Renate Kain

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. doi What is the evidence for antibodies to LAMP-2 in the pathogenesis of ANCA associated small vessel vasculitis?
    Renate Kain
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    Curr Opin Rheumatol 25:26-34. 2013
  2. pmc High prevalence of autoantibodies to hLAMP-2 in anti-neutrophil cytoplasmic antibody-associated vasculitis
    Renate Kain
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    J Am Soc Nephrol 23:556-66. 2012
  3. pmc Anti-hLAMP2-antibodies and dual positivity for anti-GBM and MPO-ANCA in a patient with relapsing pulmonary-renal syndrome
    Christoph Etter
    Division of Nephrology, University Hospital Zurich, Zurich, Switzerland
    BMC Nephrol 12:26. 2011
  4. pmc Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis
    Renate Kain
    Department of Pathology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Wien, Austria
    Nat Med 14:1088-96. 2008
  5. doi Pathogenesis of small vessel vasculitis associated with autoantibodies to neutrophil cytoplasmic antigens: new insights from animal models
    Renate Kain
    Institute of Clinical Pathology, Medical University of Vienna, Wahringer Gurtel, Vienna, Austria
    Curr Opin Rheumatol 22:15-20. 2010
  6. ncbi Histological and clinical predictors of early and late renal outcome in ANCA-associated vasculitis
    Irmgard Neumann
    Department of Nephrology, Wilhelminenspital, Vienna, Austria
    Nephrol Dial Transplant 20:96-104. 2005
  7. pmc Autoantibodies to hLAMP-2 in ANCA-negative pauci-immune focal necrotizing GN
    Andrea Peschel
    Clinical Institute of Pathology, Medical University of Vienna, Austria and
    J Am Soc Nephrol 25:455-63. 2014
  8. doi Hereditary amyloidosis caused by R554L fibrinogen Aα-chain mutation in a Spanish family and review of the literature
    Michael Haidinger
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Amyloid 20:72-9. 2013
  9. pmc B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ
    Elisabeth Salzer
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
    Blood 121:3112-6. 2013
  10. ncbi Gross proteinuria and subacute renal failure after coronary angiography - a case report of cholesterol crystal embolization
    Peter Biesenbach
    Internal Medicine III Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 122:251-4. 2010

Collaborators

Detail Information

Publications12

  1. doi What is the evidence for antibodies to LAMP-2 in the pathogenesis of ANCA associated small vessel vasculitis?
    Renate Kain
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    Curr Opin Rheumatol 25:26-34. 2013
    ..It addresses recent controversies over prevalence of anti-hLAMP-2 antibodies as well as their potential for diagnosis and monitoring disease activity...
  2. pmc High prevalence of autoantibodies to hLAMP-2 in anti-neutrophil cytoplasmic antibody-associated vasculitis
    Renate Kain
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    J Am Soc Nephrol 23:556-66. 2012
    ..Large-scale prospective studies are now needed to determine whether they are pathogenic or merely an epiphenomenon...
  3. pmc Anti-hLAMP2-antibodies and dual positivity for anti-GBM and MPO-ANCA in a patient with relapsing pulmonary-renal syndrome
    Christoph Etter
    Division of Nephrology, University Hospital Zurich, Zurich, Switzerland
    BMC Nephrol 12:26. 2011
    ..Whilst anti-GBM disease is considered a non-relapsing condition, the long-term course of double-positive patients is less predictable...
  4. pmc Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis
    Renate Kain
    Department of Pathology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Wien, Austria
    Nat Med 14:1088-96. 2008
    ..Thus, FimH-triggered autoimmunity to LAMP-2 provides a previously undescribed clinically relevant molecular mechanism for the development of pauci-immune FNGN...
  5. doi Pathogenesis of small vessel vasculitis associated with autoantibodies to neutrophil cytoplasmic antigens: new insights from animal models
    Renate Kain
    Institute of Clinical Pathology, Medical University of Vienna, Wahringer Gurtel, Vienna, Austria
    Curr Opin Rheumatol 22:15-20. 2010
    ..In-vitro experiments have provided invaluable insight into the molecular mechanisms of antibody action and their subcellular effects; however, they may not reflect the in-vivo situation that can only be assessed in animal models...
  6. ncbi Histological and clinical predictors of early and late renal outcome in ANCA-associated vasculitis
    Irmgard Neumann
    Department of Nephrology, Wilhelminenspital, Vienna, Austria
    Nephrol Dial Transplant 20:96-104. 2005
    ..Renal involvement remains a major determinant in antineutrophil cytoplasmic autoantibody-associated small vessel vasculitis (AASV). While some patients may develop persistent renal damage, others have a favourable outcome...
  7. pmc Autoantibodies to hLAMP-2 in ANCA-negative pauci-immune focal necrotizing GN
    Andrea Peschel
    Clinical Institute of Pathology, Medical University of Vienna, Austria and
    J Am Soc Nephrol 25:455-63. 2014
    ..In conclusion, in patients with ANCA-negative piFNGN, we have identified autoantibodies to hLAMP-2 that bind native glomerular but not neutrophil hLAMP-2, suggesting a role in pathogenesis...
  8. doi Hereditary amyloidosis caused by R554L fibrinogen Aα-chain mutation in a Spanish family and review of the literature
    Michael Haidinger
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Amyloid 20:72-9. 2013
    ..Here, we describe the clinical course of AFib amyloidosis associated with the rare R554L mutation, and the significance of extrarenal amyloid deposits and their possible influence on cardiovascular morbidity...
  9. pmc B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ
    Elisabeth Salzer
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
    Blood 121:3112-6. 2013
    ..Our study uncovers human PRKCD deficiency as a novel cause of common variable immunodeficiency-like B-cell deficiency with severe autoimmunity...
  10. ncbi Gross proteinuria and subacute renal failure after coronary angiography - a case report of cholesterol crystal embolization
    Peter Biesenbach
    Internal Medicine III Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 122:251-4. 2010
    ..Identification of high-risk patients is of utmost importance as efficient therapeutic strategies do not exist...
  11. doi Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1
    Christoph A Gebeshuber
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    Nat Med 19:481-7. 2013
    ..Thus, upregulation of miR-193a provides a new pathogenic mechanism for FSGS and is a potential therapeutic target...
  12. ncbi Glomerular immune deposits are associated with increased proteinuria in patients with ANCA-associated crescentic nephritis
    Irmgard Neumann
    Department of Nephrology, Wilhelminenspital, Vienna, Austria
    Nephrol Dial Transplant 18:524-31. 2003
    ..In some patients, however, significant amounts of immune deposits may be detected. Therefore, we evaluated the clinical significance of these immune deposits in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune CGN...