Research Topics
Genomes and Genes | Heidrun KarlicSummaryAffiliation: Medical University of Vienna Country: Austria Publications
| Collaborators
|
Detail Information
Publications
[Tumor stem cell research - basis and challenge for diagnosis and therapy]Heidrun Karlic
Ludwig Boltzmann Cluster Oncology LBI for Leukemia Research, Hanusch Hospital, Vienna, Austria
Wien Klin Wochenschr 122:423-36. 2010..It is the hope for the future that therapeutic approaches involving CSC-targeting concepts will lead to sustained remission and thus improvement of prognosis in leukemia and cancer patients...- Vegetarian diet affects genes of oxidative metabolism and collagen synthesisHeidrun Karlic
Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, Vienna, Austria
Ann Nutr Metab 53:29-32. 2008..This study compares expression patterns of relevant genes in oral mucosa of omnivores and vegetarians... - Extra-cellular matrix suppresses expression of the apoptosis mediator Fas by epigenetic DNA methylationRoman Thaler
Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Center Meidling, Medical Department, Vienna, Austria
Apoptosis 15:728-37. 2010..In summary, we demonstrate that ECM prevents activation of Fas by epigenetic DNA-methylation... - Neoplastic stem cells: current concepts and clinical perspectivesAxel Schulenburg
Bone Marrow Transplantation Unit, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
Crit Rev Oncol Hematol 76:79-98. 2010..The current article provides a summary of our current knowledge on neoplastic (cancer) stem cells, with special emphasis on clinical implications and therapeutic options as well as a discussion about conceptual and technical limitations... 
Effects of doxorubicin-containing chemotherapy and a combination with L-carnitine on oxidative metabolism in patients with non-Hodgkin lymphomaRaimund Waldner
3rd Department of Medicine, Hanusch Hospital, Vienna, Austria
J Cancer Res Clin Oncol 132:121-8. 2006..CONCLUSION: Biochemical and molecular analyses indicated a stimulation of oxidative metabolism in white blood cells through carnitine uptake...
DMSO is a strong inducer of DNA hydroxymethylation in pre-osteoblastic MC3T3-E1 cellsRoman Thaler
Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Center Meidling First Medical Department, Hanusch Hospital, Vienna, Austria
Epigenetics 7:635-51. 2012....- Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromesHeidrun Karlic
Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, H Collinstrasse 30, 1140 Vienna, Austria
J Mol Med (Berl) 81:435-42. 2003..The described reduction in transcription of different genes in blood cells which is well known in different tissues may reflect a systemic signaling process, associated with aging, apoptosis, and MDS... - Does mRNA level of microsomal carnitine palmitoyltransferase predict yield of peripheral blood stem cell apheresis?Michael Fillitz
3rd Department of Medicine, Hanusch Hospital, H Collinstrasse 30, 1140 Vienna, Austria
Ann Hematol 85:386-93. 2006..This gives evidence for a possible predictive value of such analyzes though further data of a larger sample are to be collected to confirm our observations... - Imatinib mesylate (IM)-induced growth inhibition is associated with production of spliced osteocalcin-mRNA in cell linesPeter Wihlidal
Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, Vienna, Austria
Leuk Res 32:437-43. 2008..In mouse osteoblastic MC3T3-E1 cells only OCNs is present, independently of treatment. As the stimulatory effect of IM on OCNs is also observed upon treatment with vitamin D, common regulatory processes may be considered... - Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylationRoman Thaler
1st Medical Department, Hanusch Hospital, Ludwig Boltzmann Institute of Osteology, Hanusch Hospital, Wiener Gebietskrankenkasse and AUVA Trauma Center Meidling, 1140 Vienna, Austria
J Biol Chem 286:5578-88. 2011..Furthermore, IL-6 stimulation results via JAK2, Fli1, and Dnmt1 in down-regulation of Lox expression by epigenetic CpG methylation revealing a new mechanism negatively affecting bone matrix formation... - Epigenetic regulation of human buccal mucosa mitochondrial superoxide dismutase gene expression by dietRoman Thaler
Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, Vienna, Austria
Br J Nutr 101:743-9. 2009..These results indicate that diet affects the epigenetic regulation of human MnSOD... - Expression and functional significance of osteocalcin splicing in disease progression of hematological malignanciesPeter Wihlidal
Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, Vienna, Austria
Leuk Res 30:1241-8. 2006..Our data indicate that OCNs mRNA and OCN protein is expressed in c-KIT positive neoplastic stem cells in hematological malignancies... - 5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS-demethylation and FAS re-expression, and synergism with FAS-ligandViviane Ghanim
Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
Blood 119:4242-52. 2012..These effects are mediated through "FAS-re-expression" and are augmented by the FAS-ligand. Whether epigenetic drugs produce antineoplastic effects in vivo in patients with ASM and MCL remains to be determined... - Osteocalcin attenuates T3- and increases vitamin D3-induced expression of MMP-13 in mouse osteoblastsFranz Varga
Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling 4th Medical Department, Hanusch Hospital, Vienna, Austria
Endocr J 56:441-50. 2009..We therefore hypothesize that OCN is a modulator of the hormonally regulated MMP-13 expression... - Myelodysplastic syndromes, aging, and age: correlations, common mechanisms, and clinical implicationsMichael Pfeilstöcker
Hanusch Hospital, 3rd Medical Department, Vienna, Austria
Leuk Lymphoma 48:1900-9. 2007..In addition, the present review discusses age as an important prognostic factor and co-variable to be considered in treatment algorithms in MDS... - Supplementation of L-carnitine in athletes: does it make sense?Heidrun Karlic
Ludwig Boltzmann Institute for Leukemia Research and Hematology, Vienna, Austria
Nutrition 20:709-15. 2004..Thus there is evidence for a beneficial effect of L-carnitine supplementation in training, competition, and recovery from strenuous exercise and in regenerative athletics... - Breaking bad news to cancer patients: survey and analysisWolfgang Spiegel
Department of General Practice, Center for Public Health, Medical University of Vienna, Austria
Psychooncology 18:179-86. 2009..To find out how patients perceived the disclosure of news about their cancer as regards the physician counselling and how they perceived the flow of information between hospital-based and family physicians... - Preanalytic removal of human DNA eliminates false signals in general 16S rDNA PCR monitoring of bacterial pathogens in bloodMichael Handschur
Ludwig Boltzmann Institute for Leukemia Research and Hematology, Vienna, Austria
Comp Immunol Microbiol Infect Dis 32:207-19. 2009..Thus, the BFEM contributes to the generation of replicable and more reliable data in general 16S rDNA PCR assays... - Cancer patients' perception of information exchange between hospital-based doctors and their general practitionersWolfgang Spiegel
Department of General Practice, Center for Public Health, Medical University of Vienna, Vienna, Austria
J Eval Clin Pract 16:1309-13. 2010..This study aims to find out what importance cancer patients in Austria attach to information exchange between hospital-based doctors and their general practitioners (GPs) and how patients perceive this flow of information... - Dietary l-carnitine stimulates carnitine acyltransferases in the liver of aged ratsHeidrun Karlic
Ludwig Boltzmann Institute for Leukemia Research and Hematology, Vienna, Austria
J Histochem Cytochem 50:205-12. 2002..These results suggest that l-carnitine stimulates transcription of CPT1, CPT2, and CRAT as well as the enzyme activity of CPT1 in the livers of aged rats...