Stefan Marlovits

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. ncbi Clinical and radiological outcomes 5 years after matrix-induced autologous chondrocyte implantation in patients with symptomatic, traumatic chondral defects
    Stefan Marlovits
    Medical University of Vienna, Department of Traumatology, Waehringer Guertel 18 20, Vienna, A 1090 Austria
    Am J Sports Med 40:2273-80. 2012
  2. ncbi Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years
    Stefan Marlovits
    Department of Traumatology, Center for Joint and Cartilage, Medical University of Vienna, Waehringer, Austria
    Eur J Radiol 57:16-23. 2006
  3. ncbi Magnetic resonance imaging for diagnosis and assessment of cartilage defect repairs
    Stefan Marlovits
    Department of Traumatology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Injury 39:S13-25. 2008
  4. ncbi Extended-duration thromboprophylaxis with enoxaparin after arthroscopic surgery of the anterior cruciate ligament: a prospective, randomized, placebo-controlled study
    Stefan Marlovits
    Department of Traumatology, General Hospital, Medical University of Vienna, Vienna, Austria
    Arthroscopy 23:696-702. 2007
  5. ncbi [Biomaterial for autologous chondrocyte transplantation]
    S Marlovits
    Universitätsklinik für Unfallchirurgie, Medizinische Universitat, Wahringer Gurtel 18 20, A 1090, Wien, Osterreich
    Orthopade 38:1045-52. 2009
  6. ncbi Cartilage repair: generations of autologous chondrocyte transplantation
    Stefan Marlovits
    Department of Traumatology, Center for Joint and Cartilage, Medical University of Vienna, Austria
    Eur J Radiol 57:24-31. 2006
  7. ncbi Differentiating normal hyaline cartilage from post-surgical repair tissue using fast gradient echo imaging in delayed gadolinium-enhanced MRI (dGEMRIC) at 3 Tesla
    Siegfried Trattnig
    MR Center High field MR, Department of Radiology, Medical University of Vienna, Lazarettgasse 14, A 1090 Vienna, Austria
    Eur Radiol 18:1251-9. 2008
  8. ncbi Changes in the endogenous BMP expression during redifferentiation of chondrocytes in 3D cultures
    Christian Albrecht
    Department of Traumatology, Center for Joint and Cartilage, Medical University of Vienna, Vienna, Austria
    Int J Mol Med 26:317-23. 2010
  9. ncbi MRI monitoring of cartilage repair in the knee: a review
    Stephan E Domayer
    MR Centre of Excellence, Department of Radiodiagnostics, Medical University of Vienna, Vienna, Austria
    Semin Musculoskelet Radiol 12:302-17. 2008
  10. ncbi Early postoperative adherence of matrix-induced autologous chondrocyte implantation for the treatment of full-thickness cartilage defects of the femoral condyle
    Stefan Marlovits
    Department of Traumatology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Knee Surg Sports Traumatol Arthrosc 13:451-7. 2005

Detail Information

Publications46

  1. ncbi Clinical and radiological outcomes 5 years after matrix-induced autologous chondrocyte implantation in patients with symptomatic, traumatic chondral defects
    Stefan Marlovits
    Medical University of Vienna, Department of Traumatology, Waehringer Guertel 18 20, Vienna, A 1090 Austria
    Am J Sports Med 40:2273-80. 2012
    ..To date, few studies have been published reporting the 5-year follow-up of clinical and radiological outcomes for chondral defects treated with matrix-induced autologous chondrocyte implantation (MACI)...
  2. ncbi Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years
    Stefan Marlovits
    Department of Traumatology, Center for Joint and Cartilage, Medical University of Vienna, Waehringer, Austria
    Eur J Radiol 57:16-23. 2006
    ..High resolution MRI and well-defined MRI variables are a reliable, reproducible and accurate tool for assessing cartilage repair tissue...
  3. ncbi Magnetic resonance imaging for diagnosis and assessment of cartilage defect repairs
    Stefan Marlovits
    Department of Traumatology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Injury 39:S13-25. 2008
    ..These techniques enable the diagnosis of early cartilage degeneration and help to monitor the effect and outcome of various surgical and non-surgical cartilage repair therapies...
  4. ncbi Extended-duration thromboprophylaxis with enoxaparin after arthroscopic surgery of the anterior cruciate ligament: a prospective, randomized, placebo-controlled study
    Stefan Marlovits
    Department of Traumatology, General Hospital, Medical University of Vienna, Vienna, Austria
    Arthroscopy 23:696-702. 2007
    ....
  5. ncbi [Biomaterial for autologous chondrocyte transplantation]
    S Marlovits
    Universitätsklinik für Unfallchirurgie, Medizinische Universitat, Wahringer Gurtel 18 20, A 1090, Wien, Osterreich
    Orthopade 38:1045-52. 2009
    ..The biomaterials used preserve the specific cellular architecture of chondrocytes and the combination of cultivated cells with biomaterials leads to the formation of cartilage-specific extracellular matrix components...
  6. ncbi Cartilage repair: generations of autologous chondrocyte transplantation
    Stefan Marlovits
    Department of Traumatology, Center for Joint and Cartilage, Medical University of Vienna, Austria
    Eur J Radiol 57:24-31. 2006
    ..These biomaterials secure the cells in the defect area and enhance their proliferation and differentiation...
  7. ncbi Differentiating normal hyaline cartilage from post-surgical repair tissue using fast gradient echo imaging in delayed gadolinium-enhanced MRI (dGEMRIC) at 3 Tesla
    Siegfried Trattnig
    MR Center High field MR, Department of Radiology, Medical University of Vienna, Lazarettgasse 14, A 1090 Vienna, Austria
    Eur Radiol 18:1251-9. 2008
    ..The new dGEMRIC technique based on dual flip angle excitation pulses showed higher GAG content in patients after MACT compared to MFX at the same postoperative interval and allowed reducing the data acquisition time to 4 min...
  8. ncbi Changes in the endogenous BMP expression during redifferentiation of chondrocytes in 3D cultures
    Christian Albrecht
    Department of Traumatology, Center for Joint and Cartilage, Medical University of Vienna, Vienna, Austria
    Int J Mol Med 26:317-23. 2010
    ..Our data indicate that a combination of BMP-2, -6 and -7 may be promising for this purpose...
  9. ncbi MRI monitoring of cartilage repair in the knee: a review
    Stephan E Domayer
    MR Centre of Excellence, Department of Radiodiagnostics, Medical University of Vienna, Vienna, Austria
    Semin Musculoskelet Radiol 12:302-17. 2008
    ..Morphological evaluation methods are recommended for each of the respective techniques. Finally, an overview of T2 mapping and delayed gadolinium-enhanced MR imaging of cartilage in cartilage repair is provided...
  10. ncbi Early postoperative adherence of matrix-induced autologous chondrocyte implantation for the treatment of full-thickness cartilage defects of the femoral condyle
    Stefan Marlovits
    Department of Traumatology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Knee Surg Sports Traumatol Arthrosc 13:451-7. 2005
    ..7 days after the implantation, as determined with high resolution MRI...
  11. ncbi The influence of scaffold architecture on chondrocyte distribution and behavior in matrix-associated chondrocyte transplantation grafts
    Sylvia Nuernberger
    Department of Traumatology, Medical University of Vienna, Vienna 1090, Austria
    Biomaterials 32:1032-40. 2011
    ..They also support the differentiated stage of chondrocytes by preventing the fibroblast-like and polygonal cell shape, at least briefly...
  12. ncbi Morphological and biochemical T2 evaluation of cartilage repair tissue based on a hybrid double echo at steady state (DESS-T2d) approach
    Goetz H Welsch
    MR Center, Department of Radiology, Medical University of Vienna, Austria
    J Magn Reson Imaging 34:895-903. 2011
    ..To use a new approach which provides, based on the widely used three-dimensional double-echo steady-state (DESS) sequence, in addition to the morphological information, the generation of biochemical T2 maps in one hybrid sequence...
  13. ncbi Scaffold-dependent differentiation of human articular chondrocytes
    Werner Schlegel
    Medical University of Vienna, Department of Traumatology, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Int J Mol Med 22:691-9. 2008
    ..These facts indicate that the nature of the matrix is of great influence in the differentiation behaviour of dedifferentiated chondrocytes...
  14. ncbi Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) for in vivo evaluation of reparative cartilage after matrix-associated autologous chondrocyte transplantation at 3.0T: Preliminary results
    Siegfried Trattnig
    MR Center, Highfield MR, Department of Radiology, Medical University of Vienna, Vienna, Austria
    J Magn Reson Imaging 26:974-82. 2007
    ....
  15. ncbi Cartilage T2 assessment at 3-T MR imaging: in vivo differentiation of normal hyaline cartilage from reparative tissue after two cartilage repair procedures--initial experience
    Goetz H Welsch
    MR Center, Department of Radiology, Medical University of Vienna, Lazarettgasse 14, A 1090 Vienna, Austria
    Radiology 247:154-61. 2008
    ..To prospectively compare cartilage T2 values after microfracture therapy (MFX) and matrix-associated autologous chondrocyte transplantation (MACT) repair procedures...
  16. ncbi Effect of accelerated weightbearing after matrix-associated autologous chondrocyte implantation on the femoral condyle on radiographic and clinical outcome after 2 years: a prospective, randomized controlled pilot study
    Barbara Wondrasch
    Center for Joints and Cartilage, Department of Traumatology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Am J Sports Med 37:88S-96S. 2009
    ..There is no consensus about the optimal time for weightbearing activities after matrix-associated autologous chondrocyte implantation (MACI) of the femoral condyle...
  17. ncbi Quantitative T2 mapping during follow-up after matrix-associated autologous chondrocyte transplantation (MACT): full-thickness and zonal evaluation to visualize the maturation of cartilage repair tissue
    Goetz H Welsch
    MR Center, Department of Radiology, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna, Austria
    J Orthop Res 27:957-63. 2009
    ..T2 mapping seems to be more sensitive in revealing changes in the repair tissue compared to morphological MRI. In vivo zonal T2 assessment may be sensitive enough to characterize the maturation of cartilage repair tissue...
  18. ncbi Magnetization transfer contrast and T2 mapping in the evaluation of cartilage repair tissue with 3T MRI
    Goetz H Welsch
    MR Center, Department of Radiology, Medical University of Vienna, Vienna, Austria
    J Magn Reson Imaging 28:979-86. 2008
    ....
  19. ncbi Evaluation of cartilage repair tissue after matrix-associated autologous chondrocyte transplantation using a hyaluronic-based or a collagen-based scaffold with morphological MOCART scoring and biochemical T2 mapping: preliminary results
    Goetz Hannes Welsch
    MR Center, Department of Radiology, Medical University of Vienna, Vienna, Austria
    Am J Sports Med 38:934-42. 2010
    ..In cartilage repair, bioregenerative approaches using tissue engineering techniques have tried to achieve a close resemblance to hyaline cartilage, which might be visualized using advanced magnetic resonance imaging...
  20. ncbi Three-dimensional magnetic resonance observation of cartilage repair tissue (MOCART) score assessed with an isotropic three-dimensional true fast imaging with steady-state precession sequence at 3.0 Tesla
    Goetz H Welsch
    Department of Radiology, MR Center, Medical University of Vienna, Vienna, Austria
    Invest Radiol 44:603-12. 2009
    ....
  21. ncbi Diffusion-weighted imaging for the follow-up of patients after matrix-associated autologous chondrocyte transplantation
    Klaus M Friedrich
    Medical University Vienna, Department of Radiology, MR Center of Excellence, Vienna, Austria
    Eur J Radiol 73:622-8. 2010
    ..To evaluate the use of diffusion-weighted imaging (DWI) for the assessment of cartilage maturation in patients after matrix-associated autologous chondrocyte transplantation (MACT)...
  22. ncbi Initial results of in vivo high-resolution morphological and biochemical cartilage imaging of patients after matrix-associated autologous chondrocyte transplantation (MACT) of the ankle
    Sebastian Quirbach
    MR Center High field MR, Department of Radiology, Medical University of Vienna, Vienna General Hospital, Waehringer Guertel 18 20, 1090, Vienna, Austria
    Skeletal Radiol 38:751-60. 2009
    ....
  23. ncbi T2 and T2* mapping in patients after matrix-associated autologous chondrocyte transplantation: initial results on clinical use with 3.0-Tesla MRI
    Goetz H Welsch
    Department of Radiology, Medical University of Vienna, MR Center, Lazarettgasse 14, 1090 Vienna, Austria
    Eur Radiol 20:1515-23. 2010
    ..To use T2 and T2* mapping in patients after matrix-associated autologous chondrocyte transplantation (MACT) of the knee, and to compare and correlate both methodologies...
  24. ncbi Alterations in CD44 isoforms and HAS expression in human articular chondrocytes during the de- and re-differentiation processes
    Christian Albrecht
    Medical University of Vienna, Department of Traumatology, Center for Joint and Cartilage, Vienna, Austria
    Int J Mol Med 23:253-9. 2009
    ..Our data point out that CD44 expression does not correlate with matrix assembly in chondrocytes and that CD44 has a regulatory function in chondrocytes, not necessarily on differentiation, but probably on proliferation...
  25. ncbi Dedifferentiation of human articular chondrocytes is associated with alterations in expression patterns of GDF-5 and its receptors
    Werner Schlegel
    Department of Traumatology, Medical University Vienna, Center for Joint and Cartilage Waehringer Guertel, Vienna, Austria
    J Cell Mol Med 13:3398-404. 2009
    ..The newly synthesized proteins were detected by immunofluorescence. There is evidence from our results that dedifferentiated chondrocytes resemble the cells from the interzone in developing synovial joints...
  26. ncbi Advanced morphological 3D magnetic resonance observation of cartilage repair tissue (MOCART) scoring using a new isotropic 3D proton-density, turbo spin echo sequence with variable flip angle distribution (PD-SPACE) compared to an isotropic 3D steady-stat
    Goetz H Welsch
    MR Center, Department of Radiology, Medical University of Vienna, Vienna, Austria
    J Magn Reson Imaging 33:180-8. 2011
    ....
  27. ncbi Advanced morphological and biochemical magnetic resonance imaging of cartilage repair procedures in the knee joint at 3 Tesla
    Goetz H Welsch
    MR Center, Department of Radiology, Medical University of Vienna, Vienna, Austria
    Semin Musculoskelet Radiol 12:196-211. 2008
    ..A combination of both, together with clinical evaluation, may represent a desirable multimodal approach in the future, also available in routine clinical use...
  28. ncbi Computer-assisted surgery of cartilage defects in the knee: comparison of rigid-body fixation techniques in a human cadaver study
    Stefan Marlovits
    Medical University of Vienna, Department of Traumatology, Vienna, Austria
    Orthopedics 30:S112-6. 2007
    ..In conclusion, the cartilage defect-managing module allows the precise measurement of full-thickness cartilage defects in the knee joint during arthroscopy and that the module can be used with noninvasive rigid-body fixation...
  29. ncbi Effects of mechanical loading on collagen propeptides processing in cartilage repair
    Rosmarie Hardmeier
    Department of Traumatology, Medical University of Vienna, Austria
    J Tissue Eng Regen Med 4:1-11. 2010
    ..These effects seemed to be dependent on the magnitude and duration of the physical stress. This review will contribute to the understanding of mechanisms for collagen assembly in both a natural and an artificial environment...
  30. ncbi Definition of pertinent parameters for the evaluation of articular cartilage repair tissue with high-resolution magnetic resonance imaging
    Stefan Marlovits
    Department of Traumatology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur J Radiol 52:310-9. 2004
    ..The new classification and grading system allows a subtle description and suitable assessment of the articular cartilage repair tissue...
  31. ncbi Matrix-based autologous chondrocyte implantation for cartilage repair: noninvasive monitoring by high-resolution magnetic resonance imaging
    Siegfried Trattnig
    Department of Radiology, University Hospital of Vienna, Medical University of Vienna, A 1090 Vienna, Austria
    Magn Reson Imaging 23:779-87. 2005
    ..Monitoring of articular cartilage repair after matrix-associated autologous chondrocyte implantation (MACI) by a new grading and point-scale system based on noninvasive cartilage-specific magnetic resonance imaging (MRI) protocol...
  32. ncbi Evaluation and comparison of cartilage repair tissue of the patella and medial femoral condyle by using morphological MRI and biochemical zonal T2 mapping
    Goetz H Welsch
    MR Center High field MR, Department of Radiology, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna, Austria
    Eur Radiol 19:1253-62. 2009
    ..The assessment of cartilage repair tissue of the patella and MFC afforded comparable morphological results, whereas biochemical T2 values showed differences, possibly due to dissimilar biomechanical loading conditions...
  33. ncbi Obesity-related juvenile form of cartilage lesions: a new affliction in the knees of morbidly obese children and adolescents
    Harald K Widhalm
    Center for Joints and Cartilage, Department of Traumatology, Medical University of Vienna, Vienna, Austria
    Eur Radiol 22:672-81. 2012
    ..The aim of the study was to assess the condition of articular cartilage in obese adolescent patients suffering from knee pain...
  34. ncbi Emergence of lyme arthritis after autologous chondrocyte transplantation
    Stefan Marlovits
    University of Vienna, Vienna, Austria
    Arthritis Rheum 50:259-64. 2004
    ..We recommend that synovial fluid and joint tissue be screened for the presence of viable Borrelia before transplantation of an autologous graft...
  35. ncbi Quantitative T2 mapping of matrix-associated autologous chondrocyte transplantation at 3 Tesla: an in vivo cross-sectional study
    Siegfried Trattnig
    MR Center, Department of Radiology, Medical University of Vienna, Vienna, Austria
    Invest Radiol 42:442-8. 2007
    ..To evaluate magnetic resonance (MR) T2 mapping for characterization of cartilage repair tissue following matrix-associated autologous cartilage transplantation (MACT)...
  36. ncbi Impact of 3D-culture on the expression of differentiation markers and hormone receptors in growth plate chondrocytes as compared to articular chondrocytes
    Christian Albrecht
    Department of Paediatrics, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Int J Mol Med 23:347-55. 2009
    ..Moreover, the porcine model is promising as defined by tissue availability, expression of relevant hormonal receptors and comparability to human conditions, in particular in the area of basic growth research...
  37. ncbi Ability to return to sports 5 years after matrix-associated autologous chondrocyte transplantation in an average population of active patients
    Lukas Zak
    Department of Traumatology, Medical University of Vienna, Vienna, Austria
    Am J Sports Med 40:2815-21. 2012
    ..Cartilage injuries often occur during sports activities, and return to sports after cartilage surgery is an important outcome parameter for different treatment methods in the competitive as well as the recreationally active population...
  38. ncbi Persistent bone marrow edema after osteochondral autograft transplantation in the knee joint
    Stefan Franz Nemec
    MR Centre of Excellence, Department of Radiology, Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Waehringerguertel 18 20, Vienna 1090, Austria
    Eur J Radiol 71:159-63. 2009
    ..This study determines the prevalence of persistent edema-like signal intensity in OCT patients and evaluates the correlation between edema and morphological imaging findings of the graft and clinical pain symptoms...
  39. ncbi High-resolution magnetic resonance imaging and conventional magnetic resonance imaging on a standard field-strength magnetic resonance system compared to arthroscopy in patients with suspected meniscal tears
    Stefan Franz Nemec
    Department of Radiology Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Waehringerguertel 18 20, A 1090 Vienna, Austria
    Acad Radiol 15:928-33. 2008
    ....
  40. ncbi Contrast-enhanced high-resolution magnetic resonance imaging of autologous cartilage implants of the knee joint
    Christina M Plank
    Department of Radiology, Medical University of Vienna, A-1190 Vienna, Austria
    Magn Reson Imaging 23:739-44. 2005
    ..Contrast-enhanced MRI of articular cartilages is a promising technique in the postoperative follow-up of patients after ACI...
  41. ncbi Chondrogenesis of aged human articular cartilage in a scaffold-free bioreactor
    Stefan Marlovits
    Department of Traumatology, University of Vienna Medical School, Vienna, Austria
    Tissue Eng 9:1215-26. 2003
    ..Moreover, the tissue-engineered constructs may be used for further in vitro studies of differentiation, aging, and regeneration of human articular cartilage...
  42. ncbi Quantitative analysis of gene expression in human articular chondrocytes in monolayer culture
    Stefan Marlovits
    Department of Traumatology, University of Vienna, A 1090 Vienna, Austria
    Int J Mol Med 13:281-7. 2004
    ..The accurate quantitative assessment of extracellular matrix gene expression in samples of chondrocytes taken from monolayer culture can be used to monitor chondrocyte metabolism as well as changes in the cell differentiation status...
  43. ncbi An in vivo mouse model for human cartilage regeneration
    Georg C Schüller
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, Vienna, Austria
    J Tissue Eng Regen Med 2:202-9. 2008
    ..Interestingly, uncovered discs filled with cells showed comparable areas of differentiating cells at the defect surface but lack of fibrous tissue in the middle. The histological results were supported by MRI measurement...
  44. ncbi Steady-state diffusion imaging for MR in-vivo evaluation of reparative cartilage after matrix-associated autologous chondrocyte transplantation at 3 tesla--preliminary results
    Tallal Charles Mamisch
    Department of Orthopaedic Surgery, University of Berne, Inselspital, CH 3010 Berne, Switzerland
    Eur J Radiol 65:72-9. 2008
    ..To demonstrate the feasibility of time-reversed fast imaging with steady-state precession (FISP) called PSIF for diffusion-weighted imaging of cartilage and cartilage transplants in a clinical study...
  45. ncbi Prevention of venous thromboembolism with fondaparinux
    Stefan Marlovits
    N Engl J Med 346:940-2; author reply 940-2. 2002
  46. ncbi Autologous chondrocyte implantation postoperative care and rehabilitation: science and practice
    Karen Hambly
    Department of Health and Sciences, 166 220 Holloway Road, London, UK
    Am J Sports Med 34:1020-38. 2006
    ....