Walter Klepetko

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. doi request reprint Assessment of pulmonary artery systolic pressures by stress Doppler echocardiography after bilateral lung transplantation
    Marie Theres Kasimir
    Department of Cardiothoracic Surgery, General Hospital Vienna, Medical University of Vienna, Vienna, Austria
    J Heart Lung Transplant 27:66-71. 2008
  2. pmc Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency
    A Rembert Koczulla
    Institute of Pathology, Hannover Medical School, Hanover, Germany
    Orphanet J Rare Dis 7:29. 2012
  3. ncbi request reprint Thoracic transplantation and stem cell therapy
    Walter Klepetko
    Department of Cardio Thoracic Surgery, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur J Cardiothorac Surg 26:S57-8; discussion S58. 2004
  4. ncbi request reprint Interventional and surgical modalities of treatment for pulmonary arterial hypertension
    Walter Klepetko
    Department of Cardio Thoracic Surgery, Vienna University Hospital, Vienna, Austria
    J Am Coll Cardiol 43:73S-80S. 2004
  5. ncbi request reprint Towards establishing standards of practice in general thoracic surgery: the European perspective
    Walter Klepetko
    Department of Cardiothoracic Surgery, Medical University of Vienna, Währinger Gartel 18 20, 1090 Vienna, Austria
    Thorac Surg Clin 17:399-402. 2007
  6. ncbi request reprint Predictors of outcome in chronic thromboembolic pulmonary hypertension
    Diana Bonderman
    Departments of Cardiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Circulation 115:2153-8. 2007
  7. doi request reprint Extracorporeal membrane oxygenation support for resection of locally advanced thoracic tumors
    Gyorgy Lang
    Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria
    Ann Thorac Surg 92:264-70. 2011
  8. ncbi request reprint Vascular endothelial growth factor increases pulmonary vascular permeability in cystic fibrosis patients undergoing lung transplantation
    Katharina Krenn
    Laboratory for Cardiovascular Research, Center for Anatomy and Cell Biology, Medical University of Vienna, Waehringerstr 13, A 1090 Vienna, Austria
    Eur J Cardiothorac Surg 32:35-41. 2007
  9. doi request reprint Considerations on infectious complications using a drowned lung for transplantation
    Konrad Hoetzenecker
    Department of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria
    Transpl Int 23:e32-4. 2010
  10. ncbi request reprint Immunoglobulin e-mediated allergies in lung-transplanted adults
    Saskia Gruber
    Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria
    Transplantation 84:275-9. 2007

Detail Information

Publications110 found, 100 shown here

  1. doi request reprint Assessment of pulmonary artery systolic pressures by stress Doppler echocardiography after bilateral lung transplantation
    Marie Theres Kasimir
    Department of Cardiothoracic Surgery, General Hospital Vienna, Medical University of Vienna, Vienna, Austria
    J Heart Lung Transplant 27:66-71. 2008
    ..Therefore, the aim of this study was to evaluate systolic pulmonary artery pressures (PASPs) at rest and during supine bicycle exercise, exercise capacity and cardiopulmonary function in post-BLTx patients...
  2. pmc Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency
    A Rembert Koczulla
    Institute of Pathology, Hannover Medical School, Hanover, Germany
    Orphanet J Rare Dis 7:29. 2012
    ..A study was undertaken to investigate gene expression patterns in end-stage COPD lungs from patients with and without AATD...
  3. ncbi request reprint Thoracic transplantation and stem cell therapy
    Walter Klepetko
    Department of Cardio Thoracic Surgery, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur J Cardiothorac Surg 26:S57-8; discussion S58. 2004
    ..Potentially, transplantation at a cellular level using various forms of stem cells becomes an additional therapeutic approach...
  4. ncbi request reprint Interventional and surgical modalities of treatment for pulmonary arterial hypertension
    Walter Klepetko
    Department of Cardio Thoracic Surgery, Vienna University Hospital, Vienna, Austria
    J Am Coll Cardiol 43:73S-80S. 2004
    ..The survival rate during the first five years after transplantation for PAH is intermediate among the lung diseases, lower than chronic obstructive pulmonary disease but higher than idiopathic pulmonary fibrosis...
  5. ncbi request reprint Towards establishing standards of practice in general thoracic surgery: the European perspective
    Walter Klepetko
    Department of Cardiothoracic Surgery, Medical University of Vienna, Währinger Gartel 18 20, 1090 Vienna, Austria
    Thorac Surg Clin 17:399-402. 2007
    ..It lies in the interest and in the discretion the individual departments and surgeons to use and to comply with these existing possibilities to perform GTS at a uniform European quality level...
  6. ncbi request reprint Predictors of outcome in chronic thromboembolic pulmonary hypertension
    Diana Bonderman
    Departments of Cardiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Circulation 115:2153-8. 2007
    ..The study aim was to define the impact of these novel risk factors on survival...
  7. doi request reprint Extracorporeal membrane oxygenation support for resection of locally advanced thoracic tumors
    Gyorgy Lang
    Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria
    Ann Thorac Surg 92:264-70. 2011
    ..The international experience with resection of advanced thoracic malignancies performed with extracorporeal membrane oxygenation (ECMO) support is limited. We examined our results to assess the risks and benefits of this approach...
  8. ncbi request reprint Vascular endothelial growth factor increases pulmonary vascular permeability in cystic fibrosis patients undergoing lung transplantation
    Katharina Krenn
    Laboratory for Cardiovascular Research, Center for Anatomy and Cell Biology, Medical University of Vienna, Waehringerstr 13, A 1090 Vienna, Austria
    Eur J Cardiothorac Surg 32:35-41. 2007
    ..The mechanisms of VEGF overproduction and its impact on CF lung pathology and pulmonary vascular permeability during lung transplantation are not fully understood...
  9. doi request reprint Considerations on infectious complications using a drowned lung for transplantation
    Konrad Hoetzenecker
    Department of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria
    Transpl Int 23:e32-4. 2010
    ..Based on this case we propose standard procedures, which should be followed when considering drowned donor lungs, in order to minimize risks for infectious complications...
  10. ncbi request reprint Immunoglobulin e-mediated allergies in lung-transplanted adults
    Saskia Gruber
    Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria
    Transplantation 84:275-9. 2007
    ..Interestingly, type 1 allergy has not been described in transplanted adults, suggesting a particular propensity in childhood...
  11. doi request reprint Prolonged venoarterial extracorporeal membrane oxygenation after transplantation restores functional integrity of severely injured lung allografts and prevents the development of pulmonary graft failure in a pig model
    Gyorgy Lang
    Department of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria
    J Thorac Cardiovasc Surg 137:1493-8. 2009
    ..This approach might have the potential to restore function of lungs that would be unsuitable for transplantation...
  12. doi request reprint Primary lung transplantation after bridge with extracorporeal membrane oxygenation: a plea for a shift in our paradigms for indications
    Gyorgy Lang
    Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria
    Transplantation 93:729-36. 2012
    ..We reviewed our institutional experience with ECMO as a bridge to LTX...
  13. doi request reprint Endothelin-1 is a useful biomarker for early detection of bronchiolitis obliterans in lung transplant recipients
    Mohamed Salama
    Department of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria
    J Thorac Cardiovasc Surg 140:1422-7. 2010
    ..Whether ET-1 could predict BO syndrome (BOS) development is unknown...
  14. doi request reprint Efficacy and safety of TachoSil® versus standard treatment of air leakage after pulmonary lobectomy
    Gabriel Mihai Marta
    Vienna University Hospital, Vienna, Austria
    Eur J Cardiothorac Surg 38:683-9. 2010
    ..The aim of this study was to evaluate the sealing efficacy and safety of the surgical patch, TachoSil®, in lung surgery...
  15. pmc Erythropoietin receptor expression is a potential prognostic factor in human lung adenocarcinoma
    Anita Rozsas
    Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, Hungary Division of Thoracic Surgery, Medical University of Vienna, Vienna, Austria
    PLoS ONE 8:e77459. 2013
    ..This study reveals high EPOR level as a potential novel positive prognostic marker in human lung ADC. ..
  16. ncbi request reprint Bronchial stump coverage with a pedicled pericardial flap: an effective method for prevention of postpneumonectomy bronchopleural fistula
    Shahrokh Taghavi
    Department of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria
    Ann Thorac Surg 79:284-8. 2005
    ..Bronchopleural fistula is a serious complication after pneumonectomy. The aim of this retrospective study was to investigate the efficacy of bronchial stump reinforcement with a pedicled flap of whole pericardium...
  17. ncbi request reprint Genome-wide CpG island methylation analyses in non-small cell lung cancer patients
    Gerwin Heller
    Department of Medicine I, Clinical Division of Oncology, Medical University of Vienna, Vienna 1090, Austria
    Carcinogenesis 34:513-21. 2013
    ..Expression of many of them is regulated by methylation. Moreover, HOXA2 and HOXA10 methylation may serve as prognostic parameters in SCC patients. Overall, our findings emphasize the impact of methylation on the pathogenesis of NSCLCs...
  18. doi request reprint Lung transplantation in children and young adults: a 20-year single-centre experience
    Saskia Gruber
    Dept of Pediatrics and Adolescent Medicine, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Eur Respir J 40:462-9. 2012
    ..A high rate of successful re-transplantation prolonged total patient survival...
  19. ncbi request reprint Cystic fibrosis and lung transplantation--determination of the survival benefit
    Clemens Aigner
    Department of Cardiothoracic Surgery, Vienna University Hospital, Vienna, Austria
    Wien Klin Wochenschr 116:318-21. 2004
    ..The aim of the present study was to determine the validity and applicability of this model...
  20. ncbi request reprint Donor total lung capacity predicts recipient total lung capacity after size-reduced lung transplantation
    Clemens Aigner
    Department of Cardiothoracic Surgery, Vienna Medical University, Vienna, Austria
    J Heart Lung Transplant 24:2098-102. 2005
    ..Limited data exist on pre-operative parameters predicting functional outcome after lung transplantation in general, especially after size-reduced lung transplantation...
  21. ncbi request reprint Cytomegalovirus prevention in high-risk lung transplant recipients: comparison of 3- vs 12-month valganciclovir therapy
    Peter Jaksch
    Department of Cardio Thoracic Surgery, General Hospital Vienna, Vienna, Austria
    J Heart Lung Transplant 28:670-5. 2009
    ..The objective of this study was to determine the incidence of CMV infections by comparing a prolonged valganciclovir prophylaxis with a standard regimen in high-risk LuTx recipients...
  22. doi request reprint Temsirolimus inhibits malignant pleural mesothelioma growth in vitro and in vivo: synergism with chemotherapy
    Mir Alireza Hoda
    Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria
    J Thorac Oncol 6:852-63. 2011
    ..Here, we investigated the feasibility of mammalian target of rapamycin (mTOR) inhibition by temsirolimus as an antimesothelioma strategy...
  23. pmc Surgical specimens, haemodynamics and long-term outcomes after pulmonary endarterectomy
    Nika Skoro-Sajer
    Department of Internal Medicine II, Division of Cardiology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
    Thorax 69:116-22. 2014
    ....
  24. ncbi request reprint Virus load dynamics of individual CMV-genotypes in lung transplant recipients with mixed-genotype infections
    Irene Görzer
    Institute of Virology, Medical University of Vienna, Vienna, Austria
    J Med Virol 80:1405-14. 2008
    ..These data show for the first time that the CMV load used as diagnostic tool after transplantation is not always a constant entity but reflects the sum of the individual CMV-genotype dynamics developing over time...
  25. doi request reprint Increased serum levels of HSP27 as a marker for incipient chronic obstructive pulmonary disease in young smokers
    Hendrik Jan Ankersmit
    Department of Thoracic Surgery, Medical University of Vienna, Austria
    Respiration 83:391-9. 2012
    ..We have recently demonstrated that COPD is accompanied by elevated serum heat shock protein (HSP) 27 levels as compared to a control population...
  26. ncbi request reprint Extended donor criteria for lung transplantation--a clinical reality
    Clemens Aigner
    Department of Cardiothoracic Surgery, Vienna Medical University, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Eur J Cardiothorac Surg 27:757-61. 2005
    ..This study therefore evaluates the outcome, achieved with the use of extended donors versus standard donors and aims to redefine lung donor criteria...
  27. doi request reprint Pulmonary vascular reactivity and prognosis in patients with chronic thromboembolic pulmonary hypertension: a pilot study
    Nika Skoro-Sajer
    Department of Internal Medicine II, Division of Cardiology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
    Circulation 119:298-305. 2009
    ....
  28. doi request reprint Cytomegalovirus DNA load patterns developing after lung transplantation are significantly correlated with long-term patient survival
    Heidrun Kerschner
    Institute of Clinical Virology, Medical University of Vienna, Vienna, Austria
    Transplantation 87:1720-6. 2009
    ....
  29. ncbi request reprint Haemodynamic complications after pneumonectomy: atrial inflow obstruction and reopening of the foramen ovale
    Clemens Aigner
    Department of Cardio Thoracic Surgery, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Eur J Cardiothorac Surg 33:268-71. 2008
    ....
  30. ncbi request reprint Treatment of severe acute lung allograft rejection with OKT3 and temporary extracorporeal membrane oxygenation bridging
    Clemens Aigner
    Department of Cardiothoracic Surgery, University of Vienna, Waehringer Guertel 18 20, A 1090, Vienna, Austria
    Eur J Cardiothorac Surg 25:184-7. 2004
    ..Temporary extracorporeal membrane oxygenation (ECMO) bridging can be used to overcome this crucial period before the beneficial effects of OKT3 can be observed...
  31. ncbi request reprint Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: a single-center experience
    Ursula M Vogl
    Department of Medicine I, Bone Marrow Transplantation Unit, Medical University Vienna, Währinger Gürtel 18 20 A 1090 Vienna, Austria
    Transplantation 95:623-8. 2013
    ..When systemic immunosuppressive treatment fails to improve, severe BO patients should be considered for lung transplantation (LuTX). We present seven patients undergoing LuTX for severe refractory BO after HCT...
  32. doi request reprint Long-term treatment, tolerability, and survival with sub-cutaneous treprostinil for severe pulmonary hypertension
    Roela Sadushi-Kolici
    Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria
    J Heart Lung Transplant 31:735-43. 2012
    ....
  33. doi request reprint Consequences of a wait-and-see strategy for benign metastasizing leiomyomatosis of the lung
    Konrad Hoetzenecker
    Department of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria
    Ann Thorac Surg 87:613-4. 2009
    ..We conclude that a wait-and-see procedure for BML is feasible, but primary resection of the BML tumor masses is preferable to avoid complications as described in our case...
  34. doi request reprint Right ventricular load at exercise is a cause of persistent exercise limitation in patients with normal resting pulmonary vascular resistance after pulmonary endarterectomy
    Diana Bonderman
    Department of Cardiology, Medical University of Vienna, Vienna, Austria
    Chest 139:122-7. 2011
    ..The purpose of the present study was to explore the cardiopulmonary exercise test (CPET) profile and the pulmonary hemodynamic response to exercise in these patients...
  35. ncbi request reprint Institutional experience with extracorporeal membrane oxygenation in lung transplantation
    Clemens Aigner
    Department of Cardio Thoracic Surgery, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Eur J Cardiothorac Surg 31:468-73; discussion 473-4. 2007
    ..The aim of this paper is to summarise our total experience with the use of ECMO in LuTX...
  36. pmc Relationship between cytomegalovirus DNA load in epithelial lining fluid and plasma of lung transplant recipients and analysis of coinfection with Epstein-Barr virus and human herpesvirus 6 in the lung compartment
    Claudia C Bauer
    Institute of Virology, Medical University of Vienna, Vienna, Austria
    J Clin Microbiol 45:324-8. 2007
    ..The significant relationship between EBV and CMV DNA loads in the ELF of LTRs and its clinical impact require further investigation...
  37. doi request reprint Pretreatment serum C-reactive protein levels predict benefit from multimodality treatment including radical surgery in malignant pleural mesothelioma: a retrospective multicenter analysis
    Bahil Ghanim
    Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Austria
    Ann Surg 256:357-62. 2012
    ..To evaluate the prognostic and predictive relevance of pretreatment serum C-reactive protein (CRP) in malignant pleural mesothelioma (MPM) patients...
  38. doi request reprint Increased soluble serum markers caspase-cleaved cytokeratin-18, histones, and ST2 indicate apoptotic turnover and chronic immune response in COPD
    Stefan Hacker
    Department of Surgery, Medical University of Vienna, Vienna, Austria
    J Clin Lab Anal 23:372-9. 2009
    ..In this study, we hypothesized that systemic markers of apoptosis are altered in patients with mild-to-severe COPD...
  39. doi request reprint Outcome after extrapleural pneumonectomy for malignant pleural mesothelioma
    Clemens Aigner
    Department of Cardio Thoracic Surgery, Medical University of Vienna, Vienna, Austria
    Eur J Cardiothorac Surg 34:204-7. 2008
    ..Its value and advantage over other therapeutic strategies remain points of discussion. We therefore analysed our experience with extrapleural pneumonectomy in the treatment of malignant pleural mesothelioma...
  40. doi request reprint Pulmonary retransplantation: is it worth the effort? A long-term analysis of 46 cases
    Clemens Aigner
    Department of Cardio Thoracic Surgery, Medical University of Vienna, Vienna, Austria
    J Heart Lung Transplant 27:60-5. 2008
    ..We analyzed our institutional experience with pulmonary retransplantation to evaluate its value for different indications...
  41. ncbi request reprint Asymmetric dimethylarginine is increased in chronic thromboembolic pulmonary hypertension
    Nika Skoro-Sajer
    Professor of Vascular Biology, Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Am J Respir Crit Care Med 176:1154-60. 2007
    ..Asymmetric dimethylarginine (ADMA), a potent endogenous nitric oxide synthase (NOS) inhibitor, is increased in idiopathic pulmonary arterial hypertension and associated with unfavorable outcome...
  42. ncbi request reprint Quality of life after lung transplantation: a cross-sectional study
    Beate Smeritschnig
    General Hospital Vienna, Department of Cardiothoracic Surgery, Vienna, Austria
    J Heart Lung Transplant 24:474-80. 2005
    ..The aim of this cross-sectional study was to provide an overview of quality of life in lung transplant patients...
  43. ncbi request reprint Broncho-alveolar lavage matrix metalloproteases as a sensitive measure of bronchiolitis obliterans
    Shahrokh Taghavi
    Department of Cardio Thoracic Surgery, Vienna Medical University, Waehringer Guertel, Austria
    Am J Transplant 5:1548-52. 2005
    ..BAL MMP-8, -9 and TIMP-1 might be useful markers to detect BO in lung transplant patients...
  44. ncbi request reprint Initial experience with oral valganciclovir for pre-emptive cytomegalovirus therapy after lung transplantation
    Clemens Aigner
    Department of Cardiothoracic Surgery, Vienna General Hospital, Vienna Medical University, Vienna, Austria
    Wien Klin Wochenschr 117:480-4. 2005
    ..The goal of this study was to describe our initial experience with oral valganciclovir for pre-emptive treatment of CMV infections after lung transplantation...
  45. doi request reprint Antithymocyte globulin induction therapy improves survival in lung transplantation for cystic fibrosis
    Peter Jaksch
    Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria
    Transpl Int 26:34-41. 2013
    ..Taken together, our results indicate that ATG induction therapy confers a significant survival benefit in CF patients undergoing LuTX and reduces rejection. We advocate the use of induction therapy in this patient cohort...
  46. ncbi request reprint Apelin expression in human non-small cell lung cancer: role in angiogenesis and prognosis
    Judit Berta
    Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria
    J Thorac Oncol 5:1120-9. 2010
    ..Therefore, our aim was to study whether apelin expression is associated with angiogenesis and/or tumor growth/behavior in human non-small cell lung cancer (NSCLC)...
  47. doi request reprint Effects of reclassification from the TNM-6 into the TNM-7 staging system in bronchoplastic resection for non-small cell lung cancer
    Thomas Klikovits
    Division of Thoracic Surgery, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Interact Cardiovasc Thorac Surg 13:29-34. 2011
    ..The newly revised TNM classification for lung cancer appears to be superior in defining different prognostic groups for this cohort and should lead to an improvement in stage specific tumor therapy...
  48. ncbi request reprint Emergence of multiple cytomegalovirus strains in blood and lung of lung transplant recipients
    Elisabeth Puchhammer-Stöckl
    Institute of Virology, Medical University of Vienna, Austria
    Transplantation 81:187-94. 2006
    ..Cytomegalovirus (CMV) is a major pathogen in lung transplant recipients (LTRs). The emergence of different CMV strains in lung and blood after transplantation has not yet been analyzed...
  49. doi request reprint Clinical-radiological, histological and genetic analyses in a lung transplant recipient with Mounier-Kuhn syndrome and end-stage chronic obstructive pulmonary disease
    Andreas Mitterbauer
    Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria
    Clin Respir J . 2014
    ..No causative treatment is available although transplantation is an option for end-stage disease. Here, we describe a patient suffering from MKS who received a double lung transplant at our department...
  50. ncbi request reprint Lung wedge resection improves outcome in stage I primary spontaneous pneumothorax
    Martin Czerny
    Department of Cardiothoracic Surgery, University of Vienna Medical School, Vienna, Austria
    Ann Thorac Surg 77:1802-5. 2004
    ..To evaluate the role of apical lung wedge resection in patients with recurrent primary spontaneous pneumothorax with no endoscopic abnormalities at surgery as compared with simple apical pleurectomy...
  51. ncbi request reprint Prediction of lung-transplant rejection by hepatocyte growth factor
    Seyedhossein Aharinejad
    Laboratory for Cardiovascular Research, Department of Anatomy, Medical University of Vienna, Vienna, Austria
    Lancet 363:1503-8. 2004
    ..We investigated whether HGF could be an accurate marker for prediction of lung-graft rejection...
  52. doi request reprint Role for staphylococci in misguided thrombus resolution of chronic thromboembolic pulmonary hypertension
    Diana Bonderman
    Department of Cardiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Arterioscler Thromb Vasc Biol 28:678-84. 2008
    ....
  53. doi request reprint Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70: a multi-institutional case-control study
    Matthias Zimmermann
    Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna, Austria
    Clin Chim Acta 413:1115-20. 2012
    ..We have recently described that patients with manifest COPD evidence elevated levels of heat shock proteins (HSPs). Based on these data, we speculated whether HSPs are also increased in patients with diagnosed lung cancer...
  54. doi request reprint A scale for decision making between whole lung transplantation or lobar transplantation
    Domenico Loizzi
    Department of Cardiothoracic Surgery, University of Vienna, Vienna, Austria
    Eur J Cardiothorac Surg 37:1122-5. 2010
    ..The goal of this study was to define a parameter helping the surgeon in the decision whether a standard lung transplantation or a lobar transplantation should be anticipated...
  55. ncbi request reprint Lobar transplantation, split lung transplantation and peripheral segmental resection--reliable procedures for downsizing donor lungs
    Clemens Aigner
    Department of Cardiothoracic Surgery, Vienna University, Waehringer Guertel 18 20, A 1090, Vienna, Austria
    Eur J Cardiothorac Surg 25:179-83. 2004
    ..This approach has only recently gained widespread use-especially for highly urgent recipients-however, it is still not considered a standard procedure...
  56. ncbi request reprint Heterotopic tracheal transplantation with omentum wrapping in the abdominal position preserves functional and structural integrity of a human tracheal allograft
    Walter Klepetko
    Department of Cardiothoracic Surgery, University Hospital of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Thorac Cardiovasc Surg 127:862-7. 2004
    ..Transplantation of a human trachea has been reported only twice in the literature with limited documentation of the functional and structural properties of the allograft...
  57. doi request reprint Growing clinical evidence for the interaction of the p53 genotype and response to induction chemotherapy in advanced non-small cell lung cancer
    Daniela Kandioler
    Division of Surgery, Medical University of Vienna, Austria
    J Thorac Cardiovasc Surg 135:1036-41. 2008
    ..The objective of this study is to establish clinical evidence that the p53 genotype can serve as a predictive marker for response to cisplatin-based induction therapy...
  58. ncbi request reprint Sleeve pneumonectomy
    Clemens Aigner
    Department of Cardio Thoracic Surgery, Medical University of Vienna, Vienna, Austria
    Semin Thorac Cardiovasc Surg 18:109-13. 2006
    ..In general sleeve pneumonectomy has become an established procedure for treatment of lung cancer involving the carina and should be performed for carefully selected patients in experienced centers only...
  59. ncbi request reprint Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension
    Diana Bonderman
    Department of Cardiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Chest 128:2599-603. 2005
    ..Bosentan, an oral endothelin (ET)-A/ET-B receptor antagonist, is effective in the treatment of pulmonary arterial hypertension...
  60. ncbi request reprint Carbonic anhydrase IX is associated with early pulmonary spreading of primary colorectal carcinoma and tobacco smoking
    Thomas Schweiger
    Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna, Austria
    Eur J Cardiothorac Surg 46:92-9. 2014
    ..Carbonic anhydrase IX (CA9) expression has been shown to be a common feature in primary tumour growth and metastasis and it negatively affects the clinical outcome in various malignancies. Data on CA9 in pulmonary metastases are lacking...
  61. ncbi request reprint Upregulated hypoxia-inducible factor-1 DNA binding activity to the vascular endothelial growth factor-A promoter mediates increased vascular permeability in donor lung grafts
    Dietmar Abraham
    Laboratory for Cardiovascular Research, Department of Anatomy, University of Vienna, Vienna, Austria
    Ann Thorac Surg 77:1751-5. 2004
    ..We hypothesized that HIF-1 regulates VEGF-mediated vascular permeability in lung grafts...
  62. doi request reprint Effect of cytomegalovirus immunoglobulin on the incidence of lymphoproliferative disease after lung transplantation: single-center experience with 1157 patients
    Peter Jaksch
    Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria
    Transplantation 95:766-72. 2013
    ..In this study, we report our experience with PTLD in lung transplantation with CMV Ig prophylaxis...
  63. doi request reprint A Th17- and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection
    Kerstin Tiringer
    Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Am J Respir Crit Care Med 187:621-9. 2013
    ..Cystic fibrosis (CF) is characterized by progressive pulmonary inflammation that is infection-triggered. Pseudomonas aeruginosa represents a risk factor for deterioration of lung function and reduced life expectancy...
  64. pmc The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophils
    Katharina Blatt
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    PLoS ONE 7:e29925. 2012
    ..Whether these potentially beneficial drug effects have clinical implications is currently under investigation...
  65. ncbi request reprint Prognosis of patients with non-small cell lung cancer with isolated brain metastases undergoing combined surgical treatment
    Vladyslav Getman
    Department of Cardiothoracic Surgery, University Hospital of Vienna, Waehringer Guertel 18 20, Vienna A 1090, Austria
    Eur J Cardiothorac Surg 25:1107-13. 2004
    ..To compare survival of patients with isolated synchronous and metachronous brain metastases from non-small cell lung cancer (NSCLC) after combined surgical treatment...
  66. ncbi request reprint Elevated HSP27, HSP70 and HSP90 alpha in chronic obstructive pulmonary disease: markers for immune activation and tissue destruction
    Stefan Hacker
    Department of Surgery, Medical University of Vienna, Austria
    Clin Lab 55:31-40. 2009
    ..This is the first study to demonstrate elevated serum levels of the described heat shock proteins in patients with COPD. We showed sensitivity and specificity of serum HSP27 and HSP70 as diagnostic markers for COPD...
  67. ncbi request reprint Reverse cardiac remodelling in patients with primary pulmonary hypertension after isolated lung transplantation
    Marie Theres Kasimir
    Department of Cardiothoracic and Vascular Anaesthesia and Intensive Care, Medical University of Vienna, Vienna, Austria
    Eur J Cardiothorac Surg 26:776-81. 2004
    ....
  68. doi request reprint A prospective interventional study on the use of extracorporeal photopheresis in patients with bronchiolitis obliterans syndrome after lung transplantation
    Peter Jaksch
    Department of Thoracic Surgery, University Hospital Vienna, Vienna, Austria
    J Heart Lung Transplant 31:950-7. 2012
    ....
  69. ncbi request reprint Extended videoscopic robotic thymectomy with the da Vinci telemanipulator for the treatment of myasthenia gravis: the Vienna experience
    Tatjana Fleck
    Department of Cardiothoracic Surgery, Medical University of Vienna, AKH Vienna, Vienna, Austria
    Interact Cardiovasc Thorac Surg 9:784-7. 2009
    ..Complete endoscopic thymus surgery with the da Vinci surgical system enables a complete and extended resection of all thymic tissue in the mediastinum. Due to the minimal trauma, patients can return to full activity within a short time...
  70. doi request reprint Current treatment paradigms of superior sulcus tumours
    Masaya Tamura
    Department of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria
    Eur J Cardiothorac Surg 36:747-53. 2009
    ....
  71. doi request reprint Imaging in pulmonary hypertension
    Irene M Lang
    Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria
    JACC Cardiovasc Imaging 3:1287-95. 2010
    ....
  72. pmc Anti-thymocyte globulin induces neoangiogenesis and preserves cardiac function after experimental myocardial infarction
    Michael Lichtenauer
    Clinic of Internal Medicine I, Department of Cardiology, University Hospital Jena, Jena, Germany
    PLoS ONE 7:e52101. 2012
    ..Acute myocardial infarction (AMI) followed by ventricular remodeling is the major cause of congestive heart failure and death in western world countries...
  73. ncbi request reprint Induction chemotherapy with the TIP regimen (paclitaxel/ifosfamide/cisplatin) in stage III non-small cell lung cancer
    Gudrun Pohl
    Department of Internal Medicine I, Division of Oncology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Lung Cancer 54:63-7. 2006
    ..05). In conclusion, the TIP regimen shows activity and good tolerance as induction chemotherapy in patients with locally advanced NSCLC...
  74. ncbi request reprint Longitudinal analysis of perfusion lung scintigrams of patients with unoperated chronic thromboembolic pulmonary hypertension
    Nika Skoro-Sajer
    Department of Cardiology, Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria
    Thromb Haemost 92:201-7. 2004
    ..Lung perfusion scintigrams analyzed by a semi-quantitative method in patients with severe unoperated CTEPH show an apparent decrease of segmental flow abnormalities over time, paralleling right ventricular decline...
  75. doi request reprint Spontaneous rupture of the inferior thyroid artery resulting in mediastinal hematoma
    Konrad Hoetzenecker
    Department of Cardiothoracic Surgery, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Interact Cardiovasc Thorac Surg 11:209-10. 2010
    ..Herein, we present a case of a patient referred to a thoracic surgeon with a huge mediastinal hematoma. Diagnostic work-up revealed a spontaneous rupture of the left inferior thyroid artery due to repetitive Valsalva maneuver...
  76. doi request reprint Chronic thromboembolic pulmonary hypertension: an updated review
    Irene M Lang
    Department of Internal Medicine II, Division of Cardiology, Austria
    Curr Opin Cardiol 23:555-9. 2008
    ..Venous thromboembolism is a spectrum of disease comprising deep vein thrombosis, thrombus in transit, acute pulmonary embolism, and chronic thromboembolic pulmonary hypertension (CTEPH) as a rare and late possible sequela...
  77. ncbi request reprint Visions and revisions--a society visiting its roots
    Walter Klepetko
    Department of Cardiothoracic Surgery, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur J Cardiothorac Surg 25:1-5. 2004
  78. ncbi request reprint Sealing of the mediastinum with a local hemostyptic agent reduces chest tube duration after complete mediastinal lymph node dissection for stage I and II non-small cell lung carcinoma
    Martin Czerny
    Department of Cardiothoracic Surgery, University of Vienna Medical School, Vienna, Austria
    Ann Thorac Surg 77:1028-32. 2004
    ....
  79. ncbi request reprint Air trapping: comparison of standard-dose and simulated low-dose thin-section CT techniques
    Alexander A Bankier
    Department of Radiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Radiology 242:898-906. 2007
    ..To prospectively investigate the effect of radiation dose reduction on the visual quantification of air trapping at expiratory thin-section computed tomography (CT)...
  80. ncbi request reprint Successful lung volume reduction surgery brings patients into better condition for later lung transplantation
    Omer Senbaklavaci
    Department of Cardiothoracic Surgery, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Eur J Cardiothorac Surg 22:363-7. 2002
    ..However, the possible impact of LVRS on a subsequent LTX has not been clearly elucidated so far. We therefore analyzed the course of 27 patients who underwent LVRS followed by LTX in our institution...
  81. ncbi request reprint Images in cardiovascular medicine. Left main coronary artery compression by the pulmonary trunk in pulmonary hypertension
    Diana Bonderman
    Department of Cardiology, University of Vienna, Vienna, Austria
    Circulation 105:265. 2002
  82. ncbi request reprint Lung transplantation. Donor selection
    Clemens Aigner
    Department of Cardiothoracic Surgery, University of Vienna, Währinger Gürtel 18 20 A 1090 Vienna, Austria
    Chest Surg Clin N Am 13:429-42. 2003
    ....
  83. ncbi request reprint Bilateral lung transplantation with intra- and postoperatively prolonged ECMO support in patients with pulmonary hypertension
    Arpad Pereszlenyi
    Department of Cardiothoracic Surgery, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Eur J Cardiothorac Surg 21:858-63. 2002
    ..These factors can be avoided with intra- and postoperatively prolonged extracorporeal membrane oxygenator (ECMO) support...
  84. pmc Identification of oncostatin M as a STAT5-dependent mediator of bone marrow remodeling in KIT D816V-positive systemic mastocytosis
    Gregor Hoermann
    Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
    Am J Pathol 178:2344-56. 2011
    ....
  85. ncbi request reprint High prevalence of elevated clotting factor VIII in chronic thromboembolic pulmonary hypertension
    Diana Bonderman
    Department of Internal Medicine II, Division of Cardiology, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Thromb Haemost 90:372-6. 2003
    ..0001) and PAH patients (22%, p = 0.022). We can conclude that elevated plasma FVIII is the first prothrombotic factor identified in a large proportion of CTEPH patients...
  86. ncbi request reprint Cyclosporine A versus tacrolimus in combination with mycophenolate mofetil and steroids as primary immunosuppression after lung transplantation: one-year results of a 2-center prospective randomized trial
    Andreas Zuckermann
    Department of Cardiothoracic Surgery, University of Vienna, Austria
    J Thorac Cardiovasc Surg 125:891-900. 2003
    ..Benefit or risk deriving from the combination with mycophenolate mofetil are yet unknown...
  87. ncbi request reprint Co-expression of endothelin-1 and vascular endothelial growth factor mediates increased vascular permeability in lung grafts before reperfusion
    Shahrokh Taghavi
    Department of Cardiothoracic Surgery, University of Vienna, Vienna, Austria
    J Heart Lung Transplant 21:600-3. 2002
    ..Hypoxia and ET-1 co-upregulate VEGF-A overexpression, therefore temporary VEGF-A antagonism during graft preservation might be of benefit in lung transplantation...
  88. ncbi request reprint The value of switching from cyclosporine to tacrolimus in the treatment of refractory acute rejection and obliterative bronchiolitis after lung transplantation
    Kambiz Sarahrudi
    Department of Cardiothoracic Surgery, University of Vienna, Wahringer Gurtel 18 20, 1090, Austria
    Transpl Int 15:24-8. 2002
    ..We conclude that the conversion from cyclosporine to tacrolimus was associated with favourable results in the treatment of RAR. Further studies are required to assess the influence of this approach in the treatment of OB...
  89. ncbi request reprint Pleurovenous shunting in the treatment of nonmalignant pleural effusion
    Omeros Artemiou
    Department of Cardiothoracic Surgery, University of Vienna, Vienna, Austria
    Ann Thorac Surg 76:231-3. 2003
    ..Treatment options include needle thoracentesis, tube thoracostomy chemical pleurodesis, and pleurectomy. Pleurovenous shunting (PVS) represents an alternative, minimally invasive method...
  90. ncbi request reprint Unilateral chronic thromboembolic pulmonary disease associated with combined inherited thrombophilia
    Klaus Laczika
    Intensive Care Unit, the Department of Internal Medicine I, Vienna University Hospital, Vienna, Austria
    Chest 121:286-9. 2002
    ..This case is unique because unilateral CTEPH is extremely uncommon, and it illustrates the severe clinical sequelae of the cosegregation of inherited thrombophilic defects...
  91. ncbi request reprint Combined cervicothoracic approaches for complex mediastinal masses
    Clemens Aigner
    Medical University of Vienna, Waehinger Guertel 18 20, 1090 Vieinna, Austria
    Thorac Surg Clin 19:107-12. 2009
    ..Careful interdisciplinary preoperative treatment planning is necessary to achieve optimal results...
  92. ncbi request reprint External vocal fold medialization in patients with recurrent nerve paralysis following cardiothoracic surgery
    Berit Schneider
    Section of Phoniatrics Logopedics, Department of Otorhinolaryngology, General Hospital, University Hospital of Vienna, Vienna, Austria
    Eur J Cardiothorac Surg 23:477-83. 2003
    ..Due to insufficient glottal closure, dysphonia and dysphagia with aspiration may occur. The purpose of the study was to outline the effect of vocal fold medialization thyroplasty on voice, swallowing and breathing impairments...
  93. ncbi request reprint [Therapy of patients with end-stage pulmonary disease. Review of lung transplantation based on four cases of our own]
    Eszter Csanky
    Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Tüdogyógyászati Klinika
    Orv Hetil 144:691-9. 2003
    ..Cases of four young patients, who were effectively treated with lung transplantation, are discussed from pre-operative preparations to post-operative follow-up, with the review of the literature...
  94. ncbi request reprint Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy
    Ralph Theo Schermuly
    University of Giessen Lung Centre, Justus Liebig Universitat Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Circulation 115:2331-9. 2007
    ..The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation...
  95. ncbi request reprint Techniques and outcomes of pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension
    Eckhard Mayer
    Department of Cardiothoracic Surgery, Johannes Gutenberg University, Mainz, Germany
    Proc Am Thorac Soc 3:589-93. 2006
    ..Adequate postoperative care is therefore essential. Preoperative hemodynamic severity and the site of anatomic obstruction are believed to be key predictors of postoperative outcome...
  96. ncbi request reprint Human RELMbeta is a mitogenic factor in lung cells and induced in hypoxia
    Aparna Renigunta
    University of Giessen Lung Center UGLC, Medical Clinic II, Biochemistry, Friedrichstr 24, Justus Liebig University, D 35392 Giessen, Germany
    FEBS Lett 580:900-3. 2006
    ..The results suggest that human RELMbeta may contribute to hypoxic-induced pulmonary vascular remodeling processes or hypoxia related fibrotic lung disease...
  97. ncbi request reprint Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension
    Soni Pullamsetti
    Department of Internal Medicine, Justus Liebig University Giessen, Giessen, Germany
    FASEB J 19:1175-7. 2005
    ..Suppression of endothelial DDAH2 expression and function represents an important underlying mechanism...
  98. ncbi request reprint Surgical intervention for T4 lung cancer with infiltration of the thoracic aorta: are we back to the archetype of surgical thinking?
    Walter Klepetko
    J Thorac Cardiovasc Surg 129:727-9. 2005
  99. ncbi request reprint International experience with conversion from cyclosporine to tacrolimus for acute and chronic lung allograft rejection
    Kambiz Sarahrudi
    Department of Cardithoracic Surgery, University of Vienna, Austria
    J Thorac Cardiovasc Surg 127:1126-32. 2004
    ..A retrospective study involving 13 institutions was performed to assess the efficacy of conversion from cyclosporine (INN: ciclosporin) to tacrolimus...
  100. ncbi request reprint Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature
    Manish Mittal
    University of Giessen Lung Center, Medical Clinic II V, Giessen, Germany
    Circ Res 101:258-67. 2007
    ..5-fold upregulated. These results support an important role for NOX4 in the vascular remodeling associated with development of pulmonary hypertension...
  101. ncbi request reprint Association of cytomegalovirus DNA concentration in epithelial lining fluid and symptomatic cytomegalovirus infection in lung transplant recipients
    Konstantin Zedtwitz-Liebenstein
    Institute of Virology, University of Vienna, Kinderspitalgasse 15, A 1095 Vienna, Austria
    Transplantation 77:1897-9. 2004
    ..The authors have investigated the effectiveness of virus detection from bronchoalveolar lavage (BAL) samples for the identification of symptomatic cytomegalovirus (CMV) infection in lung transplant recipients...