F Fazekas

Summary

Affiliation: Medical University of Graz
Country: Austria

Publications

  1. ncbi request reprint Intravenous immunoglobulin in MS: promise or failure?
    Franz Fazekas
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 259:61-6. 2007
  2. ncbi request reprint The impact of our genes: consequences of the apolipoprotein E polymorphism in Alzheimer disease and multiple sclerosis
    Franz Fazekas
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 245:35-9. 2006
  3. ncbi request reprint MTI of white matter hyperintensities
    Franz Fazekas
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Brain 128:2926-32. 2005
  4. ncbi request reprint MRI to monitor treatment efficacy in multiple sclerosis
    Franz Fazekas
    Department of Neurology, Medical University of Graz, Austria
    J Neuroimaging 17:50S-55S. 2007
  5. ncbi request reprint MRI results from the European Study on Intravenous Immunoglobulin in Secondary Progressive Multiple Sclerosis (ESIMS)
    F Fazekas
    Department of Neurology, Medical University of Graz, Graz, Austria
    Mult Scler 11:433-40. 2005
  6. doi request reprint Intravenous immunoglobulin in relapsing-remitting multiple sclerosis: a dose-finding trial
    F Fazekas
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Neurology 71:265-71. 2008
  7. doi request reprint Relevance of neuroimaging in the evaluation of cerebral ischemia
    Franz Fazekas
    Department of Neurology, Medical University of Graz, Graz, Austria
    Cerebrovasc Dis 27:1-8. 2009
  8. doi request reprint Cognitive impairment in relation to MRI metrics in patients with clinically isolated syndrome
    M Khalil
    Department of Neurology, Medical University of Graz, Austria
    Mult Scler 17:173-80. 2011
  9. doi request reprint Reorganization in cognitive networks with progression of multiple sclerosis: insights from fMRI
    M Loitfelder
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Neurology 76:526-33. 2011
  10. doi request reprint Differences and similarities in the evolution of morphologic brain abnormalities between paediatric and adult-onset multiple sclerosis
    A Pichler
    Department of Neurology, Medical University of Graz, Austria
    Mult Scler 19:167-72. 2013

Collaborators

Detail Information

Publications135 found, 100 shown here

  1. ncbi request reprint Intravenous immunoglobulin in MS: promise or failure?
    Franz Fazekas
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 259:61-6. 2007
    ..Consequently, IVIG treatment may be considered as second line option for these indications although there is still uncertainty regarding the actual mechanism(s) of action and optimal dosage of this treatment...
  2. ncbi request reprint The impact of our genes: consequences of the apolipoprotein E polymorphism in Alzheimer disease and multiple sclerosis
    Franz Fazekas
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 245:35-9. 2006
    ..In summary we presently may assume only subtle effects of the apoE polymorphism on the course of MS. These effects are probably further modulated by other genes and need further investigation...
  3. ncbi request reprint MTI of white matter hyperintensities
    Franz Fazekas
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Brain 128:2926-32. 2005
    ..We conclude that MTR measurements can serve to quantify WMH associated tissue damage. It is predominantly focal, relatively mild, increases with lesion size and may have remote effects on the frontal white matter...
  4. ncbi request reprint MRI to monitor treatment efficacy in multiple sclerosis
    Franz Fazekas
    Department of Neurology, Medical University of Graz, Austria
    J Neuroimaging 17:50S-55S. 2007
    ..For the individual patient therapeutic decisions based on MRI need experience and caution...
  5. ncbi request reprint MRI results from the European Study on Intravenous Immunoglobulin in Secondary Progressive Multiple Sclerosis (ESIMS)
    F Fazekas
    Department of Neurology, Medical University of Graz, Graz, Austria
    Mult Scler 11:433-40. 2005
    ..Magnetic resonance imaging (MRI) results may provide insights into the morphologic consequences of such treatment...
  6. doi request reprint Intravenous immunoglobulin in relapsing-remitting multiple sclerosis: a dose-finding trial
    F Fazekas
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Neurology 71:265-71. 2008
    ..We therefore set out to test two different doses of a new formulation of immunoglobulin termed IGIV-C 10% for suppression of both clinical and MRI disease activity as well as safety...
  7. doi request reprint Relevance of neuroimaging in the evaluation of cerebral ischemia
    Franz Fazekas
    Department of Neurology, Medical University of Graz, Graz, Austria
    Cerebrovasc Dis 27:1-8. 2009
    ..Using these categories, the relevance of respective neuroimaging tools can be substantiated by a large body of evidence...
  8. doi request reprint Cognitive impairment in relation to MRI metrics in patients with clinically isolated syndrome
    M Khalil
    Department of Neurology, Medical University of Graz, Austria
    Mult Scler 17:173-80. 2011
    ..It is also unclear if structural changes as detected by magnetization transfer (MT) imaging may provide an additional explanation for cognitive dysfunction...
  9. doi request reprint Reorganization in cognitive networks with progression of multiple sclerosis: insights from fMRI
    M Loitfelder
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Neurology 76:526-33. 2011
    ..We attempted to assess the concept of functional reorganization concerning cognition using a simple "Go/No-go" fMRI paradigm...
  10. doi request reprint Differences and similarities in the evolution of morphologic brain abnormalities between paediatric and adult-onset multiple sclerosis
    A Pichler
    Department of Neurology, Medical University of Graz, Austria
    Mult Scler 19:167-72. 2013
    ..Whether there are also differences regarding the accrual of brain changes is largely unknown...
  11. doi request reprint Determinants of brain iron in multiple sclerosis: a quantitative 3T MRI study
    M Khalil
    Department of Neurology, Medical University of Graz, Graz, Austria
    Neurology 77:1691-7. 2011
    ..We used this technique to assess brain iron levels in different stages of MS and healthy controls (HC) and determined their relation with demographic, clinical, neuropsychological, and other imaging variables...
  12. doi request reprint Hyperinsulinaemia in migraineurs is associated with nitric oxide stress
    H J Gruber
    Chemical Laboratory Diagnostics, Medical University Graz, Clinical Institute of Medical, Graz, Austria
    Cephalalgia 30:593-8. 2010
    ..We show here that hyperinsulinaemia is associated with migraine and, furthermore, is correlated with increased NO stress. These findings represent a new pathophysiological mechanism that may be of clinical relevance...
  13. pmc Apolipoprotein E genotype related differences in brain lesions of multiple sclerosis
    F Fazekas
    Department of Neurology, Karl Franzens University, Graz, Austria
    J Neurol Neurosurg Psychiatry 69:25-8. 2000
    ..As this could be reflected by differences in the severity of tissue damage MRI was used to obtain further support for a disease modifying effect of the apoE genotype...
  14. ncbi request reprint MRI cerebral white matter lesions and paraoxonase PON1 polymorphisms : three-year follow-up of the austrian stroke prevention study
    R Schmidt
    Department of Neurology, Karl Franzens University, Graz, Austria
    Arterioscler Thromb Vasc Biol 20:1811-6. 2000
    ..05/mm Hg), and LL paraoxonase genotype (odds ratio, 2. 65) to be significant predictors of WML progression. These data suggest that the LL PON1 genotype at position 54 influences the extent and progression of WMLs in elderly subjects...
  15. doi request reprint Reduced urinary glutamate levels are associated with the frequency of migraine attacks in females
    C Ragginer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria
    Eur J Neurol 19:1146-50. 2012
    ..The aim of the present study was to investigate the impact of glutamate on migraine and related metabolic dysfunctions...
  16. doi request reprint Increased matrix metalloproteinase activity is associated with migraine and migraine-related metabolic dysfunctions
    C Bernecker
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria
    Eur J Neurol 18:571-6. 2011
    ..The aim of this study was to investigate the impact of MMPs and TIMPs on migraine with and without aura and related metabolic dysfunctions...
  17. pmc Longitudinal multimodal imaging in mild to moderate Alzheimer disease: a pilot study with memantine
    R Schmidt
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Neurosurg Psychiatry 79:1312-7. 2008
    ....
  18. ncbi request reprint Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects
    C Enzinger
    Department of Neurology, Medical University Graz, Graz, Austria
    Neurology 64:1704-11. 2005
    ....
  19. doi request reprint Oxidative stress is associated with migraine and migraine-related metabolic risk in females
    C Bernecker
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria
    Eur J Neurol 18:1233-9. 2011
    ..The aim of this study was to investigate the oxidative stress status of female patients with migraine and its implications on migraine-related metabolic alterations...
  20. ncbi request reprint Apolipoprotein E polymorphism and silent microangiopathy-related cerebral damage. Results of the Austrian Stroke Prevention Study
    R Schmidt
    Department of Neurology, Karl Franzens University Graz, Austria
    Stroke 28:951-6. 1997
    ..The risk factors of such brain abnormalities are not fully determined. The goal of this study was to determine whether the genetic heterogeneity of apolipoprotein E (apoE) contributes to the occurrence of MARCD...
  21. doi request reprint The functional correlates of face perception and recognition of emotional facial expressions as evidenced by fMRI
    M Jehna
    Department of Neurology, Medical University of Graz, Austria Institute of Psychology, Karl Franzens University Graz, Austria
    Brain Res 1393:73-83. 2011
    ..Our approach might prove useful in future studies of patients with neurologic disorders with potential effect on emotion recognition...
  22. ncbi request reprint Predicting the severity of relapsing-remitting MS: the contribution of cross-sectional and short-term follow-up MRI data
    C Enzinger
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, Graz, Austria
    Mult Scler 17:695-701. 2011
    ..Predicting the long-term clinical course of multiple sclerosis (MS) is difficult on clinical grounds. Recent studies have suggested magnetic resonance imaging (MRI) metrics to be helpful. We wanted to confirm this...
  23. doi request reprint Decision-making for and impact of early immunomodulatory treatment: the Austrian Clinically Isolated Syndrome Study (ACISS)
    F Fazekas
    Department of Neurology, Medical University of Graz, Graz, Austria
    Eur J Neurol 17:852-60. 2010
    ..How this occurs in a routine setting is barely known. The aim of the study was to investigate the decision-making process regarding immediate or later DMT and the ensuing impact on CIS patients in Austria...
  24. pmc CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome
    M Khalil
    Department of Neurology, Medical University of Graz, Graz, Austria
    Mult Scler 19:436-42. 2013
    ..Axonal damage is considered a major cause of disability in multiple sclerosis (MS) and may start early in the disease. Specific biomarkers for this process are of great interest...
  25. ncbi request reprint MRI white matter hyperintensities: three-year follow-up of the Austrian Stroke Prevention Study
    R Schmidt
    Department of Neurology, Institute of Medical Biochemistry, Karl Franzens University, Graz, Austria
    Neurology 53:132-9. 1999
    ..To determine the rate, clinical predictors, and cognitive consequences of MRI white matter hyperintensity evolution over 3 years...
  26. ncbi request reprint The impact of sex and vascular risk factors on brain tissue changes with aging: magnetization transfer imaging results of the Austrian stroke prevention study
    Stefan Ropele
    Department of Neurology, Medical University of Graz, Graz, Austria
    AJNR Am J Neuroradiol 31:1297-301. 2010
    ..To what extent sex and cerebrovascular risk factors impact these changes is largely unknown. We attempted to study these risk factors in the context of the community-based ASPS...
  27. ncbi request reprint Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis. Austrian Immunoglobulin in Multiple Sclerosis Study Group
    F Fazekas
    Department of Neurology, Karl-Franzens University, Graz, Austria
    Lancet 349:589-93. 1997
    ..INTERPRETATION: Monthly IVIg is an effective and well-tolerated treatment for patients with relapsing-remitting multiple sclerosis...
  28. ncbi request reprint Quantitative magnetization transfer imaging of pre-lesional white-matter changes in multiple sclerosis
    F Fazekas
    Department of Neurology, Karl Franzens University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Mult Scler 8:479-84. 2002
    ..To gain further insight into pre-lesional tissue abnormalities, we investigated the time course of additional quantitative MT parameters...
  29. doi request reprint Patient-reported quality of life in multiple sclerosis differs between cultures and countries: a cross-sectional Austrian-German-Polish study
    A Pluta-Fuerst
    Department of Neurology, Medical University of Graz, Graz, Austria
    Mult Scler 17:478-86. 2011
    ..Patient-reported quality of life (QOL) is an outcome measure in clinical trials in multiple sclerosis (MS), but translated QOL instruments may affect the actual comparability of data...
  30. pmc Acute small subcortical infarctions on diffusion weighted MRI: clinical presentation and aetiology
    T Seifert
    Department of Neurology, Graz Medical University, A 8036 Graz, Austria
    J Neurol Neurosurg Psychiatry 76:1520-4. 2005
    ..DWI is both sensitive and specific in the early detection of acute ischaemic brain lesions irrespective of pre-existing vascular damage...
  31. ncbi request reprint Relapsing acute transverse myelitis: a specific entity
    T Seifert
    Department of Neurology, Graz Medical University, Graz, Austria
    Eur J Neurol 12:681-4. 2005
    ..Despite various treatment strategies, all patients became severely disabled. Relapsing ATM not related to systemic disease appears to be a specific entity which accounts for severe disability and currently lacks effective treatment...
  32. ncbi request reprint Estimation of magnetization transfer rates from PACE experiments with pulsed RF saturation
    S Ropele
    Department of Neurology, Karl Franzens University of Graz, A 8036 Graz, Austria
    J Magn Reson Imaging 12:749-56. 2000
    ..9 sec(-1)). It could be shown that conditions near to complete saturation can also be reached under common restrictions by the specific absorption rate...
  33. ncbi request reprint Differences in cerebral activation patterns in idiopathic inflammatory demyelination using the paced visual serial addition task: an fMRI study
    Dagmar Rachbauer
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 244:11-6. 2006
    ....
  34. doi request reprint Longitudinal magnetization transfer imaging in mild to severe Alzheimer disease
    S Ropele
    Department of Neurology, Medical University of Graz, Graz, Austria
    AJNR Am J Neuroradiol 33:570-5. 2012
    ..We therefore used a placebo-controlled study of memantine to follow the evolution of tissue damage in AD by means of MTR measurements and investigated how MTR changes were related to brain atrophy and cognition...
  35. ncbi request reprint Lack of association of lobar intracerebral hemorrhage with apolipoprotein E genotype in an unselected population
    T Seifert
    Department of Neurology, Medical University Graz, Graz, Austria
    Cerebrovasc Dis 21:266-70. 2006
    ..These studies were performed primarily on the North American population and investigated in partly selected patient cohorts...
  36. ncbi request reprint Clinically benign multiple sclerosis despite large T2 lesion load: can we explain this paradox?
    S Strasser-Fuchs
    Department of Neurology, Division of Neuroradiology, Medical University, Graz, Austria
    Mult Scler 14:205-11. 2008
    ..Functional compensation must come from other mechanisms such as brain plasticity...
  37. doi request reprint Brain activation patterns elicited by the 'Faces Symbol Test' -- a pilot fMRI study
    Rh Grabner
    Institute of Psychology, University of Graz, Austria, Section of Neuroradiology, Department of Radiology, Medical University of Graz, Austria
    Mult Scler 14:354-63. 2008
    ..These results suggest that the FST recruits brain networks critical for higher-order cognitive functions often impaired in MS patients...
  38. ncbi request reprint Improved diffusion-weighted single-shot echo-planar imaging (EPI) in stroke using sensitivity encoding (SENSE)
    R Bammer
    Magnetic Resonance Institute, Karl Franzens University, Graz, Austria
    Magn Reson Med 46:548-54. 2001
    ..Because of the faster k-space traversal, this novel technique is able to reduce typical EPI artifacts and increase spatial resolution while simultaneously remaining insensitive to bulk motion...
  39. doi request reprint Quantitative assessment of brain iron by R(2)* relaxometry in patients with clinically isolated syndrome and relapsing-remitting multiple sclerosis
    M Khalil
    Department of Neurology and Department of Radiology Division of Neuroradiology, Medical University of Graz, Graz, Austria
    Mult Scler 15:1048-54. 2009
    ..R(2)* relaxometry allows to assess brain iron accumulation quantitatively...
  40. ncbi request reprint TACE mRNA expression in peripheral mononudear cells precedes new lesions on MRI in multiple sclerosis
    T Seifert
    Department of Neurology, Karl Franzens University, Auenbruggerplatz 22, Graz A 8036, Austria
    Mult Scler 8:447-51. 2002
    ..Patients found positive for TACE mRNA in PBMCs showed a significantly higher mean number of new Gd-enhancing lesions per scan one month following PBMC sampling...
  41. ncbi request reprint Fast multislice T(1) and t(1sat) imaging using a phase acquisition of composite echoes (PACE) technique
    S Ropele
    Department of Neurology, Karl Franzens University of Graz, Graz, Austria
    Magn Reson Med 42:1089-97. 1999
    ..T(1) and T(1sat) measurements in brain tissue of eight healthy volunteers confirmed the stability of the fast PACE technique in a clinical setting. Magn Reson Med 42:1089-1097, 1999...
  42. ncbi request reprint Angiotensinogen gene promoter haplotype and microangiopathy-related cerebral damage: results of the Austrian Stroke Prevention Study
    H Schmidt
    Institute of Medical Biochemistry and Medical Molecular Biology, Karl Franzens University, Graz, Austria
    Stroke 32:405-12. 2001
    ..Arterial hypertension and age are the most important risk factors. We assessed the association between MARCD and sequence alterations in the promoter region of the angiotensinogen (AGT) gene...
  43. ncbi request reprint White matter lesion progression: a surrogate endpoint for trials in cerebral small-vessel disease
    R Schmidt
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Neurology 63:139-44. 2004
    ..Like any other MRI metric, the change in white matter lesion volume cannot be considered preferable to clinical outcomes unless it has been demonstrated that it matters to the patient in terms of function...
  44. doi request reprint Re-expression of N-cadherin in remyelinating lesions of experimental inflammatory demyelination
    S Hochmeister
    Department of Neurology, Medical University Graz, Austria
    Exp Neurol 237:70-7. 2012
    ..Our results show that N-cadherin plays an important role in creating a remyelination-facilitating environment...
  45. ncbi request reprint Minimizing macrovessel signal in cerebral perfusion imaging using independent component analysis
    G Reishofer
    Department of Radiology, Medical University Graz, Graz, Austria
    Magn Reson Med 57:278-88. 2007
    ..The corrected parameter images showed a clearly reduced macrovessel signal and an improved perceptibility of microvascular perfusion changes compared to the uncorrected ones...
  46. ncbi request reprint Vascular risk factors in dementia
    R Schmidt
    Department of Neurology, Karl Franzens University Graz, Austria
    J Neurol 247:81-7. 2000
    ..A modulatory effect of vascular risk factors in the development of primary degenerative dementia may extend treatment options...
  47. ncbi request reprint Midbrain ischemia presenting as vertical gaze palsy: value of diffusion-weighted magnetic resonance imaging
    T Seifert
    Department of Neurology, Karl Franzens University, Graz, Austria
    Cerebrovasc Dis 18:3-7. 2004
    ..Diffusion-weighted magnetic resonance imaging (DWI) is very sensitive and specific for acute cerebral ischemia and should contribute to the early detection of such lesions...
  48. ncbi request reprint T1 maps from shifted spin echoes and stimulated echoes
    S Ropele
    Department of Neurology, Karl Franzens University, Graz, Austria
    Magn Reson Med 46:1242-5. 2001
    ..Moreover, this method offers a higher precision for long T1 values and a further reduction of acquisition time...
  49. pmc Fast bound pool fraction mapping using stimulated echoes
    M Soellinger
    Department of Neurology, Medical University of Graz, Graz, Austria
    Magn Reson Med 66:717-24. 2011
    ..To sum up, these results suggest the proposed method useful for cross-sectional and longitudinal studies of white matter changes in the human brain...
  50. ncbi request reprint MRI characteristics of atypical idiopathic inflammatory demyelinating lesions of the brain : A review of reported findings
    A Seewann
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria
    J Neurol 255:1-10. 2008
    ..Atypical appearances of IIDLs also exist, however, and can pose significant diagnostic problems and uncertainty regarding prognosis and adequate therapy. We attempted to improve upon this situation by reviewing the literature...
  51. ncbi request reprint The prevalence of cerebral damage varies with migraine type: a MRI study
    F Fazekas
    Department of Neurology, Karl-Franzens University, Graz, Austria
    Headache 32:287-91. 1992
    ..Our findings confirm a higher prevalence of MRI lesions in a mixed group of migraineurs than in headache free individuals. Signal abnormalities are most often non-specific, however their occurrence relates to the type of migraine...
  52. doi request reprint Increased nitric oxide stress is associated with migraine
    H J Gruber
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Graz, Austria
    Cephalalgia 30:486-92. 2010
    ..We show here that migraine patients suffer under sustained increased nitrosative stress in the headache-free period, which is associated with a 3.6-fold higher risk for migraine...
  53. ncbi request reprint Pathophysiologic mechanisms in the development of age-related white matter changes of the brain
    F Fazekas
    Department of Neurology, Karl Franzens University, Graz, Austria
    Dement Geriatr Cogn Disord 9:2-5. 1998
    ..Early confluent and confluent hyperintensities, however, indicate more extensive ischemic damage consistent with advanced microangiopathy...
  54. ncbi request reprint C-reactive protein, carotid atherosclerosis, and cerebral small-vessel disease: results of the Austrian Stroke Prevention Study
    Reinhold Schmidt
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria
    Stroke 37:2910-6. 2006
    ..We examined the associations between CRP, carotid atherosclerosis, white matter lesions, and lacunes as manifestations of cerebral large- and small-vessel disease...
  55. doi request reprint Magnetization transfer MR imaging in multiple sclerosis
    Stefan Ropele
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Neuroimaging Clin N Am 19:27-36. 2009
    ..We then review the applications of MT MR imaging to multiple sclerosis. Finally we review the technique's contribution to our understanding of this disease...
  56. ncbi request reprint IVIG therapy in neurological disorders of childhood
    Juan J Archelos
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, 8036, Graz, Austria
    J Neurol 253:V80-6. 2006
    ..Despite considerable efforts to define the role and mechanisms of IVIG, more clinical studies are needed to further explore the therapeutic potential of IVIG in childhood diseases of the nervous system and muscle...
  57. ncbi request reprint Depressive symptoms following herpes simplex encephalitis--an underestimated phenomenon?
    Christian Fazekas
    Department of Medical Psychology and Psychotherapy, Medical University Graz, A 8036 Graz, Austria
    Gen Hosp Psychiatry 28:403-7. 2006
    ..We therefore set out to explore an association between herpes simplex virus encephalitis (HSE) and both depressive symptoms and HRQoL...
  58. ncbi request reprint Efficacy and safety of radiosurgical callosotomy: a retrospective analysis
    Michael Feichtinger
    Department of Neurology, Medical University Graz, Graz, Austria
    Epilepsia 47:1184-91. 2006
    ..Besides open surgery, a radiosurgical callosal disconnection using the gamma knife (GK) also can be performed, but reliable data about tolerability and efficacy are sparse...
  59. ncbi request reprint Measurement of short and ultrashort T2 components using progressive binomial RF saturation
    Stefan Ropele
    Department of Neurology, Medical University Graz, Graz, Austria
    Magn Reson Med 56:265-71. 2006
    ..We observed a short T2 component around 17 ms and an ultrashort T2 component in the range of 0.9-1.1 ms. Numerical simulations and in vitro measurements suggest that resonance offsets have effects that require further investigation...
  60. doi request reprint Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) study
    Stefan Ropele
    Department of Neurology, Medical University of Graz, Austria
    J Magn Reson Imaging 29:268-74. 2009
    ..To explore the value of diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) for the improved detection and quantification of cerebral tissue changes associated with ageing and white matter hyperintensities (WMH)...
  61. ncbi request reprint [Gender aspects of Ischemic stroke. An analysis of the Austrian Stroke-Unit Registry]
    Susanna Horner
    Universitätsklinik für Neurologie, Medizinische Universitat Graz, Graz, Austria
    Wien Med Wochenschr 158:446-52. 2008
    ..Available studies suggest gender-related differences in the management of stroke patients. We therefore aimed to address this issue in a large cohort of ischemic stroke patients admitted to Stroke-Units in Austria...
  62. ncbi request reprint Progression of cerebral white matter lesions -- clinical and radiological considerations
    Christian Enzinger
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 257:5-10. 2007
    ..Power calculations based on quantitative data of the Austrian Stroke Prevention Study (ASPS) suggest that such studies would be feasible...
  63. ncbi request reprint Automatic and remote controlled ictal SPECT injection for seizure focus localization by use of a commercial contrast agent application pump
    Michael Feichtinger
    Department of Neurology, Medical University Graz, Graz, Austria
    Epilepsia 48:1409-13. 2007
    ..In this study, therefore, we retrospectively analyzed efficiency and safety of an automatic injection system for ictal SPECT tracer application...
  64. ncbi request reprint Brain activity changes associated with treadmill training after stroke
    Christian Enzinger
    Department of Neurology, Medical University of Graz, Graz, Austria
    Stroke 40:2460-7. 2009
    ....
  65. ncbi request reprint No effect of immunomodulatory therapy in focal epilepsy with positive glutamate receptor type 3--antibodies
    Michael Feichtinger
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Seizure 15:350-4. 2006
    ..Interestingly, GluR3 serum levels remained positive after successful surgical intervention leading to patient's seizure freedom...
  66. ncbi request reprint Brain motor system function in a patient with complete spinal cord injury following extensive brain-computer interface training
    Christian Enzinger
    Department of Neurology, Medical University, Auenbruggerplatz 22, 8036, Graz, Austria
    Exp Brain Res 190:215-23. 2008
    ..We interpret our findings as evidence that BCI training as a conduit of motor imagery training may assist in maintaining access to SMC in largely preserved somatopy despite complete deafferentation...
  67. ncbi request reprint Transient global amnesia: diffusion-weighted imaging lesions and cerebrovascular disease
    Christian Enzinger
    Department of Neurology and Section of Neuroradiology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Stroke 39:2219-25. 2008
    ....
  68. ncbi request reprint Functional MRI correlates of lower limb function in stroke victims with gait impairment
    Christian Enzinger
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Stroke 39:1507-13. 2008
    ..We used ankle movement as a lower limb analog to test for similarities and differences in recovery patterns...
  69. ncbi request reprint Progression of leukoaraiosis and cognition
    Reinhold Schmidt
    Department of Neurology, Medical University of Graz, Graz, Austria
    Stroke 38:2619-25. 2007
    ..Progression of leukoaraiosis relates to cognitive decline, but this association is complex and modulated by other morphological factors like brain atrophy...
  70. ncbi request reprint Subcortical vascular cognitive impairment: similarities and differences with multiple sclerosis
    Reinhold Schmidt
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 245:3-7. 2006
    ..Involvement of these common functional anatomical structures and their modulatory transmitter systems has now led to common interventional approaches such as the use of cholinesterase inhibitors...
  71. ncbi request reprint Lower levels of N-acetylaspartate in multiple sclerosis patients with the apolipoprotein E epsilon4 allele
    Christian Enzinger
    Department of Neurology, Karl Franzens University, Graz, Austria
    Arch Neurol 60:65-70. 2003
    ..In multiple sclerosis (MS), the epsilon4 allele of apolipoprotein E (APOE epsilon4) has been associated with more rapid clinical worsening and more severe tissue damage on magnetic resonance imaging...
  72. ncbi request reprint Assessment and correction of B1-induced errors in magnetization transfer ratio measurements
    Stefan Ropele
    MR Research Unit, Medical University Graz, Auenbruggerplatz 9, A 8036 Graz, Austria
    Magn Reson Med 53:134-40. 2005
    ..The correction scheme may be useful when investigating MTR as an outcome measure in single or multicenter studies...
  73. ncbi request reprint Improved perfusion and tracer kinetic imaging using parallel imaging
    Rudolf Stollberger
    Department of Radiology, Medical University Graz, Graz, Austria
    Top Magn Reson Imaging 15:245-54. 2004
    ..From the clinical applications shown, it can be concluded that parallel imaging is a very important contribution for improved dynamic contrast enhanced imaging...
  74. ncbi request reprint Fast patient workup in acute stroke using parallel imaging
    Michael Augustin
    Department of Radiology, Auenbruggerplatz 9, Medical University, 8036 Graz, Austria
    Top Magn Reson Imaging 15:207-19. 2004
    ..Therefore, new imaging techniques are required that provide both in-depth information and short scanning times. Parallel imaging is uniquely suited for this purpose...
  75. ncbi request reprint Qualitative MRI: evidence of usual aging in the brain
    Peter Kapeller
    Department of Neurology, Medical University Graz, Graz, Austria
    Top Magn Reson Imaging 15:343-7. 2004
    ..Furthermore the meaning of darkening of the basal ganglia will be discussed and, in more general terms, the occurrence of virchow robin spaces and changes in cerebral metabolites assessable by proton magnetic resonance spectroscopy...
  76. ncbi request reprint White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study
    Reinhold Schmidt
    Department of Neurology, Medical University Graz, Austria
    Ann Neurol 58:610-6. 2005
    ....
  77. ncbi request reprint Tumefactive demyelinating lesions: conventional and advanced magnetic resonance imaging
    Christian Enzinger
    Department of Neurology, Medical University, Graz, Austria
    Mult Scler 11:135-9. 2005
    ..MRI techniques thus appear to have the potential to establish a correct diagnosis of this subtype of TDLs. Awareness of these possibilities might obviate the need for biopsy at least in some cases in future...
  78. doi request reprint MRI in dementia
    Reinhold Schmidt
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Neurol Clin 27:221-36, ix. 2009
    ..In addition, we explore the usefulness of such techniques as surrogate markers of these diseases...
  79. ncbi request reprint Lesion probability maps of white matter hyperintensities in elderly individuals: results of the Austrian stroke prevention study
    Christian Enzinger
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, 8036 Graz, Austria
    J Neurol 253:1064-70. 2006
    ..While this increase in extension is frequently seen as evidence for a continuum of changes, histological data and clinical follow-up suggest differences in underlying pathology and their progression...
  80. pmc Differences in integrity of white matter and changes with training in spelling impaired children: a diffusion tensor imaging study
    D Gebauer
    Department of Neurology, Medical University of Graz, Austria
    Brain Struct Funct 217:747-60. 2012
    ..We also provide first indications that white matter changes occur during successful training, but this needs to be more specifically addressed in future research...
  81. doi request reprint Symptomatic stenosis of the vertebrobasilar arteries: results of extra- and intracranial stent-PTA
    T Seifert
    Department of Neurology, Medical University of Graz, Austria
    Eur J Neurol 16:31-6. 2009
    ....
  82. ncbi request reprint Statins as immunomodulators: comparison with interferon-beta 1b in MS
    O Neuhaus
    Department of Neurology, Multiple Sclerosis Research Group, Karl Franzens Universität, Graz, Austria
    Neurology 59:990-7. 2002
    ..In order to evaluate the potential role of statins as immunomodulators in MS, the authors studied their immunologic effects in vitro and compared them to interferon (IFN)beta-1b...
  83. ncbi request reprint Lipid profile in normal weight migraineurs - evidence for cardiovascular risk
    H J Gruber
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria
    Eur J Neurol 17:419-25. 2010
    ..The aim of the present study is to evaluate the lipid profile in normal weight migraine patients...
  84. ncbi request reprint The contribution of magnetic resonance imaging to the diagnosis of multiple sclerosis
    F Fazekas
    Department of Neurology and MRI Center, Karl Franzens University, Graz, Austria
    Neurology 53:448-56. 1999
    ..These proposals should help to optimize and standardize the use of MRI in the diagnosis of MS...
  85. ncbi request reprint Unenhanced and enhanced magnetic resonance imaging in the diagnosis of multiple sclerosis
    F Fazekas
    Department of Neurology and MR Center, Karl Franzens University, Graz, Austria
    J Neurol Neurosurg Psychiatry 64:S2-5. 1998
    ..The high sensitivity to plaques and the opportunity to simultaneously rule out other gross morphological damage justifies the use of MRI as the primary diagnostic modality in the evaluation of multiple sclerosis...
  86. ncbi request reprint Method for quantitative imaging of the macromolecular 1H fraction in tissues
    Stefan Ropele
    Department of Neurology, Karl Franzens University of Graz, Graz, Austria
    Magn Reson Med 49:864-71. 2003
    ..Using a navigated echo planar readout, the sequence was also employed to visualize the macromolecular content of human brain in vivo...
  87. ncbi request reprint Accelerated evolution of brain atrophy and "black holes" in MS patients with APOE-epsilon 4
    Christian Enzinger
    Department of Neurology, Karl Franzens University, Graz, Austria
    Ann Neurol 55:563-9. 2004
    ..0 vs 5.7%). Accelerated brain tissue loss and a higher proportion of lesions evolving into BH therefore provide magnetic resonance imaging evidence for more pronounced tissue destruction in MS patients with APOE-epsilon4...
  88. doi request reprint Diffusion-weighted imaging and cognition in the leukoariosis and disability in the elderly study
    Reinhold Schmidt
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria
    Stroke 41:e402-8. 2010
    ..We hypothesized that ultrastructural abnormalities of the normal-appearing brain tissue (NABT) assessed by diffusion-weighted imaging played a major and independent role...
  89. ncbi request reprint Visual rating of age-related white matter changes on magnetic resonance imaging: scale comparison, interrater agreement, and correlations with quantitative measurements
    P Kapeller
    Department of Neurology, Karl Franzens University, Graz, Austria
    Stroke 34:441-5. 2003
    ..Furthermore, the correlation between visual ratings and quantitative volumetric measurement was assessed...
  90. ncbi request reprint Acupuncture using laser needles modulates brain function: first evidence from functional transcranial Doppler sonography and functional magnetic resonance imaging
    G Litscher
    Department of Biomedical Engineering and Research in Anesthesia and Critical Care, Medical University of Graz, Auenbruggerplatz 29, 8036, Austria
    Lasers Med Sci 19:6-11. 2004
    ..Therefore true double-blind studies in acupuncture research can be performed...
  91. ncbi request reprint Prevalence of multiple sclerosis in Austria. Results of a nationwide survey
    U Baumhackl
    Department of Neurology, General Hospital, St Poelten, Austria
    Neuroepidemiology 21:226-34. 2002
    ..Epidemiological studies, such as this, provide a unique source of data from which key features of a disease and its impact on patients may be examined...
  92. ncbi request reprint Clinical predominance of proximal upper limb weakness in CMT1A syndrome
    M Auer-Grumbach
    Department of Neurology, Karl Franzens University, Graz, Austria
    Muscle Nerve 23:1243-9. 2000
    ..The unusual phenotype cannot be explained by the concomitant presence of FSHD despite some evidence for coexistance in one individual...
  93. ncbi request reprint Apolipoprotein E epsilon 4 is associated with rapid progression of multiple sclerosis
    F Fazekas
    Department of Neurology, Karl Franzens University, Graz, Austria
    Neurology 57:853-7. 2001
    ..Previous findings concerning a possible modulation of the clinical course of MS have been inconsistent, however...
  94. doi request reprint Vascular dementia and Alzheimer's disease - are we in a dead-end road?
    Margherita Cavalieri
    Division of Special Neurology, Department of Neurology, Medical University of Graz, Graz, Austria
    Neurodegener Dis 7:122-6. 2010
    ..Most importantly, vascular lesions, even if subtle, exert significant effects on the patients' cognitive functioning if they coexist with AD pathology...
  95. ncbi request reprint Evolution of white matter lesions
    Reinhold Schmidt
    Department of Neurology, Karl Franzens University, Graz, Austria
    Cerebrovasc Dis 13:16-20. 2002
    ..Lesion progression had no influence on the course of neuropsychologic test performance over the observational period, but the statistical power of this analysis was low...
  96. ncbi request reprint The natural course of MRI white matter hyperintensities
    Reinhold Schmidt
    Department of Neurology, Karl Franzens University, Auenbruggerplatz 22, A 8036, Graz, Austria
    J Neurol Sci 203:253-7. 2002
    ..The Austrian Stroke Prevention Study did not find an association between the evolution of WMH and cognitive functioning but the statistical power of this analysis was small and the relationship needs to be further explored...
  97. ncbi request reprint Slow progression of white-matter changes
    Reinhold Schmidt
    Department of Neurology, Karl Franzens University, Graz, Austria
    Int Psychogeriatr 15:173-6. 2003
    ..Lesion progression had no influence on the course of neuropsychologic test performance over the observational period, but the statistical power of this analysis was low...
  98. ncbi request reprint Thrombolytic therapy for acute stroke in Austria: data from the Safe Implementation of Thrombolysis in Stroke (SITS) register
    R Topakian
    Department of Neurology, Academic Teaching Hospital Wagner Jauregg, Linz, Austria
    Eur J Neurol 18:306-11. 2011
    ....
  99. ncbi request reprint Angiotensinogen polymorphism M235T, carotid atherosclerosis, and small-vessel disease-related cerebral abnormalities
    R Schmidt
    Department of Neurology, MRI Center, Karl Franzens University, Graz, Austria
    Hypertension 38:110-5. 2001
    ..These data suggest that the angiotensinogen T/T genotype at position 235 is a genetic marker for brain lesions from and progression of small vessel disease but not for extracranial carotid atherosclerosis...
  100. ncbi request reprint Mapping of iron deposition in conjunction with assessment of nerve fiber tract integrity in amyotrophic lateral sclerosis
    Christian Langkammer
    Department of Neurology, Medical University of Graz, Austria
    J Magn Reson Imaging 31:1339-45. 2010
    ....
  101. ncbi request reprint Gender differences in MRI studies on multiple sclerosis
    Franz Fazekas
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 286:28-30. 2009
    ..Our review thus indicates no independent gender differences on brain MRI beyond demographic and clinical variables such as age, duration of disease and grade of disability...