E Malle

Summary

Affiliation: Medical University of Graz
Country: Austria

Publications

  1. doi Serum amyloid A: an acute-phase protein involved in tumour pathogenesis
    E Malle
    Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Harrachgasse 21, A 8010 Graz, Austria
    Cell Mol Life Sci 66:9-26. 2009
  2. pmc Myeloperoxidase: a target for new drug development?
    E Malle
    Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
    Br J Pharmacol 152:838-54. 2007
  3. ncbi Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid
    Ernst Malle
    Medical University Graz, Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Harrachgasse 21, A 8010 Graz, Austria
    Biochim Biophys Acta 1761:392-415. 2006
  4. ncbi Myeloperoxidase-mediated oxidation of high-density lipoproteins: fingerprints of newly recognized potential proatherogenic lipoproteins
    Ernst Malle
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University Graz, A 8010 Graz, Austria
    Arch Biochem Biophys 445:245-55. 2006
  5. ncbi Hypochlorite-modified (lipo)proteins are present in rabbit lesions in response to dietary cholesterol
    E Malle
    Institute of Medical Biochemistry and Molecular Biology, Karl Franzens University, Graz, A 8010, Austria
    Biochem Biophys Res Commun 289:894-900. 2001
  6. ncbi Inhibition of lung carcinoma cell growth by high density lipoprotein-associated alpha-tocopheryl-succinate
    A Hrzenjak
    Institute of Pathology, Medical University Graz, Harrachgasse 21, 8010 Graz, Austria
    Cell Mol Life Sci 61:1520-31. 2004
  7. ncbi Myeloperoxidase-dependent generation of hypochlorite-modified proteins in human placental tissues during normal pregnancy
    A Hammer
    Institute of Histology and Embryology, Karl-Franzens University Graz, Graz, Austria
    Lab Invest 81:543-54. 2001
  8. ncbi Modulation of microglial superoxide production by alpha-tocopherol in vitro: attenuation of p67(phox) translocation by a protein phosphatase-dependent pathway
    T Egger
    Institute of Medical Biochemistry and Molecular Biology, Karl Franzens University Graz, Graz, Austria
    J Neurochem 79:1169-82. 2001
  9. pmc Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET(B) receptor-mediated G(i)- and G(q)-pathways and MAP kinase activation
    A Rauh
    Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
    Br J Pharmacol 154:13-24. 2008
  10. ncbi Silent mutations in secondary Shine-Dalgarno sequences in the cDNA of human serum amyloid A4 promotes expression of recombinant protein in Escherichia coli
    A Hrzenjak
    Karl Franzens University Graz, Institute of Medical Biochemistry and Molecular Biology, Harrachgasse 21, A 8010 Graz, Austria
    Protein Eng 14:949-52. 2001

Collaborators

Detail Information

Publications40

  1. doi Serum amyloid A: an acute-phase protein involved in tumour pathogenesis
    E Malle
    Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Harrachgasse 21, A 8010 Graz, Austria
    Cell Mol Life Sci 66:9-26. 2009
    ....
  2. pmc Myeloperoxidase: a target for new drug development?
    E Malle
    Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
    Br J Pharmacol 152:838-54. 2007
    ..Emphasis will be put on mechanism-based inhibitors and high-throughput screening of compounds as well as the discussion of physiologically useful HOCl scavengers...
  3. ncbi Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid
    Ernst Malle
    Medical University Graz, Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Harrachgasse 21, A 8010 Graz, Austria
    Biochim Biophys Acta 1761:392-415. 2006
    ....
  4. ncbi Myeloperoxidase-mediated oxidation of high-density lipoproteins: fingerprints of newly recognized potential proatherogenic lipoproteins
    Ernst Malle
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University Graz, A 8010 Graz, Austria
    Arch Biochem Biophys 445:245-55. 2006
    ....
  5. ncbi Hypochlorite-modified (lipo)proteins are present in rabbit lesions in response to dietary cholesterol
    E Malle
    Institute of Medical Biochemistry and Molecular Biology, Karl Franzens University, Graz, A 8010, Austria
    Biochem Biophys Res Commun 289:894-900. 2001
    ..We propose that monocyte-derived MPO could connect chronic inflammatory conditions with arterial lipid/lipoprotein deposition during diet-induced atherogenesis in rabbits...
  6. ncbi Inhibition of lung carcinoma cell growth by high density lipoprotein-associated alpha-tocopheryl-succinate
    A Hrzenjak
    Institute of Pathology, Medical University Graz, Harrachgasse 21, 8010 Graz, Austria
    Cell Mol Life Sci 61:1520-31. 2004
    ..Based on our in vitro and in vivo findings, we propose that SR-BI could provide a novel route for HDL3-mediated drug delivery of anti-neoplastic drugs...
  7. ncbi Myeloperoxidase-dependent generation of hypochlorite-modified proteins in human placental tissues during normal pregnancy
    A Hammer
    Institute of Histology and Embryology, Karl-Franzens University Graz, Graz, Austria
    Lab Invest 81:543-54. 2001
    ..The present findings indicate that the generation of HOCl-modified proteins during normal pregnancy is a physiologic rather than a pathophysiologic process...
  8. ncbi Modulation of microglial superoxide production by alpha-tocopherol in vitro: attenuation of p67(phox) translocation by a protein phosphatase-dependent pathway
    T Egger
    Institute of Medical Biochemistry and Molecular Biology, Karl Franzens University Graz, Graz, Austria
    J Neurochem 79:1169-82. 2001
    ..As a result, O2(-.) production by the microglial NADPH-oxidase system is substantially inhibited...
  9. pmc Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET(B) receptor-mediated G(i)- and G(q)-pathways and MAP kinase activation
    A Rauh
    Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
    Br J Pharmacol 154:13-24. 2008
    ..Choriocarcinoma cells display many of the biochemical and morphological characteristics of in utero invasive trophoblast cells and may therefore be used as a suitable model to study epithelial tumour progression of foetal-derived cells...
  10. ncbi Silent mutations in secondary Shine-Dalgarno sequences in the cDNA of human serum amyloid A4 promotes expression of recombinant protein in Escherichia coli
    A Hrzenjak
    Karl Franzens University Graz, Institute of Medical Biochemistry and Molecular Biology, Harrachgasse 21, A 8010 Graz, Austria
    Protein Eng 14:949-52. 2001
    ..Here we show that PCR mutations of two rbs-like sequences in the human SAA4 cDNA promote expression of considerable amounts of recombinant SAA4 in E.coli...
  11. ncbi Quantitative determination of terbutaline and orciprenaline in human plasma by gas chromatography/negative ion chemical ionization/mass spectrometry
    H J Leis
    Univ Kinderklinik, Dept Mass Spectrometry, Graz, Austria
    Biomed Environ Mass Spectrom 19:382-6. 1990
    ..Plasma levels of terbutaline after oral administration of 5 mg of terbutaline sulphate were estimated...
  12. ncbi Plasma phospholipid transfer protein-mediated reactions are impaired by hypochlorite-modification of high density lipoprotein
    Pirkko J Pussinen
    Institute of Dentistry, University of Helsinki, P O Box 63, FIN 00014, Helsinki, Finland
    Int J Biochem Cell Biol 35:192-202. 2003
    ..Based on these findings, we conclude that the substrate properties of HOCl-modified HDL3 and TG-HDL3 in PLTP-mediated processes are impaired, which indicates that the anti-atherogenic properties of HDL are impaired...
  13. ncbi Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells
    Ute Panzenboeck
    Medical University Graz, Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Harrachgasse 21, A 8010 Graz, Austria
    Int J Biochem Cell Biol 38:1314-29. 2006
    ..Summarizing, in cerebrovascular endothelial cells apoA-I, ABCA1, and SR-BI represent drug targets for LXR and PPAR-agonists to interfere with cholesterol homeostasis at the periphery of the central nervous system...
  14. pmc The lipidation status of acute-phase protein serum amyloid A determines cholesterol mobilization via scavenger receptor class B, type I
    Gunther Marsche
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, A 8010 Graz, Austria
    Biochem J 402:117-24. 2007
    ..In addition, we demonstrate that SAA mediates cellular cholesterol efflux via the ABCA1 and/or SR-BI pathway in a similar way to apoA-I...
  15. ncbi Apolipoprotein A-I coating of protamine-oligonucleotide nanoparticles increases particle uptake and transcytosis in an in vitro model of the blood-brain barrier
    Ingrid Kratzer
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Harrachgasse 21, 8010 Graz, Austria
    J Control Release 117:301-11. 2007
    ..Our data indicate that apoA-I-coating of proticles could be a feasible targeting technology to improve delivery across the BBB...
  16. ncbi 2-chlorohexadecanal derived from hypochlorite-modified high-density lipoprotein-associated plasmalogen is a natural inhibitor of endothelial nitric oxide biosynthesis
    Gunther Marsche
    Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria
    Arterioscler Thromb Vasc Biol 24:2302-6. 2004
    ....
  17. ncbi Scavenger receptor class B, type I mediates uptake of lipoprotein-associated phosphatidylcholine by primary porcine cerebrovascular endothelial cells
    Andrea Sovic
    Institute of Molecular Biology and Biochemistry, Medical University Graz, Harrachgasse 21, A 8010 Graz, Austria
    Neurosci Lett 368:11-4. 2004
    ..Our results suggest that uptake of lipoprotein-associated PC by the cerebrovasculature via SR-BI could generate a pool of lipids containing polyunsaturated fatty acids available for transport into deeper regions of the brain...
  18. ncbi Effects of lipoprotein lipase on uptake and transcytosis of low density lipoprotein (LDL) and LDL-associated alpha-tocopherol in a porcine in vitro blood-brain barrier model
    Daniel Goti
    Institute of Medical Biochemistry and Molecular Biology, University Graz, Harrachgasse 21, Graz 8010, Austria
    J Biol Chem 277:28537-44. 2002
    ..The relevance of LPL-dependent alphaTocH uptake across the BBB was confirmed in LPL-deficient mice. The absence of LPL resulted in significantly lower cerebral alphaTocH concentrations than observed in control animals...
  19. ncbi Soluble RAGE blocks scavenger receptor CD36-mediated uptake of hypochlorite-modified low-density lipoprotein
    Gunther Marsche
    Medical University of Graz, Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Harrachgasse 21, 8010 Graz, Austria
    FASEB J 21:3075-82. 2007
    ..We propose that sRAGE represents a physiological antagonist that interferes with scavenger receptor-mediated cholesterol accumulation and foam cell formation of macrophages...
  20. ncbi Uptake and transport of high-density lipoprotein (HDL) and HDL-associated alpha-tocopherol by an in vitro blood-brain barrier model
    Zoltan Balazs
    Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria
    J Neurochem 89:939-50. 2004
    ....
  21. doi Hypochlorite-modified high-density lipoprotein acts as a sink for myeloperoxidase in vitro
    Gunther Marsche
    Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz, A 8010 Graz, Austria
    Cardiovasc Res 79:187-94. 2008
    ....
  22. ncbi Myeloperoxidase in kidney disease
    Ernst Malle
    Karl Franzens University Graz, Institute of Medical Biochemistry and Molecular Biology, Graz, Austria
    Kidney Int 64:1956-67. 2003
    ....
  23. ncbi ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells
    Ute Panzenboeck
    Institute of Medical Biochemistry and Medical Molecular Biology, University Graz, Harrachgasse 21, A 8010 Graz, Austria
    J Biol Chem 277:42781-9. 2002
    ..In conclusion, the apoA-I/ABCA1- and HDL/SR-BI-dependent pathways modulate polarized sterol mobilization at the BBB...
  24. ncbi Hypochlorous acid alters bronchial epithelial cell membrane properties and prevention by extracellular glutathione
    Charles J Venglarik
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    J Appl Physiol 95:2444-52. 2003
    ..Extrapolating this to cystic fibrosis suggests that HOCl can alter cell function without destruction but that elevating glutathione could be protective...
  25. ncbi Hypochlorite-modified high density lipoprotein, a high affinity ligand to scavenger receptor class B, type I, impairs high density lipoprotein-dependent selective lipid uptake and reverse cholesterol transport
    Gunther Marsche
    Institute of Medical Biochemistry and Molecular Biology, Karl Franzens University Graz, Austria
    J Biol Chem 277:32172-9. 2002
    ....
  26. ncbi Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine
    Xiaomin Deng
    Department of Pharmacology and Toxicology, Michigan State University, Food Safety and Toxicology Building, Michigan State University, Room 221, East Lansing, MI 48824
    J Pharmacol Exp Ther 322:852-61. 2007
    ..In summary, PMNs are activated in LPS/RAN-cotreated rats and participate in the liver injury in part by contributing to hemostasis and hypoxia...
  27. ncbi Hypochlorite-modified albumin colocalizes with RAGE in the artery wall and promotes MCP-1 expression via the RAGE-Erk1/2 MAP-kinase pathway
    Gunther Marsche
    Medical University of Graz, Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Harrachgasse 21, A 8010 Graz, Austria
    FASEB J 21:1145-52. 2007
    ..The present study demonstrates that HOCl-modified albumin acts as a ligand for RAGE and promotes RAGE-mediated inflammatory complications...
  28. ncbi Sulfated glycosphingolipid as mediator of phagocytosis: SM4s enhances apoptotic cell clearance and modulates macrophage activity
    Zoran V Popovic
    Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
    J Immunol 179:6770-82. 2007
    ..These data suggest that SM4s within tumors may promote apoptotic cell removal and alter the phenotype of tumor-associated macrophages...
  29. ncbi Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines
    Alenka Kovacevic
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Center of Molecular Medicine, Graz, Austria
    J Cell Biochem 103:994-1004. 2008
    ....
  30. ncbi Pro-atherogenic properties of lipopolysaccharide from the periodontal pathogen Actinobacillus actinomycetemcomitans
    Laura Lakio
    Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland
    J Endotoxin Res 12:57-64. 2006
    ..The results suggest that the pro-atherogenic potential of A. actinomycetemcomitans LPS may depend on the infecting strain and correlate with the periodontopathogenic potential of the pathogen...
  31. ncbi Patterns of oxidized epitopes, but not NF-kappa B expression, change during atherogenesis in WHHL rabbits
    Jan Hinrich Bräsen
    HELIOS Klinikum Berlin, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Atherosclerosis 166:13-21. 2003
    ..Chronic stable expression and activation of NF-kappa B could be a useful target for therapeutic interventions...
  32. ncbi Trophoblast-like human choriocarcinoma cells serve as a suitable in vitro model for selective cholesteryl ester uptake from high density lipoproteins
    Christian Wadsack
    Institute of Medical Biochemistry and Molecular Biology, Karl Franzens University Graz, Austria
    Eur J Biochem 270:451-62. 2003
    ..From our findings we propose that JAr and Jeg3 cells serve as a suitable in vitro model to study selective CE-supply to human placental cells...
  33. ncbi Scavenger receptor class B, type I on non-malignant and malignant human epithelial cells mediates cholesteryl ester-uptake from high density lipoproteins
    Christian Wadsack
    Institute of Medical Biochemistry and Molecular Biology, Karl Franzens University Graz, Harrachgasse 21, A 8010, Graz, Austria
    Int J Biochem Cell Biol 35:441-54. 2003
    ..The present findings suggest that the capacity for selective cholesteryl ester-uptake from high density lipoprotein by malignant and normal epithelial cells from the liver depends on expression of the scavenger receptor class B, type I...
  34. ncbi An apparent decrease in cholesterol biosynthesis in peroxisomal-defective Chinese hamster ovary cells is related to impaired mitochondrial oxidation
    Karl Oettl
    Institute of Medical Biochemistry and Molecular Biology, Karl Franzens University Graz, Harrachgasse 21, Graz A 8010, Austria
    Biochem Biophys Res Commun 305:957-63. 2003
    ..Actually, cholesterol biosynthesis from acetate is increased in the peroxisomal-defective cells. This explains previous conflicting conclusions...
  35. ncbi Class B scavenger receptors CD36 and SR-BI are receptors for hypochlorite-modified low density lipoprotein
    Gunther Marsche
    Karl Franzens University Graz, Institute of Medical Biochemistry and Molecular Biology, Austria
    J Biol Chem 278:47562-70. 2003
    ..Experiments with Chinese hamster ovary cells overexpressing scavenger receptor class A, type I, confirmed that LDL modified at physiologically relevant HOCl concentrations is not recognized by this receptor...
  36. pmc Influence of native and hypochlorite-modified low-density lipoprotein on gene expression in human proximal tubular epithelium
    Stefan Porubsky
    Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
    Am J Pathol 164:2175-87. 2004
    ....
  37. ncbi Regulated expression of endothelial lipase by porcine brain capillary endothelial cells constituting the blood-brain barrier
    Andrea Sovic
    Institute of Molecular Biology and Biochemistry, Centre of Molecular Medicine, Medical University Graz, Austria
    J Neurochem 94:109-19. 2005
    ..In addition PPAR and LXR agonists appear to contribute to HDL homeostasis at the BBB by regulating EL expression...
  38. ncbi Generation of hypochlorite-modified proteins by neutrophils during ischemia-reperfusion injury in rat liver: attenuation by ischemic preconditioning
    Tadashi Hasegawa
    Liver Research Institute, University of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 289:G760-7. 2005
    ..Ischemic preconditioning is an effective intervention for reduction of the overall inflammatory response and, in particular, for limitation of the cytotoxic activity of neutrophils during the later reperfusion period...
  39. ncbi Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis
    Hermann Josef Grone
    Department of Cellular and Molecular Pathology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Lab Invest 82:5-14. 2002
    ....
  40. ncbi Impaired capacity of acute-phase high density lipoprotein particles to deliver cholesteryl ester to the human HUH-7 hepatoma cell line
    Andreas Artl
    Institute of Medical Biochemistry and Molecular Biology, Karl Franzens University Graz, Harrachgasse 21, A 8010 Graz, Austria
    Int J Biochem Cell Biol 34:370-81. 2002
    ..Our in vitro findings suggest that HDL and AP-HDL interact differently with cells of hepatic origin resulting in decreased hepatic cholesterol removal from the circulation during the AP reaction...