G G Kovacs

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. ncbi request reprint The prion protein in human neurodegenerative disorders
    Gabor G Kovacs
    Institute of Neurology, University of Vienna, and Austrian Reference Centre for Human Prion Diseases, AKH 4J, Wahringer Gurtel 18 20, PO Box 48, A 1097 Vienna, Austria
    Neurosci Lett 329:269-72. 2002
  2. ncbi request reprint Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders
    Gabor G Kovacs
    Institute of Neurology, University of Vienna, Austria
    Neuroreport 14:73-6. 2003
  3. ncbi request reprint Involvement of the endosomal-lysosomal system correlates with regional pathology in Creutzfeldt-Jakob disease
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, and Austrian Reference Center for Human Prion Diseases, Vienna, Austria
    J Neuropathol Exp Neurol 66:628-36. 2007
  4. pmc White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    J Neuropathol Exp Neurol 67:963-75. 2008
  5. doi request reprint Genetic Creutzfeldt-Jakob disease associated with the E200K mutation: characterization of a complex proteinopathy
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, and Austrian Reference Center for Human Prion Diseases, AKH 4J, Wahringer Gurtel 18 20, 1097, Vienna, Austria
    Acta Neuropathol 121:39-57. 2011
  6. doi request reprint Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread
    Gabor G Kovacs
    Institute of Neurology, Medical University Vienna, Austria Electronic address
    Neurobiol Dis 69:76-92. 2014
  7. ncbi request reprint Linking pathways in the developing and aging brain with neurodegeneration
    G G Kovacs
    Institute of Neurology, Medical University of Vienna, Austria Electronic address
    Neuroscience 269:152-72. 2014
  8. pmc Developmental patterns of DR6 in normal human hippocampus and in Down syndrome
    Anand Iyer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, AZ 1105, The Netherlands
    J Neurodev Disord 5:10. 2013
  9. doi request reprint Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series
    Gabor G Kovacs
    Institute of Neurology, Medical University Vienna, AKH 4J, Wahringer Gurtel 18 20, 1097, Vienna, Austria
    Acta Neuropathol 126:365-84. 2013
  10. doi request reprint An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, AKH 4 J, Wahringer Gurtel 18 20, 1097, Vienna, Austria
    Acta Neuropathol 124:37-50. 2012

Detail Information

Publications33

  1. ncbi request reprint The prion protein in human neurodegenerative disorders
    Gabor G Kovacs
    Institute of Neurology, University of Vienna, and Austrian Reference Centre for Human Prion Diseases, AKH 4J, Wahringer Gurtel 18 20, PO Box 48, A 1097 Vienna, Austria
    Neurosci Lett 329:269-72. 2002
    ..Our results suggest that expression of PrP(C) reflects a general response to cellular stress rather than specific co-operation in aggregation of other proteins...
  2. ncbi request reprint Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders
    Gabor G Kovacs
    Institute of Neurology, University of Vienna, Austria
    Neuroreport 14:73-6. 2003
    ..Cytoskeletal pathology was present in the NCS and NROP to a variable degree. We conclude that there is disease- and nucleus-specific alteration of serotonin synthesis in the raphe...
  3. ncbi request reprint Involvement of the endosomal-lysosomal system correlates with regional pathology in Creutzfeldt-Jakob disease
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, and Austrian Reference Center for Human Prion Diseases, Vienna, Austria
    J Neuropathol Exp Neurol 66:628-36. 2007
    ..Our results indicate that effects in the ELS correlate with regional pathology. Overloading of this system might impair the function of lysosomal enzymes and thus may mimic some features of lysosomal storage disorders...
  4. pmc White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    J Neuropathol Exp Neurol 67:963-75. 2008
    ..This type of tauopathy with GGIs expands the group of neurodegenerativedisorders in which oligodendroglial pathology predominates, beyond the synucleinopathy multiple system atrophy disorders...
  5. doi request reprint Genetic Creutzfeldt-Jakob disease associated with the E200K mutation: characterization of a complex proteinopathy
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, and Austrian Reference Center for Human Prion Diseases, AKH 4J, Wahringer Gurtel 18 20, 1097, Vienna, Austria
    Acta Neuropathol 121:39-57. 2011
    ....
  6. doi request reprint Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread
    Gabor G Kovacs
    Institute of Neurology, Medical University Vienna, Austria Electronic address
    Neurobiol Dis 69:76-92. 2014
    ....
  7. ncbi request reprint Linking pathways in the developing and aging brain with neurodegeneration
    G G Kovacs
    Institute of Neurology, Medical University of Vienna, Austria Electronic address
    Neuroscience 269:152-72. 2014
    ....
  8. pmc Developmental patterns of DR6 in normal human hippocampus and in Down syndrome
    Anand Iyer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, AZ 1105, The Netherlands
    J Neurodev Disord 5:10. 2013
    ....
  9. doi request reprint Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series
    Gabor G Kovacs
    Institute of Neurology, Medical University Vienna, AKH 4J, Wahringer Gurtel 18 20, 1097, Vienna, Austria
    Acta Neuropathol 126:365-84. 2013
    ..This should be considered in diagnostic evaluation of biomarkers, and for better clinical stratification of patients...
  10. doi request reprint An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, AKH 4 J, Wahringer Gurtel 18 20, 1097, Vienna, Austria
    Acta Neuropathol 124:37-50. 2012
    ..In summary, the 5G4 antibody is most promising for re-evaluation of archival material and may offer new perspective for the development of in vivo diagnostic assays for detecting disease-associated α-synuclein in body fluids...
  11. pmc Clinical neuropathology practice news 3-2012: the "ABC" in AD-revised and updated guideline for the neuropathologic assessment of Alzheimer's disease
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    Clin Neuropathol 31:116-8. 2012
    ..Continued studies will have to assess the added value of the new approach and the influence of interlaboratory and/or methodological differences on the implementation of these new recommendations...
  12. pmc FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases
    Robert Rusina
    Department of Neurology, Thomayer Teaching Hospital and Institute for Postgraduate Education in Medicine, Prague, Czech Republic
    BMC Neurol 11:50. 2011
    ....
  13. pmc Cathepsin D SNP associated with increased risk of variant Creutzfeldt-Jakob disease
    Matthew T Bishop
    National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    BMC Med Genet 9:31. 2008
    ..This study looked at a polymorphism in the cathepsin D gene (refSNP ID: rs17571) previously examined in Alzheimer's disease (AD)...
  14. doi request reprint Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, AKH 4J, Wahringer Gurtel 18 20, 1097 Vienna, Austria
    Acta Neuropathol 119:389-408. 2010
    ....
  15. ncbi request reprint Current concepts of neuropathological diagnostics in practice: neurodegenerative diseases
    G G Kovacs
    Institute of Neurology, Medical University of Vienna, Austria
    Clin Neuropathol 29:271-88. 2010
    ....
  16. ncbi request reprint Unclassifiable tauopathy associated with an A152T variation in MAPT exon 7
    G G Kovacs
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    Clin Neuropathol 30:3-10. 2011
    ..Our observation of an apparently familial disorder with a novel neuropathological phenotype suggests a possible pathogenic role of this MAPT gene variation, which might be different from mutations affecting the microtubule binding...
  17. ncbi request reprint [Frequency of different forms of dementia at the Department of Neuropathology of the Hungarian National Institute of Psychiatry and Neurology during a 3-year period]
    Gábor Géza Kovács
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    Ideggyogy Sz 61:24-32. 2008
    ..Only neuropathologic examination gives definite diagnosis. Differences in the reported frequency may be related to factors such as the age or gender of subjects with dementia...
  18. doi request reprint A peculiar constellation of tau pathology defines a subset of dementia in the elderly
    Gabor G Kovacs
    Institute of Neurology, Medical University Vienna, Austria
    Acta Neuropathol 122:205-22. 2011
    ..These complex tauopathies in the elderly deserve specific diagnostic and eventually therapeutic considerations...
  19. ncbi request reprint Beta-CIT SPECT demonstrates reduced availability of serotonin transporters in patients with Fatal Familial Insomnia
    S Kloppel
    Institute of Neurology, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Neural Transm 109:1105-10. 2002
    ..In this study we demonstrate a reduced availability of serotonin transporters of 57% and 73% respectively in a thalamus-hypothalamus region of two FFI patients examined with beta-CIT SPECT as compared to age-expected control values...
  20. ncbi request reprint Serotonergic nuclei of the raphe are not affected in human ageing
    S Kloppel
    Institute of Neurology, University of Vienna, Austria
    Neuroreport 12:669-71. 2001
    ..We found no significant difference between age groups in the percentage of neurons able to synthesize serotonin. Other changes might relate to sleep disturbances in the elderly...
  21. ncbi request reprint MAPT S305I mutation: implications for argyrophilic grain disease
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    Acta Neuropathol 116:103-18. 2008
    ....
  22. ncbi request reprint Distribution of intraneuronal immunoreactivity for the prion protein in human prion diseases
    Gabor G Kovacs
    Institute of Neurology, University of Vienna, AKH 4J, Wahringer Gurtel 18 20, POB 48, 1097 Vienna, Austria
    Acta Neuropathol 104:320-6. 2002
    ..The up-regulation of PrP might represent an early loss of function of the non-pathological form of PrP, in parallel with a neurotoxic effect of accumulating disease-associated isoform, as part of the pathogenesis of prion diseases...
  23. ncbi request reprint Distinctive cerebellar immunoreactivity for the prion protein in familial (E200K) Creutzfeldt-Jakob disease
    Christa Jarius
    Institute of Neurology, University of Vienna, AKH 4J, Wahringer Gurtel 18 20, POB 48, 1097 Vienna, Austria
    Acta Neuropathol 105:449-54. 2003
    ....
  24. ncbi request reprint Complement activation in human prion disease
    Gabor G Kovacs
    Institute of Neurology, University of Vienna, Vienna, Austria
    Neurobiol Dis 15:21-8. 2004
    ..The neuronal localization of the membrane attack complex correlates well with the severity of disease-specific pathology and TUNEL labeling of neurons, irrespective of genotype or molecular phenotype of human prion diseases...
  25. ncbi request reprint Prion disease with a 144 base pair insertion: unusual cerebellar prion protein immunoreactivity
    Ellen Gelpi
    Institute of Neurology, Medical University of Vienna, Austria
    Acta Neuropathol 110:513-9. 2005
    ..It also widens the phenotypic spectrum of prion diseases. The phenotypic variability within the same mutation suggests further, yet uncharacterized, genetic or epigenetic influence on phenotype in these diseases...
  26. ncbi request reprint Genetic prion disease: the EUROCJD experience
    Gabor G Kovacs
    Austrian Reference Centre for Human Prion Diseases OERPE, Vienna, Austria
    Hum Genet 118:166-74. 2005
    ..Application of genetic screening in clinical practice has the advantage of early diagnosis and may lead to the identification of a risk of a TSE...
  27. ncbi request reprint Clinicopathological variability in neurodegeneration with brain iron accumulation
    András Vincze
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    Ideggyogy Sz 63:129-35. 2010
    ..Since NBIA shows similarities with other neurodegenerative disorders, genetic examination may be essential in the diagnosis of this disease, however, cranial MRI together with the clinical picture may be highly indicative of NBIA...
  28. pmc Prion diseases: from protein to cell pathology
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, AKH 4J, Waehringer Guertel 18 20, POB 48, 1097 Vienna, Austria
    Am J Pathol 172:555-65. 2008
    ..Tissue damage may result from several parallel, interacting, or subsequent pathways. Future studies should clarify the trigger(s) and sequence of these processes and whether, and which, one is dominating or decisive...
  29. doi request reprint Mixed brain pathologies in dementia: the BrainNet Europe consortium experience
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    Dement Geriatr Cogn Disord 26:343-50. 2008
    ..Dementia results from heterogeneous diseases of the brain. Mixed disease forms are increasingly recognized...
  30. doi request reprint Distribution of apoptosis-related proteins in sporadic Creutzfeldt-Jakob disease
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, and Austrian Reference Centre for Human Prion Diseases, Vienna, Austria
    Brain Res 1323:192-9. 2010
    ....
  31. doi request reprint Increased neuronal Rab5 immunoreactive endosomes do not colocalize with TDP-43 in motor neuron disease
    Radoslav Matej
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    Exp Neurol 225:133-9. 2010
    ..These data contrast with observations on neuronal cytopathology in Alzheimer's or prion diseases where the disease-specific proteins are processed within endosomes, and suggest a distinct role of the ELS in MND...
  32. doi request reprint TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    Mov Disord 24:1843-7. 2009
    ..This is the first report of a TARDBP variation associated with a neurodegenerative syndrome other than ALS...