Research Topics
Genomes and GenesSpecies | Heinz DrexelSummaryAffiliation: Landeskrankenhaus Feldkirch Country: Austria Publications
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Detail Information
Publications
Relationship between the adipose-tissue hormone resistin and coronary artery diseaseGuenter Hoefle
Department of Medicine, Academic Teaching Hospital Feldkirch, A 6807 Feldkirch, Austria
Clin Chim Acta 386:1-6. 2007..Data on the cardiovascular risk associated with the adipose-tissue-related hormone resistin are scarce...
Factors predicting cardiovascular events in statin-treated diabetic and non-diabetic patients with coronary atherosclerosisHeinz Drexel
Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Carinagasse 47, A 6807 Feldkirch, Austria
Atherosclerosis 208:484-9. 2010..We aimed at identifying which lipid factors drive vascular risk in statin-treated patients with coronary artery disease (CAD)...- Is atherosclerosis in diabetes and impaired fasting glucose driven by elevated LDL cholesterol or by decreased HDL cholesterol?Heinz Drexel
Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria
Diabetes Care 28:101-7. 2005..To evaluate the atherogenicity of lipids in coronary patients with normal fasting glucose (NFG), impaired fasting glucose (IFG), and type 2 diabetes... - Statins, fibrates, nicotinic acid, cholesterol absorption inhibitors, anion-exchange resins, omega-3 fatty acids: which drugs for which patients?Heinz Drexel
Vorarlberg Institute for Vascular Investigation and Treatment VIVIT, Feldkirch, Austria
Fundam Clin Pharmacol 23:687-92. 2009..Large ongoing trials address the decisive question whether treatment with fibrates and niacin provides additional cardiovascular risk reduction when given in addition to statin treatment... - Persistent dyslipidemia in Austrian patients treated with statins for primary and secondary prevention of atherosclerotic events - Results of the DYSlipidemia International Study (DYSIS)Heinz Drexel
VIVIT Institut, Feldkirch, Austria
Wien Klin Wochenschr 123:611-7. 2011..One reason may be that lipid targets are not met. The DYSlipidemia International Study (DYSIS) was performed to determine the prevalence of persistent dyslipidemia despite statin treatment in Austria... - Brown versus white adipose tissue: a mini-reviewChristoph H Saely
Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
Gerontology 58:15-23. 2012..In adults, it had long been considered to be absent or at least of no relevance. Recent investigations, however, have fuelled interest in adult BAT... - [High-dose statin therapy for high-risk patients]C H Saely
Abteilung für Innere Medizin und Kardiologie und VIVIT Institut, Akademisches Lehrkrankenhaus Feldkirch, Carinagasse 47, 6807, Feldkirch, Osterreich
Herz 35:497-502. 2010.... - The -11377 C>G promoter variant of the adiponectin gene, prevalence of coronary atherosclerosis, and incidence of vascular events in menGuenter Hoefle
Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
Thromb Haemost 97:451-7. 2007.... - Diabetes as a coronary artery disease risk equivalent: before a change of paradigm?Christoph H Saely
Vorarlberg Institute for Vascular Investigation and Treatment, Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
Eur J Cardiovasc Prev Rehabil 17:94-9. 2010..Current guidelines consider diabetes per se as a coronary artery disease (CAD) risk equivalent. We aimed at investigating the contribution of baseline coronary atherosclerosis to the risk of diabetic patients for future vascular events... - Adult Treatment Panel III 2001 but not International Diabetes Federation 2005 criteria of the metabolic syndrome predict clinical cardiovascular events in subjects who underwent coronary angiographyChristoph H Saely
Vorarlberg Institute for Vascular Investigation and Treatment, Carinagasse 47, A-6800 Feldkirch, Austria
Diabetes Care 29:901-7. 2006..However, among angiographied coronary patients, even the ATPIII definition of the metabolic syndrome does not provide prognostic information beyond its dyslipidemic features... 
Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosisAxel Muendlein
Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria
PLoS ONE 6:e17978. 2011..We therefore investigated the association between TCF7L2 polymorphisms and angiographically determined CAD in diabetic and non-diabetic patients...- Type 2 diabetes but not coronary atherosclerosis is an independent determinant of impaired mobility in angiographied coronary patientsChristoph H Saely
Vorarlberg Institute for Vascular Investigation and Treatment VIVIT, Feldkirch, Austria
Diabetes Res Clin Pract 82:185-9. 2008..We aimed at determining the associations of type 2 diabetes (T2DM) and of angiographically determined coronary artery disease (CAD) with impaired mobility... - Insulin resistance is associated with the metabolic syndrome and is not directly linked to coronary artery diseaseAlexander Vonbank
Vorarlberg Institute for Vascular Investigation and Treatment VIVIT, Feldkirch, Austria
Clin Chim Acta 412:1003-7. 2011..Its association with directly visualized coronary atherosclerosis is unclear. We hypothesised that insulin resistance is associated with both angiographically determined coronary artery disease (CAD) and with the MetS... - A common variant of the MACC1 gene is significantly associated with overall survival in colorectal cancer patientsAlois H Lang
Vorarlberg Institute for Vascular Investigation and Treatment, A 6800 Feldkirch, Austria
BMC Cancer 12:20. 2012..We therefore investigated the association between MACC1 tagging single nucleotide polymorphisms (SNPs) and overall survival in a large cohort of colorectal cancer patients... - Significant impact of chromosomal locus 1p13.3 on serum LDL cholesterol and on angiographically characterized coronary atherosclerosisAxel Muendlein
Vorarlberg Institute for Vascular Investigation, A 6807 Feldkirch, Austria
Atherosclerosis 206:494-9. 2009..Potential associations between variants on this locus and angiographically characterized coronary atherosclerosis are unknown. We therefore aimed at investigating the association of variants of locus 1p13.3 with coronary atherosclerosis... - Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery diseaseAxel Muendlein
Vorarlberg Institute for Vascular Investigation, Feldkirch, Austria
Atherosclerosis 205:174-80. 2009..Furthermore, no direct association with coronary atherosclerosis has been established. We therefore aimed at investigating the association of the above variants with coronary atherosclerosis... - Low serum adiponectin is independently associated with both the metabolic syndrome and angiographically determined coronary atherosclerosisChristoph H Saely
Vorarlberg Institute for Vascular Investigation and Treatment VIVIT, Carinagasse 47, A 6800 Feldkirch, Austria
Clin Chim Acta 383:97-102. 2007..We aimed at investigating serum adiponectin in patients with the metabolic syndrome (MetS), in patients with angiographically diagnosed coronary artery disease (CAD), and in patients who had both, the MetS and CAD... - Type 2 diabetes significantly modulates the cardiovascular risk conferred by the PAI-1 -675 4G/5G polymorphism in angiographied coronary patientsChristoph H Saely
Vorarlberg Institute for Vascular Investigation and Treatment VIVIT, Feldkirch, Austria
Clin Chim Acta 396:18-22. 2008..The association of the -675 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene with cardiovascular disease in patients with type 2 diabetes (T2DM) is unknown... - Relation of albuminuria to angiographically determined coronary arterial narrowing in patients with and without type 2 diabetes mellitus and stable or suspected coronary artery diseasePhilipp Rein
Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria
Am J Cardiol 107:1144-8. 2011.... - Serial decline of kidney function as a novel biomarker for the progression of atherothrombotic diseasePhilipp Rein
Vorarlberg Institute for Vascular Investigation and Treatment VIVIT, Feldkirch, Austria Private University of the Principality of Liechtenstein, Triesen, Principality of Liechtenstein, Liechtenstein
Atherosclerosis 211:348-52. 2010..We therefore tested the hypothesis that a decrease in kidney function predicts future vascular events in a high-risk population of angiographically characterized coronary patients... - Are AHSG polymorphisms directly associated with coronary atherosclerosis?Axel Muendlein
Vorarlberg Institute for Vascular Investigation and Treatment VIVIT, Feldkirch, Austria
Clin Chim Acta 413:287-90. 2012..Therefore, we aimed at investigating the association of AHSG SNPs with angiographically characterized coronary atherosclerosis... - Effectiveness of atrial fibrillation as an independent predictor of death and coronary events in patients having coronary angiographyThomas Marte
Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria
Am J Cardiol 103:36-40. 2009.... - Relationship between glomerular filtration rate and the adipokines adiponectin, resistin and leptin in coronary patients with predominantly normal or mildly impaired renal functionLorenz Risch
Vorarlberg Institute for Vascular Investigation and Treatment VIVIT, Carinagasse 47, 6800 Feldkirch, Austria
Clin Chim Acta 376:108-13. 2007..In reduced renal clearance, altered serum concentrations of these proteins might affect cardiovascular risk. The objective of the study was to investigate the relationship between adipokine concentrations and GFR... - Alanine aminotransferase and gamma-glutamyl transferase are associated with the metabolic syndrome but not with angiographically determined coronary atherosclerosisChristoph H Saely
Vorarlberg Institute for Vascular Investigation and Treatment VIVIT, Feldkirch, Austria
Clin Chim Acta 397:82-6. 2008..Recently, elevated liver enzymes have attracted great interest as potential novel markers of cardiovascular risk. Their association with angiographically determined coronary artery disease (CAD) is unknown... - Evaluation of two fully automated novel enzyme-linked immunosorbent assays for the determination of human adiponectin in serumLorenz Risch
Vorarlberg Institute for Vascular Investigation and Treatment VIVIT, Carinagasse 47, 6800 Feldkirch, Austria
Clin Chim Acta 373:121-6. 2006..To date, studies reporting on the diagnostic characteristics of ELISAs and investigating on the relationship between ELISA- and RIA-based methods are rare... - CD14 C-159T and toll-like receptor 4 Asp299Gly polymorphisms in surviving meningococcal disease patientsAriane Biebl
Department of Pediatrics, University Teaching Hospital, Feldkirch, Austria
PLoS ONE 4:e7374. 2009..However, their role in development of IMD still remains unclear. Our aim was to investigate the influence of CD14 C-159T and TLR4 Asp299Gly polymorphisms on the risk of IMD... - Key role of postchallenge hyperglycemia for the presence and extent of coronary atherosclerosis: an angiographic studyChristoph H Saely
Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria
Atherosclerosis 199:317-22. 2008..The associations between impaired glucose tolerance (IGT) and postchallenge diabetes with the presence and extent of angiographically characterized coronary atherosclerosis are unclear... - Low serum LDL cholesterol in patients with type 2 diabetes: an analysis on two different patient populationsChristoph H Saely
Vorarlberg Institute for Vascular Investigation and Treatment VIVIT, Feldkirch, Austria
Int J Cardiol 144:394-8. 2010..We aimed at investigating whether also LDL cholesterol levels are altered in diabetic patients... - Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancerThomas Winder
Department of Medicine, Academic Teaching Hospital Feldkirch, A 6807 Feldkirch, Austria
Oncol Rep 21:1283-7. 2009..44 (0.2-0.99)]. In conclusion, for the first time, our study showed clearly that different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer... - The metabolic syndrome, insulin resistance, and cardiovascular risk in diabetic and nondiabetic patientsChristoph H Saely
Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria
J Clin Endocrinol Metab 90:5698-703. 2005..007] significantly predicted vascular events independent from diabetes status. CONCLUSIONS: Both the MetS and insulin resistance are strong and mutually independent predictors of vascular risk among angiographed coronary patients... - Prevalence of decreased glomerular filtration rate in patients seeking non-nephrological medical care--an evaluation using IDMS-traceable creatinine based MDRD as well as Mayo Clinic quadratic equation estimatesLorenz Risch
Vorarlberg Institute for Vascular Investigation and Treatment VIVIT, Carinagasse 47, 6800 Feldkirch, Austria
Clin Chim Acta 378:71-7. 2007..Most of the available studies did not employ laboratory methods providing creatinine concentrations traceable to the reference method, i.e. isotope dilution mass spectrometry (IDMS)... - Identification of hypoxia-induced genes in human SGBS adipocytes by microarray analysisKathrin Geiger
Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria
PLoS ONE 6:e26465. 2011..In addition, the identified hypoxia-regulated genes are likely involved in the regulation of obesity, the incidence of type 2 diabetes, and the metabolic syndrome... - Roles of the metabolic syndrome, HDL cholesterol, and coronary atherosclerosis in subclinical inflammationPhilipp Rein
Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria
Diabetes Care 33:1853-5. 2010..The metabolic syndrome (MetS) and coronary artery disease (CAD) frequently coincide; their individual contribution to inflammation is unknown... - [Lipid therapy in patients with diabetes]Christoph H Saely
Abteilung für Innere Medizin und Kardiologie, Akademisches Lehrkrankenhaus Feldkirch, Feldkirch, Osterreich
Wien Med Wochenschr 160:25-9. 2010.... - Optimized allele-specific real-time PCR assays for the detection of common mutations in KRAS and BRAFAlois H Lang
Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria
J Mol Diagn 13:23-8. 2011..We propose these allele-specific real-time PCR assays as a low-cost and fast diagnostic tool for accurate detection of KRAS and BRAF mutations that can be applied to clinical samples... - Sex-hormone-binding globulin is negatively correlated with femoral bone-mineral density in male cardiac-transplant recipientsGünter Höfle
Department of Internal Medicine, Vorarlberg Institute for Vascular Investigation and Treatment, Landeskrankenhaus Feldkirch, Feldkirch, Austria
Wien Klin Wochenschr 116:170-5. 2004..Osteoporosis and the subsequent increase in incidence of fractures are a common problem after cardiac transplantation... - Lower serum beta-CrossLaps in male cardiac transplant recipients treated without prednisoloneGünter Höfle
Department of Internal Medicine and Vorarlberg Institute of Vascular Investigation and Treatment VIVIT, Landeskrankenhaus Feldkirch, Carinagasse 47, 6807, Feldkirch, Austria
Transpl Int 16:523-8. 2003..3+/-109.4 vs 661.7+/-337.0 pg/ml, P<0.05). Lower serum beta-CrossLaps levels in patients undergoing glucocorticosteroid-free treatment may indicate a lower risk of bone deterioration in the long term... - Phytochemicals and their impact on adipose tissue inflammation and diabetesAndreas Leiherer
Vorarlberg Institute for Vascular Investigation and Treatment VIVIT, Feldkirch, Austria Private University of the Principality of Liechtenstein, Triesen, Liechtenstein Medical Central Laboratories, Feldkirch, Austria
Vascul Pharmacol 58:3-20. 2013.... - The fate of fat: a responseChristoph H Saely
Vorarlberg Institute for Vascular Investigation and Treatment Academic Teaching Hospital Feldkirch, Feldkirch, Austria
Gerontology 58:123-5. 2012..Importantly, physical exercise is a nonpharmacological intervention which has the potential to activate BAT, promotes weight loss, has beneficial metabolic effects and may even slow the rate of aging... - A case of fulminant post-transplant lymphoproliferative disorder and septicemiaGhazaleh Gouya
Department of Internal Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
Clin Transplant 20:261-4. 2006..The sequence of septicemia, PTLD and, finally again, septicemia is an unusual challenge and urges for an aggressive diagnostic approach, where markers like procalcitonin may aid in the discrimination of fulminant PTLD from septicemia... - Nicotinic acid in the treatment of hyperlipidaemiaHeinz Drexel
Abteilung fur Innere Medizin, Landeskrankenhaus Feldkirch, Carinagasse 47, A 6807 Feldkirch, Austria
Fundam Clin Pharmacol 21:5-6. 2007..New formulations of intermediate release or a combination with anti-flush compounds should increase the compliance with the drug...