Heidrun Karlic

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. doi request reprint [Tumor stem cell research - basis and challenge for diagnosis and therapy]
    Heidrun Karlic
    Ludwig Boltzmann Cluster Oncology LBI for Leukemia Research, Hanusch Hospital, Vienna, Austria
    Wien Klin Wochenschr 122:423-36. 2010
  2. doi request reprint The role of epigenetics in the regulation of apoptosis in myelodysplastic syndromes and acute myeloid leukemia
    Heidrun Karlic
    Ludwig Boltzmann Cluster Oncology, Vienna, Austria Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, Vienna, Austria Electronic address
    Crit Rev Oncol Hematol 90:1-16. 2014
  3. doi request reprint Vegetarian diet affects genes of oxidative metabolism and collagen synthesis
    Heidrun Karlic
    Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, Vienna, Austria
    Ann Nutr Metab 53:29-32. 2008
  4. ncbi request reprint Extra-cellular matrix suppresses expression of the apoptosis mediator Fas by epigenetic DNA methylation
    Roman Thaler
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Center Meidling, Medical Department, Vienna, Austria
    Apoptosis 15:728-37. 2010
  5. ncbi request reprint Does mRNA level of microsomal carnitine palmitoyltransferase predict yield of peripheral blood stem cell apheresis?
    Michael Fillitz
    3rd Department of Medicine, Hanusch Hospital, H Collinstrasse 30, 1140 Vienna, Austria
    Ann Hematol 85:386-93. 2006
  6. ncbi request reprint Effects of doxorubicin-containing chemotherapy and a combination with L-carnitine on oxidative metabolism in patients with non-Hodgkin lymphoma
    Raimund Waldner
    3rd Department of Medicine, Hanusch Hospital, Vienna, Austria
    J Cancer Res Clin Oncol 132:121-8. 2006
  7. doi request reprint Neoplastic stem cells: current concepts and clinical perspectives
    Axel Schulenburg
    Bone Marrow Transplantation Unit, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Crit Rev Oncol Hematol 76:79-98. 2010
  8. pmc DMSO is a strong inducer of DNA hydroxymethylation in pre-osteoblastic MC3T3-E1 cells
    Roman Thaler
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Center Meidling First Medical Department, Hanusch Hospital, Vienna, Austria
    Epigenetics 7:635-51. 2012
  9. ncbi request reprint Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromes
    Heidrun Karlic
    Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, H Collinstrasse 30, 1140 Vienna, Austria
    J Mol Med (Berl) 81:435-42. 2003
  10. ncbi request reprint Epigenetic regulation of human buccal mucosa mitochondrial superoxide dismutase gene expression by diet
    Roman Thaler
    Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, Vienna, Austria
    Br J Nutr 101:743-9. 2009

Collaborators

Detail Information

Publications23

  1. doi request reprint [Tumor stem cell research - basis and challenge for diagnosis and therapy]
    Heidrun Karlic
    Ludwig Boltzmann Cluster Oncology LBI for Leukemia Research, Hanusch Hospital, Vienna, Austria
    Wien Klin Wochenschr 122:423-36. 2010
    ..It is the hope for the future that therapeutic approaches involving CSC-targeting concepts will lead to sustained remission and thus improvement of prognosis in leukemia and cancer patients...
  2. doi request reprint The role of epigenetics in the regulation of apoptosis in myelodysplastic syndromes and acute myeloid leukemia
    Heidrun Karlic
    Ludwig Boltzmann Cluster Oncology, Vienna, Austria Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, Vienna, Austria Electronic address
    Crit Rev Oncol Hematol 90:1-16. 2014
    ..Thus, promoter-demethylation of FAS and DAPK1 represents a critical mechanism of drug-induced apoptosis in neoplastic cells in MDS and AML which underscores the clinical implication of epigenetically active therapies. ..
  3. doi request reprint Vegetarian diet affects genes of oxidative metabolism and collagen synthesis
    Heidrun Karlic
    Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, Vienna, Austria
    Ann Nutr Metab 53:29-32. 2008
    ..This study compares expression patterns of relevant genes in oral mucosa of omnivores and vegetarians...
  4. ncbi request reprint Extra-cellular matrix suppresses expression of the apoptosis mediator Fas by epigenetic DNA methylation
    Roman Thaler
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Center Meidling, Medical Department, Vienna, Austria
    Apoptosis 15:728-37. 2010
    ..In summary, we demonstrate that ECM prevents activation of Fas by epigenetic DNA-methylation...
  5. ncbi request reprint Does mRNA level of microsomal carnitine palmitoyltransferase predict yield of peripheral blood stem cell apheresis?
    Michael Fillitz
    3rd Department of Medicine, Hanusch Hospital, H Collinstrasse 30, 1140 Vienna, Austria
    Ann Hematol 85:386-93. 2006
    ..This gives evidence for a possible predictive value of such analyzes though further data of a larger sample are to be collected to confirm our observations...
  6. ncbi request reprint Effects of doxorubicin-containing chemotherapy and a combination with L-carnitine on oxidative metabolism in patients with non-Hodgkin lymphoma
    Raimund Waldner
    3rd Department of Medicine, Hanusch Hospital, Vienna, Austria
    J Cancer Res Clin Oncol 132:121-8. 2006
    ..Chemotherapy regimens based on anthracycline (doxorubicin) are well established in lymphoma therapy. The purpose of this study was to examine the effects of L-carnitine with a view to reducing cytotoxic side-effects...
  7. doi request reprint Neoplastic stem cells: current concepts and clinical perspectives
    Axel Schulenburg
    Bone Marrow Transplantation Unit, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Crit Rev Oncol Hematol 76:79-98. 2010
    ..The current article provides a summary of our current knowledge on neoplastic (cancer) stem cells, with special emphasis on clinical implications and therapeutic options as well as a discussion about conceptual and technical limitations...
  8. pmc DMSO is a strong inducer of DNA hydroxymethylation in pre-osteoblastic MC3T3-E1 cells
    Roman Thaler
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Center Meidling First Medical Department, Hanusch Hospital, Vienna, Austria
    Epigenetics 7:635-51. 2012
    ....
  9. ncbi request reprint Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromes
    Heidrun Karlic
    Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, H Collinstrasse 30, 1140 Vienna, Austria
    J Mol Med (Berl) 81:435-42. 2003
    ..The described reduction in transcription of different genes in blood cells which is well known in different tissues may reflect a systemic signaling process, associated with aging, apoptosis, and MDS...
  10. ncbi request reprint Epigenetic regulation of human buccal mucosa mitochondrial superoxide dismutase gene expression by diet
    Roman Thaler
    Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, Vienna, Austria
    Br J Nutr 101:743-9. 2009
    ..These results indicate that diet affects the epigenetic regulation of human MnSOD...
  11. doi request reprint 5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS-demethylation and FAS re-expression, and synergism with FAS-ligand
    Viviane Ghanim
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Blood 119:4242-52. 2012
    ..These effects are mediated through "FAS-re-expression" and are augmented by the FAS-ligand. Whether epigenetic drugs produce antineoplastic effects in vivo in patients with ASM and MCL remains to be determined...
  12. pmc Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation
    Roman Thaler
    1st Medical Department, Hanusch Hospital, Ludwig Boltzmann Institute of Osteology, Hanusch Hospital, Wiener Gebietskrankenkasse and AUVA Trauma Center Meidling, 1140 Vienna, Austria
    J Biol Chem 286:5578-88. 2011
    ..Furthermore, IL-6 stimulation results via JAK2, Fli1, and Dnmt1 in down-regulation of Lox expression by epigenetic CpG methylation revealing a new mechanism negatively affecting bone matrix formation...
  13. ncbi request reprint Imatinib mesylate (IM)-induced growth inhibition is associated with production of spliced osteocalcin-mRNA in cell lines
    Peter Wihlidal
    Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, Vienna, Austria
    Leuk Res 32:437-43. 2008
    ..In mouse osteoblastic MC3T3-E1 cells only OCNs is present, independently of treatment. As the stimulatory effect of IM on OCNs is also observed upon treatment with vitamin D, common regulatory processes may be considered...
  14. ncbi request reprint Myelodysplastic syndromes, aging, and age: correlations, common mechanisms, and clinical implications
    Michael Pfeilstöcker
    Hanusch Hospital, 3rd Medical Department, Vienna, Austria
    Leuk Lymphoma 48:1900-9. 2007
    ..In addition, the present review discusses age as an important prognostic factor and co-variable to be considered in treatment algorithms in MDS...
  15. ncbi request reprint Osteocalcin attenuates T3- and increases vitamin D3-induced expression of MMP-13 in mouse osteoblasts
    Franz Varga
    Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling 4th Medical Department, Hanusch Hospital, Vienna, Austria
    Endocr J 56:441-50. 2009
    ..We therefore hypothesize that OCN is a modulator of the hormonally regulated MMP-13 expression...
  16. ncbi request reprint Expression and functional significance of osteocalcin splicing in disease progression of hematological malignancies
    Peter Wihlidal
    Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, Vienna, Austria
    Leuk Res 30:1241-8. 2006
    ..Our data indicate that OCNs mRNA and OCN protein is expressed in c-KIT positive neoplastic stem cells in hematological malignancies...
  17. ncbi request reprint Supplementation of L-carnitine in athletes: does it make sense?
    Heidrun Karlic
    Ludwig Boltzmann Institute for Leukemia Research and Hematology, Vienna, Austria
    Nutrition 20:709-15. 2004
    ..Thus there is evidence for a beneficial effect of L-carnitine supplementation in training, competition, and recovery from strenuous exercise and in regenerative athletics...
  18. doi request reprint Breaking bad news to cancer patients: survey and analysis
    Wolfgang Spiegel
    Department of General Practice, Center for Public Health, Medical University of Vienna, Austria
    Psychooncology 18:179-86. 2009
    ..To find out how patients perceived the disclosure of news about their cancer as regards the physician counselling and how they perceived the flow of information between hospital-based and family physicians...
  19. doi request reprint Preanalytic removal of human DNA eliminates false signals in general 16S rDNA PCR monitoring of bacterial pathogens in blood
    Michael Handschur
    Ludwig Boltzmann Institute for Leukemia Research and Hematology, Vienna, Austria
    Comp Immunol Microbiol Infect Dis 32:207-19. 2009
    ..Thus, the BFEM contributes to the generation of replicable and more reliable data in general 16S rDNA PCR assays...
  20. doi request reprint Cancer patients' perception of information exchange between hospital-based doctors and their general practitioners
    Wolfgang Spiegel
    Department of General Practice, Center for Public Health, Medical University of Vienna, Vienna, Austria
    J Eval Clin Pract 16:1309-13. 2010
    ..This study aims to find out what importance cancer patients in Austria attach to information exchange between hospital-based doctors and their general practitioners (GPs) and how patients perceive this flow of information...
  21. ncbi request reprint Dietary l-carnitine stimulates carnitine acyltransferases in the liver of aged rats
    Heidrun Karlic
    Ludwig Boltzmann Institute for Leukemia Research and Hematology, Vienna, Austria
    J Histochem Cytochem 50:205-12. 2002
    ..These results suggest that l-carnitine stimulates transcription of CPT1, CPT2, and CRAT as well as the enzyme activity of CPT1 in the livers of aged rats...