P A Kyrle

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. pmc Prediction of recurrent venous thromboembolism by clot lysis time: a prospective cohort study
    Ludwig Traby
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    PLoS ONE 7:e51447. 2012
  2. doi Predicting the risk of recurrent venous thromboembolism. The Austrian study on recurrent venous thromboembolism (AUREC)
    P A Kyrle
    Department of Medicine I, Medical University of Vienna, Austria
    Hamostaseologie 33:201-9. 2013
  3. doi Clinical scores to predict recurrence risk of venous thromboembolism
    Paul A Kyrle
    Dept of Medicine I, Medical University of Vienna, Vienna, Austria
    Thromb Haemost 108:1061-4. 2012
  4. ncbi Idiopathic venous thrombosis. Long-term anticoagulant therapy? No
    P A Kyrle
    Klinik fur Innere Medizin I, Allgemeines Krankenhaus Wien, Wahringer Gurtel 18 20, 1090 Wien, Austria
    Hamostaseologie 26:52-4. 2006
  5. ncbi The optimal duration of secondary thromboprophylaxis in patients with venous thromboembolism. The importance of thrombophilia screening
    Paul Alexander Kyrle
    Division of Hematology and Hemostasis, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Wien Med Wochenschr 155:17-21. 2005
  6. ncbi The risk of recurrent venous thromboembolism in men and women
    Paul A Kyrle
    Department of Internal Medicine I, Division of Hematology and Hemostasis, Ludwig Boltzmann Institut fur Thromboseforschung, Vienna, Austria
    N Engl J Med 350:2558-63. 2004
  7. ncbi Circulating P-selectin and the risk of recurrent venous thromboembolism
    Paul A Kyrle
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    Thromb Haemost 97:880-3. 2007
  8. doi New diagnostic strategies for pulmonary embolism
    Paul A Kyrle
    Department of Medicine, Medical University of Vienna, 1090 Vienna, Austria
    Lancet 371:1312-5. 2008
  9. doi Risk assessment for recurrent venous thrombosis
    Paul Alexander Kyrle
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    Lancet 376:2032-9. 2010
  10. ncbi Deep vein thrombosis
    Paul A Kyrle
    Medical University of Vienna, Department of Internal Medicine I, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Lancet 365:1163-74. 2005

Collaborators

Detail Information

Publications36

  1. pmc Prediction of recurrent venous thromboembolism by clot lysis time: a prospective cohort study
    Ludwig Traby
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    PLoS ONE 7:e51447. 2012
    ..No association between CLT and recurrence risk was found in men. Hypofibrinolysis as assessed by CLT confers a moderate increase in the risk of recurrent VTE. A weak association between CLT and risk of recurrence was found in women only...
  2. doi Predicting the risk of recurrent venous thromboembolism. The Austrian study on recurrent venous thromboembolism (AUREC)
    P A Kyrle
    Department of Medicine I, Medical University of Vienna, Austria
    Hamostaseologie 33:201-9. 2013
    ..This article describes strategies to distinguish between patients with high risk of recurrent VTE from those with a lower risk, who might not benefit from long-term antithrombotic therapy. ..
  3. doi Clinical scores to predict recurrence risk of venous thromboembolism
    Paul A Kyrle
    Dept of Medicine I, Medical University of Vienna, Vienna, Austria
    Thromb Haemost 108:1061-4. 2012
    ..The aim of this report is to describe currently available scoring systems in more detail...
  4. ncbi Idiopathic venous thrombosis. Long-term anticoagulant therapy? No
    P A Kyrle
    Klinik fur Innere Medizin I, Allgemeines Krankenhaus Wien, Wahringer Gurtel 18 20, 1090 Wien, Austria
    Hamostaseologie 26:52-4. 2006
    ..Thus, patients with antithrombin deficiency, combined or homozygous defects, more than one unprovoked episode of thrombosis, the lupus anticoagulant or high factor VIII plasma levels are good candidates for long-term prevention...
  5. ncbi The optimal duration of secondary thromboprophylaxis in patients with venous thromboembolism. The importance of thrombophilia screening
    Paul Alexander Kyrle
    Division of Hematology and Hemostasis, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Wien Med Wochenschr 155:17-21. 2005
    ..The clinical relevance of new treatment strategies such as extended low-intensity warfarin or administration of the direct thrombin inhibitor (xi-)melagatran is at present unclear...
  6. ncbi The risk of recurrent venous thromboembolism in men and women
    Paul A Kyrle
    Department of Internal Medicine I, Division of Hematology and Hemostasis, Ludwig Boltzmann Institut fur Thromboseforschung, Vienna, Austria
    N Engl J Med 350:2558-63. 2004
    ..Whether a patient's sex is associated with the risk of recurrent venous thromboembolism is unknown...
  7. ncbi Circulating P-selectin and the risk of recurrent venous thromboembolism
    Paul A Kyrle
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    Thromb Haemost 97:880-3. 2007
    ..7-fold (95% CI 1.0-2.9, p = 0.045) increased among patients with P-selectin levels exceeding the 75(th) percentile. We conclude that high circulating P-selectin is a risk factor of recurrent VTE...
  8. doi New diagnostic strategies for pulmonary embolism
    Paul A Kyrle
    Department of Medicine, Medical University of Vienna, 1090 Vienna, Austria
    Lancet 371:1312-5. 2008
  9. doi Risk assessment for recurrent venous thrombosis
    Paul Alexander Kyrle
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    Lancet 376:2032-9. 2010
    ..Analysis of preliminary data suggests that risk assessment can also be refined through integration of prothrombotic coagulation changes and clinical risk factors...
  10. ncbi Deep vein thrombosis
    Paul A Kyrle
    Medical University of Vienna, Department of Internal Medicine I, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Lancet 365:1163-74. 2005
    ..Women seem to have a lower thrombosis risk than men, but pregnancy or use of oral contraceptives or hormone replacement therapy represent important risk factors...
  11. ncbi High plasma levels of factor VIII and the risk of recurrent venous thromboembolism
    P A Kyrle
    Department of Internal Medicine I, Vienna University Hospital, Austria
    N Engl J Med 343:457-62. 2000
    ..We evaluated the risk of a recurrence of thrombosis after an initial episode of spontaneous venous thromboembolism among patients with high plasma levels of factor VIII...
  12. ncbi Risk of pregnancy-associated recurrent venous thromboembolism in women with a history of venous thrombosis
    I Pabinger
    Department of Internal Medicine I, Division of Haematology and Blood Coagulation, Medical University, Vienna, Austria
    J Thromb Haemost 3:949-54. 2005
    ..Objective: To evaluate the risk of recurrent pregnancy-associated thrombosis in women with previous VTE in a large retrospective cohort study...
  13. ncbi The post-thrombotic syndrome: risk factors and impact on the course of thrombotic disease
    M Stain
    Division of Hematology and Hemostasis, Department of Internal Medicine I, Vienna, Austria
    J Thromb Haemost 3:2671-6. 2005
    ..The post-thrombotic syndrome (PTS) is a frequent complication of deep vein thrombosis (DVT). Patients with recurrent ipsilateral DVT have an increased risk of PTS; other risk factors are unknown...
  14. doi 6 versus 30 months anticoagulation for recurrent venous thrombosis in patients with high factor VIII
    L Eischer
    Department of Internal Medicine I, Medical University of Vienna, Austria
    Ann Hematol 88:485-90. 2009
    ..Our findings in a small number of patients indicate that prolonged anticoagulation seems to be effective but that the benefit is not maintained after discontinuation of anticoagulation...
  15. ncbi Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V Leiden
    S Eichinger
    Department of Internal Medicine I, University Vienna, Austria
    Thromb Haemost 82:1232-6. 1999
    ..Higher levels of D-Dimer in women with FVL than in women with wildtype factor V at baseline as well as during pregnancy indicate increased fibrinolytic system activation in carriers of the mutation...
  16. ncbi Impact of the factor II: G20210A variant on the risk of venous thromboembolism in relatives from families with the factor V: R506Q mutation
    C Rintelen
    University of Vienna Medical School, First Department of Medicine, Division of Hematology and Blood Coagulation, Vienna, Austria
    Eur J Haematol 67:165-9. 2001
    ..The aim of this study was to investigate the impact of the coinheritance of both mutations on the risk of VTE in relatives of symptomatic carriers of the factor V: R506Q mutation and the factor II: G20210A variant...
  17. ncbi Comparison between idiopathic deep vein thrombosis of the upper and lower extremity regarding risk factors and recurrence
    D Lechner
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    J Thromb Haemost 6:1269-74. 2008
    ..The pathogenesis and natural course of idiopathic upper extremity deep vein thrombosis (UEDVT) are unclear...
  18. doi Thrombin generation in haemophilia A patients with factor VIII inhibitors after infusion of recombinant factor VIIa
    S Eichinger
    Department of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Eur J Clin Invest 39:707-13. 2009
    ..Development of factor VIII inhibitors is a serious complication in haemophilia A patients. Recombinant factor VIIa (rVIIa) is clinically effective, but its effects on haemostatic system need still to be fully elucidated...
  19. ncbi Prediction of recurrent venous thromboembolism by the activated partial thromboplastin time
    G Hron
    Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    J Thromb Haemost 4:752-6. 2006
    ..Venous thromboembolism (VTE) is a multi-factorial disease. Extensive thrombophilia screening is costly and often inconclusive. Simple laboratory methods are required to predict the risk of recurrence...
  20. ncbi The risk of recurrent venous thromboembolism among patients with high factor IX levels
    A Weltermann
    Department of Internal Medicine I, Division of Hematology and Hemostasis, Vienna University Hospital, Vienna, Austria
    J Thromb Haemost 1:28-32. 2003
    ..6 among patients with high FIX and high FVIII. High levels of FIX confer an increased risk of recurrent venous thromboembolism and enhance the risk of recurrence among patients with high FVIII...
  21. ncbi Duration of anticoagulation after initial idiopathic venous thrombosis--the swinging pendulum: risk assessment to predict recurrence
    S Eichinger
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    J Thromb Haemost 7:291-5. 2009
    ..Reproducible and simple scoring systems may improve stratification of patients according to their recurrence risk and optimize duration of anticoagulant therapy...
  22. ncbi The risk of recurrent venous thromboembolism
    P A Kyrle
    Department of Internal Medicine I, Division of Hematology and Hemostasis, Ludwig Boltzmann Institute for Thrombosis Research, Vienna University Hospital, Vienna, Austria
    Vasa 31:163-6. 2002
    ..In these patients short-term secondary thromboprophylaxis (6 to 12 weeks) is justified whereas patients with a first episode of spontaneous VTE should be treated with oral anticoagulants for a longer period of time (3 to 6 months)...
  23. doi The influence of thrombophilia on the long-term survival of patients with a history of venous thromboembolism
    Sylvia Reitter-Pfoertner
    Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Waehringerguertel 18 20, A 1090 Vienna, Austria
    Thromb Haemost 109:79-84. 2013
    ..However, hyperhomocysteinaemia, known as a risk factor for recurrent VTE and arterial disease, might impact survival...
  24. ncbi Efficacy and safety of splenectomy in adult chronic immune thrombocytopenia
    C Zoghlami-Rintelen
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, University Hospital of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Ann Hematol 82:290-4. 2003
    ..Patients aged >45 years had a similar success rate as compared with younger patients. Three patients had infections (one pneumonia and two fever of unknown origin) requiring hospitalization, but none had overwhelming septicemia...
  25. ncbi Prevention of deep vein thrombosis in orthopedic surgery
    Sabine Eichinger
    Dept of Internal Medicine I, Div of Hematology and Hemostasis, Medical University of Vienna, Austria
    Eur J Med Res 9:112-8. 2004
    ..g., an increased bleeding risk) and high costs the role of these new drugs in the prophylaxis of VTE in patients undergoing major orthopedic surgery of the lower extremities remains to be established...
  26. ncbi Symptomatic pulmonary embolism and the risk of recurrent venous thromboembolism
    Sabine Eichinger
    Division of Hematology and Hemostasis, Department of Internal Medicine I, University of Vienna, Vienna, Austria
    Arch Intern Med 164:92-6. 2004
    ..We therefore investigated the risk of recurrence among patients with spontaneous symptomatic PE and among those with deep vein thrombosis (DVT) without symptoms of PE...
  27. ncbi Unilateral chronic thromboembolic pulmonary disease associated with combined inherited thrombophilia
    Klaus Laczika
    Intensive Care Unit, the Department of Internal Medicine I, Vienna University Hospital, Vienna, Austria
    Chest 121:286-9. 2002
    ..This case is unique because unilateral CTEPH is extremely uncommon, and it illustrates the severe clinical sequelae of the cosegregation of inherited thrombophilic defects...
  28. ncbi Family history for venous thromboembolism and the risk for recurrence
    Gregor Hron
    Department of Internal Medicine I, Division of Angiology, Medical University of Vienna, Vienna, Austria
    Am J Med 119:50-3. 2006
    ..The relevance of a family history for venous thromboembolism with regard to the likelihood for recurrence is unknown...
  29. ncbi The risk of recurrence in women with venous thromboembolism while using estrogens: a prospective cohort study
    L Eischer
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    J Thromb Haemost 12:635-40. 2014
    ..The optimal duration of anticoagulation for women who had venous thromboembolism (VTE) associated with estrogen use is unknown...
  30. pmc Dabigatran in patients with atrial fibrillation: perioperative and periinterventional management
    A Weltermann
    Department of Medicine I, Elisabethinen Hospital Linz, Fadinger Straße 1, 4020, Linz, Austria
    Wien Klin Wochenschr 124:340-7. 2012
    ....
  31. ncbi Pregnancy-associated risk for venous thromboembolism and pregnancy outcome in women homozygous for factor V Leiden
    I Pabinger
    I Department of Internal Medicine, Division of Hematology Blood Coagulation, University Hospital, Vienna, Austria
    Hematol J 1:37-41. 2000
    ....
  32. doi Mechanisms underlying acquired von Willebrand syndrome associated with an IgM paraprotein
    M Mayerhofer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 39:833-6. 2009
    ..The patient required surgery and was successfully managed by chemotherapy consisting of rituximab and fludarabin as well as plasma exchange...
  33. ncbi Chemotherapy-induced thrombin generation via procoagulant endothelial microparticles is independent of tissue factor activity
    D Lechner
    Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    J Thromb Haemost 5:2445-52. 2007
    ..Cisplatin-based chemotherapy predisposes cancer patients to thromboembolic events...
  34. ncbi The risk of recurrent venous thromboembolism: the Austrian Study on Recurrent Venous Thromboembolism
    Paul Alexander Kyrle
    Division of Hematology and Hemostasis, Ludwig Boltzmann Institute for Thrombosis Research, Department of Internal Medicine I, Vienna University Hospital, Vienna, Austria
    Wien Klin Wochenschr 115:471-4. 2003
    ....
  35. ncbi Mortality in severe, non aggressively treated adult autoimmune thrombocytopenia
    Thomas Sailer
    Department of Medicine I, Division of Hematology and Blood Coagulation, University of Vienna, Austria
    Hematol J 4:366-9. 2003
    ..These data show that AITP is a relatively benign disease that does not require aggressive treatment. Bleeding can be prevented if the platelet count can be kept above 10,000 microL...
  36. ncbi The course of severe autoimmune thrombocytopenia in patients not undergoing splenectomy
    Thomas Sailer
    Department of Internal Medicine I, Division Haematology and Haemostaseology, Medical University of Vienna, 1090 Vienna, Währingergürtel 18 20, Austria
    Haematologica 91:1041-5. 2006
    ..There is no consensus on the indications and optimal timing of splenectomy, since it is unknown up to which time from onset of symptoms a remission can be expected without splenectomy...