H Mangge

Summary

Affiliation: Medical University of Graz
Country: Austria

Publications

  1. ncbi request reprint 25OH-Vitamin D3 Levels in Obesity and Metabolic Syndrome-Unaltered in Young and not Correlated to Carotid IMT in All Ages
    Harald Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Curr Pharm Des 21:2243-9. 2015
  2. doi request reprint Hypothyroidism Exacerbates Thrombophilia in Female Rats Fed with a High Fat Diet
    Harald Mangge
    Clinical Institute for Medical and Chemical Laboratory Diagnostics, Medical University Graz, 8036 Graz, Austria
    Int J Mol Sci 16:15776-84. 2015
  3. ncbi request reprint The Role of Vitamin D in Atherosclerosis Inflammation Revisited: More a Bystander than a Player?
    Harald Mangge
    Research Unit on Lifestyle and Inflammation associated Risk Biomarkers, Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria
    Curr Vasc Pharmacol 13:392-8. 2015
  4. doi request reprint Laboratory medicine for molecular imaging of atherosclerosis
    Harald Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria BioTechMed Graz, Austria Electronic address
    Clin Chim Acta 437:19-24. 2014
  5. pmc Rs9939609 variant of the fat mass and obesity-associated gene and trunk obesity in adolescents
    Harald Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria
    J Obes 2011:186368. 2011
  6. pmc Globular domain of adiponectin: promising target molecule for detection of atherosclerotic lesions
    Gunter Almer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz
    Biologics 5:95-105. 2011
  7. pmc Interleukin-10: an anti-inflammatory marker to target atherosclerotic lesions via PEGylated liposomes
    Gunter Almer
    Institute of Biophysics and Nanosystems Research, Austrian Academy of Science, Graz, Austria
    Mol Pharm 10:175-86. 2013
  8. ncbi request reprint Disturbed tryptophan metabolism in cardiovascular disease
    H Mangge
    Research Unit on Lifestyle and Inflammation associated Risk Biomarkers, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Bio TechMed Graz, Austria, Auenbruggerplatz 30 8036 Graz, Austria
    Curr Med Chem 21:1931-7. 2014
  9. ncbi request reprint Antioxidant food supplements and obesity-related inflammation
    H Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria
    Curr Med Chem 20:2330-7. 2013
  10. doi request reprint Uric acid best predicts metabolically unhealthy obesity with increased cardiovascular risk in youth and adults
    Harald Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria
    Obesity (Silver Spring) 21:E71-7. 2013

Collaborators

Detail Information

Publications34

  1. ncbi request reprint 25OH-Vitamin D3 Levels in Obesity and Metabolic Syndrome-Unaltered in Young and not Correlated to Carotid IMT in All Ages
    Harald Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Curr Pharm Des 21:2243-9. 2015
    ..This, together with the complete lack of association with carotid IMT in both juveniles and adults, argues against a causative role of vitD in obesity-associated vascular pathology. ..
  2. doi request reprint Hypothyroidism Exacerbates Thrombophilia in Female Rats Fed with a High Fat Diet
    Harald Mangge
    Clinical Institute for Medical and Chemical Laboratory Diagnostics, Medical University Graz, 8036 Graz, Austria
    Int J Mol Sci 16:15776-84. 2015
    ..This effect may be relevant for cardiovascular disease where thyroid function is poorly understood as a pathological contributor in the context of clotting activity and obesogenic nutrition. ..
  3. ncbi request reprint The Role of Vitamin D in Atherosclerosis Inflammation Revisited: More a Bystander than a Player?
    Harald Mangge
    Research Unit on Lifestyle and Inflammation associated Risk Biomarkers, Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria
    Curr Vasc Pharmacol 13:392-8. 2015
    ..Large randomized controlled studies of vitD with multiple outcomes (skeletal, metabolic, cardiovascular and mental) are urgently needed. ..
  4. doi request reprint Laboratory medicine for molecular imaging of atherosclerosis
    Harald Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria BioTechMed Graz, Austria Electronic address
    Clin Chim Acta 437:19-24. 2014
    ....
  5. pmc Rs9939609 variant of the fat mass and obesity-associated gene and trunk obesity in adolescents
    Harald Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria
    J Obes 2011:186368. 2011
    ..Taken together, to the best of our knowledge we are the first to report that the rs9939609 FTO SNP is associated with trunk weighted obesity as early as in adolescence...
  6. pmc Globular domain of adiponectin: promising target molecule for detection of atherosclerotic lesions
    Gunter Almer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz
    Biologics 5:95-105. 2011
    ..In this study, we investigated the potential of different adiponectin subfractions with special emphasis on globular adiponectin (gAd) to recognize and visualize atherosclerotic lesions...
  7. pmc Interleukin-10: an anti-inflammatory marker to target atherosclerotic lesions via PEGylated liposomes
    Gunter Almer
    Institute of Biophysics and Nanosystems Research, Austrian Academy of Science, Graz, Austria
    Mol Pharm 10:175-86. 2013
    ....
  8. ncbi request reprint Disturbed tryptophan metabolism in cardiovascular disease
    H Mangge
    Research Unit on Lifestyle and Inflammation associated Risk Biomarkers, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Bio TechMed Graz, Austria, Auenbruggerplatz 30 8036 Graz, Austria
    Curr Med Chem 21:1931-7. 2014
    ..The review leads to a novel framework for successful therapeutic modification of several cardinal pathophysiological processes leading to adverse cardiovascular outcome...
  9. ncbi request reprint Antioxidant food supplements and obesity-related inflammation
    H Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria
    Curr Med Chem 20:2330-7. 2013
    ..Based on these facts, the involvement of antioxidant food supplements in the mechanisms of the reward-deficiency syndrome which perpetuates obesity will be discussed...
  10. doi request reprint Uric acid best predicts metabolically unhealthy obesity with increased cardiovascular risk in youth and adults
    Harald Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria
    Obesity (Silver Spring) 21:E71-7. 2013
    ....
  11. doi request reprint N-terminal pro-B-type natriuretic peptide in early and advanced phases of obesity
    Harald Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria
    Clin Chem Lab Med 49:1539-45. 2011
    ..As only older adults were investigated so far, it remains unclear when during the evolution of obesity the state of a natriuretic handicap develops, and whether NT-proBNP may still serve as a relevant cardiac marker in obese juveniles...
  12. doi request reprint Nuchal thickness of subcutaneous adipose tissue is tightly associated with an increased LMW/total adiponectin ratio in obese juveniles
    Harald Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, A 8036 Graz, Austria
    Atherosclerosis 203:277-83. 2009
    ..Taken together, our data provide the first evidence that nuchal SAT thickness is tightly positively associated with an increased LMW/total adiponectin ratio...
  13. doi request reprint Preatherosclerosis and adiponectin subfractions in obese adolescents
    Harald Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    Obesity (Silver Spring) 16:2578-84. 2008
    ....
  14. ncbi request reprint Inflammation, adiponectin, obesity and cardiovascular risk
    H Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria
    Curr Med Chem 17:4511-20. 2010
    ....
  15. doi request reprint Asymmetric dimethylarginine (ADMA) is tightly correlated with growth in juveniles without correlations to obesity related disorders
    H J Gruber
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria
    Exp Clin Endocrinol Diabetes 116:520-4. 2008
    ..Asymmetrical dimethylarginine (ADMA) was found to be increased in conditions associated with atherosclerosis and metabolic disorders. We investigated ADMA in obese juveniles with pre-atherosclerotic symptoms and in normal weight juveniles...
  16. doi request reprint Normalization of haemostatic alterations in overweight children with weight loss due to lifestyle intervention
    P Fritsch
    Department of Pediatrics, Medical University of Graz, Austria
    Atherosclerosis 216:170-3. 2011
    ..However, the effect of weight loss on these haemostatic alterations has not been studied yet with an overall function test such as the thrombin generating test (TG) in obese children...
  17. doi request reprint Haemostatic alterations in overweight children: associations between metabolic syndrome, thrombin generation, and fibrinogen levels
    P Fritsch
    Department of Paediatrics, Medical University of Graz, Austria
    Atherosclerosis 212:650-5. 2010
    ..Since obesity is associated with a hypercoagulable state, it has been speculated that hypercoagulation is linking MetS to CVD...
  18. ncbi request reprint Low grade inflammation in juvenile obesity and type 1 diabetes associated with early signs of atherosclerosis
    H Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Austria
    Exp Clin Endocrinol Diabetes 112:378-82. 2004
    ..In contrast to adults, little information exists concerning low grade inflammation in young type 1 diabetes and juvenile obesity...
  19. ncbi request reprint IgG antibodies against food antigens are correlated with inflammation and intima media thickness in obese juveniles
    M Wilders-Truschnig
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Austria
    Exp Clin Endocrinol Diabetes 116:241-5. 2008
    ..We examined the relationship between IgG antibodies specific for food components, low grade inflammation and early atherosclerotic lesions in obese and normal weight juveniles...
  20. doi request reprint Obesity reduces the bioavailability of nitric oxide in juveniles
    H J Gruber
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    Int J Obes (Lond) 32:826-31. 2008
    ..We hypothesize that NO is already involved in the pathophysiology of juvenile obesity. We here determined the role of NO, its metabolites arginine and citrulline in obese and normal weight children...
  21. doi request reprint Oxidative stress: Determination of 4-hydroxy-2-nonenal by gas chromatography/mass spectrometry in human and rat plasma
    S Zelzer
    a Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria
    Free Radic Res 49:1233-8. 2015
    ..This is important for a reorientation of oxidative stress analytics in other human diseases first of atherosclerosis and cancer...
  22. doi request reprint Ultra-endurance exercise induces stress and inflammation and affects circulating hematopoietic progenitor cell function
    I Stelzer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    Scand J Med Sci Sports 25:e442-50. 2015
    ....
  23. pmc Thiomer-coated liposomes harbor permeation enhancing and efflux pump inhibitory properties
    K Gradauer
    Institute of Biophysics and Nanosystems Research, Austrian Academy of Sciences, Schmiedlstraße 6, 8042 Graz, Austria
    J Control Release 165:207-15. 2013
    ....
  24. doi request reprint Smoking denial in cardiovascular disease studies
    S J Wallner-Liebmann
    Center of Molecular Medicine, Institute of Pathophysiology and Immunology, Medical University Graz, Graz, Austria
    Adv Exp Med Biol 788:35-8. 2013
    ..The results of the present study substantiate the importance of biochemical markers for smoking assessment in cardiovascular studies. ..
  25. ncbi request reprint [Peripheral lymphadenopathy in childhood--recommendations for diagnostic evaluation]
    M Benesch
    Universitätsklinik für Kinder und Jugendheilkunde, Karl Franzens Universitat Graz
    Klin Padiatr 212:277-82. 2000
    ..The aim of the present study was to analyze the most common causes of peripheral lymphadenopathy and to develop a simple algorithm for the primary diagnostic evaluation of peripheral lymph node enlargement in this age group...
  26. ncbi request reprint More reliable brain death diagnosis with chromatographic analysis of midazolam, diazepam, thiopentone, and active metabolites
    Andreas Meinitzer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 19, 8036 Graz, Austria
    J Anal Toxicol 30:196-201. 2006
    ..These assays were accurate in that the relative difference between actually measured and expected concentration never exceeded 12%. Utilization of these assays will render the diagnosis of brain death more reliable...
  27. ncbi request reprint Early atherosclerosis in obese juveniles is associated with low serum levels of adiponectin
    Stefan Pilz
    Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, A 8036 Graz, Austria
    J Clin Endocrinol Metab 90:4792-6. 2005
    ..There is growing evidence that adiponectin, the most abundant adipocytokine of adipose tissue cells, plays a crucial role in advanced atherosclerosis...
  28. doi request reprint Patatin-like phospholipase 3 (rs738409) gene polymorphism is associated with increased liver enzymes in obese adolescents and metabolic syndrome in all ages
    H Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    Aliment Pharmacol Ther 42:99-105. 2015
    ..Carriers have been reported to better respond to lifestyle modification...
  29. pmc Liposomes coated with thiolated chitosan enhance oral peptide delivery to rats
    K Gradauer
    Institute of Biophysics, Medical University of Graz, Schmiedlstraße 6, 8042 Graz, Austria Electronic address
    J Control Release 172:872-8. 2013
    ..According to these results, liposomes coated with S-protected thiomers have demonstrated to be highly valuable carriers for enhancing the oral bioavailability of salmon calcitonin...
  30. ncbi request reprint Visfatin/pre-B-cell colony-enhancing factor: a protein with various suggested functions
    S Pilz
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    J Endocrinol Invest 30:138-44. 2007
    ..This review summarizes the current knowledge of the various functions of PBEF/visfatin towards involvements in pathophysiology of several diseases...
  31. ncbi request reprint Cystatin C, an early indicator for incipient renal disease in rheumatoid arthritis
    H Mangge
    Department of Laboratory Medicine Blocklabor III and Pediatric Immunology Rheumatology, University of Graz, School of Medicine, A 8036, Graz, Austria
    Clin Chim Acta 300:195-202. 2000
    ..Elevated cystatin C indicates such incipient renal disease, and is, not least because of a simple, well reproducible technique, more recommendable for screening purposes than tedious clearance determinations...
  32. ncbi request reprint Subcutaneous adipose tissue exerts proinflammatory cytokines after minimal trauma in humans
    Christoph Pachler
    Department of Internal Medicine, Diabetes and Metabolism, Medical University Graz, Graz, Austria
    Am J Physiol Endocrinol Metab 293:E690-6. 2007
    ..In conclusion, SAT exerts a highly reproducible and consistent proinflammatory cytokine response after minimally invasive trauma caused by the insertion of a catheter in humans...
  33. ncbi request reprint Therapeutic experience with infliximab in a patient with polyarticular juvenile idiopathic arthritis and uveitis
    Harald Mangge
    Clinical Institute of Medical and Chemical Laboratory Diagnosis, University Clinic of Graz, 8036 Graz, Austria
    Rheumatol Int 23:258-61. 2003
    ..To conclude, in polyarticular seronegative JIA, infliximab showed a transient beneficial effect which was more pronounced on uveitis than arthritis...
  34. ncbi request reprint Adiponectin serum concentrations in men with coronary artery disease: the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study
    Stefan Pilz
    Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University, Graz, Austria
    Clin Chim Acta 364:251-5. 2006
    ..Data concerning adiponectin in different stages of CAD are rare, and it was not investigated if adiponectin levels are influenced by the severity of angina pectoris...