Research Topics
Genomes and GenesSpecies | Valery N BochkovSummaryAffiliation: Medical University of Vienna Country: Austria Publications
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Detail Information
Publications
Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivoStephanie Nonas
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Crit Care 12:R27. 2008....
Inflammatory profile of oxidized phospholipidsValery N Bochkov
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
Thromb Haemost 97:348-54. 2007..In this review, the inflammatory properties of OxPL are discussed together with the underlying receptor, signalling and transcriptional mechanisms...- Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesionsValery N Bochkov
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Circ Res 99:900-8. 2006..Our data suggest that accumulation of OxPLs may contribute to increased growth of blood capillaries in advanced lesions, thus leading to progression and destabilization of atherosclerotic plaques... - Generation and biological activities of oxidized phospholipidsValery N Bochkov
Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
Antioxid Redox Signal 12:1009-59. 2010..Furthermore, potential applications of OxPLs as disease biomarkers, as well as experimental therapies targeting OxPLs, are described, providing a broad overview of an emerging class of lipid mediators... 
Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipidsStephan Blüml
Institute of Immunology, Medical University of Vienna, Vienna, Austria
Blood 114:5481-9. 2009..Furthermore, the presence of Ox-Pls blocked histone modifications required for full activation of DCs. Therefore, inflammation-derived Ox-Pls control DC functions in part by epigenetic mechanisms...- Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipidsElena von Schlieffen
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
Arterioscler Thromb Vasc Biol 29:356-62. 2009..Molecular mechanisms of their effects are largely unknown. Here we present novel information on the mechanisms whereby OxPLs modulate activation of TLR4 by lipopolysaccharide (LPS)... - Oxidized phospholipids induce anergy in human peripheral blood T cellsMaria Seyerl
Institute of Immunology, Medical University of Vienna, Vienna, Austria
Eur J Immunol 38:778-87. 2008..Taken together, our results demonstrate that ox-PL are potent and specific regulators of T cell activation and function... - Oxidized phospholipids trigger atherogenic inflammation in murine arteriesAlexander Furnkranz
Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
Arterioscler Thromb Vasc Biol 25:633-8. 2005.... - The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathwaysJoakim Huber
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, A-1090 Vienna, Austria
Antioxid Redox Signal 5:163-9. 2003..Thus, formation of 8-iso-PGE(2) may play an important role in chronic inflammatory diseases such as atherosclerosis by increasing adhesion and extravasation of monocytes... - Analysis of inflammatory gene induction by oxidized phospholipids in vivo by quantitative real-time RT-PCR in comparison with effects of LPSAlexandra Kadl
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Vascul Pharmacol 38:219-27. 2002..In addition, we demonstrate that the quantitative real-time RT-PCR technology is a proper tool to investigate differential inflammatory gene induction in vivo... - Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathwaysTaras Afonyushkin
Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Arterioscler Thromb Vasc Biol 30:1007-13. 2010..In this study, we analyzed the mechanism of ATF4 upregulation by OxPLs and more specifically the involvement of NRF2, the major transcriptional mediator of electrophilic stress response... - The oxidation state of phospholipids controls the oxidative burst in neutrophil granulocytesStephan Blüml
Institute of Immunology, Medical University Vienna, Vienna, Austria
J Immunol 181:4347-53. 2008..Therefore, phospholipids may act as sensors of oxidative stress in tissues and either positively or negatively regulate neutrophil ROS production according to their oxidation state... - Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenaseJoakim Huber
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
J Lipid Res 47:1054-62. 2006..Further analysis of signaling pathways induced by oxidized phospholipids that lead to specific monocyte adhesion should ultimately lead to the development of novel therapeutic approaches against chronic inflammatory diseases... - Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40Stefan Bluml
Institute of Immunology, Medical University of Vienna, Medical University of Vienna, Vienna, Austria
J Immunol 175:501-8. 2005..Thus, formation of ox-PLs during the course of an inflammatory response may represent a negative-feedback loop preventing excessive and sustained immune reactions through regulating DC maturation... - Oncostatin M-enhanced vascular endothelial growth factor expression in human vascular smooth muscle cells involves PI3K-, p38 MAPK-, Erk1/2- and STAT1/STAT3-dependent pathways and is attenuated by interferon-γSvitlana Demyanets
Department of Internal Medicine II, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
Basic Res Cardiol 106:217-31. 2011..IFN-γ reduced OSM-induced VEGF production by vascular SMC... - Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding proteinGerhard Kronke
Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna A 1090, Austria
J Biol Chem 278:51006-14. 2003..Induction of HO-1 expression by lipid oxidation products via CREB may represent a feedback mechanism to limit inflammation and associated tissue damage... - Protective role of phospholipid oxidation products in endotoxin-induced tissue damageValery N Bochkov
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Nature 419:77-81. 2002..Furthermore, identified chemical structures capable of inhibiting the effects of endotoxins such as LPS could be used for the development of new drugs for treatment of sepsis... - Apoptotic cells as sources for biologically active oxidized phospholipidsAlexandra Kadl
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
Antioxid Redox Signal 6:311-20. 2004..In this review, we discuss the hypothesis that oxidized phospholipids generated in apoptotic cells (a) propagate chronic inflammation and (b) contribute to the resolution of acute inflammation... - In human macrophages the complement component C5a induces the expression of oncostatin M via AP-1 activationStefan P Kastl
Department of Internal Medicine II, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Arterioscler Thromb Vasc Biol 28:498-503. 2008..The complement component C5a mobilizes and activates these cells at inflammatory sites. We examined the effect of C5a on OSM production in human monocytes and in human monocyte-derived macrophages... - ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein responseOlga V Oskolkova
Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
Blood 112:330-9. 2008.... - Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathwayJoakim Huber
Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna, Austria
Arterioscler Thromb Vasc Biol 22:581-6. 2002..Thus, oxidized cholesteryl esters may play an important role as novel mediators in the initiation and progression of atherosclerosis... - Oxidized phospholipids are more potent antagonists of lipopolysaccharide than inducers of inflammationOlga V Oskolkova
Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, A 1090 Vienna, Austria
J Immunol 185:7706-12. 2010..g., in atherosclerotic vessels)... - Anti-inflammatory properties of lipid oxidation productsValery N Bochkov
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
J Mol Med (Berl) 81:613-26. 2003..We discuss confirmed and suggested mechanisms as well as the (patho)physiological significance of these findings... - Involvement of CK2 in activation of electrophilic genes in endothelial cells by oxidized phospholipidsTaras Afonyushkin
Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
J Lipid Res 52:98-103. 2011..This work characterizes novel cross-talk between CK2 and cellular stress pathways, which may provide additional insights into the mechanisms of beneficial action and side-effects of CK2 inhibitors... - Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cellsFlorian Gruber
Deparment of Dermatology, Medical University of Vienna, Vienna 1090, Austria
J Biol Chem 282:16934-41. 2007.... - A simplified procedure for semi-targeted lipidomic analysis of oxidized phosphatidylcholines induced by UVA irradiationFlorian Gruber
Department of Dermatology, Medical University of Vienna, Vienna, Austria
J Lipid Res 53:1232-42. 2012.... - The inflammatory cytokine oncostatin M induces PAI-1 in human vascular smooth muscle cells in vitro via PI 3-kinase and ERK1/2-dependent pathwaysSvitlana Demyanets
Department of Internal Medicine II, Medical University of Vienna, Austria
Am J Physiol Heart Circ Physiol 293:H1962-8. 2007.... - Permissive role of miR-663 in induction of VEGF and activation of the ATF4 branch of unfolded protein response in endothelial cells by oxidized phospholipidsTaras Afonyushkin
Department of Vascular Biology and Thrombosis Research, Centre of Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, A 1090 Vienna, Austria
Atherosclerosis 225:50-5. 2012..In order to get further insights into the mechanisms of cellular stress-induced angiogenesis we studied the role of a specific microRNA (miR-663) in the mechanisms of VEGF induction by OxPLs and inducers of UPR... - Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFATValery N Bochkov
Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
Blood 99:199-206. 2002..Thus, oxidized phospholipids may contribute to inflammation by activating pathways alternative to the classical NF-kappa B pathway... - Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteinsKonstantin G Birukov
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Microvasc Res 67:18-28. 2004.... - Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and RacKonstantin G Birukov
Division of Pulmonary and Critical Care Medicine, Center for Translational Respiratory Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circ Res 95:892-901. 2004..Thus, oxidative modification of phospholipids during inflammation leads to the formation of novel regulators that may be critically involved in restoration of vascular barrier function... - Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injuryStephanie Nonas
Division of Pulmonary and Critical Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Respir Crit Care Med 173:1130-8. 2006..CONCLUSIONS: These studies demonstrate in vivo and in vitro protective effects of oxidized phospholipids on LPS-induced lung dysfunction... - Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivoHenna Kaisa Jyrkkänen
Department of Biotechnology and Molecular Medicine, A I Virtanen Institute, University of Kuopio, Finland
Circ Res 103:e1-9. 2008..We suggest that the activation of Nrf2 by oxidized phospholipids provides a mechanism by which their deleterious effects are limited in the vasculature... - Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endotheliumAnna A Birukova
Section of Pulmonary and Critical Medicine, Department of Medicine, Division of Biomedical Sciences, University of Chicago, 929 East 57th St, CIS Bldg, W410, Chicago, IL 60637, USA
Am J Physiol Lung Cell Mol Physiol 292:L924-35. 2007.... - Signaling pathways involved in OxPAPC-induced pulmonary endothelial barrier protectionAnna A Birukova
Section of Pulmonary and Critical Medicine, Department of Medicine, Division of Biomedical Sciences, University of Chicago, 929 East 57th Street, CIS Bldg, W410, Chicago, IL 60637, USA
Microvasc Res 73:173-81. 2007.... - Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptorsGerhard Kronke
Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, P O Box 801394, Charlottesville, VA, USA
Arterioscler Thromb Vasc Biol 27:1276-82. 2007..Here we investigate if the vasculoprotective and anti-inflammatory enzyme heme oxygenase-1 (HO-1) is regulated by PPAR ligands in vascular cells... - The estrogen metabolite 17beta-dihydroequilenin counteracts interleukin-1alpha induced expression of inflammatory mediators in human endothelial cells in vitro via NF-kappaB pathwaySvitlana Demyanets
Department of Internal Medicine II, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Thromb Haemost 95:107-16. 2006..Characterization of specific estrogens--as shown in our study--could provide the basis for tailored therapies, which might be able to achieve vasoprotection without adverse side effects...