Genomes and Genes


Balazs Dome


Affiliation: Medical University of Vienna
Country: Austria


  1. László V, Valkó Z, Kovacs I, Ozsvar J, Hoda M, Klikovits T, et al. Nintedanib Is Active in Malignant Pleural Mesothelioma Cell Models and Inhibits Angiogenesis and Tumor Growth In Vivo. Clin Cancer Res. 2018;24:3729-3740 pubmed publisher
    ..i>Clin Cancer Res; 24(15); 3729-40. ©2018 AACR. ..
  2. Sárosi V, Losonczy G, Francovszky E, Tolnay E, Torok S, Gálffy G, et al. Effectiveness of erlotinib treatment in advanced KRAS mutation-negative lung adenocarcinoma patients: Results of a multicenter observational cohort study (MOTIVATE). Lung Cancer. 2014;86:54-8 pubmed publisher
  3. Klikovits T, Lohinai Z, Fabian K, Gyulai M, Szilasi M, Varga J, et al. New insights into the impact of primary lung adenocarcinoma location on metastatic sites and sequence: A multicenter cohort study. Lung Cancer. 2018;126:139-148 pubmed publisher
    ..Central LADC is associated with early metastatic disease, bone involvement and, consequently, decreased survival. ..
  4. László V, Valkó Z, Ozsvar J, Kovacs I, Garay T, Hoda M, et al. The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma. J Mol Med (Berl). 2019;97:231-242 pubmed publisher
    ..KEY MESSAGES: Response to FAK inhibition in MPM is independent of NF2 expression or histotype. FAK inhibition strongly interfered with MPM spheroid formation. BI 853520 has been shown to exert anti-tumor effect in MPM. ..
  5. Bugyik E, Szabó V, Dezso K, Rókusz A, Szücs A, Nagy P, et al. Role of (myo)fibroblasts in the development of vascular and connective tissue structure of the C38 colorectal cancer in mice. Cancer Commun (Lond). 2018;38:46 pubmed publisher
    ..We concluded that not only the host tissue characteristics but also the tumor-derived fibrogenic signals determine the vascular and connective tissue structure of tumors. ..
  6. Cserepes M, Ostoros G, Lohinai Z, Raso E, Barbai T, Timar J, et al. Subtype-specific KRAS mutations in advanced lung adenocarcinoma: a retrospective study of patients treated with platinum-based chemotherapy. Eur J Cancer. 2014;50:1819-1828 pubmed publisher
  7. Bugyik E, Renyi Vamos F, Szabó V, Dezso K, Ecker N, Rókusz A, et al. Mechanisms of vascularization in murine models of primary and metastatic tumor growth. Chin J Cancer. 2016;35:19 pubmed publisher
    ..In this article, we briefly review the biological features of these mechanisms and discuss on their significance in medical oncology. ..