Valery N Bochkov

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. pmc Ligand selectivity of 105 kDa and 130 kDa lipoprotein-binding proteins in vascular-smooth-muscle-cell membranes is unique
    V N Bochkov
    Laboratory of Molecular Endocrinology, Cardiology Research Center, Moscow, Russia
    Biochem J 317:297-304. 1996
  2. pmc Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo
    Stephanie Nonas
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Crit Care 12:R27. 2008
  3. pmc Generation and biological activities of oxidized phospholipids
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Antioxid Redox Signal 12:1009-59. 2010
  4. ncbi request reprint Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Circ Res 99:900-8. 2006
  5. ncbi request reprint Inflammatory profile of oxidized phospholipids
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
    Thromb Haemost 97:348-54. 2007
  6. doi request reprint Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids
    Stephan Blüml
    Institute of Immunology, Medical University of Vienna, Vienna, Austria
    Blood 114:5481-9. 2009
  7. doi request reprint Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipids
    Elena von Schlieffen
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 29:356-62. 2009
  8. ncbi request reprint Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40
    Stefan Bluml
    Institute of Immunology, Medical University of Vienna, Medical University of Vienna, Vienna, Austria
    J Immunol 175:501-8. 2005
  9. ncbi request reprint Oxidized phospholipids trigger atherogenic inflammation in murine arteries
    Alexander Furnkranz
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 25:633-8. 2005
  10. doi request reprint Oxidized phospholipids induce anergy in human peripheral blood T cells
    Maria Seyerl
    Institute of Immunology, Medical University of Vienna, Vienna, Austria
    Eur J Immunol 38:778-87. 2008

Collaborators

Detail Information

Publications41

  1. pmc Ligand selectivity of 105 kDa and 130 kDa lipoprotein-binding proteins in vascular-smooth-muscle-cell membranes is unique
    V N Bochkov
    Laboratory of Molecular Endocrinology, Cardiology Research Center, Moscow, Russia
    Biochem J 317:297-304. 1996
    ..The similar ligand selectivity of 105 and 130 kDa proteins suggests that they may represent variant forms of an atypical lipoprotein-binding protein...
  2. pmc Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo
    Stephanie Nonas
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Crit Care 12:R27. 2008
    ....
  3. pmc Generation and biological activities of oxidized phospholipids
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Antioxid Redox Signal 12:1009-59. 2010
    ..Furthermore, potential applications of OxPLs as disease biomarkers, as well as experimental therapies targeting OxPLs, are described, providing a broad overview of an emerging class of lipid mediators...
  4. ncbi request reprint Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Circ Res 99:900-8. 2006
    ..Our data suggest that accumulation of OxPLs may contribute to increased growth of blood capillaries in advanced lesions, thus leading to progression and destabilization of atherosclerotic plaques...
  5. ncbi request reprint Inflammatory profile of oxidized phospholipids
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
    Thromb Haemost 97:348-54. 2007
    ..In this review, the inflammatory properties of OxPL are discussed together with the underlying receptor, signalling and transcriptional mechanisms...
  6. doi request reprint Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids
    Stephan Blüml
    Institute of Immunology, Medical University of Vienna, Vienna, Austria
    Blood 114:5481-9. 2009
    ..Furthermore, the presence of Ox-Pls blocked histone modifications required for full activation of DCs. Therefore, inflammation-derived Ox-Pls control DC functions in part by epigenetic mechanisms...
  7. doi request reprint Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipids
    Elena von Schlieffen
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 29:356-62. 2009
    ..Molecular mechanisms of their effects are largely unknown. Here we present novel information on the mechanisms whereby OxPLs modulate activation of TLR4 by lipopolysaccharide (LPS)...
  8. ncbi request reprint Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40
    Stefan Bluml
    Institute of Immunology, Medical University of Vienna, Medical University of Vienna, Vienna, Austria
    J Immunol 175:501-8. 2005
    ..Thus, formation of ox-PLs during the course of an inflammatory response may represent a negative-feedback loop preventing excessive and sustained immune reactions through regulating DC maturation...
  9. ncbi request reprint Oxidized phospholipids trigger atherogenic inflammation in murine arteries
    Alexander Furnkranz
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 25:633-8. 2005
    ..Therefore, the aim of this study was to investigate if structurally defined oxidized phospholipids induce expression of atherogenic chemokines and monocyte adhesion in intact murine arteries...
  10. doi request reprint Oxidized phospholipids induce anergy in human peripheral blood T cells
    Maria Seyerl
    Institute of Immunology, Medical University of Vienna, Vienna, Austria
    Eur J Immunol 38:778-87. 2008
    ..Taken together, our results demonstrate that ox-PL are potent and specific regulators of T cell activation and function...
  11. ncbi request reprint Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
    J Lipid Res 47:1054-62. 2006
    ..Further analysis of signaling pathways induced by oxidized phospholipids that lead to specific monocyte adhesion should ultimately lead to the development of novel therapeutic approaches against chronic inflammatory diseases...
  12. doi request reprint Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways
    Taras Afonyushkin
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Arterioscler Thromb Vasc Biol 30:1007-13. 2010
    ..In this study, we analyzed the mechanism of ATF4 upregulation by OxPLs and more specifically the involvement of NRF2, the major transcriptional mediator of electrophilic stress response...
  13. ncbi request reprint The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathways
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, A 1090 Vienna, Austria
    Antioxid Redox Signal 5:163-9. 2003
    ..Thus, formation of 8-iso-PGE(2) may play an important role in chronic inflammatory diseases such as atherosclerosis by increasing adhesion and extravasation of monocytes...
  14. ncbi request reprint Analysis of inflammatory gene induction by oxidized phospholipids in vivo by quantitative real-time RT-PCR in comparison with effects of LPS
    Alexandra Kadl
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Vascul Pharmacol 38:219-27. 2002
    ..In addition, we demonstrate that the quantitative real-time RT-PCR technology is a proper tool to investigate differential inflammatory gene induction in vivo...
  15. ncbi request reprint The oxidation state of phospholipids controls the oxidative burst in neutrophil granulocytes
    Stephan Blüml
    Institute of Immunology, Medical University Vienna, Vienna, Austria
    J Immunol 181:4347-53. 2008
    ..Therefore, phospholipids may act as sensors of oxidative stress in tissues and either positively or negatively regulate neutrophil ROS production according to their oxidation state...
  16. doi request reprint Oncostatin M-enhanced vascular endothelial growth factor expression in human vascular smooth muscle cells involves PI3K-, p38 MAPK-, Erk1/2- and STAT1/STAT3-dependent pathways and is attenuated by interferon-γ
    Svitlana Demyanets
    Department of Internal Medicine II, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Basic Res Cardiol 106:217-31. 2011
    ..IFN-γ reduced OSM-induced VEGF production by vascular SMC...
  17. ncbi request reprint Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein
    Gerhard Kronke
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna A 1090, Austria
    J Biol Chem 278:51006-14. 2003
    ..Induction of HO-1 expression by lipid oxidation products via CREB may represent a feedback mechanism to limit inflammation and associated tissue damage...
  18. ncbi request reprint Protective role of phospholipid oxidation products in endotoxin-induced tissue damage
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Nature 419:77-81. 2002
    ..Furthermore, identified chemical structures capable of inhibiting the effects of endotoxins such as LPS could be used for the development of new drugs for treatment of sepsis...
  19. doi request reprint In human macrophages the complement component C5a induces the expression of oncostatin M via AP-1 activation
    Stefan P Kastl
    Department of Internal Medicine II, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Arterioscler Thromb Vasc Biol 28:498-503. 2008
    ..The complement component C5a mobilizes and activates these cells at inflammatory sites. We examined the effect of C5a on OSM production in human monocytes and in human monocyte-derived macrophages...
  20. ncbi request reprint Apoptotic cells as sources for biologically active oxidized phospholipids
    Alexandra Kadl
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
    Antioxid Redox Signal 6:311-20. 2004
    ..In this review, we discuss the hypothesis that oxidized phospholipids generated in apoptotic cells (a) propagate chronic inflammation and (b) contribute to the resolution of acute inflammation...
  21. ncbi request reprint Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathway
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna, Austria
    Arterioscler Thromb Vasc Biol 22:581-6. 2002
    ..Thus, oxidized cholesteryl esters may play an important role as novel mediators in the initiation and progression of atherosclerosis...
  22. pmc ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response
    Olga V Oskolkova
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Blood 112:330-9. 2008
    ....
  23. doi request reprint Oxidized phospholipids are more potent antagonists of lipopolysaccharide than inducers of inflammation
    Olga V Oskolkova
    Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, A 1090 Vienna, Austria
    J Immunol 185:7706-12. 2010
    ..g., in atherosclerotic vessels)...
  24. doi request reprint Autophagy is induced by UVA and promotes removal of oxidized phospholipids and protein aggregates in epidermal keratinocytes
    Yi Zhao
    Department of Dermatology, Medical University of Vienna, Vienna, Austria
    J Invest Dermatol 133:1629-37. 2013
    ....
  25. doi request reprint Permissive role of miR-663 in induction of VEGF and activation of the ATF4 branch of unfolded protein response in endothelial cells by oxidized phospholipids
    Taras Afonyushkin
    Department of Vascular Biology and Thrombosis Research, Centre of Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, A 1090 Vienna, Austria
    Atherosclerosis 225:50-5. 2012
    ..In order to get further insights into the mechanisms of cellular stress-induced angiogenesis we studied the role of a specific microRNA (miR-663) in the mechanisms of VEGF induction by OxPLs and inducers of UPR...
  26. ncbi request reprint Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cells
    Florian Gruber
    Deparment of Dermatology, Medical University of Vienna, Vienna 1090, Austria
    J Biol Chem 282:16934-41. 2007
    ....
  27. pmc Involvement of CK2 in activation of electrophilic genes in endothelial cells by oxidized phospholipids
    Taras Afonyushkin
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    J Lipid Res 52:98-103. 2011
    ..This work characterizes novel cross-talk between CK2 and cellular stress pathways, which may provide additional insights into the mechanisms of beneficial action and side-effects of CK2 inhibitors...
  28. ncbi request reprint Anti-inflammatory properties of lipid oxidation products
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    J Mol Med (Berl) 81:613-26. 2003
    ..We discuss confirmed and suggested mechanisms as well as the (patho)physiological significance of these findings...
  29. pmc A simplified procedure for semi-targeted lipidomic analysis of oxidized phosphatidylcholines induced by UVA irradiation
    Florian Gruber
    Department of Dermatology, Medical University of Vienna, Vienna, Austria
    J Lipid Res 53:1232-42. 2012
    ....
  30. ncbi request reprint The inflammatory cytokine oncostatin M induces PAI-1 in human vascular smooth muscle cells in vitro via PI 3-kinase and ERK1/2-dependent pathways
    Svitlana Demyanets
    Department of Internal Medicine II, Medical University of Vienna, Austria
    Am J Physiol Heart Circ Physiol 293:H1962-8. 2007
    ....
  31. pmc WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs
    Ulrich Matt
    Research Center for Molecular Medicine of Austrian Academy of Sciences, Vienna, Austria
    J Clin Invest 123:3014-24. 2013
    ..Collectively, these data uncover an unanticipated role for WAVE1 as a critical modulator of the innate immune response to severe bacterial infections...
  32. doi request reprint Retinal pigment epithelium cells produce VEGF in response to oxidized phospholipids through mechanisms involving ATF4 and protein kinase CK2
    Andreas Pollreisz
    Department of Ophthalmology and Optometry, Medical University Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Exp Eye Res 116:177-84. 2013
    ..Our data show that different species of OxPLs, which are present in the human eye are capable of stimulating expression of VEGF in fetal and primary RPE cells via ATF4-dependent mechanisms. ..
  33. ncbi request reprint Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Blood 99:199-206. 2002
    ..Thus, oxidized phospholipids may contribute to inflammation by activating pathways alternative to the classical NF-kappa B pathway...
  34. ncbi request reprint Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, Division of Biomedical Sciences, University of Chicago, 929 East 57th St, CIS Bldg, W410, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 292:L924-35. 2007
    ....
  35. ncbi request reprint Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Center for Translational Respiratory Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 95:892-901. 2004
    ..Thus, oxidative modification of phospholipids during inflammation leads to the formation of novel regulators that may be critically involved in restoration of vascular barrier function...
  36. ncbi request reprint Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Microvasc Res 67:18-28. 2004
    ....
  37. doi request reprint Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo
    Henna Kaisa Jyrkkänen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute, University of Kuopio, Finland
    Circ Res 103:e1-9. 2008
    ..We suggest that the activation of Nrf2 by oxidized phospholipids provides a mechanism by which their deleterious effects are limited in the vasculature...
  38. pmc Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury
    Stephanie Nonas
    Division of Pulmonary and Critical Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Respir Crit Care Med 173:1130-8. 2006
    ....
  39. ncbi request reprint Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors
    Gerhard Kronke
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, P O Box 801394, Charlottesville, VA, USA
    Arterioscler Thromb Vasc Biol 27:1276-82. 2007
    ..Here we investigate if the vasculoprotective and anti-inflammatory enzyme heme oxygenase-1 (HO-1) is regulated by PPAR ligands in vascular cells...
  40. ncbi request reprint The estrogen metabolite 17beta-dihydroequilenin counteracts interleukin-1alpha induced expression of inflammatory mediators in human endothelial cells in vitro via NF-kappaB pathway
    Svitlana Demyanets
    Department of Internal Medicine II, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Thromb Haemost 95:107-16. 2006
    ..Characterization of specific estrogens--as shown in our study--could provide the basis for tailored therapies, which might be able to achieve vasoprotection without adverse side effects...
  41. pmc Signaling pathways involved in OxPAPC-induced pulmonary endothelial barrier protection
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, Division of Biomedical Sciences, University of Chicago, 929 East 57th Street, CIS Bldg, W410, Chicago, IL 60637, USA
    Microvasc Res 73:173-81. 2007
    ....