfred Hecking
    Department of Nephrology, Medical University of Vienna, Vienna, Austria
    Diabetes Care 36:2763-71. 2013
    ..We determined prevalence, risk factors, phenotype, and pathophysiological mechanism of new-onset diabetes after transplantation (NODAT) to generate strategies for optimal pharmacological management of hyperglycemia in NODAT patients...
  24. pmc Early basal insulin therapy decreases new-onset diabetes after renal transplantation
    Manfred Hecking
    Department of Nephrology, Medical University of Vienna, Vienna, Austria
    J Am Soc Nephrol 23:739-49. 2012
    ..In conclusion, this study suggests regimens that include basal insulin significantly reduce the odds for NODAT after renal transplantation, presumably via insulin-mediated protection of β cells...
  25. ncbi request reprint Antithymocyte globulin impairs T-cell/antigen-presenting cell interaction: disruption of immunological synapse and conjugate formation
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Transplantation 84:117-21. 2007
    ..In conclusion, ATG impairs T-cell/APC conjugate formation, a mechanism that may help to understand the functional inactivation of peripheral blood T-cells that have escaped cellular depletion after ATG treatment...
  26. pmc Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    J Clin Invest 115:468-75. 2005
    ..These data show that THP is a regulatory factor of innate and adaptive immunity and therefore could have significant impact on host immunity in the urinary tract...
  27. pmc p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin
    Karl Katholnig
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria
    J Immunol 190:1519-27. 2013
    ..Our data link p38α to mTOR signaling in myeloid immune cells that is decisive for tuning the immune response in dependence on the environmental milieu...
  28. pmc A randomized, placebo-controlled, double-blind, prospective trial to evaluate the effect of vildagliptin in new-onset diabetes mellitus after kidney transplantation
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Austria
    Trials 11:91. 2010
    ..This study will evaluate the safety and efficacy of vildagliptin monotherapy in renal transplant recipients with recently diagnosed NODAT...
  29. doi request reprint Hereditary amyloidosis caused by R554L fibrinogen Aα-chain mutation in a Spanish family and review of the literature
    Michael Haidinger
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Amyloid 20:72-9. 2013
    ..Here, we describe the clinical course of AFib amyloidosis associated with the rare R554L mutation, and the significance of extrarenal amyloid deposits and their possible influence on cardiovascular morbidity...
  30. pmc Eicosanoid modulation by the short-chain fatty acid n-butyrate in human monocytes
    Johannes J Kovarik
    Institute of Immunology, Centre of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
    Immunology 139:395-405. 2013
    ..This underscores the role of n-butyrate as a crucial mediator of gut-specific immunity...
  31. doi request reprint Rapid isolation of nuclei from living immune cells by a single centrifugation through a multifunctional lysis gradient
    Marko Poglitsch
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Immunol Methods 373:167-73. 2011
    ..This easy and highly reproducible procedure allows an effective preparation of nuclei and the cytoplasm in only 15 min with the ability to handle as little as one million cells per sample and easy parallel processing of multiple samples...
  32. ncbi request reprint Effect of the proteasome inhibitor bortezomib on humoral immunity in two presensitized renal transplant candidates
    Markus Wahrmann
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Transplantation 89:1385-90. 2010
    ..However, the ability of this agent to desensitize nonimmunosuppressed transplant candidates before transplantation is currently unknown...
  33. ncbi request reprint Analysis of liver function in renal transplant recipients undergoing C2-monitoring for cyclosporine
    Manfred Hecking
    Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Transpl Int 21:223-33. 2008
    ..Collectively, our data emphasize the need for increased awareness toward individual predispositions for CsA-sensitivity...
  34. doi request reprint Targeting the dysregulated mammalian target of rapamycin pathway in organ transplantation: killing 2 birds with 1 stone
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Wien, Austria
    Transplant Rev (Orlando) 25:145-53. 2011
    ....
  35. pmc The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function
    Bernhard M Kirsch
    Department of Internal Medicine III Clinical Division of Nephrology, Medical University of Vienna, Vienna, Austria
    Arthritis Res Ther 7:R694-703. 2005
    ..These data indicate that interference with several aspects of DC function could significantly contribute to the beneficial effects of leflunomide in inflammatory diseases, including RA...
  36. ncbi request reprint Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin
    Rene Geyeregger
    Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Austria
    Blood 109:4288-95. 2007
    ..Due to the central position of DCs in immunity, LXRalpha could be a potential novel target for immunomodulation...
  37. ncbi request reprint Capillary C4d deposition in kidney allografts: a specific marker of alloantibody-dependent graft injury
    Georg A Böhmig
    Department of Internal Medicine III, Institute of Nephrology and Dialysis, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Am Soc Nephrol 13:1091-9. 2002
    ..In conclusion, these data demonstrate that positive C4d staining, which is an independent predictor of kidney graft dysfunction, represents a reliable specific marker for antibody-dependent graft injury...
  38. doi request reprint Apoptotic cell-free DNA promotes inflammation in haemodialysis patients
    Johanna Atamaniuk
    Institute of Laboratory Diagnostics, Kaiser Franz Josef Hospital, Vienna, Austria
    Nephrol Dial Transplant 27:902-5. 2012
    ..The presence of circulating cell-free DNA (cfDNA) has been demonstrated as biomarker in many pathologies...
  39. doi request reprint Assessment of batch to batch variation in polyclonal antithymocyte globulin preparations
    Irene Popow
    Institute of Immunology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
    Transplantation 93:32-40. 2012
    ..Differences not only in the amounts of leukocyte reactive antibodies but also in the antigens targeted by ATGs could potentially affect the clinical efficacy of different batches of these polyclonal antibody preparations...
  40. ncbi request reprint n-Butyrate inhibits Jun NH(2)-terminal kinase activation and cytokine transcription in mast cells
    Christos Diakos
    Institute of Immunology, Medical University of Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
    Biochem Biophys Res Commun 349:863-8. 2006
    ..These results indicate that n-butyrate inhibits critical inflammatory mediators in mast cells by relatively selectively targeting the JNK signalling...
  41. doi request reprint Detecting adaptive immunity: applications in transplantation monitoring
    Georg A Böhmig
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Mol Diagn Ther 14:1-11. 2010
    ..Nonetheless, before implementation of immune monitoring in routine clinical practice, there is still a need for prospective trials designed to clarify the actual diagnostic potential of individual test systems in a therapeutic context...
  42. pmc Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance
    Florian W Kiefer
    Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Diabetes 59:935-46. 2010
    ..Here, we studied OPN effects in obesity-induced inflammation and insulin resistance by targeting OPN action in vivo...
  43. ncbi request reprint The multiple functions of Tamm-Horsfall protein in human health and disease: a mystery clears up
    Thomas Weichhart
    Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 117:316-22. 2005
    ..In light of these novel findings the particular role of THP as a specialized defense molecule in the urinary tract is discussed...
  44. pmc Serum amyloid A in uremic HDL promotes inflammation
    Thomas Weichhart
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Austria
    J Am Soc Nephrol 23:934-47. 2012
    ..These data suggest a potential link between the high levels of inflammation and cardiovascular mortality in uremia...
  45. doi request reprint Significance of interdialytic weight gain versus chronic volume overload: consensus opinion
    Manfred Hecking
    Department of Nephrology, Medical University of Vienna, Vienna, Austria
    Am J Nephrol 38:78-90. 2013
    ..Consensually, the present authors agree that this discrimination should be among the primary goals for dialysis caretakers today. In consequence, we recommend objective measures of volume status beyond mere evaluations of IDWG. ..
  46. doi request reprint Novel views on new-onset diabetes after transplantation: development, prevention and treatment
    Manfred Hecking
    Department of Internal Medicine, Medical University of Vienna, Vienna, Austria
    Nephrol Dial Transplant 28:550-66. 2013
    ..This approach has widespread implications for future research and is intended to tackle NODAT and also ultimately cardiovascular disease...
  47. ncbi request reprint Selective inhibition of T cell activation via CD147 through novel modulation of lipid rafts
    Gunther Staffler
    Institute of Immunology, University of Vienna, Vienna, Austria
    J Immunol 171:1707-14. 2003
    ..These results indicate that negative regulating signals can modulate microdomains and suggest a general mechanism for inhibition of receptor signaling...
  48. doi request reprint Impaired anti-inflammatory efficacy of n-butyrate in patients with IBD
    Johannes J Kovarik
    Institute of Immunology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 41:291-8. 2011
    ..In the present study, we tested the hypothesis that immune cells from patients with IBD are less sensitive to anti-inflammatory agents in the gut as exemplified by the short-chain fatty acid (SCFA) n-butyrate...
  49. doi request reprint Cytomegalovirus neutralization by hyperimmune and standard intravenous immunoglobulin preparations
    Christina B Planitzer
    Baxter AG, Global Pathogen Safety, Vienna, Austria
    Transplantation 92:267-70. 2011
    ..However, CMV ELISA titers do not necessarily correlate with CMV antibody function which is determined by virus neutralization tests...
  50. doi request reprint The multiple facets of mTOR in immunity
    Thomas Weichhart
    Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Trends Immunol 30:218-26. 2009
    ..These results place mTOR in a novel immunoregulatory context that highlights the potential of mTOR inhibitors as both immunosuppressant and anti-cancer agents...
  51. ncbi request reprint Effects of Tamm-Horsfall protein on polymorphonuclear leukocyte function
    Thomas Wimmer
    Division of Nephrology and Dialysis, Department of Medicine III, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Nephrol Dial Transplant 19:2192-7. 2004
    ..The specific effects of THP on inflammatory cells, however, are not yet well known. Therefore, the present study investigates the effects of THP in its soluble form on distinct polymorphonuclear leukocyte (PMNL) functions...
  52. ncbi request reprint Gross proteinuria and subacute renal failure after coronary angiography - a case report of cholesterol crystal embolization
    Peter Biesenbach
    Internal Medicine III Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 122:251-4. 2010
    ..Identification of high-risk patients is of utmost importance as efficient therapeutic strategies do not exist...