H Dobnig

Summary

Affiliation: Medical University of Graz
Country: Austria

Publications

  1. pmc Pharmacokinetics of teriparatide (rhPTH[1-34]) and calcium pharmacodynamics in postmenopausal women with osteoporosis
    Julie Satterwhite
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
    Calcif Tissue Int 87:485-92. 2010
  2. doi request reprint Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality
    Harald Dobnig
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Arch Intern Med 168:1340-9. 2008
  3. ncbi request reprint Hip and nonvertebral fracture prediction in nursing home patients: role of bone ultrasound and bone marker measurements
    Harald Dobnig
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Clin Endocrinol Metab 92:1678-86. 2007
  4. ncbi request reprint Type 2 diabetes mellitus in nursing home patients: effects on bone turnover, bone mass, and fracture risk
    Harald Dobnig
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Clin Endocrinol Metab 91:3355-63. 2006
  5. ncbi request reprint Changes in the RANK ligand/osteoprotegerin system are correlated to changes in bone mineral density in bisphosphonate-treated osteoporotic patients
    H Dobnig
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University Graz, Auenbruggerplatz 15, 8036, Graz, Austria
    Osteoporos Int 17:693-703. 2006
  6. ncbi request reprint Early changes in biochemical markers of bone formation correlate with improvements in bone structure during teriparatide therapy
    Harald Dobnig
    Department of Internal Medicine, Division of Endocrinology, Medical University, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Clin Endocrinol Metab 90:3970-7. 2005
  7. ncbi request reprint Calcium supply, bone mineral density and genetically defined lactose maldigestion in a cohort of elderly men
    M Gugatschka
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University Graz, Auenbruggerplatz, 8036 Graz, Austria
    J Endocrinol Invest 30:46-51. 2007
  8. ncbi request reprint Adult-type hypolactasia and calcium availability: decreased calcium intake or impaired calcium absorption?
    B M Obermayer-Pietsch
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036, Graz, Austria
    Osteoporos Int 18:445-51. 2007
  9. doi request reprint Associations of homoarginine with bone metabolism and density, muscle strength and mortality: cross-sectional and prospective data from 506 female nursing home patients
    S Pilz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria
    Osteoporos Int 24:377-81. 2013
  10. doi request reprint Bone markers predict cardiovascular events in chronic kidney disease
    Astrid Fahrleitner-Pammer
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University, Graz, Austria
    J Bone Miner Res 23:1850-8. 2008

Detail Information

Publications39

  1. pmc Pharmacokinetics of teriparatide (rhPTH[1-34]) and calcium pharmacodynamics in postmenopausal women with osteoporosis
    Julie Satterwhite
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
    Calcif Tissue Int 87:485-92. 2010
    ..The excursion in serum calcium is brief, due to the short length of time that teriparatide concentrations are elevated...
  2. doi request reprint Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality
    Harald Dobnig
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Arch Intern Med 168:1340-9. 2008
    ..This study aimed to determine whether endogenous 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels are related to all-cause and cardiovascular mortality...
  3. ncbi request reprint Hip and nonvertebral fracture prediction in nursing home patients: role of bone ultrasound and bone marker measurements
    Harald Dobnig
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Clin Endocrinol Metab 92:1678-86. 2007
    ..Absolute fracture risk in nursing home patients is the highest among the communities studied. Screening for high-risk patients in such an environment is usually difficult...
  4. ncbi request reprint Type 2 diabetes mellitus in nursing home patients: effects on bone turnover, bone mass, and fracture risk
    Harald Dobnig
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Clin Endocrinol Metab 91:3355-63. 2006
    ..Type 2 diabetes mellitus (DM) has a high prevalence in nursing home patients and has been associated with positive effects on bone mass in younger, community-dwelling elderly...
  5. ncbi request reprint Changes in the RANK ligand/osteoprotegerin system are correlated to changes in bone mineral density in bisphosphonate-treated osteoporotic patients
    H Dobnig
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University Graz, Auenbruggerplatz 15, 8036, Graz, Austria
    Osteoporos Int 17:693-703. 2006
    ....
  6. ncbi request reprint Early changes in biochemical markers of bone formation correlate with improvements in bone structure during teriparatide therapy
    Harald Dobnig
    Department of Internal Medicine, Division of Endocrinology, Medical University, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Clin Endocrinol Metab 90:3970-7. 2005
    ..Biochemical markers of bone turnover may reflect bone structure during anabolic treatment...
  7. ncbi request reprint Calcium supply, bone mineral density and genetically defined lactose maldigestion in a cohort of elderly men
    M Gugatschka
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University Graz, Auenbruggerplatz, 8036 Graz, Austria
    J Endocrinol Invest 30:46-51. 2007
    ..Furthermore, to reveal gender differences in BMD, calcium consumption rates and parameters of bone metabolism according to LCT polymorphism in an existing female cohort...
  8. ncbi request reprint Adult-type hypolactasia and calcium availability: decreased calcium intake or impaired calcium absorption?
    B M Obermayer-Pietsch
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036, Graz, Austria
    Osteoporos Int 18:445-51. 2007
    ..A lactose-reduced diet and lactose-free calcium supplements may reverse this imbalance...
  9. doi request reprint Associations of homoarginine with bone metabolism and density, muscle strength and mortality: cross-sectional and prospective data from 506 female nursing home patients
    S Pilz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria
    Osteoporos Int 24:377-81. 2013
    ..In female nursing home patients, homoarginine was associated with lower bone turnover, higher bone density, lower mortality and, by trend, with muscle strength...
  10. doi request reprint Bone markers predict cardiovascular events in chronic kidney disease
    Astrid Fahrleitner-Pammer
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University, Graz, Austria
    J Bone Miner Res 23:1850-8. 2008
    ..001); (2) BSALP (p = 0.03); and (3) TRACP-5b (p = 0.04). Markers of bone formation (BSALP) and resorption (TRACP-5b) can serve as predictors of cardiovascular morbidity and mortality in CKD...
  11. doi request reprint Low bone turnover and increase of bone mineral density in a premenopausal woman with postoperative hypoparathyroidism and thyroxine suppressive therapy
    K Amrein
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Auenbruggerplatz 15, Graz, Austria
    Osteoporos Int 22:2903-5. 2011
    ..A 6-year follow-up showed an increase of 11% in absolute bone mineral density at the spine and 6% at the hip accompanied by low bone turnover despite thyroid-stimulating hormone suppressive thyroxine therapy...
  12. ncbi request reprint Variable bone mass recovery in hyperthyroid bone disease after radioiodine therapy in postmenopausal patients
    B Obermayer-Pietsch
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Karl Franzens University School of Medicine, Auenbruggerplatz 15, A 8036, Graz, Austria
    Maturitas 35:159-66. 2000
    ..Long-term follow-up of postmenopausal hyperthyroid females after radioiodine therapy, since hyperthyroidism is known to cause impressive bone loss which may increase the risk of bone fractures...
  13. ncbi request reprint Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures
    Barbara M Obermayer-Pietsch
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Karl Franzens University Hospital, Graz, Austria
    J Bone Miner Res 19:42-7. 2004
    ..PCR-based genotyping of lactase gene polymorphisms may complement diagnostic procedures to identify persons at risk for both lactose malabsorption and osteoporosis...
  14. pmc N-terminal proatrial natriuretic peptide correlates with systolic dysfunction and left ventricular filling pattern in patients with idiopathic dilated cardiomyopathy
    F M Fruhwald
    Department of Internal Medicine, Division of Cardiology, Karl Franzens University, Auenbruggerplatz 15, A 8036 Graz, Austria
    Heart 82:630-3. 1999
    ..To investigate the diastolic Doppler filling pattern in patients with idiopathic dilated cardiomyopathy and its relation to N-terminal pro-atrial natriuretic peptide (NT-pro-ANP)...
  15. doi request reprint Ibandronate prevents bone loss and reduces vertebral fracture risk in male cardiac transplant patients: a randomized double-blind, placebo-controlled trial
    Astrid Fahrleitner-Pammer
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Graz, Austria
    J Bone Miner Res 24:1335-44. 2009
    ..05) could be shown. Intravenous IBN reduced fractures, preserved bone mass, and prevented uncoupling of bone formation and resorption after CTP. The favorable effects on bone turnover were also supported by histomorphometric findings...
  16. ncbi request reprint A review of teriparatide and its clinical efficacy in the treatment of osteoporosis
    Harald Dobnig
    Department of Internal Medicine, Medical University Graz, Austria
    Expert Opin Pharmacother 5:1153-62. 2004
    ....
  17. ncbi request reprint Comparing beta-blocking effects of bisoprolol, carvedilol and nebivolol
    Kurt Stoschitzky
    Division of Cardiology, Department of Medicine, Medical University of Graz, Graz, Austria
    Cardiology 106:199-206. 2006
    ..Bisoprolol, carvedilol and nebivolol have been shown to be effective in the treatment of heart failure. However, the beta-blocking effects of these drugs have never been compared directly...
  18. ncbi request reprint Molecularly-defined lactose malabsorption, milk consumption and anthropometric differences in adult males
    M Gugatschka
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University Hospital, Auenbruggerplatz 15, A 8036 Graz, Austria
    QJM 98:857-63. 2005
    ..Diagnosis to date has been based on indirect methods, with a high false-negative rate. Identification of the LCT polymorphism led to development of a PCR-based test...
  19. ncbi request reprint Osteoprotegerin serum levels in women: correlation with age, bone mass, bone turnover and fracture status
    Astrid Fahrleitner-Pammer
    Department of Internal Medicine, Division of Endocrinology, Karl Franzens University, Graz, Austria
    Wien Klin Wochenschr 115:291-7. 2003
    ..Finally, low OPG serum levels seem to be associated with vertebral fractures. We hypothesise that low OPG levels in preset conditions of bone turnover may indicate a higher risk of fracture in patients with osteoporosis...
  20. ncbi request reprint Intermittent parathyroid hormone (PTH) treatment and age-dependent effects on rat cancellous bone and mineral metabolism
    Gerald Friedl
    Department of Orthopedics and Orthopedic Surgery, Medical University of Graz, A 8036 Graz, Austria
    J Orthop Res 25:1454-64. 2007
    ..8-77.8 microm, p < 0.001). Although PTH increased bone formation at all ages, we found significant age-related differences in the cellular and molecular mechanisms involved in the bone anabolic response to the hormone...
  21. doi request reprint Teriparatide reduces bone microdamage accumulation in postmenopausal women previously treated with alendronate
    Harald Dobnig
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Graz, Austria
    J Bone Miner Res 24:1998-2006. 2009
    ..In conclusion, teriparatide reduces microdamage accumulation in the iliac crest of patients previously treated with alendronate. There is insufficient evidence to suggest that age or bone turnover would be associated with this change...
  22. pmc Vitamin D deficiency and secondary hyperparathyroidism are common complications in patients with peripheral arterial disease
    Astrid Fahrleitner
    Department of Internal Medicine, Division of Endocrinology, Karl Franzens University, Graz, Austria
    J Gen Intern Med 17:663-9. 2002
    ..To investigate via the vitamin D status whether patients with peripheral arterial disease (PAD) tend to develop vitamin D deficiency that in turn influences their clinical symptoms...
  23. ncbi request reprint Serum osteoprotegerin is a major determinant of bone density development and prevalent vertebral fracture status following cardiac transplantation
    A Fahrleitner
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Karl Franzens University, Auenbruggerplatz 15, A 8036 Graz, Austria
    Bone 32:96-106. 2003
    ..We hypothesize that OPG plays a major role in the development of transplantation osteoporosis...
  24. doi request reprint Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography
    Stefan Pilz
    Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    J Clin Endocrinol Metab 93:3927-35. 2008
    ..Vitamin D has been shown to influence cardiac contractility and myocardial calcium homeostasis...
  25. doi request reprint Apheresis affects bone and mineral metabolism
    Karin Amrein
    Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Austria
    Bone 46:789-95. 2010
    ..Apheresis is a procedure to selectively obtain blood components. For the collection process citrate is routinely used. It inhibits coagulation by binding to ionized calcium and leads to metabolic alkalosis...
  26. doi request reprint Aldosterone/renin ratio determines peripheral and central blood pressure values over a broad range
    Andreas Tomaschitz
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    J Am Coll Cardiol 55:2171-80. 2010
    ....
  27. ncbi request reprint Hypovitaminosis D, impaired bone turnover and low bone mass are common in patients with peripheral arterial disease
    Astrid Fahrleitner-Pammer
    Department of Internal Medicine, Division of Endocrinology, University Medical Center, Graz, Austria
    Osteoporos Int 16:319-24. 2005
    ..Patients with PAD are at high risk for osteoporosis and osteomalacia and should be regularly monitored and treated for their vitamin D deficiencies...
  28. ncbi request reprint Serum osteoprotegerin levels in patients after liver transplantation and correlation to bone turnover, bone mineral density and fracture status
    Astrid Fahrleitner
    Division of Endocrinology, Department of Internal Medicine, Karl Franzens University, Graz, Austria
    Wien Klin Wochenschr 114:717-24. 2002
    ..Serum OPG was not correlated to bone mass or fracture status in this cross sectional setting but was elevated together with other bone resorption and -formation markers...
  29. doi request reprint Vitamin D and mortality in older men and women
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Auenbruggerplatz 15, Graz, Austria
    Clin Endocrinol (Oxf) 71:666-72. 2009
    ..The aim of our study was to elucidate whether low serum levels of 25-hydroxyvitamin D [25(OH)D] are associated with an increased risk of all-cause and cardiovascular mortality...
  30. ncbi request reprint Vitamin D receptor initiation codon polymorphism, bone density and inflammatory activity of patients with ankylosing spondylitis
    Barbara M Obermayer-Pietsch
    Department of Internal Medicine, Division of Endocrinology Nuclear Medicine, Karl Franzens University, Auenbruggerplatz 15, 8036, Graz, Austria
    Osteoporos Int 14:995-1000. 2003
    ..We investigated initiation codon ( FokI) and 3'UTR ( BsmI) polymorphisms of the VDR for whether there could be an association with bone mineral density (BMD) in relation to bone metabolism or inflammatory activity in patients with AS...
  31. ncbi request reprint Epidemiology of vitamin D insufficiency and cancer mortality
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Graz, Austria
    Anticancer Res 29:3699-704. 2009
    ....
  32. doi request reprint Low vitamin d levels predict stroke in patients referred to coronary angiography
    Stefan Pilz
    Synlab Center of Laboratory Diagnostics, Heidelberg, PO Box 10470, D 69037 Heidelberg, Germany
    Stroke 39:2611-3. 2008
    ..Vitamin D deficiency is common among the elderly and may contribute to cerebrovascular diseases. We aimed to elucidate whether low vitamin D levels are predictive for fatal stroke...
  33. pmc Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008
    ..Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population...
  34. doi request reprint Low serum levels of 25-hydroxyvitamin D predict fatal cancer in patients referred to coronary angiography
    Stefan Pilz
    Department of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany
    Cancer Epidemiol Biomarkers Prev 17:1228-33. 2008
    ....
  35. doi request reprint Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study
    Bente L Langdahl
    Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark
    Bone 42:969-81. 2008
    ....
  36. ncbi request reprint Low bone mineral density is associated with bone microdamage accumulation in postmenopausal women with osteoporosis
    Jan J Stepan
    Institute of Rheumatology, Charles University, Faculty of Medicine, Prague, Czech Republic
    Bone 41:378-85. 2007
    ..04 for Cr.Dn and P=0.03 for Cr.S.Dn). We conclude that increased microdamage accumulation may occur in low BMD patients treated with alendronate...
  37. ncbi request reprint Osteoporosis in patients with diabetes mellitus
    Lorenz C Hofbauer
    Division of Gastroenterology and Endocrinology, Department of Medicine, Philipps University, Marburg, Germany
    J Bone Miner Res 22:1317-28. 2007
    ..Patients with type 2 diabetes mellitus may additionally benefit from early visual assessment, regular exercise to improve muscle strength and balance, and specific measures for preventing falls...
  38. ncbi request reprint Show a heart for bones in time--fractures remain a common problem following cardiac transplantation
    Harald Dobnig
    Wien Klin Wochenschr 116:151-4. 2004
  39. ncbi request reprint The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis
    Andre G Uitterlinden
    Erasmus MC, Rotterdam, The Netherlands
    Ann Intern Med 145:255-64. 2006
    ..Polymorphisms of the vitamin D receptor (VDR) gene have been implicated in the genetic regulation of bone mineral density (BMD). However, the clinical impact of these variants remains unclear...