Siegfried Kasper

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Efficacy and safety of aripiprazole vs. haloperidol for long-term maintenance treatment following acute relapse of schizophrenia
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Vienna, Austria
    Int J Neuropsychopharmacol 6:325-37. 2003
  2. ncbi request reprint Placebo controlled continuation treatment with Hypericum extract WS 5570 after recovery from a mild or moderate depressive episode
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University Vienna, Austria
    Wien Med Wochenschr 157:362-6. 2007
  3. doi request reprint Do we need another atypical antipsychotic?
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wein, Austria
    Eur Neuropsychopharmacol 18:S146-52. 2008
  4. pmc Superior efficacy of St John's wort extract WS 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]
    Siegfried Kasper
    Department of General Psychiatry, Vienna Medical University, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    BMC Med 4:14. 2006
  5. ncbi request reprint Escitalopram in the treatment of social anxiety disorder: randomised, placebo-controlled, flexible-dosage study
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Br J Psychiatry 186:222-6. 2005
  6. ncbi request reprint Efficacy of St. John's wort extract WS 5570 in acute treatment of mild depression: a reanalysis of data from controlled clinical trials
    S Kasper
    Department of Psychiatry und Psychotherapy, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, 1090, Austria
    Eur Arch Psychiatry Clin Neurosci 258:59-63. 2008
  7. ncbi request reprint Tardive Dyskinesia: analysis of outpatients with schizophrenia from Africa and the Middle East, Asia, Central and Eastern Europe, and Latin America
    Siegfried Kasper
    Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Schizophr Res 81:139-43. 2006
  8. ncbi request reprint Onset of action of escitalopram compared with other antidepressants: results of a pooled analysis
    Siegfried Kasper
    Department of General Psychiatry, Medical University of Vienna, Austria
    Int Clin Psychopharmacol 21:105-10. 2006
  9. ncbi request reprint Escitalopram in the treatment of depressed elderly patients
    Siegfried Kasper
    Dept of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Am J Geriatr Psychiatry 13:884-91. 2005
  10. ncbi request reprint Maintenance of long-term efficacy and safety of quetiapine in the open-label treatment of schizophrenia
    Siegfried Kasper
    Department of General Psychiatry, Medical University Vienna, Vienna, Austria
    Int Clin Psychopharmacol 19:281-9. 2004

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Efficacy and safety of aripiprazole vs. haloperidol for long-term maintenance treatment following acute relapse of schizophrenia
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Vienna, Austria
    Int J Neuropsychopharmacol 6:325-37. 2003
    ..001). In summary, aripiprazole demonstrated efficacy equivalent or superior to haloperidol with associated benefits for safety and tolerability. Aripiprazole represents a promising new option for the long-term treatment of schizophrenia...
  2. ncbi request reprint Placebo controlled continuation treatment with Hypericum extract WS 5570 after recovery from a mild or moderate depressive episode
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University Vienna, Austria
    Wien Med Wochenschr 157:362-6. 2007
    ..8 (600 mg WS 5570/day) and 0.4 (1200 mg WS 5570/day) points during treatment phase, while patients in the placebo group deteriorated by 2.1 points. The incidence of adverse events was low in all therapy groups...
  3. doi request reprint Do we need another atypical antipsychotic?
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wein, Austria
    Eur Neuropsychopharmacol 18:S146-52. 2008
    ..The propensity of sertindole to cause anticholinergic effects, which can be particularly troublesome, is small and, more recently, there have been suggestions that sertindole may have beneficial effects on cognition...
  4. pmc Superior efficacy of St John's wort extract WS 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]
    Siegfried Kasper
    Department of General Psychiatry, Vienna Medical University, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    BMC Med 4:14. 2006
    ..The aim of the current study was to assess the antidepressant efficacy and safety of Hypericum perforatum (St. John's wort) extract WS 5570 at doses of 600 mg/day in a single dose and 1200 mg/day in two doses...
  5. ncbi request reprint Escitalopram in the treatment of social anxiety disorder: randomised, placebo-controlled, flexible-dosage study
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Br J Psychiatry 186:222-6. 2005
    ..Selective serotonin reuptake inhibitors are effective in the treatment of social anxiety disorder and are currently regarded as the pharmacotherapy of choice...
  6. ncbi request reprint Efficacy of St. John's wort extract WS 5570 in acute treatment of mild depression: a reanalysis of data from controlled clinical trials
    S Kasper
    Department of Psychiatry und Psychotherapy, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, 1090, Austria
    Eur Arch Psychiatry Clin Neurosci 258:59-63. 2008
    ..The analysis shows that St. John's wort extract WS 5570 has a meaningful beneficial effect during acute treatment of patients suffering from mild depression and leads to a substantial increase in the probability of remission...
  7. ncbi request reprint Tardive Dyskinesia: analysis of outpatients with schizophrenia from Africa and the Middle East, Asia, Central and Eastern Europe, and Latin America
    Siegfried Kasper
    Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Schizophr Res 81:139-43. 2006
    ..This study provides new data in a non-Western population with a unique regional geography comparison...
  8. ncbi request reprint Onset of action of escitalopram compared with other antidepressants: results of a pooled analysis
    Siegfried Kasper
    Department of General Psychiatry, Medical University of Vienna, Austria
    Int Clin Psychopharmacol 21:105-10. 2006
    ....
  9. ncbi request reprint Escitalopram in the treatment of depressed elderly patients
    Siegfried Kasper
    Dept of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Am J Geriatr Psychiatry 13:884-91. 2005
    ..The authors examined the efficacy and tolerability of escitalopram and fluoxetine versus placebo in the treatment of elderly patients with major depressive disorder (MDD)...
  10. ncbi request reprint Maintenance of long-term efficacy and safety of quetiapine in the open-label treatment of schizophrenia
    Siegfried Kasper
    Department of General Psychiatry, Medical University Vienna, Vienna, Austria
    Int Clin Psychopharmacol 19:281-9. 2004
    ..In conclusion, quetiapine may be a suitable therapy in the long-term treatment of schizophrenia...
  11. ncbi request reprint Escitalopram in the long-term treatment of major depressive disorder in elderly patients
    Siegfried Kasper
    Medical University of Vienna, Vienna, Austria
    Neuropsychobiology 54:152-9. 2006
    ..The secondary aim was to examine response to treatment, as measured by change in the Montgomery-Asberg Depression Rating Scale (MADRS) total score from study entry to each visit, using observed cases...
  12. doi request reprint Light-dependent alteration of serotonin-1A receptor binding in cortical and subcortical limbic regions in the human brain
    Christoph Spindelegger
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    World J Biol Psychiatry 13:413-22. 2012
    ..Higher serotonin transporter availability in healthy human subjects in times of lesser light exposure and lower serotonin levels have been shown in winter...
  13. doi request reprint Area-specific modulation of neural activation comparing escitalopram and citalopram revealed by pharmaco-fMRI: a randomized cross-over study
    Christian Windischberger
    MR Center of Excellence, Center for Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria
    Neuroimage 49:1161-70. 2010
    ..We believe that reduced reactivity in the medial frontal gyrus found for escitalopram compared to citalopram administration might explain the response differences between study drugs as demonstrated in previous clinical trials...
  14. doi request reprint Cortisol plasma levels in social anxiety disorder patients correlate with serotonin-1A receptor binding in limbic brain regions
    Rupert Lanzenberger
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int J Neuropsychopharmacol 13:1129-43. 2010
    ..Dysregulation of the cortisol level might increase the vulnerability for mood disorders by altering limbic 5-HT1A receptors...
  15. doi request reprint Application of image-derived and venous input functions in major depression using [carbonyl-(11)C]WAY-100635
    Andreas Hahn
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
    Nucl Med Biol 40:371-7. 2013
    ..The aim of this study was to apply a previously validated approach to a clinical sample of patients with major depressive disorder (MDD) before and after electroconvulsive therapy (ECT)...
  16. ncbi request reprint Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study
    Nikolas Klein
    Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Psychopharmacology (Berl) 191:333-9. 2007
    ..In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioligand [(123)I]ADAM and single photon emission computed tomography (SPECT)...
  17. doi request reprint Interaction between serotonin 5-HT2A receptor gene and dopamine transporter (DAT1) gene polymorphisms influences personality trait of persistence in Austrian Caucasians
    Alexandra Schosser
    Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University Vienna, Vienna, Austria
    World J Biol Psychiatry 11:417-24. 2010
    ..004; homo-/heterozygous gene variants: P=0.0004). We conclude that an interaction between DAT1 and 5HT2A genes might influence the temperamental personality trait persistence...
  18. doi request reprint Lateralization of the serotonin-1A receptor distribution in language areas revealed by PET
    Martin Fink
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Neuroimage 45:598-605. 2009
    ..For the first time, this PET study shows lateralization of the main inhibitory receptor of the serotonergic system in functionally asymmetric organized regions of the healthy human brain in vivo...
  19. doi request reprint Escitalopram enhances the association of serotonin-1A autoreceptors to heteroreceptors in anxiety disorders
    Andreas Hahn
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, 1090 Vienna, Austria
    J Neurosci 30:14482-9. 2010
    ..These findings provide complementary information about treatment effects on a network level and confirm the central role of the DRN as a prime regulatory area...
  20. doi request reprint Differences in the dynamics of serotonin reuptake transporter occupancy may explain superior clinical efficacy of escitalopram versus citalopram
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int Clin Psychopharmacol 24:119-25. 2009
    ....
  21. doi request reprint Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder
    Andreas Hahn
    Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University of Vienna, Vienna, Austria
    Neuroimage 56:881-9. 2011
    ....
  22. ncbi request reprint Striatal D(2) receptor occupancy in bipolar patients treated with olanzapine
    Trawat Attarbaschi
    Department of General Psychiatry, Medical University Vienna, Vienna, Austria
    Eur Neuropsychopharmacol 17:102-7. 2007
    ..Although we did not find an increased vulnerability for acute EPS in bipolar patients receiving olanzapine at clinical relevant doses, this needs to be replicated with larger sample sizes...
  23. doi request reprint Prediction of SSRI treatment response in major depression based on serotonin transporter interplay between median raphe nucleus and projection areas
    Rupert Lanzenberger
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
    Neuroimage 63:874-81. 2012
    ..These findings may indicate a promising molecular predictor of treatment response and stimulate new treatment approaches based on regional differences in SERT binding...
  24. doi request reprint The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635
    Patrycja Stein
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Eur J Nucl Med Mol Imaging 35:2159-68. 2008
    ..The present positron emission tomography (PET) study investigated the influence of sex on the major inhibitory serotonergic receptor subtype, the serotonin-1A (5-HT(1A)) receptor...
  25. doi request reprint Hypothalamic serotonin-1A receptor binding measured by PET predicts the plasma level of dehydroepiandrosterone sulfate in healthy women
    Ulrike Moser
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
    Neurosci Lett 476:161-5. 2010
    ..As disturbances of the HPA axis as well as changes of the 5-HT(1A) receptor distribution have been reported in affective disorders, future studies should focus on these interactions...
  26. ncbi request reprint Season of birth in siblings of patients with seasonal affective disorder. A test of the parental conception habits hypothesis
    Edda Pjrek
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Eur Arch Psychiatry Clin Neurosci 257:378-82. 2007
    ..Further research could be conducted in non-seasonal depression as there is still a lack of studies on seasonality of birth in affective disorders...
  27. doi request reprint Therapeutic effects of escitalopram and reboxetine in seasonal affective disorder: a pooled analysis
    Edda Pjrek
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    J Psychiatr Res 43:792-7. 2009
    ..Reboxetine displayed a faster onset of action, but was associated with more pronounced side effects. Further studies comparing SSRI and NARI in SAD are warranted...
  28. ncbi request reprint Serum lipid levels in seasonal affective disorder
    Edda Pjrek
    Dept of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Eur Arch Psychiatry Clin Neurosci 257:197-202. 2007
    ..56 +/- 0.96 mmol/l; p = 0.126). The results of this study support the idea that low cholesterol levels may be of pathogenetic importance in SAD. Further study in larger clinical samples is warranted to clarify our findings...
  29. ncbi request reprint A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study
    Nicole Praschak-Rieder
    Department of General Psychiatry, Medical University of Vienna, Austria
    J Psychiatr Res 39:561-7. 2005
    ....
  30. ncbi request reprint Seasonality of birth in seasonal affective disorder
    Edda Pjrek
    Department of General Psychiatry, Medical University of Vienna, Austria
    J Clin Psychiatry 65:1389-93. 2004
    ..The aim of this investigation was to examine seasonal differences in the frequency of birth in a clinical sample of patients with seasonal affective disorder (SAD)...
  31. doi request reprint Serotonin-1A receptor binding is positively associated with gray matter volume -- a multimodal neuroimaging study combining PET and structural MRI
    Christoph Kraus
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
    Neuroimage 63:1091-8. 2012
    ....
  32. ncbi request reprint Enhanced serotonin transporter function during depression in seasonal affective disorder
    Matthaus Willeit
    Department of Biological Psychiatry, Medical University of Vienna, Vienna, Austria
    Neuropsychopharmacology 33:1503-13. 2008
    ..5-HTTLPR was not associated with any of the 5-HTT parameters. In sum, we conclude that the 5-HTT is in a hyperfunctional state during depression in SAD and normalizes after light therapy and in natural summer remission...
  33. ncbi request reprint Serotonin transporter promoter gene polymorphic region (5-HTTLPR) and personality in female patients with seasonal affective disorder and in healthy controls
    Nikolaus Thierry
    Department of General Psychiatry, Waehringer Guertel 18 20, University of Vienna, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 14:53-8. 2004
    ..The s allele was associated with lower Self-Directedness scores in SAD patients, whereas there were no significant differences in TCI dimensions between patients and controls in carriers of the long allele...
  34. doi request reprint Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University Vienna, MUV, AKH, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    J Clin Psychiatry 71:109-20. 2010
    ....
  35. ncbi request reprint Social anxiety disorder: epidemiology, biology and treatment
    Martin Fink
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wien, Austria
    Psychiatr Danub 21:533-42. 2009
    ..There is still a substantial lack of data on therapeutic options in cases of non-responsive SAD as well as on add-on therapy. A combined treatment-approach including psychotherapy (e.g. cognitive behavioural therapy) may prove useful...
  36. ncbi request reprint Actigraphy in patients with seasonal affective disorder and healthy control subjects treated with light therapy
    Dietmar Winkler
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Biol Psychiatry 58:331-6. 2005
    ..The purpose of this study was to investigate if bright light therapy (BLT) is able to reverse these disturbances...
  37. doi request reprint Imaging treatment effects in depression
    Anna Höflich
    Department of Psychiatry and Psychotherapy, Medical University of Vienna Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Rev Neurosci 23:227-52. 2012
    ..However, it seems that not all dysfunctional processes can be reversed by antidepressant treatment and that state and trait factors are evident not only on a behavioral but also on a neurobiological level...
  38. doi request reprint Bright-light therapy in the treatment of mood disorders
    Gerald Pail
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Neuropsychobiology 64:152-62. 2011
    ..In the third part, the mode of action, application, efficacy, tolerability and safety of BLT in SAD and other mood disorders are explored...
  39. doi request reprint Self-poisonings with tricyclic antidepressants and selective serotonin reuptake inhibitors in Tehran, Iran
    Angela Naderi-Heiden
    Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University of Vienna, A 1090 Vienna, Austria
    World J Biol Psychiatry 10:302-12. 2009
    ..042), while there was no significant difference between TCA multiple- and single-substance intoxications. This study suggests that an overdose with SSRIs results in a more favourable clinical outcome than an overdose with TCAs...
  40. doi request reprint Regional sex differences in grey matter volume are associated with sex hormones in the young adult human brain
    A Veronica Witte
    Department of Psychiatry, Functional NeuroImaging Unit PET and fMRI, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Neuroimage 49:1205-12. 2010
    ..This might help to shed further light on the underlying mechanisms of both functional diversities and congruence between female and male brains...
  41. ncbi request reprint Effects of olanzapine and ziprasidone on glucose tolerance in healthy volunteers
    Julia Sacher
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Neuropsychopharmacology 33:1633-41. 2008
    ..Our finding is suggestive that not all atypical antipsychotics cause acute direct effects on glucose disposal and that accurate determination of side effect profile should be performed when choosing an atypical antipsychotic...
  42. doi request reprint Efficacy and safety of silexan, a new, orally administered lavender oil preparation, in subthreshold anxiety disorder - evidence from clinical trials
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Wien Med Wochenschr 160:547-56. 2010
    ..4 ± 7.1 and 12.0 ± 7.2 points at week 6 and by between 11.8 ± 7.7 and 16.0 ± 8.3 points at week 10. In GAD silexan and lorazepam showed comparable HAMA total score reductions (90% CI for mean value difference: -2.3; 2.8 points)...
  43. ncbi request reprint Typical neuroleptics vs. atypical antipsychotics in the treatment of acute mania in a natural setting
    Martin Letmaier
    Department of General Psychiatry, Medical University of Vienna, Austria
    Int J Neuropsychopharmacol 9:529-37. 2006
    ....
  44. ncbi request reprint Reduced serotonin-1A receptor binding in social anxiety disorder
    Rupert R Lanzenberger
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Biol Psychiatry 61:1081-9. 2007
    ..The objective of this study was to investigate 5-HT1A receptor binding potential (BP) in social anxiety disorder (SAD)...
  45. doi request reprint Combining image-derived and venous input functions enables quantification of serotonin-1A receptors with [carbonyl-11C]WAY-100635 independent of arterial sampling
    Andreas Hahn
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
    Neuroimage 62:199-206. 2012
    ..This study aims for a direct validation of IDIFs and venous data for the quantification of serotonin-1A receptor binding (5-HT(1A)) with [carbonyl-(11)C]WAY-100635 before and after hormone treatment...
  46. ncbi request reprint Agomelatine in the treatment of seasonal affective disorder
    Edda Pjrek
    Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Psychopharmacology (Berl) 190:575-9. 2007
    ..Previous studies showed that agomelatine is able to restore disrupted circadian rhythms, which were implicated in the pathophysiology of seasonal affective disorder (SAD)...
  47. ncbi request reprint Escitalopram in a working population: results from an observational study of 2378 outpatients in Austria
    Dietmar Winkler
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Hum Psychopharmacol 22:245-51. 2007
    ..The aim of this observational study was to evaluate the effectiveness of escitalopram in a naturalistic sample of employed people with mood and anxiety disorders...
  48. ncbi request reprint Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder
    Dietmar Winkler
    Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Eur Neuropsychopharmacol 13:129-34. 2003
    ..Due to methodological limitations our results need to be replicated in controlled double-blind randomized clinical trials...
  49. ncbi request reprint Anger attacks in seasonal affective disorder
    Dietmar Winkler
    Department of General Psychiatry, Medical University of Vienna, Austria
    Int J Neuropsychopharmacol 9:215-9. 2006
    ..021) and obtained lower global seasonality scores than SAD patients without anger attacks (p=0.001). Anger attacks are experienced as particularly intense in SAD patients and seem to contribute considerably to their symptomatology...
  50. doi request reprint The European post-marketing observational sertindole study: an investigation of the safety of antipsychotic drug treatment
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Eur Arch Psychiatry Clin Neurosci 260:59-68. 2010
    ..Although CIs remained large, this post-marketing study does not provide any evidence against the use of sertindole under normal conditions. Sertindole was well tolerated and posed no significant safety problems...
  51. ncbi request reprint Quetiapine is effective against anxiety and depressive symptoms in long-term treatment of patients with schizophrenia
    Siegfried Kasper
    Medical University of Vienna, Department of General Psychiatry, Vienna, Austria
    Depress Anxiety 20:44-7. 2004
    ..13 (-1.23, -1.04) and after 156 weeks, it was -1.33 (-1.78, -0.87). Therefore, the efficacy of quetiapine for the treatment of anxiety and depressive symptoms is maintained in long-term treatment...
  52. ncbi request reprint Bright light therapy in seasonal affective disorder--does it suffice?
    Edda Pjrek
    Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 14:347-51. 2004
    ..Opposed to treatment guidelines, patients with several depressive episodes did not receive antidepressant maintenance medication or mood stabilizers more often than patients with only a few episodes...
  53. ncbi request reprint Better tolerability of St. John's wort extract WS 5570 compared to treatment with SSRIs: a reanalysis of data from controlled clinical trials in acute major depression
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int Clin Psychopharmacol 25:204-13. 2010
    ..In conclusion, WS 5570 exhibits substantially lower incidence rates of adverse events than paroxetine and other SSRIs...
  54. ncbi request reprint Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacology
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    World J Biol Psychiatry 3:133-46. 2002
    ..Our data provide insight into the pathophysiology of neuropsychiatric disorders and may guide future psychopharmacological drug developments...
  55. ncbi request reprint Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29
    Alexandra Schosser
    Department of General Psychiatry, University Hospital for Psychiatry, Medical University Vienna, Austria
    Eur Neuropsychopharmacol 17:501-5. 2007
    ..1r3. A NPL score Z(all) of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs)...
  56. doi request reprint Sex-specific predictors of criminal recidivism in a representative sample of incarcerated youth
    Belinda Plattner
    Universitätsklinik für Psychiatrie des Kindes und Jugendalters, Medizinische Universität Wien, Vienna, Austria
    Compr Psychiatry 50:400-7. 2009
    ..The objective of the study was to identify sex-specific psychopathologic predictors of criminal recidivism among a representative sample of incarcerated youths...
  57. doi request reprint Neuropsychiatric deep brain stimulation for translational neuroimaging
    Anna Höflich
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
    Neuroimage 79:30-41. 2013
    ....
  58. doi request reprint Gray matter and intrinsic network changes in the posterior cingulate cortex after selective serotonin reuptake inhibitor intake
    Christoph Kraus
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria Functional, Molecular and Translational Neuroimaging Lab PET and MRI, Medical University of Vienna, Austria
    Neuroimage 84:236-44. 2014
    ..Our novel findings provide convergent evidence for dynamic alterations of brain structure and function associated with SSRI pharmacotherapy. ..
  59. doi request reprint Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects
    A Veronica Witte
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Hum Brain Mapp 30:2558-70. 2009
    ..The present study aimed to elucidate potential interactions between human aggression, the inhibitory serotonergic 5-HT(1A) receptor, and sex hormones...
  60. doi request reprint Beyond the monoaminergic hypothesis: agomelatine, a new antidepressant with an innovative mechanism of action
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    World J Biol Psychiatry 10:117-26. 2009
    ..Collectively, its efficacy, together with its excellent tolerability, makes agomelatine an especially promising antidepressant for the near future...
  61. doi request reprint No association of the neuropeptide Y (Leu7Pro) and ghrelin gene (Arg51Gln, Leu72Met, Gln90Leu) single nucleotide polymorphisms with eating disorders
    Jochen Kindler
    Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University Vienna, Vienna, Austria
    Nord J Psychiatry 65:203-7. 2011
    ..Genetic factors likely contribute to the biological vulnerability of eating disorders...
  62. ncbi request reprint Validation of a simplified definition of anger attacks
    Dietmar Winkler
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Psychother Psychosom 75:103-6. 2006
    ..Assessment normally requires the use of specific instruments. The aim of this study was the validation of a simplified definition for anger attacks...
  63. ncbi request reprint Efficacy of pregabalin and venlafaxine-XR in generalized anxiety disorder: results of a double-blind, placebo-controlled 8-week trial
    Siegfried Kasper
    Department of General Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int Clin Psychopharmacol 24:87-96. 2009
    ..1%) and PBO (7.8%), but higher for VXR (20.0%; P < 0.05). In conclusion, PGB was a safe and effective treatment of GAD, with a significantly earlier onset of anxiolytic activity than VXR...
  64. ncbi request reprint Effect of intravenous magnesium sulphate in reducing irritability and restlessness in pure and polysubstance opiate detoxification
    Angela Naderi-Heiden
    Department of General Psychiatry, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Psychiatry Res 135:53-63. 2005
    ..Despite promising pilot studies, the administration of Mg did not enable a dose reduction of tranquilizing medication (chlormethiazole) in pure and polysubstance opiate detoxification...
  65. doi request reprint The role of pharmacogenetics in the treatment of depression and anxiety disorders
    Alexandra Schosser
    Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University Vienna, Austria
    Int Clin Psychopharmacol 24:277-88. 2009
    ..The current review not only updates pharmacogenetic research in depression but also focuses on antidepressant treatment response in anxiety disorders...
  66. doi request reprint Actigraphic measurements in opioid detoxification with methadone or buprenorphine
    Edda Pjrek
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    J Clin Psychopharmacol 32:75-82. 2012
    ..Opioid tapering with methadone or buprenorphine leads to characteristic changes of the rest-activity cycle, but further study is required to validate these results...
  67. ncbi request reprint Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects
    A Veronica Witte
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Hum Brain Mapp 31:339. 2010
    ..The article to which this erratum refers was published in Hum Brain Mapp 2008, DOI: . (c) 2009 Wiley-Liss, Inc...
  68. doi request reprint Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, placebo controlled trial
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int Clin Psychopharmacol 25:277-87. 2010
    ..Lavandula oil preparation silexan is both efficacious and safe for the relief of anxiety disorder not otherwise specified. It has a clinically meaningful anxiolytic effect and alleviates anxiety related disturbed sleep...
  69. doi request reprint Psychosocial background in incarcerated adolescents from Austria, Turkey and former Yugoslavia
    Susanne Monika Bauer
    Department of Psychiatry and Psychotherapy, Medical University of Vienna MUW, Vienna, Austria
    Psychiatry Res 185:193-9. 2011
    ..Family systems, even if substantially dysfunctional, seem to be perceived as more stable by migrant youth than by Austrian youth...
  70. ncbi request reprint Atypical antipsychotics in mood disorders
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Vienna, Austria
    Int Clin Psychopharmacol 17:S1-10. 2002
    ....
  71. doi request reprint Multimodal imaging of human early visual cortex by combining functional and molecular measurements with fMRI and PET
    Florian Gerstl
    MR Centre of Excellence, Centre for Biomedical Engineering and Physics, Medical University of Vienna, Austria
    Neuroimage 41:204-11. 2008
    ..Our in vivo findings clearly support prior assumptions of a link between receptor distribution and functional fields of the human cortex...
  72. ncbi request reprint C825T polymorphism in the G protein beta3-subunit gene is associated with seasonal affective disorder
    Matthaus Willeit
    Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria
    Biol Psychiatry 54:682-6. 2003
    ....
  73. ncbi request reprint A longitudinal view of triggers and thresholds of suicidal behavior in depression
    Lukas Pezawas
    Department of General Psychiatry, University of Vienna, Austria
    J Clin Psychiatry 63:866-73. 2002
    ..RBD and MDD diagnoses were based on DSM-IV criteria. Furthermore, the goal of this study was to determine if impulsivity as an underlying factor could explain high suicide attempt rates in CD...
  74. ncbi request reprint Dopaminergic deficit and the role of amisulpride in the treatment of schizophrenia
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Vienna, Austria
    Int Clin Psychopharmacol 17:S19-26. 2002
    ....
  75. doi request reprint The psychiatrist confronted with a fibromyalgia patient
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
    Hum Psychopharmacol 24:S25-30. 2009
    ..Thus the psychiatrist is well placed to initiate treatment in these patients...
  76. ncbi request reprint Possible linkage of schizophrenia and bipolar affective disorder to chromosome 3q29; a follow-up
    Alexandra Schosser
    Department of General Psychiatry, University Hospital for Psychiatry, A 1090 Vienna, Austria
    J Psychiatr Res 38:357-64. 2004
    ..The results of our follow-up study support our previous linkage finding of schizophrenia and bipolar affective disorder to chromosome 3q29...
  77. doi request reprint Longitudinal analysis of the suicidal behaviour risk in short-term placebo-controlled studies of mirtazapine in major depressive disorder
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    World J Biol Psychiatry 11:36-44. 2010
    ..To examine suicidal behaviour risk in the short-term placebo-controlled studies of mirtazapine in Major Depressive Disorder (MDD)...
  78. ncbi request reprint Guided self-help versus cognitive-behavioral group therapy in the treatment of bulimia nervosa
    Ursula Bailer
    Department of General Psychiatry, University Hospital of Psychiatry, Medical University of Vienna, Vienna, Austria
    Int J Eat Disord 35:522-37. 2004
    ..The aim of the current study was to evaluate whether guided self-help was effective in the short and long term in the treatment of bulimia nervosa...
  79. ncbi request reprint Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with and without premenstrual dysphoric disorder
    Nicole Praschak-Rieder
    Department of General Psychiatry, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 12:129-34. 2002
    ..The elevated rate of affective disorders in relatives of patients with SAD and PMDD suggests higher genetic vulnerability in this subgroup when compared to patients with SAD alone...
  80. ncbi request reprint Treatment of seasonal affective disorder
    Dietmar Winkler
    Medical University of Vienna, Department of General Psychiatry Währinger Gürtel 18 20 A 1090 Vienna, Austria
    Expert Rev Neurother 6:1039-48. 2006
    ..However, numerous studies have also investigated suitable psychopharmacological treatments for SAD. This report is aimed to provide an overview on the clinical management and current therapeutic options for SAD...
  81. ncbi request reprint Binding kinetics of 123I[ADAM] in healthy controls: a selective SERT radioligand
    Julia Sacher
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Int J Neuropsychopharmacol 10:211-8. 2007
    ..Our data suggest that the acquisition time for the SPECT scan is optimally, under pseudo-equilibrium conditions, between 205-320 min post-bolus injection of the tracer...
  82. ncbi request reprint Pharmacotherapy of seasonal affective disorder
    Edda Pjrek
    Department of General Psychiatry at the Medical University of Vienna, Vienna, Austria
    CNS Spectr 10:664-9; quiz 672. 2005
    ..Furthermore, there are no studies specifically addressing bipolar seasonal depression. This article will review the published literature on pharmacotherapy of seasonal affective disorder...
  83. ncbi request reprint Anger attacks in depression--evidence for a male depressive syndrome
    Dietmar Winkler
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Psychother Psychosom 74:303-7. 2005
    ..It has been proposed that aggression and especially anger attacks play an important role in the symptomatology of depression. Furthermore, it has been hypothesized that these symptoms are more prevalent in males than in females...
  84. ncbi request reprint Optimisation of long-term treatment in schizophrenia: treating the true spectrum of symptoms
    Siegfried Kasper
    Department of Psychiatry, Medical University of Vienna, Austria
    Eur Neuropsychopharmacol 16:S135-41. 2006
    ....
  85. doi request reprint Superiority of escitalopram to paroxetine in the treatment of depression
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
    Eur Neuropsychopharmacol 19:229-37. 2009
    ..Escitalopram is a good therapeutic option for the long-term treatment of MDD, particularly in severely depressed patients...
  86. ncbi request reprint Neurobiological and clinical effects of the antidepressant tianeptine
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    CNS Drugs 22:15-26. 2008
    ..The neurobiological properties of tianeptine may provide an explanation not only for its antidepressant activity, but also for its anxiolytic effects in depressed patients and its lack of adverse effects on cognitive function and memory...
  87. ncbi request reprint Genome scan for susceptibility loci for schizophrenia and bipolar disorder
    Ursula Bailer
    Department of General Psychiatry, University Hospital for Psychiatry, Vienna, Austria
    Biol Psychiatry 52:40-52. 2002
    ..The objective of our analyses was to search for vulnerability loci for the two disorders...
  88. ncbi request reprint European College of Neuropsychopharmacology - 16th Congress. 20-24 September 2003, Prague, Czech Republic
    Dietmar Winkler
    University Hospital for Psychiatry, Vienna, Austria
    IDrugs 6:1020-3. 2003
  89. ncbi request reprint Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression
    Timo Partonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Ann Med 39:229-38. 2007
    ..We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, predispose to winter depression...
  90. ncbi request reprint Escitalopram in the treatment of social anxiety disorder: analysis of efficacy for different clinical subgroups and symptom dimensions
    Dan J Stein
    MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    Depress Anxiety 20:175-81. 2004
    ..A six-factor model of social anxiety symptoms is supported by the distinctive association between these symptom dimensions and different areas of disability, but did not predict differential response to escitalopram...
  91. ncbi request reprint St John's wort extract (LI 160) in somatoform disorders: results of a placebo-controlled trial
    Hans Peter Volz
    Psychiatric Department, University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Psychopharmacology (Berl) 164:294-300. 2002
    ..Therefore, the efficacy of the Hypericum extract LI 160 in patients with somatoform disorders should be studied in a double-blind placebo-controlled fashion...
  92. ncbi request reprint Severe depression and antidepressants: focus on a pooled analysis of placebo-controlled studies on agomelatine
    Stuart A Montgomery
    Imperial College School of Medicine, University of London, London, UK
    Int Clin Psychopharmacol 22:283-91. 2007
    ..06 rising to 4.45 points on the Hamilton Depression Rating Scale. In conclusion, agomelatine is effective in treating severe depression...
  93. ncbi request reprint Partial response and nonresponse to antidepressant therapy: current approaches and treatment options
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
    J Clin Psychiatry 63:826-37. 2002
    ....
  94. ncbi request reprint Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression
    Alexander Neumeister
    National Institutes of Health, NIMH, Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670
    Arch Gen Psychiatry 59:613-20. 2002
    ..We studied the behavioral responses to tryptophan depletion (TD) in healthy women with and without a first-degree family history of depression and examined the relationship to 5HTTLPR alleles...
  95. ncbi request reprint Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635
    Johannes Tauscher
    PET Centre, Toronto, Ontario
    Arch Gen Psychiatry 59:514-20. 2002
    ....
  96. ncbi request reprint A meta-analysis of clinical trials comparing reboxetine, a norepinephrine reuptake inhibitor, with selective serotonin reuptake inhibitors for the treatment of major depressive disorder
    George I Papakostas
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, WAC 812 Boston, MA 02114, USA
    Eur Neuropsychopharmacol 18:122-7. 2008
    ..These results suggest that the NRI reboxetine and the SSRIs differ with respect to their side-effect profile and overall tolerability but not their efficacy in treating MDD...
  97. ncbi request reprint Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference
    Carolina Johansson
    Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 28:734-9. 2003
    ..In conclusion, our results suggest involvement of circadian clock-related polymorphisms both in susceptibility to SAD and diurnal preference...
  98. ncbi request reprint Effectiveness, tolerability, and safety of ziprasidone in patients with schizophrenia or schizoaffective disorder: results of a multi-centre observational trial
    Duerten Kudla
    Centre for Psychosocial Medicine, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur Psychiatry 22:195-202. 2007
    ..Secondary objectives included quality of life, subjective well-being, tolerability, and safety...
  99. ncbi request reprint Efficacy and safety of pregabalin in the treatment of generalized anxiety disorder: a 6-week, multicenter, randomized, double-blind, placebo-controlled comparison of pregabalin and venlafaxine
    Stuart A Montgomery
    Imperial College School of Medicine, London, UK
    J Clin Psychiatry 67:771-82. 2006
    ..The current study compared the efficacy and safety of pregabalin and venlafaxine in patients diagnosed with moderate to severe GAD...
  100. ncbi request reprint Efficacy of agomelatine, a MT1/MT2 receptor agonist with 5-HT2C antagonistic properties, in major depressive disorder
    Jean Pierre Olie
    Sainte Anne Hospital, University Department of Psychiatry, Paris, France
    Int J Neuropsychopharmacol 10:661-73. 2007
    ....
  101. ncbi request reprint A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder
    Guy M Goodwin
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, England, UK
    J Clin Psychiatry 65:432-41. 2004
    ..Two clinical trials, prospectively designed for combined analysis, compared placebo, lithium, and lamotrigine for treatment of bipolar I disorder in recently depressed or manic patients...