Affiliation: Medical University of Vienna
- Hypericin and photodynamic treatment do not interfere with transport of vitamin C during respiratory burstHildegard Laggner
Department of Medical Chemistry, Medical University of Vienna, Währinger Strasse 10, A 1090 Vienna, Austria
Free Radic Res 38:1073-81. 2004..Results from this work indicate that ascorbate transport per se is not altered during photodynamic therapy and vitamin C does not interfere with hypericin-induced photodamage of cellular targets...
- Investigating the role of H₂S in 4-HNE scavengingHilde Laggner
Department of Medical Chemistry and Pathobiochemistry, Center of Pathobiochemistry and Genetics, Medical University of Vienna, Vienna, Austria Electronic address
Methods Enzymol 555:3-18. 2015..Assuming that the low-molecular thiol H2S may react with 4-HNE, methods to monitor the ability of H2S to counteract the protein-modifying and cytotoxic activity of 4-HNE are described in this chapter. ..
- Free zinc inhibits transport of vitamin C in differentiated HL-60 cells during respiratory burstHildegard Laggner
Center of Physiology and Pathophysiology, Department of Medical Chemistry, Medical University of Vienna, Währinger Strasse 10, A 1090 Vienna, Austria
Free Radic Biol Med 40:436-43. 2006..Suppression of the respiratory burst as well as inhibition of the uptake of the antioxidant vitamin C may disturb the balance between oxidative damage of invading particles and antioxidant protection in activated neutrophils...
- Cholesterol efflux via HDL resecretion occurs when cholesterol transport out of the lysosome is impairedTamara A Pagler
Center for Physiology and Pathophysiology, Department of Medical Chemistry, Medical University of Vienna, A 1090, Vienna, Austria
J Lipid Res 48:2141-50. 2007..Thus, [(3)H]cholesterol efflux via HDL resecretion is independent of the cholesterol uptake pathway via the LDL receptor and may be an alternative way to remove excess cholesterol...
- A Chinese hamster ovarian cell line imports cholesterol by high density lipoprotein degradationTamara A Pagler
Center for Physiology and Pathophysiology, Institute of Medical Chemistry, Medical University of Vienna, Währingerstrasse 10, A 1090 Vienna, Austria
J Biol Chem 281:38159-71. 2006..Thus, we demonstrate that CHO7 cells degrade HDL and LDL to supply themselves with cholesterol via a novel degradation pathway. Interestingly, HDL degradation with similar properties was also observed in a human placental cell line...
- Redox-sensitive impairment of porcine coronary artery vasodilation by hypochlorite-modified LDLChristian A Plass
Institute of Physiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Schwarzspanierstr 17, A 1090 Vienna, Austria
Atherosclerosis 190:330-7. 2007....
- Products of the reaction of HOCl with tryptophan protect LDL from atherogenic modificationStylianos Kapiotis
Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
Biochimie 88:785-91. 2006..We conclude that, in vivo, the activated myeloperoxidase system can generate antioxidative metabolites from tryptophan by the reaction of hypochlorite with this essential amino acid...
- Intravenous iron preparations and ascorbic acid: effects on chelatable and bioavailable ironBrigitte Sturm
Department of Medical Chemistry, Medical University of Vienna, Austria
Kidney Int 67:1161-70. 2005..However, whether ascorbic acid directly affects stability and cellular metabolism of intravenous iron preparations (IVI) is not well understood...
- SR-BI-mediated high density lipoprotein (HDL) endocytosis leads to HDL resecretion facilitating cholesterol effluxTamara A Pagler
Center for Physiology and Pathophysiology, Department of Medical Chemistry, Medical University of Vienna, Währingerstrasse 10, A 1090 Vienna, Austria
J Biol Chem 281:11193-204. 2006..Finally, we present evidence that HDL retroendocytosis represents one of the pathways for cholesterol efflux...
- Sulfite facilitates LDL lipid oxidation by transition metal ions: a pro-oxidant in wine?Hildegard Laggner
Centre of Physiology and Pathophysiology, Department of Medical Chemistry, Medical University Vienna
FEBS Lett 579:6486-92. 2005..We propose that formation of Cu(+), sulfite radicals (SO(3)*(-)) and hydroxyl radicals (OH(*)) is a mechanism by which sulfite could act as a pro-atherogenic agent in presence of transition metal ions...