Hildegard Laggner

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Hypericin and photodynamic treatment do not interfere with transport of vitamin C during respiratory burst
    Hildegard Laggner
    Department of Medical Chemistry, Medical University of Vienna, Währinger Strasse 10, A 1090 Vienna, Austria
    Free Radic Res 38:1073-81. 2004
  2. doi request reprint Investigating the role of H₂S in 4-HNE scavenging
    Hilde Laggner
    Department of Medical Chemistry and Pathobiochemistry, Center of Pathobiochemistry and Genetics, Medical University of Vienna, Vienna, Austria Electronic address
    Methods Enzymol 555:3-18. 2015
  3. ncbi request reprint Free zinc inhibits transport of vitamin C in differentiated HL-60 cells during respiratory burst
    Hildegard Laggner
    Center of Physiology and Pathophysiology, Department of Medical Chemistry, Medical University of Vienna, Währinger Strasse 10, A 1090 Vienna, Austria
    Free Radic Biol Med 40:436-43. 2006
  4. ncbi request reprint Cholesterol efflux via HDL resecretion occurs when cholesterol transport out of the lysosome is impaired
    Tamara A Pagler
    Center for Physiology and Pathophysiology, Department of Medical Chemistry, Medical University of Vienna, A 1090, Vienna, Austria
    J Lipid Res 48:2141-50. 2007
  5. ncbi request reprint A Chinese hamster ovarian cell line imports cholesterol by high density lipoprotein degradation
    Tamara A Pagler
    Center for Physiology and Pathophysiology, Institute of Medical Chemistry, Medical University of Vienna, Währingerstrasse 10, A 1090 Vienna, Austria
    J Biol Chem 281:38159-71. 2006
  6. ncbi request reprint Redox-sensitive impairment of porcine coronary artery vasodilation by hypochlorite-modified LDL
    Christian A Plass
    Institute of Physiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Schwarzspanierstr 17, A 1090 Vienna, Austria
    Atherosclerosis 190:330-7. 2007
  7. ncbi request reprint Products of the reaction of HOCl with tryptophan protect LDL from atherogenic modification
    Stylianos Kapiotis
    Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
    Biochimie 88:785-91. 2006
  8. ncbi request reprint Intravenous iron preparations and ascorbic acid: effects on chelatable and bioavailable iron
    Brigitte Sturm
    Department of Medical Chemistry, Medical University of Vienna, Austria
    Kidney Int 67:1161-70. 2005
  9. ncbi request reprint SR-BI-mediated high density lipoprotein (HDL) endocytosis leads to HDL resecretion facilitating cholesterol efflux
    Tamara A Pagler
    Center for Physiology and Pathophysiology, Department of Medical Chemistry, Medical University of Vienna, Währingerstrasse 10, A 1090 Vienna, Austria
    J Biol Chem 281:11193-204. 2006
  10. ncbi request reprint Sulfite facilitates LDL lipid oxidation by transition metal ions: a pro-oxidant in wine?
    Hildegard Laggner
    Centre of Physiology and Pathophysiology, Department of Medical Chemistry, Medical University Vienna
    FEBS Lett 579:6486-92. 2005

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Hypericin and photodynamic treatment do not interfere with transport of vitamin C during respiratory burst
    Hildegard Laggner
    Department of Medical Chemistry, Medical University of Vienna, Währinger Strasse 10, A 1090 Vienna, Austria
    Free Radic Res 38:1073-81. 2004
    ..Results from this work indicate that ascorbate transport per se is not altered during photodynamic therapy and vitamin C does not interfere with hypericin-induced photodamage of cellular targets...
  2. doi request reprint Investigating the role of H₂S in 4-HNE scavenging
    Hilde Laggner
    Department of Medical Chemistry and Pathobiochemistry, Center of Pathobiochemistry and Genetics, Medical University of Vienna, Vienna, Austria Electronic address
    Methods Enzymol 555:3-18. 2015
    ..Assuming that the low-molecular thiol H2S may react with 4-HNE, methods to monitor the ability of H2S to counteract the protein-modifying and cytotoxic activity of 4-HNE are described in this chapter. ..
  3. ncbi request reprint Free zinc inhibits transport of vitamin C in differentiated HL-60 cells during respiratory burst
    Hildegard Laggner
    Center of Physiology and Pathophysiology, Department of Medical Chemistry, Medical University of Vienna, Währinger Strasse 10, A 1090 Vienna, Austria
    Free Radic Biol Med 40:436-43. 2006
    ..Suppression of the respiratory burst as well as inhibition of the uptake of the antioxidant vitamin C may disturb the balance between oxidative damage of invading particles and antioxidant protection in activated neutrophils...
  4. ncbi request reprint Cholesterol efflux via HDL resecretion occurs when cholesterol transport out of the lysosome is impaired
    Tamara A Pagler
    Center for Physiology and Pathophysiology, Department of Medical Chemistry, Medical University of Vienna, A 1090, Vienna, Austria
    J Lipid Res 48:2141-50. 2007
    ..Thus, [(3)H]cholesterol efflux via HDL resecretion is independent of the cholesterol uptake pathway via the LDL receptor and may be an alternative way to remove excess cholesterol...
  5. ncbi request reprint A Chinese hamster ovarian cell line imports cholesterol by high density lipoprotein degradation
    Tamara A Pagler
    Center for Physiology and Pathophysiology, Institute of Medical Chemistry, Medical University of Vienna, Währingerstrasse 10, A 1090 Vienna, Austria
    J Biol Chem 281:38159-71. 2006
    ..Thus, we demonstrate that CHO7 cells degrade HDL and LDL to supply themselves with cholesterol via a novel degradation pathway. Interestingly, HDL degradation with similar properties was also observed in a human placental cell line...
  6. ncbi request reprint Redox-sensitive impairment of porcine coronary artery vasodilation by hypochlorite-modified LDL
    Christian A Plass
    Institute of Physiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Schwarzspanierstr 17, A 1090 Vienna, Austria
    Atherosclerosis 190:330-7. 2007
    ....
  7. ncbi request reprint Products of the reaction of HOCl with tryptophan protect LDL from atherogenic modification
    Stylianos Kapiotis
    Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
    Biochimie 88:785-91. 2006
    ..We conclude that, in vivo, the activated myeloperoxidase system can generate antioxidative metabolites from tryptophan by the reaction of hypochlorite with this essential amino acid...
  8. ncbi request reprint Intravenous iron preparations and ascorbic acid: effects on chelatable and bioavailable iron
    Brigitte Sturm
    Department of Medical Chemistry, Medical University of Vienna, Austria
    Kidney Int 67:1161-70. 2005
    ..However, whether ascorbic acid directly affects stability and cellular metabolism of intravenous iron preparations (IVI) is not well understood...
  9. ncbi request reprint SR-BI-mediated high density lipoprotein (HDL) endocytosis leads to HDL resecretion facilitating cholesterol efflux
    Tamara A Pagler
    Center for Physiology and Pathophysiology, Department of Medical Chemistry, Medical University of Vienna, Währingerstrasse 10, A 1090 Vienna, Austria
    J Biol Chem 281:11193-204. 2006
    ..Finally, we present evidence that HDL retroendocytosis represents one of the pathways for cholesterol efflux...
  10. ncbi request reprint Sulfite facilitates LDL lipid oxidation by transition metal ions: a pro-oxidant in wine?
    Hildegard Laggner
    Centre of Physiology and Pathophysiology, Department of Medical Chemistry, Medical University Vienna
    FEBS Lett 579:6486-92. 2005
    ..We propose that formation of Cu(+), sulfite radicals (SO(3)*(-)) and hydroxyl radicals (OH(*)) is a mechanism by which sulfite could act as a pro-atherogenic agent in presence of transition metal ions...