Berthold Huppertz

Summary

Affiliation: Medical University of Graz
Country: Austria

Publications

  1. doi request reprint The anatomy of the normal placenta
    B Huppertz
    Institute of Cell Biology, Histology and Embryology, Centre of Molecular Medicine, Medical University of Graz, Graz, Austria
    J Clin Pathol 61:1296-302. 2008
  2. doi request reprint Placental origins of preeclampsia: challenging the current hypothesis
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Center of Molecular Medicine, Medical University Graz, Harrachgasse 21 7, 8010 Graz, Austria
    Hypertension 51:970-5. 2008
  3. ncbi request reprint Placental morphology: from molecule to mother -- a dedication to Peter Kaufmann -- a review
    B Huppertz
    Department of Cell Biology, Histology and Embryology, Medical University of Graz, Harrachgasse 21, 8010 Graz, Austria
    Placenta 27:S3-8. 2006
  4. ncbi request reprint Trophoblast fusion: fusogenic proteins, syncytins and ADAMs, and other prerequisites for syncytial fusion
    Berthold Huppertz
    Department of Cell Biology, Histology and Embryology, Medical University Graz, Harrachgasse 21, 8010 Graz, Austria
    Micron 37:509-17. 2006
  5. ncbi request reprint Placental angiogenesis, maternal and fetal vessels--a workshop report
    B Huppertz
    Institute of Cell Biology, Histology and Embryology, Center of Molecular Medicine, Medical University of Graz, Austria
    Placenta 28:S94-6. 2007
  6. doi request reprint Longitudinal determination of serum placental protein 13 during development of preeclampsia
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Centre of Molecular Medicine, Medical University of Graz, Graz, Austria
    Fetal Diagn Ther 24:230-6. 2008
  7. pmc Oxygen as modulator of trophoblast invasion
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Centre for Molecular Medicine, Medical University of Graz, Harrachgasse 21 7, Graz, Austria
    J Anat 215:14-20. 2009
  8. ncbi request reprint The feto-maternal interface: setting the stage for potential immune interactions
    Berthold Huppertz
    Institute of Cell Biology, Histology, and Embryology, Medical University of Graz, Harrachgasse 21 7, 8010, Graz, Austria
    Semin Immunopathol 29:83-94. 2007
  9. doi request reprint The choriocarcinoma cell line BeWo: syncytial fusion and expression of syncytium-specific proteins
    Kristina Orendi
    Institute of Cell Biology, Histology and Embryology, Centre for Molecular Medicine, Medical University of Graz, Harrachgasse 21 VII, 8010 Graz, Austria
    Reproduction 140:759-66. 2010
  10. doi request reprint Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Harrachgasse 21 7, Graz 8010, Austria
    Hum Reprod Update 19:391-405. 2013

Collaborators

Detail Information

Publications54

  1. doi request reprint The anatomy of the normal placenta
    B Huppertz
    Institute of Cell Biology, Histology and Embryology, Centre of Molecular Medicine, Medical University of Graz, Graz, Austria
    J Clin Pathol 61:1296-302. 2008
    ..This includes the different types of villi and the most important cellular components of the villi such as villous trophoblast, Hofbauer cells, mesenchymal cells and endothelium. Fibrinoid and its localisation is also described...
  2. doi request reprint Placental origins of preeclampsia: challenging the current hypothesis
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Center of Molecular Medicine, Medical University Graz, Harrachgasse 21 7, 8010 Graz, Austria
    Hypertension 51:970-5. 2008
  3. ncbi request reprint Placental morphology: from molecule to mother -- a dedication to Peter Kaufmann -- a review
    B Huppertz
    Department of Cell Biology, Histology and Embryology, Medical University of Graz, Harrachgasse 21, 8010 Graz, Austria
    Placenta 27:S3-8. 2006
    ..In this review, we try to shed light on various aspects of placental development, and on how important morphology is in combination with other disciplines to elucidate the differences between a normal and a pathological placenta...
  4. ncbi request reprint Trophoblast fusion: fusogenic proteins, syncytins and ADAMs, and other prerequisites for syncytial fusion
    Berthold Huppertz
    Department of Cell Biology, Histology and Embryology, Medical University Graz, Harrachgasse 21, 8010 Graz, Austria
    Micron 37:509-17. 2006
    ..In this review, we present some details on the above events and proteins with their most important properties that could explain their roles in trophoblast fusion...
  5. ncbi request reprint Placental angiogenesis, maternal and fetal vessels--a workshop report
    B Huppertz
    Institute of Cell Biology, Histology and Embryology, Center of Molecular Medicine, Medical University of Graz, Austria
    Placenta 28:S94-6. 2007
  6. doi request reprint Longitudinal determination of serum placental protein 13 during development of preeclampsia
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Centre of Molecular Medicine, Medical University of Graz, Graz, Austria
    Fetal Diagn Ther 24:230-6. 2008
    ..To determine maternal serum placental protein 13 (PP13) in normal pregnancy and preeclampsia...
  7. pmc Oxygen as modulator of trophoblast invasion
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Centre for Molecular Medicine, Medical University of Graz, Harrachgasse 21 7, Graz, Austria
    J Anat 215:14-20. 2009
    ..The respective consequences of a failure in trophoblast invasion are growth restrictions of the baby and perhaps other pregnancy complications...
  8. ncbi request reprint The feto-maternal interface: setting the stage for potential immune interactions
    Berthold Huppertz
    Institute of Cell Biology, Histology, and Embryology, Medical University of Graz, Harrachgasse 21 7, 8010, Graz, Austria
    Semin Immunopathol 29:83-94. 2007
    ..In this study, these sites of interaction are introduced on a morphological level to help immunologists create their hypotheses on how the immunological interactions may work...
  9. doi request reprint The choriocarcinoma cell line BeWo: syncytial fusion and expression of syncytium-specific proteins
    Kristina Orendi
    Institute of Cell Biology, Histology and Embryology, Centre for Molecular Medicine, Medical University of Graz, Harrachgasse 21 VII, 8010 Graz, Austria
    Reproduction 140:759-66. 2010
    ..We postulate that CGB protein expression is not necessarily linked to syncytial fusion, and thus CGB should be used with great caution as a marker of BeWo cell fusion...
  10. doi request reprint Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Harrachgasse 21 7, Graz 8010, Austria
    Hum Reprod Update 19:391-405. 2013
    ..In cases where this protein is mutated, the frequency of pre-eclampsia is higher...
  11. doi request reprint Amnion-derived mesenchymal stromal cells show angiogenic properties but resist differentiation into mature endothelial cells
    Julia König
    Institute of Cell Biology, Histology, and Embryology, Medical University of Graz, Graz, Austria
    Stem Cells Dev 21:1309-20. 2012
    ..Nevertheless, they had a survival-enhancing effect on endothelial cells that might be useful in a variety of cell therapy or tissue-engineering approaches...
  12. doi request reprint Endoglandular trophoblast, an alternative route of trophoblast invasion? Analysis with novel confrontation co-culture models
    G Moser
    Institute of Cell Biology, Histology and Embryology, Medical University Graz, Austria Harrachgasse 21 7, 8010 Graz, Austria
    Hum Reprod 25:1127-36. 2010
    ..We developed novel three-dimensional confrontation co-culture models to elucidate invasion of EVTs into uterine glands...
  13. ncbi request reprint A variety of opportunities for immune interactions during trophoblast development and invasion
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Austria
    Am J Reprod Immunol 67:349-57. 2012
    ....
  14. doi request reprint Oxygen modulates the response of first-trimester trophoblasts to hyperglycemia
    Julia D Fröhlich
    Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria
    Am J Pathol 180:153-64. 2012
    ..This may account for reduced placental growth and, therefore, also for embryonic growth during the first-trimester pregestational diabetic pregnancies when the oxygen tension increases...
  15. doi request reprint First trimester serum markers to predict preeclampsia
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria
    Wien Med Wochenschr 162:191-5. 2012
    ..There is still the hope that - even in the absence of any treatment regimen today - such predictive markers will help to speed the development of a cure for preeclampsia...
  16. ncbi request reprint Regulation of proliferation and apoptosis during development of the preimplantation embryo and the placenta
    Berthold Huppertz
    Department of Cell Biology, Histology and Embryology, Medical University of Graz, Austria
    Birth Defects Res C Embryo Today 75:249-61. 2005
    ..Furthermore, we highlight what happens when regulation of proliferation or apoptosis fails in these systems, and attempt to show that apoptosis is only the consequence of poor embryo or trophoblast development -- not its cause...
  17. doi request reprint Placenta trophoblast fusion
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria
    Methods Mol Biol 475:135-47. 2008
    ..Finally, we speculate on why trophoblast cells fuse in vitro and deal with in vitro models of trophoblast fusion and how their fusion rates can be quantified...
  18. doi request reprint Trophoblast fusion
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Center for Molecular Medicine, Medical University of Graz, 8010, Graz, Austria
    Adv Exp Med Biol 713:81-95. 2011
    ..In this chapter we focus on factors that may be involved in the fusion process of trophoblast directly or that may prepare the cytotrophoblast to fuse...
  19. doi request reprint Fibulin-5 expression in the human placenta
    Martin Gauster
    Institute of Cell Biology, Histology and Embryology, Center for Molecular Medicine, Medical University of Graz, Harrachgasse 21 7, 8010 Graz, Austria
    Histochem Cell Biol 135:203-13. 2011
    ..The spatiotemporal shift from the trophoblast compartment in first trimester to the villous vasculature at term suggests a dual role of fibulin-5 in human placental development...
  20. doi request reprint Trophoblastic invasion in vitro and in vivo: similarities and differences
    C Helige
    Institute of Cell Biology, Histology and Embryology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria
    Hum Reprod 23:2282-91. 2008
    ..In the present study, a three-dimensional co-culture model is used for comparing two factors considered to be implicated in the regulation of trophoblast invasion, the expression of HLA-G and apoptosis, in vitro and in vivo...
  21. doi request reprint Factors involved in regulating trophoblast fusion: potential role in the development of preeclampsia
    M Gauster
    Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Harrachgasse 21 VII, 8010 Graz, Austria
    Placenta 30:S49-54. 2009
    ..Unbalanced trophoblast fusion and release of apoptotic material into the intervillous space may provoke a massive systemic inflammatory response by the mother and thus lead to preeclampsia...
  22. ncbi request reprint Keratins in the human trophoblast
    Martin Gauster
    Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Austria
    Histol Histopathol 28:817-25. 2013
    ..Here, we focus on the keratin composition of different trophoblast subtypes, how these keratins are used in trophoblast research and what is known about placental keratins in pregnancy pathologies. ..
  23. ncbi request reprint Soluble factors of amnion-derived cells in treatment of inflammatory and fibrotic pathologies
    Antonietta Silini
    Centro di Ricerca E Menni, Fondazione Poliambulanza, Brescia, Italy
    Curr Stem Cell Res Ther 8:6-14. 2013
    ..Indeed, determining the specific cascade of events that may define the role of the amnion in a given clinical situation remains a challenge...
  24. pmc The first trimester human trophoblast cell line ACH-3P: a novel tool to study autocrine/paracrine regulatory loops of human trophoblast subpopulations--TNF-alpha stimulates MMP15 expression
    Ursula Hiden
    Department of Obstetrics and Gynecology, Medical University Graz, Austria
    BMC Dev Biol 7:137. 2007
    ..We established a first trimester trophoblast cell line (ACH-3P) by fusion of primary human first trimester trophoblasts (week 12 of gestation) with a human choriocarcinoma cell line (AC1-1)...
  25. doi request reprint Placental pathology in pregnancy complications
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Center for Molecular Medicine, Medical University of Graz, Austria
    Thromb Res 127:S96-9. 2011
    ..Recent development in preeclampsia specific biomarkers and the intense use of Doppler ultrasound measurements already in the first trimester of pregnancy has resulted in a new understanding of the pathways leading to preeclampsia or FGR...
  26. doi request reprint Fusion of villous trophoblast can be visualized by localizing active caspase 8
    M Gauster
    Institute of Cell Biology, Histology and Embryology, Center for Molecular Medicine, Medical University of Graz, Harrachgasse 21 VII, 8010 Graz, Austria
    Placenta 30:547-50. 2009
    ..The staining suggests that caspase 8 is activated in villous cytotrophoblasts just prior to fusion of these cells and escorts the nuclei from the mononucleated to the syncytial state...
  27. doi request reprint The paradox of caspase 8 in human villous trophoblast fusion
    M Gauster
    Institute of Cell Biology, Histology and Embryology, Center for Molecular Medicine, Medical University of Graz, Austria
    Placenta 31:82-8. 2010
    ..Moreover, we revisit the knowledge on fusogens in the villous trophoblast, compare in vitro models for trophoblast fusion and discuss methods to quantify fusion...
  28. doi request reprint Effects of vitamins C and E, acetylsalicylic acid and heparin on fusion, beta-hCG and PP13 expression in BeWo cells
    K Orendi
    Institute of Cell Biology, Histology and Embryology, Center for Molecular Medicine, Medical University of Graz, Harrachgasse 21 VII, 8010 Graz, Austria
    Placenta 31:431-8. 2010
    ....
  29. doi request reprint Caspases rather than calpains mediate remodelling of the fodrin skeleton during human placental trophoblast fusion
    M Gauster
    Institute of Cell Biology, Histology and Embryology, Center for Molecular Medicine, Medical University of Graz, Harrachgasse 21 VII, Graz 8010, Austria
    Cell Death Differ 17:336-45. 2010
    ..These results suggest that caspase-dependent fragmentation of alpha-fodrin may be important for reorganization of the sub-membranous cytoskeleton during trophoblast fusion...
  30. doi request reprint IFPA Award in Placentology Lecture: Biology of the placental syncytiotrophoblast--myths and facts
    B Huppertz
    Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Harrachgasse 21 7, 8010 Graz, Austria
    Placenta 31:S75-81. 2010
    ..Finally, different modes of release of trophoblast fragments such as apoptotic, aponecrotic and necrotic are discussed as being responsible for the maternal inflammatory response during pre-eclampsia...
  31. ncbi request reprint Vascular biology in implantation and placentation
    Berthold Huppertz
    Department of Anatomy II, University Hospital RWTH Aachen, Aachen, Germany
    Angiogenesis 8:157-67. 2005
    ..This review tries to cover all the above-mentioned topics and will try to depict the consequences of poor placentation on mother and fetus...
  32. ncbi request reprint Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies complicated by maternal anemia and early-onset preeclampsia/intrauterine growth restriction
    Mamed Kadyrov
    Department of Anatomy II, University Hospital, Aachen, Germany
    Am J Obstet Gynecol 194:557-63. 2006
    ..We compared trophoblast invasion into spiral arteries in pregnancies with maternal anemia or early-onset preeclampsia/intrauterine growth restriction and related these findings to trophoblast apoptosis...
  33. ncbi request reprint Apoptosis and its role in the trophoblast
    Berthold Huppertz
    Department of Anatomy II, University Hospital RWTH, Aachen, Germany
    Am J Obstet Gynecol 195:29-39. 2006
    ..This review summarizes recent findings on trophoblast apoptosis in normal and pathologic pregnancies...
  34. ncbi request reprint Developmental biology of the placenta and the origins of placental insufficiency
    Vandana Chaddha
    Department of Obstetrics and Gynaecology Maternal Fetal Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Canada M5G 1X5
    Semin Fetal Neonatal Med 9:357-69. 2004
    ....
  35. ncbi request reprint Apoptosis in the trophoblast--role of apoptosis in placental morphogenesis
    Berthold Huppertz
    Department of Anatomy II, University Hospital RWTH, Aachen, Germany
    J Soc Gynecol Investig 11:353-62. 2004
    ..Moreover, this review presents hypotheses of how dysregulation of the apoptosis cascade may be linked to endothelial dysfunction of the maternal vasculature in preeclampsia...
  36. ncbi request reprint Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia
    Peter Kaufmann
    Department of Anatomy II, University of Technology Aachen, D 52057 Aachen, Germany
    Biol Reprod 69:1-7. 2003
    ..e., the placental bed...
  37. ncbi request reprint Altered protease expression by periarterial trophoblast cells in severe early-onset preeclampsia with IUGR
    Frank Reister
    Department of Obstetrics and Gynecology, University Hospital Ulm, Ulm, Germany
    J Perinat Med 34:272-9. 2006
    ....
  38. ncbi request reprint 3-dimensional colour power angiography for staging human placental development
    Justin C Konje
    Fetal Growth and Development Research Group, Department of Obstetrics and Gynaecology, University of Leicester, Leicester, UK
    Lancet 362:1199-201. 2003
    ....
  39. ncbi request reprint Circulating fetal DNA in maternal plasma is increased in pregnancies at high altitude and is further enhanced by preeclampsia
    Xiao Yan Zhong
    University Women s Hospital Department of Research, University of Basel, Basel, Switzerland
    Clin Chem 50:2403-5. 2004
  40. ncbi request reprint Invasive depth of extravillous trophoblast correlates with cellular phenotype: a comparison of intra- and extrauterine implantation sites
    Birgit Kemp
    Department of Obstetrics and Gynaecology, University Hospital RWTH Aachen, Germany
    Histochem Cell Biol 117:401-14. 2002
    ....
  41. ncbi request reprint Adverse effects of lupus anticoagulant positive blood sera on placental viability can be prevented by heparin in vitro
    Patrick Bose
    Department of Anatomy, University Hospital, Aachen, Germany
    Am J Obstet Gynecol 191:2125-31. 2004
    ..Pathophysiology of antiphospholipid antibodies on placental function involves coagulopathies and thrombosis but also dysregulated trophoblast turnover...
  42. ncbi request reprint Heparin and aspirin attenuate placental apoptosis in vitro: implications for early pregnancy failure
    Patrick Bose
    Department of Anatomy II, University Hospital RWTH, Aachen, Germany
    Am J Obstet Gynecol 192:23-30. 2005
    ..Both drugs may attenuate miscarriage by inhibiting aberrant coagulation or by modulating trophoblast apoptosis. Here we assessed their roles in trophoblast apoptosis in vitro...
  43. ncbi request reprint Detection of fetal DNA and RNA in placenta-derived syncytiotrophoblast microparticles generated in vitro
    Anurag Kumar Gupta
    Laboratory for Prenatal Medicine, University Women s Hospital Department of Research, University of Basel, Basel, Switzerland
    Clin Chem 50:2187-90. 2004
  44. ncbi request reprint Soluble factors released by placental villous tissue: Interleukin-1 is a potential mediator of endothelial dysfunction
    Corinne Rusterholz
    Laboratory for Prenatal Medicine, University Women s Hospital Department of Research, University of Basel, Basel, Switzerland
    Am J Obstet Gynecol 192:618-24. 2005
    ..The purpose of this study was to analyze the potential of placental-conditioned medium to activate endothelial cells in vitro and to identify the placental factors that mediate this effect...
  45. doi request reprint Trophoblasts reduce the vascular smooth muscle cell proatherogenic response
    Lydia Hering
    Experimental and Clinical Research Center, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 51:554-9. 2008
    ..The findings also implicate C3 in the placental vasculopathy observed in preeclampsia...
  46. ncbi request reprint Vasculogenesis and angiogenesis in the early human placenta
    Ramazan Demir
    Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey
    Acta Histochem 109:257-65. 2007
    ..This review depicts the molecular and morphological steps of vasculogenesis and angiogenesis, which can give further insights into human placental development and maturation disorders...
  47. ncbi request reprint Proliferative responses in the placenta after endotoxin exposure in preterm fetal sheep
    Yves Garnier
    Department of Obstetrics and Gynecology, University Hospital RWTH Aachen, Germany
    Eur J Obstet Gynecol Reprod Biol 138:152-7. 2008
    ..We studied morphological alterations of the placenta in response to fetal inflammation in the preterm sheep...
  48. ncbi request reprint Matrix metalloproteinases-2, -3 and -9 in human term placenta
    Ayse Yasemin Demir-Weusten
    Department of Clinical Biochemistry, Medical Faculty of Utrecht University, Utrecht, The Netherlands
    Acta Histochem 109:403-12. 2007
    ..This study describes the site-specific distribution and activities of MMPs and therefore might help in elucidating the molecular mechanisms in pathologies such as premature rupture of membranes...
  49. ncbi request reprint Effect of high oxygen on placental function in short-term explant cultures
    Nicole G Reti
    Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, Victoria, 3084, Australia
    Cell Tissue Res 328:607-16. 2007
    ..These data are consistent with the hypothesis that hyperoxia activates pathways and mechanisms involved in cellular metabolism, necrosis and apoptosis, thereby shifting the balance from a steady state towards cell death...
  50. ncbi request reprint Expression of the actin stress fiber-associated protein CLP36 in the human placenta
    Ulrich Miehe
    Department of Obstetrics and Gynecology, University Hospital RWTH, Aachen, Germany
    Histochem Cell Biol 126:465-71. 2006
    ..Pathological pregnancy syndromes such as preeclampsia are driven by alterations of trophoblast differentiation and turnover, where it needs to be elucidated whether CLP36 is involved in these alterations...
  51. ncbi request reprint Minimal alteration in the ratio of circulatory fetal DNA to fetal corticotropin-releasing hormone mRNA level in preeclampsia
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine Department of Research, University Women s Hospital, University of Basel, Switzerland
    Fetal Diagn Ther 21:246-9. 2006
    ..Hence, we examined whether these ratios varied in maternal plasma samples taken from normotensive and preeclamptic pregnancies in vivo...
  52. ncbi request reprint New insights into the biology of preeclampsia
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, 04103 Leipzig, Germany
    Biol Reprod 74:772-6. 2006
    ..This review focuses on the most recent and relevant insights into the biology of preeclampsia and develops hypotheses regarding possible links between the reported aspects of preeclampsia...
  53. ncbi request reprint Molecular markers for human placental investigation
    Berthold Huppertz
    Department of Anatomy II, University Hospital RWTH Aachen, Germany
    Methods Mol Med 121:337-50. 2006
    ..This chapter focuses on methods that are available in the majority of laboratories, and therefore concentrates on methods that are used together with light microscopy...
  54. ncbi request reprint Extracellular pH modulates the secretion of fibronectin isoforms by human trophoblast
    Gabriele Gaus
    Department of Anatomy, University Hospital Aachen, Germany
    Acta Histochem 104:51-63. 2002
    ..Therefore, it is concluded that the local pH plays an important role as regulator of differentiation of human trophoblast as reflected by the synthesis of oncofetal fibronectins by the invasive phenotype of extravillous trophoblast...