Research Topics
Genomes and Genes
| Sylvia KnappSummaryAffiliation: Medical University of Vienna Country: Austria Publications
| Collaborators
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Detail Information
Publications
Diabetes and infection: is there a link?--A mini-reviewSylvia Knapp
Center for Molecular Medicine of the Austrian Academy of Sciences, and Division of Infectious Diseases and Tropical Medicine, Department of Medicine 1, Medical University of Vienna, Vienna, Austria
Gerontology 59:99-104. 2013....- Update on the role of Toll-like receptors during bacterial infections and sepsisSylvia Knapp
Center for Molecular Medicine of the Austrian Academy of Sciences CeMM and Division of Infectious Diseases and Tropical Medicine, Department of Medicine 1, Medical University of Vienna, Vienna, Austria
Wien Med Wochenschr 160:107-11. 2010..This brief review summarizes the impact of selected TLRs in the host response to clinically important bacteria and provides insights into TLR-associated therapeutic approaches during sepsis and inflammation... 
Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptorSylvia Knapp
Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 180:3478-84. 2008....- Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivoSylvia Knapp
Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 178:993-1001. 2007..These data suggest that oxidized phospholipids such as produced during inflammatory reactions may contribute to mortality during Gram-negative sepsis in vivo via impairment of the phagocytic properties of professional phagocytes... - Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivoSylvia Knapp
Laboratory of Experimental Internal Medicine, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 176:3189-95. 2006..This newly identified function of pulmonary LBP might prove beneficial by enabling a protective immune response to low LPS doses while preventing an overwhelming, potentially harmful immune response to higher doses of LPS... - Pneumonia models and innate immunity to respiratory bacterial pathogensSylvia Knapp
Department of Internal Medicine, Medical University, Department of Intensive Care, University of Amsterdam, 1105AZ Amsterdam, The Netherlands
Shock 24:12-8. 2005..In this review, we will give insights into pneumonia models and discuss results and differences in the innate immune responses during distinct pulmonary infection models... - Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumoniaGernot Schabbauer
Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Austrian Academy of Sciences, Vienna, Austria
J Immunol 185:468-76. 2010.... - LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumoniaJudith Branger
Department of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
Int Immunol 16:1605-11. 2004..These data suggest that LBP is important for a protective immune response in Klebsiella pneumonia, but does not contribute to an effective host response in pneumococcal pneumonia... - CD14 facilitates invasive respiratory tract infection by Streptococcus pneumoniaeMark C Dessing
Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Am J Respir Crit Care Med 175:604-11. 2007..Knowledge of the contribution of CD14 to host defense against gram-positive infections is limited... - Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2Catharina W Wieland
Laboratory of Experimental Internal Medicine, Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Am J Respir Crit Care Med 170:1367-74. 2004..These data indicate that TLR2 is the signaling receptor for purified AraLAM in the lung in vivo and that this receptor contributes to an effective clearance of M. smegmatis from the pulmonary compartment... - Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defenseSylvia Knapp
Laboratory of Experimental Internal Medicine, Department of Pathology, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 172:3132-8. 2004..These data suggest that TLR2 plays a limited role in the innate immune response to pneumococcal pneumonia, and that additional pattern recognition receptors likely are involved in host defense against this common respiratory pathogen... - The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii PneumoniaRosemarijn Renckens
Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Infect Dis 193:187-95. 2006..Acinetobacter baumannii is an emerging pathogen in nosocomial pneumonia. Trauma and postsurgical patients display a profound acute-phase protein response and are susceptible to pneumonia... - Aspiration pneumonitis primes the host for an exaggerated inflammatory response during pneumoniaDavid J van Westerloo
Divisions of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Crit Care Med 33:1770-8. 2005.... - Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumoniaSylvia Knapp
Laboratory of Experimental Internal Medicine Academic Medical Center, University of Amsterdam, Meibergdreef 9, G2 132, 1105 AZ Amsterdam, The Netherlands
Am J Respir Crit Care Med 173:122-9. 2006..baumannii infection have not been elucidated... - Bbeta(15-42) protects against acid-induced acute lung injury and secondary pseudomonas pneumonia in vivoUlrich Matt
Research Center for Molecular Medicine of the Austrian Academy of Sciences CeMM, Vienna, Austria
Am J Respir Crit Care Med 180:1208-17. 2009..The fibrin-derived peptide Bbeta(15-42) was shown to preserve endothelial barriers, thereby reducing vascular leak. The potential therapeutic role of Bbeta(15-42) in ALI has not been addressed so far... 
Lipopolysaccharide binding protein is an essential component of the innate immune response to Escherichia coli peritonitis in miceSylvia Knapp
Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
Infect Immun 71:6747-53. 2003..Locally produced LBP is an essential component of an effective innate immune response to E. coli peritonitis...- Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in miceJudith Branger
Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
Infect Immun 72:788-94. 2004..These data suggest that TLR4 contributes to a protective immune response in both pneumococcal and Klebsiella pneumonia and that its role is more important in respiratory tract infection caused by the latter (gram-negative) pathogen... - TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumoniaHeimo Lagler
Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University Vienna, Vienna, Austria
J Immunol 183:2027-36. 2009.... - Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipidsElena von Schlieffen
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
Arterioscler Thromb Vasc Biol 29:356-62. 2009..Molecular mechanisms of their effects are largely unknown. Here we present novel information on the mechanisms whereby OxPLs modulate activation of TLR4 by lipopolysaccharide (LPS)... - Activation of neutrophils and inhibition of the proinflammatory cytokine response by endogenous granulocyte colony-stimulating factor in murine pneumococcal pneumoniaSylvia Knapp
Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Infect Dis 189:1506-15. 2004..During pneumococcal pneumonia, G-CSF is produced locally at the site of the infection, where it exerts both pro- and anti-inflammatory effects... - TLR 2 and CD14 mediate innate immunity and lung inflammation to staphylococcal Panton-Valentine leukocidin in vivoAna Zivkovic
Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
J Immunol 186:1608-17. 2011..These results highlight the proinflammatory properties of PVL and identify CD14/TLR2 as an essential receptor complex for PVL-induced lung inflammation... - Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumoniaSylvia Knapp
Laboratory of Experimental Internal Medicine, Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
Am J Respir Crit Care Med 167:171-9. 2003..These data suggest that AMs are indispensable in the host response to pneumococcal pneumonia by means of their capacity to modulate inflammation, possibly via elimination of apoptotic PMNs... - Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosaMarc J Schultz
Laboratory of Experimental Internal Medicine, Department of Intensive Care Medicine, C3 326, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Infect Immun 71:1630-4. 2003..These results demonstrate that the presence of endogenous IL-18 activity facilitates inflammatory responses in the lung during Pseudomonas pneumonia, concurrently impairing bacterial clearance... - Apolipoprotein B100 is a suppressor of Staphylococcus aureus-induced innate immune responses in humans and miceStefanie Sigel
Research Center for Molecular Medicine of Austrian Academy of Sciences, Vienna, Austria
Eur J Immunol 42:2983-9. 2012..aureus in vivo. The present study identifies ApoB100 as an important suppressor of innate immune activation in response to S. aureus and its LTA... - Peptide Bbeta(15-42) preserves endothelial barrier function in shockMarion Groger
Department of Dermatology, Medical University Vienna, Vienna, Austria
PLoS ONE 4:e5391. 2009..It stabilizes endothelial barriers and thus could be an attractive adjuvant in the treatment of shock... - Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemiaSylvia Knapp
Laboratory of Experimental Internal Medicine, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 173:7131-4. 2004..Inhibitor studies disclosed a PI3K-dependent pathway in LPS-induced up-regulation of TREM-1 on monocytes, whereas MAPK played a limited role... - The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subsetNicole Boucheron
Division of Immunobiology, Institute of Immunology, Medical University of Vienna, Vienna, Austria
J Immunol 185:5111-9. 2010..pneumoniae. Taken together, our data indicated a critical role for Tec in T cell-intrinsic signaling pathways that regulate the in vivo generation of CD44(high)CD62L(-) effector/memory Th17 populations... - Anti-inflammatory properties of the PI3K pathway are mediated by IL-10/DUSP regulationPhilipp Günzl
Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
J Leukoc Biol 88:1259-69. 2010..Our data suggest that differential DUSP1 regulation coupled with enhanced IL-10 production contributes to the anti-inflammatory properties of the PI3K pathway... - Advances in research of the inflammatory response: the importance of toll-like receptorsSylvia Knapp
Laboratory of Experimental Internal Medicine, Academic Medical Centre, Room G2 108, University of Amsterdam, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
Wien Med Wochenschr 152:552-4. 2002.... - Tyrosine kinase 2 controls IL-1ß production at the translational levelMarta Radwan
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria
J Immunol 185:3544-53. 2010..Enhanced IL-1beta production in Tyk2- and IFN receptor 1-deficient macrophages is also observed following Listeria monocytogenes infection. Taken together, the data describe a novel mechanism for the control of IL-1beta synthesis... - Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protectionNina Gratz
Max F Perutz Laboratories, Department of Microbiology, Immunobiology and Genetics, University of Vienna, Vienna, Austria
PLoS Pathog 7:e1001345. 2011..These results demonstrate that the innate immune system employs several strategies to efficiently recognize S. pyogenes, a pathogenic bacterium that succeeded in avoiding recognition by the standard arsenal of TLRs... - From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infectionOmar Sharif
Center for Molecular Medicine CeMM of the Austrian Academy of Sciences, Medical University Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
Immunobiology 213:701-13. 2008..Here, we discuss the current state of the literature on TREMs, with a focus on TREM-1 and TREM-2 and their expression, signaling in mononuclear phagocytes and roles in innate immunity and bacterial infection... - Lipoteichoic acid from Staphylococcus aureus is a potent stimulus for neutrophil recruitmentSonja von Aulock
Biochemical Pharmacology, University of Konstanz, 78457 Konstanz, Germany
Immunobiology 208:413-22. 2003..aureus of the same strain. LTA does not appear to activate neutrophils directly, but is a strong stimulus for the recruitment of phagocytes to the site of infection... - Bedside exclusion of clinically significant recirculation volume during venovenous ECMO using conventional blood gas analysesGottfried J Locker
Department of Internal Medicine I, Intensive Care Unit, University Hospital of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
J Clin Anesth 15:441-5. 2003..To investigate prospectively whether blood gas samples drawn from extracorporeal membrane oxygenation (ECMO) cannulae help to exclude at least clinically significant recirculation volumes in patients with acute respiratory failure...