Research Topics
Genomes and GenesSpecies | B LieglSummaryAffiliation: Medical University of Graz Country: Austria Publications
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Detail Information
Publications
Immunohistochemical and mutational analysis of PDGF and PDGFR in desmoid tumours: is there a role for tyrosine kinase inhibitors in c-kit-negative desmoid tumours?B Liegl
Institute of Pathology, Medical University of Graz, Graz, Austria
Histopathology 49:576-81. 2006..Therapy with Imatinib has been proposed as a therapeutic option, although in most reports desmoid tumours are reported to be c-kit-...- Mammary and extramammary Paget's disease: an immunohistochemical study of 83 casesB Liegl
Department of Pathology, Medical University of Graz, Graz, Austria
Histopathology 50:439-47. 2007..The aim of this study was, by the use of immunohistochemistry, to derive further information about the cell(s) of origin, find a diagnostically useful immunohistochemical panel and investigate candidates for possible targeted therapy... - Androgen receptors are frequently expressed in mammary and extramammary Paget's diseaseBernadette Liegl
Department of Pathology, Medical University of Graz, Graz, Austria
Mod Pathol 18:1283-8. 2005..The knowledge about frequent expression of AR in Paget's disease could lead to the development of a new adjuvant therapy, particularly in patients with recurrent disease... - Expression of platelet-derived growth factor receptor in low-grade endometrial stromal sarcomas in the absence of activating mutationsB Liegl
Institute of Pathology, Medical University of Graz, Graz, Austria
Histopathology 50:448-52. 2007.... - p53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker of differentiated vulvar intraepithelial neoplasia (d-VIN)B Liegl
Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria
Histopathology 48:268-74. 2006..CONCLUSION: d-VIN in LS is rare, while p53 staining is common and best explained as an ischaemic stress response due to poor oxygenation, vasculitis and inflammation rather than as a marker of a precancerous lesion in LS... - Early vulvar lichen sclerosus: a histopathological challengeS Regauer
Institute of Pathology, Working Groups of Dermatopathology and Gynaecopathology and Department of Gynaecology and Obstetrics, Medical University Graz, Graz, Austria sigrid
Histopathology 47:340-7. 2005..Recognition and treatment of these early stages of LS may result in longstanding remission. Progression to atrophic stages with their associated morbidity and even to squamous cell carcinoma may be prevented... - Vasculitis in lichen sclerosus: an under recognized feature?S Regauer
Institute of Pathology, Medical University of Graz, Graz, Austria
Histopathology 45:237-44. 2004..LS is a skin disease of presumed autoimmune origin. Autoimmune diseases are mediated by lymphocytes which occasionally produce a lymphocytic vasculitis... - Malignant transformation within benign adnexal skin tumoursB Liegl
Institute of Pathology, Medical University of Graz, Graz, Austria
Histopathology 45:162-70. 2004..Therefore, patients with systemic diseases or malignancy should be carefully examined and followed for sudden changes in pre-existing benign cutaneous tumours... 
Primary cutaneous PEComa: distinctive clear cell lesions of skinBernadette Liegl
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 32:608-14. 2008..Primary cutaneous PEComas are rare and thus far apparently benign cutaneous tumors. Accurate recognition of this entity is essential because of potential misdiagnosis as malignant tumors, especially malignant melanoma...- Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumorsKatherine A Janeway
Department of Medicine, Children s Hospital Boston, MA, USA
Cancer Res 67:9084-8. 2007..KIT activation levels in pediatric KIT-wild-type GISTs are comparable with those in KIT-mutant GISTs. Therapies that inhibit KIT activation, or crucial KIT signaling intermediates, should be explored in pediatric KIT-wild-type GIST... - Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skinHaohai Liang
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Surg Pathol 31:304-10. 2007..Our results suggest that podoplanin can be a useful tool to distinguish primary skin adnexal carcinomas form adenocarcinomas metastatic to skin with high sensitivity (94.5%) and specificity (97.2%)... - p185HER2 overexpression and HER2 oncogene amplification in recurrent vulvar Paget's diseaseOlaf Reich
Department of Obstetrics and Gynecology, Medical University of Graz, Austria
Mod Pathol 18:354-7. 2005..All patients with scores 2 and 3 showed HER2 oncogene amplification. Overexpression of p185Her2 and HER2 oncogene amplification appears to be common in recurrent vulvar Paget's disease... - Microcystic/reticular schwannoma: a distinct variant with predilection for visceral locationsBernadette Liegl
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 32:1080-7. 2008..Recognition of this distinct entity is essential to avoid confusion with malignant tumors, especially in the gastrointestinal and upper respiratory tracts...