Research Topics
Genomes and GenesSpecies | Farid MoinfarSummaryAffiliation: Medical University of Graz Country: Austria Publications
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Detail Information
Publications
Flat ductal intraepithelial neoplasia of the breast: evolution of Azzopardi's "clinging" conceptFarid Moinfar
Unit of Breast and Gynecologic Pathology, Institute of Pathology, Medical University of Graz, Graz, Austria
Semin Diagn Pathol 27:37-48. 2010..This type of breast lesion is an indicator for coexisting neoplastic lesions, such as low-grade ductal intraepithelial neoplasia (atypical ductal hyperplasia/low-grade ductal carcinoma in situ) and lobular intraepithelial neoplasia...
Flat ductal intraepithelial neoplasia of the breast: a review of diagnostic criteria, differential diagnoses, molecular-genetic findings, and clinical relevance--it is time to appreciate the Azzopardi concept!Farid Moinfar
Unit of Breast and Gynecologic Pathology, Department of Pathology, Medical University of Graz, Graz, Austria
Arch Pathol Lab Med 133:879-92. 2009..The lesion remained widely unrecognized and/or ignored until recent years when its neoplastic nature was confirmed at the molecular-genetic level...- Endometrial stromal sarcomas frequently express epidermal growth factor receptor (EGFR, HER-1): potential basis for a new therapeutic approachFarid Moinfar
Institute of Pathology, Medical University Graz, Graz, Austria
Am J Surg Pathol 29:485-9. 2005..This finding may provide the basis for a new therapeutic strategy using monoclonal antibodies against EGFR (such as cetuximab) or small molecule inhibitors of EGFR (such as gefitinib) in patients with endometrial sarcomas... - Is 'basal-like' carcinoma of the breast a distinct clinicopathological entity? A critical review with cautionary notesFarid Moinfar
Unit of Breast and Gynecologic Pathology, Department of Pathology, Medical University of Graz, Graz, Austria
Pathobiology 75:119-31. 2008.... - Macro-environment of breast carcinoma: frequent genetic alterations in the normal appearing skins of patients with breast cancerFarid Moinfar
Department of Pathology, Medical University of Graz, Graz, Austria
Mod Pathol 21:639-46. 2008..These data indicate that more global assessment of tumor micro- and macro-environment is crucial for our understanding of breast carcinogenesis... 
JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissueAndelko Hrzenjak
Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria
J Mol Diagn 7:388-95. 2005..In combination with other established methods, accurate reverse transcriptase-polymerase chain reaction analysis of JAZF1/JJAZ1 gene fusion may be useful in diagnosing difficult or unusual ESS/UES cases...- Allelic imbalances in endometrial stromal neoplasms: frequent genetic alterations in the nontumorous normal-appearing endometrial and myometrial tissuesFarid Moinfar
Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
Gynecol Oncol 95:662-71. 2004..The aim of this study was to examine the possibility of loss of heterozygosity (LOH) and microsatellite instability (MIS) in different tissue components of ESS... - Expression of androgen receptors in benign and malignant endometrial stromal neoplasmsFarid Moinfar
Department of Pathology, Medical University Graz, 8036, Graz, Austria
Virchows Arch 444:410-4. 2004..In addition to determination of ER and PR, the results of immunohistochemical examination of AR in these rare uterine tumors may have some impact on the postoperative management of the patients... - Chromosomal aberrations as detected by array comparative genomic hybridization in early low-grade intraepithelial neoplasias of the breastElvira Stacher
Institute of Pathology, Medical University of Graz, Graz, Austria
Histopathology 59:549-55. 2011..Frequently, it occurs concomitantly with lobular intraepithelial neoplasia (LIN). We aimed to elucidate chromosomal aberrations in these early neoplastic breast lesions with the use of array comparative genomic hybridization analysis... - Mammary NOS-type sarcoma with CD10 expression: a rare entity with features of myoepithelial differentiationSebastian Leibl
Institute of Pathology, Medical University of Graz, Graz, Austria
Am J Surg Pathol 30:450-6. 2006..The immunophenotype of NOS-type sarcomas with CD10 expression suggests that these neoplasms represent a mammary sarcoma variant with myoepithelial features... - Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivoAndelko Hrzenjak
Lore Saldow Research Unit for Molecular Pathology of Gynecologic Tumors, Department of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria
Mol Cancer 9:49. 2010..We analyzed the influence of vorinostat on expression of different HDACs, p21(WAF1) and activation of apoptosis. Finally, we examined the antitumor effects of vorinostat on uterine sarcoma in vivo... - Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cellsAndelko Hrzenjak
Department of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria
Mol Cancer Ther 5:2203-10. 2006..Our results suggest that HDAC2 might be considered as potential drug target in the therapy of ESS and that HDAC inhibitors should be further evaluated in clinical trials in ESS... - Chromosomal alterations in low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma as detected by comparative genomic hybridizationIris Halbwedl
Department of Pathology, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria
Gynecol Oncol 97:582-7. 2005..Despite the karyotypic variations, chromosomal deletion on 7p was the most common finding (55.6%) in low-grade ESS and may play a role in tumor development and progression... - Metaplastic breast carcinomas: are they of myoepithelial differentiation?: immunohistochemical profile of the sarcomatoid subtype using novel myoepithelial markersSebastian Leibl
Department of Pathology, Medical University of Graz, Graz, Austria
Am J Surg Pathol 29:347-53. 2005..CD29 and 14-3-3sigma represent valuable novel myoepithelial markers in these diagnostically difficult cases... - Inverse correlation of secreted frizzled-related protein 4 and beta-catenin expression in endometrial stromal sarcomasAndelko Hrzenjak
Department of Pathology, Medical University, Graz, Austria
J Pathol 204:19-27. 2004..SFRP4 may therefore be a putative tumour suppressor involved in deregulation of the Wnt pathway and in the pathogenesis of ESS and UES... - Androgen receptor expression in breast cancer patients tested for BRCA1 and BRCA2 mutationsGunda Pristauz
Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria
Histopathology 57:877-84. 2010.... - Ovarian granulosa cell tumors frequently express EGFR (Her-1), Her-3, and Her-4: An immunohistochemical studySebastian Leibl
Department of Pathology, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria
Gynecol Oncol 101:18-23. 2006..These findings provide some evidence to further explore the potential use of agents targeting these receptors (particularly EGFR) in the treatment of ovarian GCTs... - Bilateral ovarian well-differentiated Sertoli-Leydig cell tumors with heterologous elements associated with unilateral serous cystadenoma--a case reportElvira Stacher
Institute of Pathology, Department of Gynecology and Obstetrics, Medical University of Graz, Auenbruggerplatz 25, Graz, Austria
Int J Gynecol Pathol 29:419-22. 2010..Furthermore, on the left side it also was associated with a serous cystadenoma... - Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancerWalter Schippinger
Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
Virchows Arch 449:24-30. 2006..In conclusion, SAR is significantly longer in patients with AR-expressing breast carcinoma. However, AR expression is not an independent prognostic factor for SAR in metastatic breast cancer... - Androgen receptors are frequently expressed in mammary and extramammary Paget's diseaseBernadette Liegl
Department of Pathology, Medical University of Graz, Graz, Austria
Mod Pathol 18:1283-8. 2005..The knowledge about frequent expression of AR in Paget's disease could lead to the development of a new adjuvant therapy, particularly in patients with recurrent disease... - Isolated recurrence at the residual uterine cervix after abdominal radical trachelectomy for early cervical cancerArnim A Bader
Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, A 8036 Graz, Austria
Gynecol Oncol 99:785-7. 2005..We report an isolated recurrence at the residual cervix shortly after abdominal radical trachelectomy for cervical cancer... - Regulation of the E2F family: a further step in understanding ovarian cancer biologyEdgar Petru
Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria
Cancer Biol Ther 5:777-8. 2006 - Androgen receptors frequently are expressed in breast carcinomas: potential relevance to new therapeutic strategiesFarid Moinfar
Department of Pathology, School of Medicine, Karl Franzens University Graz, Graz, Austria
Cancer 98:703-11. 2003..The aim of the current study was to examine the presence of androgen receptors (AR) in breast carcinomas... - Molecular classification of breast carcinomas with particular emphasis on "basal-like" carcinoma: a critical reviewMohammad Ali Lavasani
Unit of Breast and Gynecologic Pathology, Department of Pathology, Medical University of Graz, Graz, Austria
J Biophotonics 5:345-66. 2012.... - Is intraoperative frozen section analysis of pelvic lymph nodes accurate after neoadjuvant chemotherapy in patients with cervical cancer?Arnim A Bader
Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, A 8036 Graz, Austria
Gynecol Oncol 103:106-12. 2006..We analyzed the accuracy of frozen section examination of pelvic lymph nodes in patients after NACT for cervical cancer... - Diagnostic yield of touch imprint cytology of prostate core needle biopsiesSebastian Mannweiler
Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036, Graz, Austria
Pathol Oncol Res 15:97-101. 2009..We conclude, that in problematic cases the additional use of touch imprint cytology and serial sectioning of prostate core needle biopsies significantly improve the diagnostic accuracy... - Uterine sarcomasFarid Moinfar
Department of Pathology, Graz University School of Medicine, Austria
Pathology 39:55-71. 2007..Clinical information necessary for accurate diagnosis of these lesions is emphasised. A multidisciplinary approach to management of patients with uterine sarcomas is essential for optimal management... - Molecular evidence for the bi-clonal origin of neuroendocrine tumor derived metastasesBeate Rinner
Center for Medical Research, Medical University of Graz, Stiftingtalstraße 24, Graz, 8010, Austria
BMC Genomics 13:594. 2012.... - Accurate size measurement in infiltrating lobular carcinoma of the breast--gross versus microscopic evaluationFarid Moinfar
Breast J 12:509-10. 2006 - Metaplastic sarcomatoid carcinoma of the breast: not a misnomerSebastian Leibl
Am J Surg Pathol 30:1052-3; author reply 1053-5. 2006 - Combined E-cadherin and high molecular weight cytokeratin immunoprofile differentiates lobular, ductal, and hybrid mammary intraepithelial neoplasiasGary L Bratthauer
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA
Hum Pathol 33:620-7. 2002..This group needs further evaluation for better understanding of its significance, pattern of progression, and behavior...