Winfried März

Summary

Affiliation: Medical University of Graz
Country: Austria

Publications

  1. pmc The MHC2TA -168A>G gene polymorphism is not associated with rheumatoid arthritis in Austrian patients
    Babak Yazdani-Biuki
    Department of Internal Medicine, Division of Rheumatology, Medical University Graz, Austria
    Arthritis Res Ther 8:R97. 2006
  2. ncbi request reprint The apolipoprotein E polymorphism is associated with circulating C-reactive protein (the Ludwigshafen risk and cardiovascular health study)
    Winfried März
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbrugger Platz 15, A 8036 Graz, Austria
    Eur Heart J 25:2109-19. 2004
  3. ncbi request reprint The PlA1/A2 polymorphism of platelet glycoprotein IIIa is not associated with the risk of type 2 diabetes. The Ludwigshafen Risk and Cardiovascular Health study
    W Marz
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Diabetologia 47:1969-73. 2004
  4. ncbi request reprint Low-density lipoprotein triglycerides associated with low-grade systemic inflammation, adhesion molecules, and angiographic coronary artery disease: the Ludwigshafen Risk and Cardiovascular Health study
    Winfried März
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Circulation 110:3068-74. 2004
  5. ncbi request reprint G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus
    Winfried März
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Circulation 109:2844-9. 2004
  6. ncbi request reprint [Atorvastatin for primary prevention of cardiovascular events. ASCOT-LLA Study]
    W Marz
    Klinisches Institut für Medizinische und Chemische Labordiagnostik, LKH und Universitätsklinikum Graz, Osterreich
    Internist (Berl) 45:355-7. 2004
  7. ncbi request reprint HMG-CoA reductase inhibition: anti-inflammatory effects beyond lipid lowering?
    Winfried März
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Karl Franzens University, Graz, Austria
    J Cardiovasc Risk 10:169-79. 2003
  8. ncbi request reprint Effects of statins on C-reactive protein and interleukin-6 (the Ludwigshafen Risk and Cardiovascular Health study)
    Winfried März
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, University and General Hospital, Graz, Austria
    Am J Cardiol 92:305-8. 2003
  9. doi request reprint Low homoarginine concentration is a novel risk factor for heart disease
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria
    Heart 97:1222-7. 2011
  10. doi request reprint Vitamin D and mortality: a Mendelian randomization study
    Olivia Trummer
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    Clin Chem 59:793-7. 2013

Detail Information

Publications70

  1. pmc The MHC2TA -168A>G gene polymorphism is not associated with rheumatoid arthritis in Austrian patients
    Babak Yazdani-Biuki
    Department of Internal Medicine, Division of Rheumatology, Medical University Graz, Austria
    Arthritis Res Ther 8:R97. 2006
    ..There was no association between the presence of RA-specific autoantibodies and the MHC2TA -168 GG genotype. In this cohort of Austrian patients, no association between the MHC2TA polymorphism and RA was found...
  2. ncbi request reprint The apolipoprotein E polymorphism is associated with circulating C-reactive protein (the Ludwigshafen risk and cardiovascular health study)
    Winfried März
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbrugger Platz 15, A 8036 Graz, Austria
    Eur Heart J 25:2109-19. 2004
    ..The genetic polymorphism of apolipoprotein (apo) E is a strong endogenous determinant of sterol homeostasis. We therefore examined the relationship of CRP to the apoE polymorphism...
  3. ncbi request reprint The PlA1/A2 polymorphism of platelet glycoprotein IIIa is not associated with the risk of type 2 diabetes. The Ludwigshafen Risk and Cardiovascular Health study
    W Marz
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Diabetologia 47:1969-73. 2004
    ..The PlA1/A2 polymorphism of platelet glycoprotein IIIa (GPIIIa) has been implicated in the pathogenesis of type 2 diabetes. We studied this polymorphism in a homogenous, extensively phenotyped cohort using the candidate gene approach...
  4. ncbi request reprint Low-density lipoprotein triglycerides associated with low-grade systemic inflammation, adhesion molecules, and angiographic coronary artery disease: the Ludwigshafen Risk and Cardiovascular Health study
    Winfried März
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Circulation 110:3068-74. 2004
    ..We examined whether alterations of LDL metabolism not reflected by LDL-C were associated with low-grade inflammation, vascular injury, and CAD...
  5. ncbi request reprint G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus
    Winfried März
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Circulation 109:2844-9. 2004
    ..A G(-30)A polymorphism in the beta-cell-specific promoter of glucokinase (GK-30PM) has been implicated in reduced pancreatic beta-cell function. Its impact on CAD has not been examined...
  6. ncbi request reprint [Atorvastatin for primary prevention of cardiovascular events. ASCOT-LLA Study]
    W Marz
    Klinisches Institut für Medizinische und Chemische Labordiagnostik, LKH und Universitätsklinikum Graz, Osterreich
    Internist (Berl) 45:355-7. 2004
  7. ncbi request reprint HMG-CoA reductase inhibition: anti-inflammatory effects beyond lipid lowering?
    Winfried März
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Karl Franzens University, Graz, Austria
    J Cardiovasc Risk 10:169-79. 2003
    ..Further investigation is now necessary in order to determine the relative significance of cholesterol lowering and of ancillary effects on the net clinical benefit of statin treatment...
  8. ncbi request reprint Effects of statins on C-reactive protein and interleukin-6 (the Ludwigshafen Risk and Cardiovascular Health study)
    Winfried März
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, University and General Hospital, Graz, Austria
    Am J Cardiol 92:305-8. 2003
    ....
  9. doi request reprint Low homoarginine concentration is a novel risk factor for heart disease
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria
    Heart 97:1222-7. 2011
    ..Homoarginine is an amino acid which may play a role in nitric oxide and energy metabolism. Low homoarginine concentrations have previously been linked to increased mortality, but the underlying mechanisms remain unknown...
  10. doi request reprint Vitamin D and mortality: a Mendelian randomization study
    Olivia Trummer
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    Clin Chem 59:793-7. 2013
    ..We performed a Mendelian randomization study and analyzed whether 3 common single-nucleotide polymorphisms (SNPs) associated with 25-OH-vitamin D concentrations are causal for mortality rates...
  11. doi request reprint Low-dose atorvastatin improves dyslipidemia and vascular function in patients with primary biliary cirrhosis after one year of treatment
    Tatjana Stojakovic
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    Atherosclerosis 209:178-83. 2010
    ..The aim of our study was to prospectively examine the efficacy of low-dose atorvastatin on cholestasis as well as cardiovascular risk markers such as dyslipidemia and vascular function in patients with PBC...
  12. doi request reprint Circulating aldosterone and mortality in female nursing home residents
    Andreas Tomaschitz
    Department of Cardiology, Medical University of Graz, Graz, Austria
    Exp Gerontol 48:313-8. 2013
    ..We therefore aimed to assess the relationship between circulating aldosterone levels and mortality in a population-based cohort study of female nursing home residents...
  13. ncbi request reprint Free fatty acids are independently associated with all-cause and cardiovascular mortality in subjects with coronary artery disease
    Stefan Pilz
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Clin Endocrinol Metab 91:2542-7. 2006
    ..Free fatty acids (FFAs) are associated with several cardiovascular risk factors and exert harmful effects on the myocardium...
  14. doi request reprint Low 25-hydroxyvitamin D is associated with increased mortality in female nursing home residents
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    J Clin Endocrinol Metab 97:E653-7. 2012
    ..Whether low 25-hydroxyvitamin D (25[OH]D) concentrations are an independent risk factor for mortality in these patients is, however, unclear...
  15. doi request reprint Homoarginine, cardiovascular risk, and mortality
    Winfried März
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Graz, Austria
    Circulation 122:967-75. 2010
    ..Homoarginine is an amino acid derivative that may increase nitric oxide availability and enhance endothelial function. The effect of the level of homoarginine on cardiovascular outcome and mortality is unknown...
  16. doi request reprint Combination of low free testosterone and low vitamin D predicts mortality in older men referred for coronary angiography
    Elisabeth Lerchbaum
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria
    Clin Endocrinol (Oxf) 77:475-83. 2012
    ..Experimental studies show a complex interplay of vitamin D and androgen metabolism suggesting that a deficiency of both hormones may be associated with a particularly adverse clinical outcome...
  17. doi request reprint Vitamin D status and mortality in chronic kidney disease
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria
    Nephrol Dial Transplant 26:3603-9. 2011
    ..73 m(2). Whether low 25(OH)D levels in these patients are associated with higher mortality is unclear. This issue was addressed in the present work...
  18. doi request reprint Hyperparathyroidism in patients with primary aldosteronism: cross-sectional and interventional data from the GECOH study
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    J Clin Endocrinol Metab 97:E75-9. 2012
    ..Experimental studies suggest that aldosterone induces hypercalciuria and might contribute to hyperparathyroidism...
  19. doi request reprint Symmetrical and asymmetrical dimethylarginine as predictors for mortality in patients referred for coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study
    Andreas Meinitzer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    Clin Chem 57:112-21. 2011
    ..Asymmetrical dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, has been linked to cardiovascular risk. The clinical role of its structural isomer symmetrical dimethylarginine (SDMA) remains largely unclear...
  20. doi request reprint Low serum homoarginine is a novel risk factor for fatal strokes in patients undergoing coronary angiography
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Austria, Auenbruggerplatz 15, 8036 Graz, Austria
    Stroke 42:1132-4. 2011
    ..We aimed to investigate whether homoarginine levels are also associated with fatal strokes and a history of nonfatal cerebrovascular disease...
  21. doi request reprint Aldosterone and parathyroid hormone: a precarious couple for cardiovascular disease
    Andreas Tomaschitz
    Division of Cardiology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Cardiovasc Res 94:10-9. 2012
    ..In view of the reciprocal interaction between aldosterone and PTH and the potentially ensuing CV damage, studies are urgently needed to evaluate diagnostic and therapeutic strategies addressing the interaction between the two hormones...
  22. doi request reprint The lipid accumulation product is associated with increased mortality in normal weight postmenopausal women
    Elisabeth Wehr
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University Graz, Graz, Austria
    Obesity (Silver Spring) 19:1873-80. 2011
    ..Type 2 diabetes (T2DM) was highly associated with LAP in women and men. Our study validates an inexpensive and simple risk profiling that may allow identifying postmenopausal women at high cardiovascular risk...
  23. ncbi request reprint Low density lipoprotein triglycerides and lipoprotein(a) are risk factors for retinal vascular occlusion
    Tatjana Stojakovic
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, Graz, Austria
    Clin Chim Acta 382:77-81. 2007
    ....
  24. doi request reprint Serum gamma-glutamyl transferase and mortality in persons undergoing coronary angiography-The Ludwigshafen Risk and Cardiovascular Health Study
    Tatjana Stojakovic
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Atherosclerosis 208:564-71. 2010
    ..Serum gamma-glutamyl transferase (GGT) seems to be a predictor for coronary artery disease (CAD). The objective of this study was to elucidate the relationship between GGT and total as well as cardiovascular mortality...
  25. pmc Circulating dopamine and C-peptide levels in fasting nondiabetic hypertensive patients: the Graz Endocrine Causes of Hypertension study
    Andreas Tomaschitz
    Department of Internal Medicine, Division of Cardiology, Medical University of Graz, Graz, Austria
    Diabetes Care 35:1771-3. 2012
    ..We examined the association between circulating dopamine and C-peptide concentrations using data from the Graz Endocrine Causes of Hypertension (GECOH) study...
  26. doi request reprint Vitamin D and cardiovascular disease: update and outlook
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria
    Scand J Clin Lab Invest Suppl 243:83-91. 2012
    ..It should, however, be noted that justification for the prevention and treatment of vitamin D deficiency comes from evidence based benefits of vitamin D supplementation on musculoskeletal health...
  27. doi request reprint Arginine bioavailability ratios are associated with cardiovascular mortality in patients referred to coronary angiography
    Harald Sourij
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    Atherosclerosis 218:220-5. 2011
    ..The aim of the current study is to investigate the association of arginine bioavailability ratios with markers of endothelial function and cardiovascular mortality in patients referred to coronary angiography...
  28. ncbi request reprint Elevated plasma free fatty acids predict sudden cardiac death: a 6.85-year follow-up of 3315 patients after coronary angiography
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Austria
    Eur Heart J 28:2763-9. 2007
    ..Free fatty acids (FFAs) exert several harmful effects on the myocardium and may therefore contribute to SCD. We examined whether fasting FFA predict SCD in patients who had undergone coronary angiography...
  29. doi request reprint Association of plasma aldosterone with cardiovascular mortality in patients with low estimated GFR: the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study
    Andreas Tomaschitz
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Austria
    Am J Kidney Dis 57:403-14. 2011
    ..We hypothesized that level of kidney function might modify the association between plasma aldosterone level and CVD mortality...
  30. ncbi request reprint Asymmetrical dimethylarginine independently predicts total and cardiovascular mortality in individuals with angiographic coronary artery disease (the Ludwigshafen Risk and Cardiovascular Health study)
    Andreas Meinitzer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    Clin Chem 53:273-83. 2007
    ..Asymmetrical dimethylarginine (ADMA) is increased in conditions associated with increased risk of atherosclerosis. We investigated the use of ADMA to predict total and cardiovascular mortality in patients scheduled for coronary angiography...
  31. ncbi request reprint Role of the interleukin-6 -174 G>C gene polymorphism in retinal artery occlusion
    Martin Weger
    Department of Ophthalmology, Medical University, Graz, Austria
    Stroke 36:249-52. 2005
    ..The aim of the present case-control study was to investigate the role of this polymorphism for retinal artery occlusion (RAO)...
  32. ncbi request reprint G-protein beta3 subunit (GNB3) gene polymorphisms and cardiovascular disease: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study
    Wilfried Renner
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Atherosclerosis 192:108-12. 2007
    ..None of the GNB3 polymorphisms was associated with CAD, MI, diabetes, hypertension, blood pressure, body weight or body mass index. We conclude that a major contribution of GNB3 gene variants to CAD or MI risk is unlikely...
  33. doi request reprint Vitamin D, cardiovascular disease and mortality
    Stefan Pilz
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    Clin Endocrinol (Oxf) 75:575-84. 2011
    ..In current clinical practice, the overall risks and costs of vitamin D supplementation should be weighed against the potential adverse consequences of untreated vitamin D deficiency...
  34. doi request reprint Associations of plasma renin with 10-year cardiovascular mortality, sudden cardiac death, and death due to heart failure
    Andreas Tomaschitz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Eur Heart J 32:2642-9. 2011
    ..This study in a large cohort of patients sought to evaluate the association between plasma renin concentration (PRC) and cardiovascular mortality after long-term follow-up of almost 10 years...
  35. doi request reprint Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography
    Stefan Pilz
    Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    J Clin Endocrinol Metab 93:3927-35. 2008
    ..Vitamin D has been shown to influence cardiac contractility and myocardial calcium homeostasis...
  36. doi request reprint Association of polymorphisms in the chemokine receptor CX3CR1 gene with coronary artery disease
    Eva M Matzhold
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University, Graz, Austria
    Cytokine 47:224-7. 2009
    ..In conclusion, present data of LURIC do not support the hypothesis that common variants of the CX3CR1 gene are associated with the presence of CAD or MI...
  37. ncbi request reprint Association of complement factor H Y402H gene polymorphism with different subtypes of exudative age-related macular degeneration
    Beate J Wegscheider
    Department of Ophthalmology, Medical University Graz, Graz, Austria
    Ophthalmology 114:738-42. 2007
    ....
  38. pmc Low free testosterone levels are associated with all-cause and cardiovascular mortality in postmenopausal diabetic women
    Elisabeth Wehr
    Department of Internal Medicine, Medical UniversityGraz, Graz, Austria
    Diabetes Care 34:1771-7. 2011
    ..We aimed to evaluate whether total testosterone (TT), free testosterone (FT), and sex hormone-binding globulin (SHBG) are associated with all-cause and cardiovascular mortality in a cohort of postmenopausal women...
  39. ncbi request reprint Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid
    Tatjana Stojakovic
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    Hepatology 46:776-84. 2007
    ..001). Precursors of cholesterol biosynthesis (lanosterol, desmosterol, lathosterol) showed a similar pattern. No changes in serum bile acid levels and composition were observed during treatment...
  40. doi request reprint Vitamin D deficiency and myocardial diseases
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Graz, Austria
    Mol Nutr Food Res 54:1103-13. 2010
    ..In our opinion, the current knowledge of the beneficial effects of vitamin D on myocardial and overall health strongly argue for vitamin D supplementation in all vitamin D-deficient patients with or at high risk for myocardial diseases...
  41. ncbi request reprint Association of angiotensinogen haplotypes with angiotensinogen levels but not with blood pressure or coronary artery disease: the Ludwigshafen Risk and Cardiovascular Health Study
    Wilfried Renner
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, University and General Hospital, Medical University, Auenbruggerplatz 30, 8036, Graz, Austria
    J Mol Med (Berl) 83:235-9. 2005
    ..We conclude that a common haplotype of the angiotensinogen gene is linked to angiotensinogen levels but has no major impact on blood pressure, hypertension, or cardiovascular risk...
  42. doi request reprint Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study
    Andreas Tomaschitz
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Austria
    Clin Chim Acta 411:1354-60. 2010
    ..Antihypertensive and tissue-protective properties of vitamin D metabolites are increasingly attributed to the inhibition of renin synthesis by 1,25-dihydroxyvitamin D [1,25(OH)2D] in the kidney...
  43. ncbi request reprint Implications of resistin plasma levels in subjects undergoing coronary angiography
    Stefan Pilz
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria
    Clin Endocrinol (Oxf) 66:380-6. 2007
    ..The adipokine resistin, which is thought to serve as a link between obesity and insulin resistance, was recently shown to exert proatherosclerotic features...
  44. ncbi request reprint ApoE: crossroads between Alzheimer's disease and atherosclerosis
    Tatjana Stojakovic
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, A 8036 Graz, Austria
    Semin Vasc Med 4:279-85. 2004
    ..The genetic polymorphism of apoE is among the strongest determinants of the risk and mean age of onset of Alzheimer's disease. The mechanism by which apoE isoforms differentially contribute to disease expression is not known...
  45. ncbi request reprint Clinical-pathological conference series from the Medical University of Graz : case no. 131: elevated transaminases in a 30-year-old male
    Csilla Putz-Bankuti
    Department of Internal Medicine, Medical University of Graz, Austria
    Wien Klin Wochenschr 118:769-75. 2006
  46. doi request reprint Drugs and brain death diagnostics: determination of drugs capable of inducing EEG zero line
    Andreas Meinitzer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    Clin Chem Lab Med 46:1732-8. 2008
    ..Several drugs may affect the diagnosis of brain death by depressing the electroencephalographic signal. Serum levels of these drugs must be below their respective therapeutic ranges...
  47. doi request reprint Parathyroid hormone level is associated with mortality and cardiovascular events in patients undergoing coronary angiography
    Stefan Pilz
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Eur Heart J 31:1591-8. 2010
    ..We aimed to elucidate whether PTH levels are associated with mortality and fatal cardiovascular events in patients referred for coronary angiography...
  48. doi request reprint Plasma aldosterone levels are associated with increased cardiovascular mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study
    Andreas Tomaschitz
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Graz, Austria
    Eur Heart J 31:1237-47. 2010
    ..With the present analysis, we aimed at evaluating prospectively whether plasma aldosterone correlates with all-cause and CV disease (CVD) mortality in a large cohort of patients...
  49. ncbi request reprint Vitamin D supplementation: a promising approach for the prevention and treatment of strokes
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Austria
    Curr Drug Targets 12:88-96. 2011
    ....
  50. doi request reprint Low free testosterone is associated with heart failure mortality in older men referred for coronary angiography
    Elisabeth Wehr
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria
    Eur J Heart Fail 13:482-8. 2011
    ..Accumulating evidence suggests that androgen deficiency is associated with cardiovascular disease. We aimed at evaluating whether total testosterone (TT) and free testosterone (FT) are associated with specific cardiovascular events...
  51. ncbi request reprint Efficacy and safety of fluvastatin-extended release in hypercholesterolemic patients: morning administration is equivalent to evening administration
    Hubert Scharnagl
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University, Graz, Austria
    Cardiology 106:241-8. 2006
    ..This study compared the efficacy and tolerability of morning and evening administration of the extended-release formulation of fluvastatin (fluvastatin XL)...
  52. ncbi request reprint Double-blind, randomized study comparing the effects of two monophasic oral contraceptives containing ethinylestradiol (20 microg or 30 microg) and levonorgestrel (100 microg or 150 microg) on lipoprotein metabolism
    Hubert Scharnagl
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, University and General Hospital Graz, Auenbrugger Platz 15, A 8036 Graz, Austria
    Contraception 69:105-13. 2004
    ..It is not likely that the changes in lipoprotein metabolism brought about by the two preparations will alter the risk of future cardiovascular disease in a clinically relevant fashion...
  53. doi request reprint Differential effects of fluvastatin alone or in combination with ezetimibe on lipoprotein subfractions in patients at high risk of coronary events
    T Stojakovic
    Medical University of Graz, A 8036 Graz, Austria
    Eur J Clin Invest 40:187-94. 2010
    ..The objective of the study was to examine the effects of fluvastatin plus ezetimibe on lipoprotein subfractions in patients with type 2 diabetes and/or coronary heart disease...
  54. ncbi request reprint Low density lipoprotein cholesterol, statins and cardiovascular events: a meta-analysis
    Bernd Genser
    BGStats Consulting, Hochstrasse 7, 8071, Graz, Austria
    Clin Res Cardiol 95:393-404. 2006
    ..We conclude that the extent to which statins lower LDL-C is strongly related to the improvement of clinical outcomes achieved by this class of drugs...
  55. ncbi request reprint Effect of Helicobacter pylori eradication on high-density lipoprotein cholesterol
    Hubert Scharnagl
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, University and General Hospital, University of Graz, Graz, Austria
    Am J Cardiol 93:219-20. 2004
    ..Our results suggest that chronic H. pylori infection reduces plasma levels of HDL cholesterol and that eradication improves the lipoprotein pattern...
  56. ncbi request reprint Reference values for plasma concentrations of asymmetrical dimethylarginine (ADMA) and other arginine metabolites in men after validation of a chromatographic method
    Andreas Meinitzer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria
    Clin Chim Acta 384:141-8. 2007
    ..Additionally, levels of ADMA in comparable patient groups of different studies vary widely, even when similar methods have been used...
  57. doi request reprint Free fatty acids as a cardiovascular risk factor
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Graz, Austria
    Clin Chem Lab Med 46:429-34. 2008
    ..In this review, we present an overview of the metabolism and role of FFAs as a cardiovascular risk factor and discuss the potential of FFAs in the diagnosis and treatment of cardiovascular diseases...
  58. ncbi request reprint [LDL cholesterol in normal range. The lower the better? Implications of the GREACE study]
    W Marz
    Klinisches Institut für Medizinische und Chemische Labordiagnostik, Universitätsklinikum Graz, Osterreich
    MMW Fortschr Med 145:46-9. 2003
    ..For a given baseline value, greater risk reduction results from a larger reduction in LDL cholesterol. LDL cholesterol measurement is thus essential before and on treatment...
  59. ncbi request reprint Rosuvastatin reduces interleukin-6-induced expression of C-reactive protein in human hepatocytes in a STAT3- and C/EBP-dependent fashion
    C Mayer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Austria
    Int J Clin Pharmacol Ther 45:319-27. 2007
    ..In the present study we investigated the possibility that rosuvastatin directly affected CRP expression in stimulated human hepatocytes...
  60. ncbi request reprint Inhibition of HMG-CoA reductase with cerivastatin lowers dense low density lipoproteins in patients with elevated fasting glucose, impaired glucose tolerance and type 2 diabetes mellitus
    H Scharnagl
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Karl Franzens University, Graz, Austria
    Exp Clin Endocrinol Diabetes 112:269-77. 2004
    ..While 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors effectively decrease LDL cholesterol, it remains controversial whether these agents also lower dense LDL, which are considered particularly atherogenic...
  61. ncbi request reprint The HMG-CoA reductase inhibitor cerivastatin lowers advanced glycation end products in patients with type 2 diabetes
    H Scharnagl
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria
    Exp Clin Endocrinol Diabetes 115:372-5. 2007
    ..003) and LDL apoB (r=0.239, P=0.05). In addition to the lipid-lowering effects of HMGRI, the reduction of AGE-CML observed in our study may entail an improvement of the cardiovascular prognosis in patients with chronic hyperglycemia...
  62. doi request reprint Asymmetric dimethylarginine (ADMA) is tightly correlated with growth in juveniles without correlations to obesity related disorders
    H J Gruber
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria
    Exp Clin Endocrinol Diabetes 116:520-4. 2008
    ..Asymmetrical dimethylarginine (ADMA) was found to be increased in conditions associated with atherosclerosis and metabolic disorders. We investigated ADMA in obese juveniles with pre-atherosclerotic symptoms and in normal weight juveniles...
  63. ncbi request reprint IgG antibodies against food antigens are correlated with inflammation and intima media thickness in obese juveniles
    M Wilders-Truschnig
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Austria
    Exp Clin Endocrinol Diabetes 116:241-5. 2008
    ..We examined the relationship between IgG antibodies specific for food components, low grade inflammation and early atherosclerotic lesions in obese and normal weight juveniles...
  64. ncbi request reprint New lipid-lowering agents acting on LDL receptors
    Hubert Scharnagl
    Clinical Institute of Medical and Clinical Laboratory Diagnositcs, Medical University, Auenbruggerplatz 15, A 8036 Graz, Austria
    Curr Top Med Chem 5:233-42. 2005
    ..Although these actions are not primary targets of the compounds discussed here, it is interesting that drugs inducing the LDL-R usually also lower TG and, in the case of HMGRI, increase HDL-C...
  65. ncbi request reprint Beyond cholesterol--inflammatory cytokines, the key mediators in atherosclerosis
    Harald Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria
    Clin Chem Lab Med 42:467-74. 2004
    ..Furthermore, based on recent experiences of our own with very early stages of atherosclerosis, possible new ways to make use of these parameters toward improved early detection, prevention and treatment of this disease are indicated...
  66. ncbi request reprint Time-of-intake (morning versus evening) of extended-release fluvastatin in hyperlipemic patients is without influence on the pharmacodynamics (mevalonic acid excretion) and pharmacokinetics
    G Fauler
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Austria
    Int J Clin Pharmacol Ther 45:328-34. 2007
    ....
  67. ncbi request reprint More reliable brain death diagnosis with chromatographic analysis of midazolam, diazepam, thiopentone, and active metabolites
    Andreas Meinitzer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 19, 8036 Graz, Austria
    J Anal Toxicol 30:196-201. 2006
    ..These assays were accurate in that the relative difference between actually measured and expected concentration never exceeded 12%. Utilization of these assays will render the diagnosis of brain death more reliable...
  68. ncbi request reprint The serotonin transporter gene polymorphism is not associated with smoking behavior
    O Trummer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria
    Pharmacogenomics J 6:397-400. 2006
    ..We conclude that the SLC6A4 promoter polymorphism is not a major determinant of smoking behavior in Caucasian...
  69. ncbi request reprint Effect of HMG CoA reductase inhibitors on low-density lipoprotein cholesterol and C-reactive protein: systematic review and meta-analysis
    B Genser
    BGStats Consulting, Graz, Austria
    Int J Clin Pharmacol Ther 46:497-510. 2008
    ..We conducted a systematic review and meta-analysis to investigate whether a relationship between the average effect of statins on LDL-C and CRP exists...
  70. ncbi request reprint Visfatin/pre-B-cell colony-enhancing factor: a protein with various suggested functions
    S Pilz
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    J Endocrinol Invest 30:138-44. 2007
    ..This review summarizes the current knowledge of the various functions of PBEF/visfatin towards involvements in pathophysiology of several diseases...