Research Topics
| Christian RadauerSummaryAffiliation: Medical University of Vienna Country: Austria Publications
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Detail Information
Publications
The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligandsChristian Radauer
Department of Pathophysiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
BMC Evol Biol 8:286. 2008..In this study, we aimed to identify and classify all Bet v 1-related structures from the Protein Data Bank and all Bet v 1-related sequences from the Uniprot database...
Comparison of natural and recombinant forms of the major fish allergen parvalbumin from cod and carpYan Ma
Center for Physiology, Pathophysiology and Immunology, Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
Mol Nutr Food Res 52:S196-207. 2008..High crossreactivity among cod and carp parvalbumins was observed in immunoblots as well as in fluid phase assays. Natural and recombinant parvalbumins gave comparable results when performing various in vitro diagnostic assays...
Naturally occurring hypoallergenic Bet v 1 isoforms fail to induce IgE responses in individuals with birch pollen allergyStefan Wagner
Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
J Allergy Clin Immunol 121:246-52. 2008..Naturally occurring hypoallergens have by and large not been considered as a source of vaccine candidates...- Effects of gastrointestinal digestion and heating on the allergenicity of the kiwi allergens Act d 1, actinidin, and Act d 2, a thaumatin-like proteinMerima Bublin
Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
Mol Nutr Food Res 52:1130-9. 2008..IgE binding to Act d 2 but not Act d 1 was detected in processed food products. The stability of Act d 1 and Act d 2 provides one explanation for the allergenic potency of kiwifruit... - Differential T-cell responses and allergen uptake after exposure of dendritic cells to the birch pollen allergens Bet v 1.0101, Bet v 1.0401 and Bet v 1.1001Ursula Smole
Department of Pathophysiology, Centre for Physiology, Pathophysiology and Immunology Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
Immunobiology 215:903-9. 2010..These results provide evidence that DCs discriminate between allergens and highly related hypoallergens. This process may have an impact on the early phase of sensitisation... - Physicochemical properties and thermal stability of Lep w 1, the major allergen of whiffUlrike Griesmeier
Department of Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
Mol Nutr Food Res 54:861-9. 2010..In contrast to a raw fish extract, the cooked extract showed higher resistance to pepsinolysis. The stability of Lep w 1 to thermal denaturation and digestion explains the high allergenicity of whiff... - Purification and structural stability of the peach allergens Pru p 1 and Pru p 3Sonja Gaier
Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
Mol Nutr Food Res 52:S220-9. 2008..5. In contrast, Pru p 3 was unable to refold after heating under neutral conditions but readily refolded after heating at pH 3... - Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergyChristian Radauer
Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
Mol Immunol 48:600-9. 2011..Despite considerable cross-reactivity between these allergens, no correlation between latex-associated plant food allergy and sensitization to hevein or HLDs was found... - Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergensMerima Bublin
Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
J Allergy Clin Immunol 125:687-94, 694.e1. 2010..Kiwifruit is one of the most common causes of food allergic reactions. Component-resolved diagnostics may enable significantly improved detection of sensitization to kiwifruit... - Production and characterization of an allergen panel for component-resolved diagnosis of celery allergyMerima Bublin
Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
Mol Nutr Food Res 52:S241-50. 2008..These well-defined celery allergens will be used to prove the concept of component-resolved diagnosis and will contribute to improve food allergy diagnosis in the future... - Allergens are distributed into few protein families and possess a restricted number of biochemical functionsChristian Radauer
Department of Pathophysiology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
J Allergy Clin Immunol 121:847-52.e7. 2008..Existing allergen databases classify their entries by source and route of exposure, thus lacking an evolutionary, structural, and functional classification of allergens... - IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countriesMerima Bublin
Department of Pathophysiology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria
J Allergy Clin Immunol 114:1169-75. 2004..CONCLUSION: The presence of common allergens and the IgE cross-reactivity to green kiwifruit qualifies gold kiwifruit as a potential new allergen source for patients allergic to green kiwifruits... - Mal d 2, the thaumatin-like allergen from apple, is highly resistant to gastrointestinal digestion and thermal processingUrsula Smole
Department of Pathophysiology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
Int Arch Allergy Immunol 147:289-98. 2008..The stability of food allergens to proteolysis and thermal denaturation contributes considerably to their allergenicity... - Use of a genetic cholera toxin B subunit/allergen fusion molecule as mucosal delivery system with immunosuppressive activity against Th2 immune responsesMerima Bublin
Department of Pathophysiology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
Vaccine 25:8395-404. 2007.... - Evolutionary biology of plant food allergensChristian Radauer
Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
J Allergy Clin Immunol 120:518-25. 2007..The study of the distribution of allergenic and nonallergenic members of protein families will provide new insights into the evolution of allergenicity and the factors that make proteins allergenic... - Pollen allergens are restricted to few protein families and show distinct patterns of species distributionChristian Radauer
Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
J Allergy Clin Immunol 117:141-7. 2006..CONCLUSION: This classification of pollen allergens into protein families will aid in predicting cross-reactivity, designing comprehensive diagnostic devices, and assessing the allergenic potential of novel proteins... - A classification of plant food allergensHeimo Breiteneder
Department of Pathophysiology, Medical University of Vienna, AKH-EBO-3Q, Waehringer Guertel 18-20, 1090 Vienna, Austria
J Allergy Clin Immunol 113:821-30; quiz 831. 2004..This review focuses on a classification system of plant food allergens that is emerging from the synopsis of allergology and protein evolution... - Expression of the B subunit of the heat-labile enterotoxin of Escherichia coli in tobacco mosaic virus-infected Nicotiana benthamiana plants and its characterization as mucosal immunogen and adjuvantBirgit Wagner
Department of Pathophysiology, Medical University of Vienna, General Hospital Vienna EBO 3.Q, Waehringer Guertel 18-20, A-1090 Vienna, Austria
J Immunol Methods 287:203-15. 2004..In conclusion, these results indicate that the plant viral expression system is suitable for the rapid large-scale production of biologically active LTB with strong mucosal adjuvant capacity... - Cross-reactive N-glycans of Api g 5, a high molecular weight glycoprotein allergen from celery, are required for immunoglobulin E binding and activation of effector cells from allergic patientsMerima Bublin
Department of Pathophysiology, University of Vienna, Austria
FASEB J 17:1697-9. 2003..All these observations taken together confer convincing evidence that IgE directed to cross-reactive carbohydrates is capable of eliciting allergic reactions in vivo... - NADP-dependent mannitol dehydrogenase, a major allergen of Cladosporium herbarumBirgit Simon-Nobbe
Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, A-5020 Salzburg, Austria
J Biol Chem 281:16354-60. 2006..This protein therefore is a new major allergen of C. herbarum... - Lab scale and medium scale production of recombinant allergens in Escherichia coliMichael Wallner
Institute of Genetics, University of Salzburg, Salzburg, Austria
Methods 32:219-26. 2004..In the following paper, several prokaryotic expression systems, purification strategies, and analytical methods will be presented and pitfalls discussed...