L A Hefler

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. pmc OCT-4 expression in follicular and luteal phase endometrium: a pilot study
    Eva Katrin Bentz
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Reprod Biol Endocrinol 8:38. 2010
  2. pmc The prognostic value of four interleukin-1 gene polymorphisms in Caucasian women with breast cancer: a multicenter study
    Christoph Grimm
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    BMC Cancer 9:78. 2009
  3. pmc The presence of postmenopausal bleeding as prognostic parameter in patients with endometrial cancer: a retrospective multi-center study
    Veronika Seebacher
    Department of Obstetrics and Gynecology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    BMC Cancer 9:460. 2009
  4. ncbi request reprint Interleukin-1 and interleukin-6 gene polymorphisms and the risk of breast cancer in caucasian women
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Austria
    Clin Cancer Res 11:5718-21. 2005
  5. doi request reprint The intraoperative complication rate of nonobstetric dilation and curettage
    Lukas Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Obstet Gynecol 113:1268-71. 2009
  6. doi request reprint Serum C-reactive protein as independent prognostic variable in patients with ovarian cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Clin Cancer Res 14:710-4. 2008
  7. ncbi request reprint A model for predicting age at menopause in white women
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Fertil Steril 85:451-4. 2006
  8. ncbi request reprint Squamous cell carcinoma antigen serum levels as prognostic parameter in patients with early stage vulvar cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Gynecol Oncol 97:904-7. 2005
  9. doi request reprint Influence of the time interval between hysteroscopy, dilation and curettage, and hysterectomy on survival in patients with endometrial cancer
    Lukas Hefler
    Department of Obstetrics, Medical University of Vienna, Vienna, Austria
    Obstet Gynecol 112:1098-101. 2008
  10. ncbi request reprint Inguinal sentinel lymph node dissection vs. complete inguinal lymph node dissection in patients with vulvar cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Anticancer Res 28:515-7. 2008

Detail Information

Publications73

  1. pmc OCT-4 expression in follicular and luteal phase endometrium: a pilot study
    Eva Katrin Bentz
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Reprod Biol Endocrinol 8:38. 2010
    ..The stem cell marker Octamer-4 (OCT-4) is expressed in human endometrium. Menstrual cycle-dependency of OCT-4 expression has not been investigated to date...
  2. pmc The prognostic value of four interleukin-1 gene polymorphisms in Caucasian women with breast cancer: a multicenter study
    Christoph Grimm
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    BMC Cancer 9:78. 2009
    ..Although IL-1 gene polymorphisms were reported to be associated with increased risk of breast cancer, their influence on survival of Caucasian breast cancer patients remains to be shown...
  3. pmc The presence of postmenopausal bleeding as prognostic parameter in patients with endometrial cancer: a retrospective multi-center study
    Veronika Seebacher
    Department of Obstetrics and Gynecology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    BMC Cancer 9:460. 2009
    ..This study was conducted to evaluate whether asymptomatic patients with endometrial cancer have a better prognosis than symptomatic patients with endometrial cancer diagnosed after postmenopausal bleeding...
  4. ncbi request reprint Interleukin-1 and interleukin-6 gene polymorphisms and the risk of breast cancer in caucasian women
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Austria
    Clin Cancer Res 11:5718-21. 2005
    ..Interleukin (IL)-1 and IL-6 are crucially involved in breast carcinogenesis. Whether polymorphisms of the genes encoding IL-1 (IL1) and IL-6 (IL6) also influence breast cancer risk is unknown...
  5. doi request reprint The intraoperative complication rate of nonobstetric dilation and curettage
    Lukas Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Obstet Gynecol 113:1268-71. 2009
    ..To evaluate the intraoperative complication rate of nonobstetric dilation and curettage (D&C) in a large series of consecutive patients...
  6. doi request reprint Serum C-reactive protein as independent prognostic variable in patients with ovarian cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Clin Cancer Res 14:710-4. 2008
    ..To evaluate serum C-reactive protein (CRP) as prognostic variable in patients with epithelial ovarian cancer (EOC)...
  7. ncbi request reprint A model for predicting age at menopause in white women
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Fertil Steril 85:451-4. 2006
    ..To develop a model to predict the age at natural menopause and the risk for premenopausal hysterectomy...
  8. ncbi request reprint Squamous cell carcinoma antigen serum levels as prognostic parameter in patients with early stage vulvar cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Gynecol Oncol 97:904-7. 2005
    ..To determine whether SCC-Ag serum levels can be used as a prognostic parameter in surgically treated early stage vulvar cancer...
  9. doi request reprint Influence of the time interval between hysteroscopy, dilation and curettage, and hysterectomy on survival in patients with endometrial cancer
    Lukas Hefler
    Department of Obstetrics, Medical University of Vienna, Vienna, Austria
    Obstet Gynecol 112:1098-101. 2008
    ..To evaluate whether a prolonged time interval between dilation and curettage (D&C) and hysterectomy has an effect on survival in patients with surgically treated endometrial cancer...
  10. ncbi request reprint Inguinal sentinel lymph node dissection vs. complete inguinal lymph node dissection in patients with vulvar cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Anticancer Res 28:515-7. 2008
    ..The aim of this retrospective study was to ascertain the postoperative morbidity in patients with vulvar cancer undergoing sentinel lymph node vs. complete inguinal lymph node dissection...
  11. ncbi request reprint Repeat surgery in patients with cervical cancer stage FIGO IA1: a series of 156 cases and a review of the literature
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, A 1090 Vienna, Waehringer Gurtel 18 20, Austria
    Anticancer Res 30:565-8. 2010
    ..In a multicenter trial, whether repeat surgery is a necessary therapeutic procedure in the treatment of cervical cancer stage FIGO IA1 was evaluated and a literature review performed...
  12. ncbi request reprint Necessity of colposcopy and biopsy prior to large loop excision of the transformation zone (LLETZ)
    Lukas Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Anticancer Res 28:519-21. 2008
    ..The clinical value of colposcopy and biopsy prior to large loop excision of the cervical transformation zone (LLETZ) with respect to negative histology and positive specimen margin rates, was evaluated...
  13. ncbi request reprint The cyclooxygenase-2 inhibitor rofecoxib (Vioxx) in the treatment of cervical dysplasia grade II-III A phase II trial
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur J Obstet Gynecol Reprod Biol 125:251-4. 2006
    ..To determine whether the cyclooxygenase (COX)-2 inhibitor rofecoxib increases the regression rates of cervical intraepithelial neoplasia (CIN) grade II and III...
  14. ncbi request reprint Vascular endothelial growth factor gene polymorphisms are associated with prognosis in ovarian cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology and Core Unit for Medical Statistics and Informatics, Medical University of Vienna, Austria
    Clin Cancer Res 13:898-901. 2007
    ..Gene polymorphisms within the gene encoding VEGF were shown to be independently associated with an adverse outcome in various malignancies. No data are available for ovarian cancer...
  15. ncbi request reprint Preoperative serum vascular endothelial growth factor as a prognostic parameter in ovarian cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, A 1090 Vienna, Wahringer Gurtel, Austria
    Gynecol Oncol 103:512-7. 2006
    ..Serum vascular endothelial growth factor (VEGF) levels have been shown to be associated with an adverse outcome in patients with ovarian cancer. We studied the clinical value of serum VEGF as an independent prognostic parameter...
  16. ncbi request reprint Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Breast Cancer Res Treat 98:151-5. 2006
    ..No significant associations were ascertained with respect to the intron 4 Nos3 polymorphism. In our series, presence of the mutant exon7 Nos3 polymorphism was associated with an increased risk for breast cancer in Caucasian women...
  17. ncbi request reprint Treatment with vaginal progesterone in women with low-grade cervical dysplasia: a phase II trial
    Lukas Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Anticancer Res 30:1257-61. 2010
    ..We hypothesized that vaginal progesterone would increase the regression rate in women with CIN I...
  18. ncbi request reprint Estrogen-metabolizing gene polymorphisms and age at natural menopause in Caucasian women
    L A Hefler
    Departments of Obstetrics and Gynecology, University of Vienna, Austria
    Hum Reprod 20:1422-7. 2005
    ..Based on their biological function, estrogen-metabolizing gene polymorphisms have been regarded as candidate genes for early menopause...
  19. doi request reprint Serologic markers of autoimmunity in women with polycystic ovary syndrome
    Katrin Hefler-Frischmuth
    Department of Laboratory Medicine, Wilhelminen Hospital Vienna, Vienna, Austria
    Fertil Steril 93:2291-4. 2010
    ..To evaluate whether women with the polycystic ovary syndrome (PCOS) have an increased rate of elevated serum levels of common autoimmunologic parameters...
  20. ncbi request reprint Polymorphisms of the interleukin-1 gene cluster and ovarian cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, University of Vienna Medical School, Vienna, Austria
    J Soc Gynecol Investig 9:386-90. 2002
    ..Interleukin-1 (IL-1) is known to be critically involved in ovarian carcinogenesis. We investigated a panel of polymorphisms of the IL-1 and the IL-1 receptor antagonist (IL-1 RA) genes in patients with ovarian cancer...
  21. ncbi request reprint An interleukin-6 gene promoter polymorphism influences the biological phenotype of ovarian cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, University of Vienna Medical School, A 1090 Vienna, Austria
    Cancer Res 63:3066-8. 2003
    ..We conclude that the mutant -174 C allele of IL6 influences the biological phenotype of ovarian cancer because it is associated with early stage and improved DFS and overall survival...
  22. ncbi request reprint Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions
    Ambros Huber
    Department of Obstetrics and Gynecology, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Obstet Gynecol 106:1025-31. 2005
    ..We aimed to investigate the association among 10 single nucleotide polymorphisms (SNPs) involved in the estrogen metabolism and endometriosis and to develop a multiple genetic model...
  23. ncbi request reprint A polymorphism of the interleukin-1 receptor antagonist plays a prominent role within the interleukin-1 gene cluster in vulvar carcinogenesis
    Christoph Grimm
    Department of Obstetrics, University of Vienna School of Medicine, A 1090 Vienna, Austria
    Gynecol Oncol 92:936-40. 2004
    ..Although various studies showed a certain association between genes encoding the IL-1 family and human malignancies, no data with respect to vulvar cancer have been published to date...
  24. ncbi request reprint A polymorphism of the interleukin-1beta gene and idiopathic recurrent miscarriage
    L A Hefler
    Department of Obstetrics and Gynecology, University of Vienna Medical School, Vienna, Austria
    Fertil Steril 76:377-9. 2001
    ..We investigated the association between IRM and a polymorphism in exon 5 of the interleukin-1beta gene (IL1B) and interleukin-1beta (IL-1beta) serum levels...
  25. ncbi request reprint The PROGINS progesterone receptor gene polymorphism and idiopathic recurrent miscarriage
    C Kurz
    Department of Endocrinology and Reproductive Medicine, University of Vienna School of Medicine, Vienna, Austria
    J Soc Gynecol Investig 8:295-8. 2001
    ....
  26. ncbi request reprint A polymorphism of the Nos3 gene and age at natural menopause
    Lukas A Hefler
    Department of Obstetrics and Gynecology, University of Vienna Medical School, Vienna, Austria
    Fertil Steril 78:1184-6. 2002
    ..Smoking and increased body mass index were associated with an earlier onset of natural menopause.In contrast to mouse models, in humans Nos3 does not seem to modulate onset and cessation of menses...
  27. ncbi request reprint A polymorphism of the CYP17 gene related to sex steroid metabolism is associated with female-to-male but not male-to-female transsexualism
    Eva Katrin Bentz
    Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University Vienna, Vienna, Austria
    Fertil Steril 90:56-9. 2008
    ..To assess the association between transsexualism and allele and genotype frequencies of the common cytochrome P450 (CYP) 17 -34 T>C single nucleotide polymorphism (SNP)...
  28. ncbi request reprint C-reactive protein serum levels are closely associated with lymph node status, but not with prognosis in patients with vulvar cancer
    Lucia Six
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur J Obstet Gynecol Reprod Biol 137:217-21. 2008
    ..To evaluate whether C-reactive protein (CRP) serum levels can be used as prognostic parameter in patients with vulvar cancer...
  29. ncbi request reprint A common interleukin-6 promoter polymorphism in patients with vulvar cancer
    Christoph Grimm
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    J Soc Gynecol Investig 12:617-20. 2005
    ..No data are available with respect to vulvar cancer. Therefore, we determined the prognostic potential of the common -174(G-->C) single nucleotide polymorphism in the promoter region of IL6 in a series of patients with this disease...
  30. ncbi request reprint The influence of Nos3 polymorphisms on age at menarche and natural menopause
    Christof Worda
    Department of Obstetrics and Gynecology, University of Vienna Medical School, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Maturitas 49:157-62. 2004
    ..Deficiency of the gene encoding endothelial nitric oxide synthase, i.e. Nos3, has been reported to be associated with late menarche, reduced ovulation rates, fewer deliveries, and earlier onset of menopause in a mouse model...
  31. ncbi request reprint Vascular endothelial growth factor gene polymorphisms in ovarian cancer
    Stephan Polterauer
    Department of Obstetrics and Gynecology, Medical University of Vienna, A 1090 Vienna, Wahringer Gurtel 18 20, Austria
    Gynecol Oncol 105:385-9. 2007
    ..No data have been reported in ovarian cancer...
  32. ncbi request reprint Polymorphisms of the endothelial nitric oxide synthase gene in ovarian cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, University of Vienna Medical School, Vienna, Austria
    Gynecol Oncol 86:134-7. 2002
    ..The free radical nitric oxide is known to be critically involved in ovarian carcinogenesis by inducing apoptosis and by mediating various cytostatic and cytotoxic effects, but also by promoting growth, invasion, and metastasis...
  33. ncbi request reprint The influence of a Vitamin D receptor gene polymorphism on the timing of female reproductive functions in humans
    Christoph Grimm
    Department of Obstetrics and Gynecology, University of Vienna Medical School, Vienna, Austria
    Maturitas 51:135-9. 2005
    ..To evaluate the association between a common polymorphism of the Vitamin D receptor gene (VDR) and the timing of female reproductive functions in humans...
  34. ncbi request reprint Polymorphisms of the angiotensinogen gene, the endothelial nitric oxide synthase gene, and the interleukin-1beta gene promoter in women with idiopathic recurrent miscarriage
    Lukas A Hefler
    Department of Obstetrics and Gynecology, University of Vienna Medical School, Vienna, Austria
    Mol Hum Reprod 8:95-100. 2002
    ....
  35. ncbi request reprint Endocervical cytobrush for the detection of cervical dysplasia before large loop excision of the transformation zone (LLETZ)
    Clemens Tempfer
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Anticancer Res 28:3131-4. 2008
    ....
  36. ncbi request reprint A polymorphism of the interleukin-1 beta gene is associated with sperm pathology in humans
    Eva Katrin Bentz
    Departments of Gynecologic Endocrinology and Reproductive Medicine, University of Vienna School of Medicine, Vienna, Austria
    Fertil Steril 88:751-3. 2007
    ..8; 95% confidence interval, 1.13 to 20.28). This association was restricted to men with the oligoasthenoteratozoospermia (OAT) syndrome. We conclude that the investigated polymorphism is associated with sperm pathology in Caucasians...
  37. ncbi request reprint A polymorphism of the plasminogen activator inhibitor-1 gene promoter and the polycystic ovary syndrome
    Katharina Walch
    Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Infertility Treatment, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur J Obstet Gynecol Reprod Biol 123:77-81. 2005
    ..To investigate the association of a common 5G/4G polymorphism of the plasminogen activator inhibitor-1 gene (PAI1) with occurrence and clinical characteristics of the polycystic ovary syndrome (PCOS)...
  38. ncbi request reprint Two multidrug-resistance (ABCB1) gene polymorphisms as prognostic parameters in women with ovarian cancer
    Christoph Grimm
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Anticancer Res 30:3487-91. 2010
    ..Treatment response to paclitaxel has been shown to correlate with ABCB1 gene polymorphisms. Data regarding the prognostic value of ABCB1 gene polymorphisms in ovarian cancer patients is conflicting...
  39. ncbi request reprint Frequency of 23 human papillomavirus types using DNA microarray in women with and without cytological anomalies
    Clemens Tempfer
    Department of Obstetrics and Gynecology, University of Vienna School of Medicine, Vienna, Austria
    Anticancer Res 27:1721-6. 2007
    ..To evaluate the frequency of single and multiple human papillomavirus (HPV) infections in women with and without cervical dysplasia...
  40. doi request reprint Intrauterine fetal death and delivery complications associated with coagulopathy: a retrospective analysis of 104 cases
    Clemens B Tempfer
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    J Womens Health (Larchmt) 18:469-74. 2009
    ..To assess the prevalence of delivery complications associated with coagulopathy in women with intrauterine fetal death (IUFD)...
  41. doi request reprint Side effects of phytoestrogens: a meta-analysis of randomized trials
    Clemens B Tempfer
    Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
    Am J Med 122:939-46.e9. 2009
    ..Phytoestrogens are widely used by postmenopausal women for the treatment of the climacteric syndrome. The risk of adverse effects of this treatment, however, is unknown...
  42. ncbi request reprint The prohibitin 3' untranslated region polymorphism in patients with ovarian cancer
    Christoph Grimm
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Eur J Obstet Gynecol Reprod Biol 137:236-9. 2008
    ..Based on these findings we studied whether the presence of this prohibitin polymorphism increases the risk and worsens the prognosis of ovarian cancer in Caucasian women...
  43. ncbi request reprint An estrogen metabolism-related polymorphism of the 17-alpha HSD gene is associated with perimenopausal body mass index
    Clemens B Tempfer
    Department of Gynecologic Endocrinology and Infertility Treatment, Medical University Vienna, Vienna, Austria
    Fertil Steril 87:1494-6. 2007
    ..23.5 +/- 4.2 kg/m(2); P<.001), and obesity was more frequent among mutant allele carriers (P=.06; odds ratio 1.38; 95% confidence interval 0.97-1.95), providing evidence of 17-alpha HSD as a candidate gene of perimenopausal obesity...
  44. ncbi request reprint A common interleukin-6 gene promoter polymorphism influences the clinical characteristics of women with polycystic ovary syndrome
    Katharina Walch
    Department of Obstetrics and Gynecology, University of Vienna Medical School, Vienna, Austria
    Fertil Steril 81:1638-41. 2004
    ..To investigate the association of a common polymorphism of the interleukin-6 gene (IL6) promoter with the occurence and the clinical characteristics of polycystic ovary syndrome (PCOS)...
  45. ncbi request reprint Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
    Cancer 101:264-9. 2004
    ..In these candidate genes, no critical combination of single-nucleotide polymorphisms (SNPs) for assessing breast carcinoma risk has been reported to date...
  46. ncbi request reprint A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women
    Katharina Walch
    Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
    Fertil Steril 83:1565-7. 2005
    ..In this prospective case-control study, the odds for women with at least one mutant GG allele of the MMP1 promoter to be diagnosed with PCOS was 2.7...
  47. ncbi request reprint A common polymorphism within the steroid 5-alpha-reductase type 2 gene and timing of menopause in Caucasian women
    Ambros Huber
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur J Obstet Gynecol Reprod Biol 125:221-5. 2006
    ..We evaluated the association between a common polymorphism of the steroid 5-alpha-reductase type 2 gene (SRD5A2) involved in androgen metabolism and the timing of menopause...
  48. ncbi request reprint A common polymorphism of the SRD5A2 gene and transsexualism
    Eva Katrin Bentz
    Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University Vienna, Vienna, Austria
    Reprod Sci 14:705-9. 2007
    ..6; OR, 0.61; 95% CI, 0.11-3.32). Of note, there is no gender-specific genotype distribution among controls. The SRD5A2 Val89Leu SNP is not associated with transsexualism, refuting SRD5A2 as a candidate gene of transsexualism...
  49. ncbi request reprint How valid is single nucleotide polymorphism (SNP) diagnosis for the individual risk assessment of breast cancer?
    Clemens B Tempfer
    Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria
    Gynecol Endocrinol 22:155-9. 2006
    ..Specific surgical or drug interventions such as prophylactic mastectomy and oophorectomy or prophylactic intake of tamoxifen are not indicated based on SNP analysis at this time...
  50. doi request reprint Serum C-reactive protein in the differential diagnosis of ovarian masses
    Katrin Hefler-Frischmuth
    Department of Laboratory Medicine, Wilhelminenspital, Vienna, Austria
    Eur J Obstet Gynecol Reprod Biol 147:65-8. 2009
    ..Serum C-reactive protein (CRP) is a widely used biomarker of inflammation and has been previously shown to be a promising biomarker in patients with ovarian cancer...
  51. ncbi request reprint The prognostic value of immunohistochemically detected CD44v3 and CD44v6 expression in patients with surgically staged vulvar carcinoma: a multicenter study
    Lukas A Hefler
    Department of Gynecology and Obstetrics, University of Vienna Medical School, Vienna, Austria
    Cancer 94:125-30. 2002
    ..The current multicenter study aimed to determine the prognostic value of CD44v3 and CD44v6 in patients with surgically staged vulvar carcinoma...
  52. ncbi request reprint The perioperative morbidity of laparoscopic pelvic lymph node staging in patients with advanced cervical cancer
    Stephan Polterauer
    Department of Obstetrics and Gynecology, Medical University of Vienna, Austria
    Anticancer Res 28:1849-51. 2008
    ..Laparoscopic pelvic lymph node staging is widely used in patients with cervical cancer prior to the initiation of primary chemoradiation therapy. Data on the morbidity of this procedure are sparse...
  53. doi request reprint Clinical outcome monitoring in a reproductive surgery unit: a prospective cohort study in 796 patients
    Eva Katrin Bentz
    Department of Gynecological Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria
    Fertil Steril 91:2638-42. 2009
    ..To systematically monitor the frequency and risk factors of adverse events (AEs) in a reproductive surgery endoscopy unit...
  54. ncbi request reprint Immunohistochemical expression of thrombospondin-1 in invasive vulvar squamous cell carcinoma
    Barbara Tringler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Gynecol Oncol 99:80-3. 2005
    ..The present study was designed to investigate the expression of TSP-1 in invasive vulvar squamous cell carcinoma...
  55. ncbi request reprint The lack of laminin-5 as a prognostic marker in low-grade cervical squamous intraepithelial lesions: correlation with clinical follow-up data
    Barbara Tringler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Int J Gynecol Pathol 26:89-94. 2007
    ..These data indicate that laminin-5 is not a useful diagnostic adjunct in histopathology for the identification of CIN lesions with progressive capacity...
  56. ncbi request reprint C-reactive protein is a prognostic parameter in patients with cervical cancer
    Stephan Polterauer
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Gynecol Oncol 107:114-7. 2007
    ..To evaluate whether C-reactive protein (CRP) serum levels can be used as a prognostic parameter in patients with cervical cancer...
  57. ncbi request reprint A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the prognosis of patients with ovarian cancer
    Lucia Six
    Department of Obstetrics and Gynecology, Molecular Oncology Group, Medical University of Vienna, A 1090 Vienna, Austria
    Gynecol Oncol 100:506-10. 2006
    ..We investigated whether this common polymorphism can also serve as independent prognostic parameter in a large series of affected women...
  58. ncbi request reprint p16INK4a expression in invasive vulvar squamous cell carcinoma
    Barbara Tringler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Appl Immunohistochem Mol Morphol 15:279-83. 2007
    ..p16 expression was not associated with survival in a multivariate Cox-regression model. Our data add on those published in the literature and suggest that p16 may be of prognostic significance in invasive vulvar squamous cell carcinoma...
  59. ncbi request reprint A tumor necrosis factor-alpha promoter polymorphism and pregnancy complications: results of a prospective cohort study in 1652 pregnant women
    Felix Stonek
    Department of Obstetrics and Gynecology, Ludwig Boltzmann Institute of Clinical Obstetrics and Gynecology, Danube Hospital SMZ Ost, Vienna, Austria
    Reprod Sci 14:425-9. 2007
    ..TNF-alpha -308 G/A is not a genetic marker for identifying women at increased risk of common pregnancy complications...
  60. ncbi request reprint Methylenetetrahydrofolate reductase C677T polymorphism and pregnancy complications
    Felix Stonek
    Department of Obstetrics and Gynecology, Ludwig Boltzmann Institute of Clinical Obstetrics and Gynecology, Danube Hospital SMZ Ost, Vienna, Austria
    Obstet Gynecol 110:363-8. 2007
    ..To investigate the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in women with intrauterine fetal death, preeclampsia, preterm delivery, and small for gestational age (SGA) infants...
  61. ncbi request reprint Accuracy of intraoperative frozen section analysis in borderline tumors of the ovary: a retrospective analysis of 96 cases and review of the literature
    Clemens B Tempfer
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Gynecol Oncol 107:248-52. 2007
    ..To assess the sensitivity and positive predictive value (PPV) of intraoperative frozen section diagnosis of borderline tumors of the ovary (BTO)...
  62. ncbi request reprint Role of the vaginally administered aromatase inhibitor anastrozole in women with rectovaginal endometriosis: a pilot study
    Lukas A Hefler
    Division of Gynecologic Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Fertil Steril 84:1033-6. 2005
    ..In a series of 10 patients, dysmenorrhea, physical and social functioning, but not chronic pelvic pain and dyspareunia, improved during therapy...
  63. ncbi request reprint Ultrasound criteria for ductal invasive breast cancer are modified by age, tumor size, and axillary lymph node status
    Dirk O Watermann
    Gynecology and Obstetrics, Freiburg University Medical Center, Hugstetter Str 55, 79106, Freiburg im Breisgau, Germany
    Breast Cancer Res Treat 89:127-33. 2005
    ..To evaluate the influence of distinct clinicopathological parameters on ultrasound criteria for ductal invasive breast cancer...
  64. ncbi request reprint Recurrent pregnancy failure is associated with a polymorphism in the p53 tumour suppressor gene
    Detlef Pietrowski
    Department of Obstetrics and Gynecology, University of Freiburg School of Medicine, Freiburg, Germany
    Hum Reprod 20:848-51. 2005
    ..In this study, we assess whether an established polymorphism in the p53 gene is associated with the occurrence of IRM...
  65. ncbi request reprint Multilocus genotypes spanning estrogen metabolism associated with breast cancer and fibroadenoma
    Elizabeth H Corder
    Center for Demographic Studies, Duke University, Durham, North Carolina 27708 0408, USA
    Rejuvenation Res 9:56-60. 2006
    ..Carriage of the respective multilocus genotypes increased risk 25-fold. We conclude that GoM latent classification may be useful to identify genetic risk sets and estimate risk for individuals...
  66. ncbi request reprint DNA microarray-based analysis of single nucleotide polymorphisms may be useful for assessing the risks and benefits of hormone therapy
    Clemens B Tempfer
    Department of Obstetrics and Gynecology, University of Freiburg Medical School, Freiburg, Germany
    Fertil Steril 82:132-7. 2004
    ....
  67. ncbi request reprint Polymorphisms associated with thrombophilia and vascular homeostasis and the timing of menarche and menopause in 728 white women
    Clemens B Tempfer
    Department of Obstetrics and Gynecology, University of Freiburg School of Medicine, Freiburg, Germany
    Menopause 12:325-30. 2005
    ..We attempted to assess the association of SNPs and the timing of menarche and natural and surgical menopause in an ethnically homogenous cohort of Middle European white women...
  68. ncbi request reprint Body mass index but not a polymorphism of the interleukin-1 receptor antagonist (IL-1 RA) gene is associated with age at natural menopause
    Eva Katrin Riener
    Department of Obstetrics and Gynecology, University of Freiburg Medical School, Freiburg, Germany
    Gynecol Obstet Invest 58:117-20. 2004
    ..We hypothesized that carriage of a polymorphism of the interleukin-1 receptor antagonist gene (IL-1 RA) is associated with an early age at menopause...
  69. ncbi request reprint Polymorphisms of the endothelial nitric oxide synthase gene in women with vulvar cancer
    Eva Katrin Riener
    Department of Obstetrics and Gynecology, University of Freiburg, Freiburg, Germany
    Gynecol Oncol 93:686-90. 2004
    ..Nitric oxide (NO) is involved in angiogenesis and tumor growth. We attempted to establish an association between two polymorphisms of the endothelial nitric oxide synthase (NOS3) gene and vulvar cancer...
  70. ncbi request reprint Lack of association of TNFalpha gene polymorphisms and recurrent pregnancy loss in Caucasian women
    Detlef Pietrowski
    Department of Gynecology and Obstetrics, University of Freiburg School of Medicine, Freiburg, Germany
    J Reprod Immunol 61:51-58. 2004
    ..We conclude that TNFalpha polymorphisms and resting blood TNFalpha levels do not correlate with the propensity to recurrent pregnancy loss in Caucasian women...
  71. ncbi request reprint Serum parameters of iron metabolism in patients with breast cancer
    Eva J Ulbrich
    Department of Obstetrics and Gynecology, Martin Luther University Halle Wittenberg, Magdeburger Strasse 24, 06097 Halle, Germany
    Anticancer Res 23:5107-9. 2003
    ....
  72. ncbi request reprint Ultrasound morphology of invasive lobular breast cancer is different compared with other types of breast cancer
    Dirk O Watermann
    Department of Obstetrics and Gynecology, University Medical Center, Freiburg, Germany
    Ultrasound Med Biol 31:167-74. 2005
    ..4 +/- 12.0 mm) (p = 0.015). In summary, we found that histologic differentiation significantly influences ultrasonographic appearance of breast cancer. The underestimation of tumor size of ILC might compromise the operative strategy...
  73. ncbi request reprint Inducible and endothelial nitric oxide synthase: genetic background affects ovulation in mice
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Fertil Steril 77:147-51. 2002
    ..We sought to investigate the influence of the inducible (Nos2) and endothelial (Nos3) NOS genes as a function of genetic background on ovulatory capacity and early embryonic development in a mouse model...