Research Topics


Hildegard Laggner


Affiliation: Medical University of Vienna
Country: Austria


  1. request reprint
    Laggner H, Schmid S, Goldenberg H. Hypericin and photodynamic treatment do not interfere with transport of vitamin C during respiratory burst. Free Radic Res. 2004;38:1073-81 pubmed
    ..Results from this work indicate that ascorbate transport per se is not altered during photodynamic therapy and vitamin C does not interfere with hypericin-induced photodamage of cellular targets. ..
  2. Laggner H, Gmeiner B. Investigating the role of Hâ‚‚S in 4-HNE scavenging. Methods Enzymol. 2015;555:3-18 pubmed publisher
    ..Assuming that the low-molecular thiol H2S may react with 4-HNE, methods to monitor the ability of H2S to counteract the protein-modifying and cytotoxic activity of 4-HNE are described in this chapter. ..
  3. Lohninger L, Tomášová L, Praschberger M, Hintersteininger M, Erker T, Gmeiner B, et al. Hydrogen sulphide induces HIF-1α and Nrf2 in THP-1 macrophages. Biochimie. 2015;112:187-95 pubmed publisher
    ..Inhibition of the p38 mitogen-activated protein kinase (MAPK) reversed H2S mediated effects, suggesting that the p38 MAPK pathway may be involved in H2S induced HIF-1α/Nrf2 signalling pathways. ..
  4. Praschberger M, Hermann M, Wanner J, Jirovetz L, Exner M, Kapiotis S, et al. The uremic toxin indoxyl sulfate acts as a pro- or antioxidant on LDL oxidation. Free Radic Biol Med. 2014;75 Suppl 1:S36 pubmed publisher
    ..A scheme for the generation of tryptanthrine from IS via indoxyl radicals is proposed, which may facilitate LDL lipid oxidation. Our observations add further insight in the Janus-faced properties of this important uremic toxin. ..