Christian Radauer

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. pmc The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands
    Christian Radauer
    Department of Pathophysiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    BMC Evol Biol 8:286. 2008
  2. doi request reprint Comparison of natural and recombinant forms of the major fish allergen parvalbumin from cod and carp
    Yan Ma
    Center for Physiology, Pathophysiology and Immunology, Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Mol Nutr Food Res 52:S196-207. 2008
  3. ncbi request reprint Naturally occurring hypoallergenic Bet v 1 isoforms fail to induce IgE responses in individuals with birch pollen allergy
    Stefan Wagner
    Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 121:246-52. 2008
  4. doi request reprint Differential T-cell responses and allergen uptake after exposure of dendritic cells to the birch pollen allergens Bet v 1.0101, Bet v 1.0401 and Bet v 1.1001
    Ursula Smole
    Department of Pathophysiology, Centre for Physiology, Pathophysiology and Immunology Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Immunobiology 215:903-9. 2010
  5. doi request reprint Physicochemical properties and thermal stability of Lep w 1, the major allergen of whiff
    Ulrike Griesmeier
    Department of Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Mol Nutr Food Res 54:861-9. 2010
  6. doi request reprint Effects of gastrointestinal digestion and heating on the allergenicity of the kiwi allergens Act d 1, actinidin, and Act d 2, a thaumatin-like protein
    Merima Bublin
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Mol Nutr Food Res 52:1130-9. 2008
  7. doi request reprint Purification and structural stability of the peach allergens Pru p 1 and Pru p 3
    Sonja Gaier
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Mol Nutr Food Res 52:S220-9. 2008
  8. doi request reprint Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergens
    Merima Bublin
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 125:687-94, 694.e1. 2010
  9. pmc Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergy
    Christian Radauer
    Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Mol Immunol 48:600-9. 2011
  10. doi request reprint Production and characterization of an allergen panel for component-resolved diagnosis of celery allergy
    Merima Bublin
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Mol Nutr Food Res 52:S241-50. 2008

Collaborators

Detail Information

Publications22

  1. pmc The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands
    Christian Radauer
    Department of Pathophysiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    BMC Evol Biol 8:286. 2008
    ..In this study, we aimed to identify and classify all Bet v 1-related structures from the Protein Data Bank and all Bet v 1-related sequences from the Uniprot database...
  2. doi request reprint Comparison of natural and recombinant forms of the major fish allergen parvalbumin from cod and carp
    Yan Ma
    Center for Physiology, Pathophysiology and Immunology, Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Mol Nutr Food Res 52:S196-207. 2008
    ..High crossreactivity among cod and carp parvalbumins was observed in immunoblots as well as in fluid phase assays. Natural and recombinant parvalbumins gave comparable results when performing various in vitro diagnostic assays...
  3. ncbi request reprint Naturally occurring hypoallergenic Bet v 1 isoforms fail to induce IgE responses in individuals with birch pollen allergy
    Stefan Wagner
    Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 121:246-52. 2008
    ..Naturally occurring hypoallergens have by and large not been considered as a source of vaccine candidates...
  4. doi request reprint Differential T-cell responses and allergen uptake after exposure of dendritic cells to the birch pollen allergens Bet v 1.0101, Bet v 1.0401 and Bet v 1.1001
    Ursula Smole
    Department of Pathophysiology, Centre for Physiology, Pathophysiology and Immunology Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Immunobiology 215:903-9. 2010
    ..These results provide evidence that DCs discriminate between allergens and highly related hypoallergens. This process may have an impact on the early phase of sensitisation...
  5. doi request reprint Physicochemical properties and thermal stability of Lep w 1, the major allergen of whiff
    Ulrike Griesmeier
    Department of Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Mol Nutr Food Res 54:861-9. 2010
    ..In contrast to a raw fish extract, the cooked extract showed higher resistance to pepsinolysis. The stability of Lep w 1 to thermal denaturation and digestion explains the high allergenicity of whiff...
  6. doi request reprint Effects of gastrointestinal digestion and heating on the allergenicity of the kiwi allergens Act d 1, actinidin, and Act d 2, a thaumatin-like protein
    Merima Bublin
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Mol Nutr Food Res 52:1130-9. 2008
    ..IgE binding to Act d 2 but not Act d 1 was detected in processed food products. The stability of Act d 1 and Act d 2 provides one explanation for the allergenic potency of kiwifruit...
  7. doi request reprint Purification and structural stability of the peach allergens Pru p 1 and Pru p 3
    Sonja Gaier
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Mol Nutr Food Res 52:S220-9. 2008
    ..5. In contrast, Pru p 3 was unable to refold after heating under neutral conditions but readily refolded after heating at pH 3...
  8. doi request reprint Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergens
    Merima Bublin
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 125:687-94, 694.e1. 2010
    ..Kiwifruit is one of the most common causes of food allergic reactions. Component-resolved diagnostics may enable significantly improved detection of sensitization to kiwifruit...
  9. pmc Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergy
    Christian Radauer
    Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Mol Immunol 48:600-9. 2011
    ..Despite considerable cross-reactivity between these allergens, no correlation between latex-associated plant food allergy and sensitization to hevein or HLDs was found...
  10. doi request reprint Production and characterization of an allergen panel for component-resolved diagnosis of celery allergy
    Merima Bublin
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Mol Nutr Food Res 52:S241-50. 2008
    ..These well-defined celery allergens will be used to prove the concept of component-resolved diagnosis and will contribute to improve food allergy diagnosis in the future...
  11. doi request reprint IgE cross-reactivity between the major peanut allergen Ara h 2 and the nonhomologous allergens Ara h 1 and Ara h 3
    Merima Bublin
    Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 132:118-24. 2013
    ..Ara h 2 is an important predictor of clinical reactivity to peanut, but cosensitization to all 3 allergens is correlated with the severity of patients' symptoms...
  12. doi request reprint Allergens are distributed into few protein families and possess a restricted number of biochemical functions
    Christian Radauer
    Department of Pathophysiology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 121:847-52.e7. 2008
    ..Existing allergen databases classify their entries by source and route of exposure, thus lacking an evolutionary, structural, and functional classification of allergens...
  13. doi request reprint Mal d 2, the thaumatin-like allergen from apple, is highly resistant to gastrointestinal digestion and thermal processing
    Ursula Smole
    Department of Pathophysiology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 147:289-98. 2008
    ..The stability of food allergens to proteolysis and thermal denaturation contributes considerably to their allergenicity...
  14. ncbi request reprint IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countries
    Merima Bublin
    Department of Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Allergy Clin Immunol 114:1169-75. 2004
    ..In 1999, the yellow-fleshed cultivar Actinidia chinensis cv Hort16A was introduced into the international market...
  15. ncbi request reprint Use of a genetic cholera toxin B subunit/allergen fusion molecule as mucosal delivery system with immunosuppressive activity against Th2 immune responses
    Merima Bublin
    Department of Pathophysiology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
    Vaccine 25:8395-404. 2007
    ....
  16. ncbi request reprint Evolutionary biology of plant food allergens
    Christian Radauer
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 120:518-25. 2007
    ..The study of the distribution of allergenic and nonallergenic members of protein families will provide new insights into the evolution of allergenicity and the factors that make proteins allergenic...
  17. ncbi request reprint Pollen allergens are restricted to few protein families and show distinct patterns of species distribution
    Christian Radauer
    Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 117:141-7. 2006
    ..Inhalative allergies are elicited predominantly by pollen of various plant species. However, a classification of the large number of identified pollen allergens is still missing...
  18. ncbi request reprint A classification of plant food allergens
    Heimo Breiteneder
    Department of Pathophysiology, Medical University of Vienna, AKH EBO 3Q, Waehringer Guertel 18 20, 1090 Vienna, Austria
    J Allergy Clin Immunol 113:821-30; quiz 831. 2004
    ..This review focuses on a classification system of plant food allergens that is emerging from the synopsis of allergology and protein evolution...
  19. ncbi request reprint Expression of the B subunit of the heat-labile enterotoxin of Escherichia coli in tobacco mosaic virus-infected Nicotiana benthamiana plants and its characterization as mucosal immunogen and adjuvant
    Birgit Wagner
    Department of Pathophysiology, Medical University of Vienna, General Hospital Vienna EBO 3 Q, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Immunol Methods 287:203-15. 2004
    ..In conclusion, these results indicate that the plant viral expression system is suitable for the rapid large-scale production of biologically active LTB with strong mucosal adjuvant capacity...
  20. ncbi request reprint Cross-reactive N-glycans of Api g 5, a high molecular weight glycoprotein allergen from celery, are required for immunoglobulin E binding and activation of effector cells from allergic patients
    Merima Bublin
    Department of Pathophysiology, University of Vienna, Austria
    FASEB J 17:1697-9. 2003
    ..All these observations taken together confer convincing evidence that IgE directed to cross-reactive carbohydrates is capable of eliciting allergic reactions in vivo...
  21. ncbi request reprint NADP-dependent mannitol dehydrogenase, a major allergen of Cladosporium herbarum
    Birgit Simon-Nobbe
    Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
    J Biol Chem 281:16354-60. 2006
    ..This protein therefore is a new major allergen of C. herbarum...
  22. ncbi request reprint Lab scale and medium scale production of recombinant allergens in Escherichia coli
    Michael Wallner
    Institute of Genetics, University of Salzburg, Salzburg, Austria
    Methods 32:219-26. 2004
    ..In the following paper, several prokaryotic expression systems, purification strategies, and analytical methods will be presented and pitfalls discussed...