Affiliation: Medical University of Vienna
Kulnigg Dabsch S, Resch M, Oberhuber G, Klinglmueller F, Gasche A, Gasche C. Iron deficiency workup reveals high incidence of autoimmune gastritis with parietal cell antibody as reliable screening test. Semin Hematol. 2018;55:256-261 pubmed publisher
..PCA above 100 U/mL are a sensitive and specific cut-off for workup of patients with ID prior to endoscopy. Serologic suspicion of AIG helps preselection of patients for endoscopic workup for ID. ..
Khare V, Krnjic A, Frick A, Gmainer C, Asboth M, Jimenez K, et al
. Mesalamine and azathioprine modulate junctional complexes and restore epithelial barrier function in intestinal inflammation. Sci Rep. 2019;9:2842 pubmed publisher
..This study provides mechanistic evidence that molecular actions of 5-ASA and AZTP on intestinal epithelia are fundamental in the resolution of barrier dysfunction. ..
Jimenez K, Gasche C. Management of Iron Deficiency Anaemia in Inflammatory Bowel Disease. Acta Haematol. 2019;142:30-36 pubmed publisher
..Herein, we discuss the screening, diagnosis, selection of therapy, and follow-up for iron deficiency anaemia in IBD. ..
Dammann K, Khare V, Harpain F, Lang M, Kurtović A, Mesteri I, et al
. PAK1 promotes intestinal tumor initiation. Cancer Prev Res (Phila). 2015;8:1093-101 pubmed publisher
..IHC further revealed that 5-ASA blocked Î²-catenin signaling via inhibition of PAK1/p-AKT. These data indicate that PAK1 contributes to initiation of intestinal carcinogenesis. ..
Dammann K, Khare V, Lang M, Claudel T, Harpain F, Granofszky N, et al
. PAK1 modulates a PPARÎ³/NF-ÎºB cascade in intestinal inflammation. Biochim Biophys Acta. 2015;1853:2349-60 pubmed publisher
..Altogether these data demonstrate that PAK1 overexpression and activation in inflammation and colitis-associated cancer promote NF-ÎºB activity via suppression of PPARÎ³ in intestinal epithelial cells. ..
Lang M, Berry D, Passecker K, Mesteri I, Bhuju S, Ebner F, et al
. HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis. Cancer Res. 2017;77:2424-2438 pubmed publisher
..Furthermore, our results offer a preclinical proof of concept for HuR inhibition as an effective means of FAP chemoprevention, with caution advised in the setting of IBD. Cancer Res; 77(9); 2424-38. ©2017 AACR. ..
Frick A, Khare V, Paul G, Lang M, Ferk F, KnasmÃ¼ller S, et al
. Overt Increase of Oxidative Stress and DNA Damage in Murine and Human Colitis and Colitis-Associated Neoplasia. Mol Cancer Res. 2018;16:634-642 pubmed publisher
..These data indicate that inflammation-driven colon carcinogenesis in IL10 KO mice and IBD patients is associated with oxidative DNA damage and overt presence of DSB. Mol Cancer Res; 16(4); 634-42. Â©2018 AACR. ..
Gasche C, Nemeth M, Grundtner P, Willheim Polli C, Ferenci P, Schwarzenbacher R. Evolution of Crohn's disease-associated Nod2 mutations. Immunogenetics. 2008;60:115-20 pubmed publisher
..As mutations in exons 4e, 8, and 12 were only found in association with SNP5, this variant may have allowed selection pressure to arise. ..
Khare V, Lang M, Dammann K, Campregher C, Lyakhovich A, Gasche C. Modulation of N-glycosylation by mesalamine facilitates membranous E-cadherin expression in colon epithelial cells. Biochem Pharmacol. 2014;87:312-20 pubmed publisher
..Induction of membranous expression of E-cadherin by 5-ASA is a novel mechanism for mucosal healing in colitis that might impede tumor progression by modulation of GnT-III expression. ..