Walter Klepetko

..Therefore, the aim of this study was to evaluate systolic pulmonary artery pressures (PASPs) at rest and during supine bicycle exercise, exercise capacity and cardiopulmonary function in post-BLTx patients...

..The survival rate during the first five years after transplantation for PAH is intermediate among the lung diseases, lower than chronic obstructive pulmonary disease but higher than idiopathic pulmonary fibrosis...

..Potentially, transplantation at a cellular level using various forms of stem cells becomes an additional therapeutic approach...

..It lies in the interest and in the discretion the individual departments and surgeons to use and to comply with these existing possibilities to perform GTS at a uniform European quality level...

..The study aim was to define the impact of these novel risk factors on survival...

..Based on this case we propose standard procedures, which should be followed when considering drowned donor lungs, in order to minimize risks for infectious complications...

..We reviewed our institutional experience with ECMO as a bridge to LTX...

..The mechanisms of VEGF overproduction and its impact on CF lung pathology and pulmonary vascular permeability during lung transplantation are not fully understood...

..The international experience with resection of advanced thoracic malignancies performed with extracorporeal membrane oxygenation (ECMO) support is limited. We examined our results to assess the risks and benefits of this approach...

..Whether ET-1 could predict BO syndrome (BOS) development is unknown...

..The aim of this study was to evaluate the sealing efficacy and safety of the surgical patch, TachoSil®, in lung surgery...

..Expression of many of them is regulated by methylation. Moreover, HOXA2 and HOXA10 methylation may serve as prognostic parameters in SCC patients. Overall, our findings emphasize the impact of methylation on the pathogenesis of NSCLCs...

..A high rate of successful re-transplantation prolonged total patient survival...

..This approach might have the potential to restore function of lungs that would be unsuitable for transplantation...

..The objective of this study was to determine the incidence of CMV infections by comparing a prolonged valganciclovir prophylaxis with a standard regimen in high-risk LuTx recipients...

..6%. According to our experience, cystic fibrosis patients with a 5-year probability of survival < 30% and also those between 30% and 50% gain a clear survival benefit from bilateral lung transplantation...

..01; Pearson's correlation coefficient = 0.667). CONCLUSIONS: Post-operative recipient TLC in size-reduced lung transplantation can be predicted by donor TLC rather than pre-operative recipient TLC...

..Interestingly, type 1 allergy has not been described in transplanted adults, suggesting a particular propensity in childhood...

..These data show for the first time that the CMV load used as diagnostic tool after transplantation is not always a constant entity but reflects the sum of the individual CMV-genotype dynamics developing over time...

..Here, we investigated the feasibility of mammalian target of rapamycin (mTOR) inhibition by temsirolimus as an antimesothelioma strategy...

..We have recently demonstrated that COPD is accompanied by elevated serum heat shock protein (HSP) 27 levels as compared to a control population...

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..The strict application of standard lung donor criteria excludes a considerable number of lungs potentially suitable for transplantation, thus liberalisation of donor criteria might help to overcome donor shortage...

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..One-year and 2-year survival was 65.7% and 44.8%, respectively. CONCLUSIONS: Bronchial stump reinforcement with a pericardial flap is a highly effective method for preventing postpneumonectomy bronchopleural fistula in selected patients...

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..When systemic immunosuppressive treatment fails to improve, severe BO patients should be considered for lung transplantation (LuTX). We present seven patients undergoing LuTX for severe refractory BO after HCT...

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..We conclude that a wait-and-see procedure for BML is feasible, but primary resection of the BML tumor masses is preferable to avoid complications as described in our case...

..The purpose of the present study was to explore the cardiopulmonary exercise test (CPET) profile and the pulmonary hemodynamic response to exercise in these patients...

..The significant relationship between EBV and CMV DNA loads in the ELF of LTRs and its clinical impact require further investigation...

..The aim of this paper is to summarise our total experience with the use of ECMO in LuTX...

..To evaluate the prognostic and predictive relevance of pretreatment serum C-reactive protein (CRP) in malignant pleural mesothelioma (MPM) patients...

..Asymmetric dimethylarginine (ADMA), a potent endogenous nitric oxide synthase (NOS) inhibitor, is increased in idiopathic pulmonary arterial hypertension and associated with unfavorable outcome...

..However, regular blood counts should be performed to detect developing leucopenia...

..BAL MMP-8, -9 and TIMP-1 might be useful markers to detect BO in lung transplant patients...

..We analyzed our institutional experience with pulmonary retransplantation to evaluate its value for different indications...

..In this study, we hypothesized that systemic markers of apoptosis are altered in patients with mild-to-severe COPD...

..The aim of this cross-sectional study was to provide an overview of quality of life in lung transplant patients...

..Its value and advantage over other therapeutic strategies remain points of discussion. We therefore analysed our experience with extrapleural pneumonectomy in the treatment of malignant pleural mesothelioma...

..Cytomegalovirus (CMV) is a major pathogen in lung transplant recipients (LTRs). The emergence of different CMV strains in lung and blood after transplantation has not yet been analyzed...

..The newly revised TNM classification for lung cancer appears to be superior in defining different prognostic groups for this cohort and should lead to an improvement in stage specific tumor therapy...

..Therefore, our aim was to study whether apelin expression is associated with angiogenesis and/or tumor growth/behavior in human non-small cell lung cancer (NSCLC)...

..We have recently described that patients with manifest COPD evidence elevated levels of heat shock proteins (HSPs). Based on these data, we speculated whether HSPs are also increased in patients with diagnosed lung cancer...

..In general sleeve pneumonectomy has become an established procedure for treatment of lung cancer involving the carina and should be performed for carefully selected patients in experienced centers only...

..CONCLUSIONS: Our study suggests a beneficial effect of the oral dual ET receptor antagonist bosentan in patients with inoperable CTEPH, urging the need for a randomized, placebo-controlled trial...

..The goal of this study was to define a parameter helping the surgeon in the decision whether a standard lung transplantation or a lobar transplantation should be anticipated...

..CONCLUSIONS: Size reduced lung transplantation, including split lung transplantation, lobar transplantation and peripheral segmental resection, is a reliable procedure providing equal results compared to standard lung transplantation...

..Transplantation of a human trachea has been reported only twice in the literature with limited documentation of the functional and structural properties of the allograft...

..The objective of this study is to establish clinical evidence that the p53 genotype can serve as a predictive marker for response to cisplatin-based induction therapy...

..Cystic fibrosis (CF) is characterized by progressive pulmonary inflammation that is infection-triggered. Pseudomonas aeruginosa represents a risk factor for deterioration of lung function and reduced life expectancy...

..In this study, we report our experience with PTLD in lung transplantation with CMV Ig prophylaxis...

..Whether these potentially beneficial drug effects have clinical implications is currently under investigation...

..Quality of life is excellent. Therefore, LuTX is preferred and safe in patients with advanced PPH even with severe cardiac dysfunction...

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..This is the first study to demonstrate elevated serum levels of the described heat shock proteins in patients with COPD. We showed sensitivity and specificity of serum HSP27 and HSP70 as diagnostic markers for COPD...

..However, these data suggest that apical pleurectomy should be accompanied by apical lung wedge resection even for this favorable category of patients...

..This questions the value of lung resection in patients with isolated synchronous brain metastases...

..We investigated whether HGF could be an accurate marker for prediction of lung-graft rejection...

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..Complete endoscopic thymus surgery with the da Vinci surgical system enables a complete and extended resection of all thymic tissue in the mediastinum. Due to the minimal trauma, patients can return to full activity within a short time...

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..Acute myocardial infarction (AMI) followed by ventricular remodeling is the major cause of congestive heart failure and death in western world countries...

..Herein, we present a case of a patient referred to a thoracic surgeon with a huge mediastinal hematoma. Diagnostic work-up revealed a spontaneous rupture of the left inferior thyroid artery due to repetitive Valsalva maneuver...

..Lung perfusion scintigrams analyzed by a semi-quantitative method in patients with severe unoperated CTEPH show an apparent decrease of segmental flow abnormalities over time, paralleling right ventricular decline...

..05). In conclusion, the TIP regimen shows activity and good tolerance as induction chemotherapy in patients with locally advanced NSCLC...

..Venous thromboembolism is a spectrum of disease comprising deep vein thrombosis, thrombus in transit, acute pulmonary embolism, and chronic thromboembolic pulmonary hypertension (CTEPH) as a rare and late possible sequela...

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..To prospectively investigate the effect of radiation dose reduction on the visual quantification of air trapping at expiratory thin-section computed tomography (CT)...

..Patients after failed LVRS, however, should be considered as poor candidates for later transplantation...

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..This results in improved outcome even in advanced forms of PH...

..0001) and PAH patients (22%, p = 0.022). We can conclude that elevated plasma FVIII is the first prothrombotic factor identified in a large proportion of CTEPH patients...

..Hypoxia and ET-1 co-upregulate VEGF-A overexpression, therefore temporary VEGF-A antagonism during graft preservation might be of benefit in lung transplantation...

..We conclude that the conversion from cyclosporine to tacrolimus was associated with favourable results in the treatment of RAR. Further studies are required to assess the influence of this approach in the treatment of OB...

..Benefit or risk deriving from the combination with mycophenolate mofetil are yet unknown...

..This case is unique because unilateral CTEPH is extremely uncommon, and it illustrates the severe clinical sequelae of the cosegregation of inherited thrombophilic defects...

..Treatment options include needle thoracentesis, tube thoracostomy chemical pleurodesis, and pleurectomy. Pleurovenous shunting (PVS) represents an alternative, minimally invasive method...

..We hypothesized that HIF-1 regulates VEGF-mediated vascular permeability in lung grafts...

..Careful interdisciplinary preoperative treatment planning is necessary to achieve optimal results...

..Due to insufficient glottal closure, dysphonia and dysphagia with aspiration may occur. The purpose of the study was to outline the effect of vocal fold medialization thyroplasty on voice, swallowing and breathing impairments...

..The results suggest that human RELMbeta may contribute to hypoxic-induced pulmonary vascular remodeling processes or hypoxia related fibrotic lung disease...

..Conversion for bronchiolitis obliterans syndrome allows short-term stabilization of lung function in most patients...

..Suppression of endothelial DDAH2 expression and function represents an important underlying mechanism...

..The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation...

..Cases of four young patients, who were effectively treated with lung transplantation, are discussed from pre-operative preparations to post-operative follow-up, with the review of the literature...

..CONCLUSION: The CMV DNA level in ELF may be a marker for symptomatic CMV infection...

..5-fold upregulated. These results support an important role for NOX4 in the vascular remodeling associated with development of pulmonary hypertension...

..Adequate postoperative care is therefore essential. Preoperative hemodynamic severity and the site of anatomic obstruction are believed to be key predictors of postoperative outcome...

..In conclusion, NOX4 maintains ROS levels under normoxic and hypoxic conditions and enhances proliferation and inhibits apoptosis of PAFB...

..Persisting air leakage after pulmonary resection remains a significant problem. The aim of the study was to evaluate the incidence of air leakage after standard lobectomy and test the efficacy and safety of TachoComb (TC)...

..b>Walter Klepetko. Our patients went through lung transplantation for the following indications: cystic fibrosis (22), ..

..Lung harvesting was introduced in 2002 in Hungary. Before 2002 Hungarian patients get 16 donor lungs from abroad, and 4 patients died while being on the waiting list for transplantation...

..Continued research and clinical trials investigating possible applications of new medical treatments are required...