Martin Koestenberger

Summary

Country: Austria

Publications

  1. doi request reprint Right ventricular performance in preterm and term neonates: reference values of the tricuspid annular peak systolic velocity measured by tissue Doppler imaging
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Graz, Austria
    Neonatology 103:281-6. 2013
  2. doi request reprint Tricuspid annular peak systolic velocity (S') in children and young adults with pulmonary artery hypertension secondary to congenital heart diseases, and in those with repaired tetralogy of Fallot: echocardiography and MRI data
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Auenbruggerplatz 34 2, Graz, Austria
    J Am Soc Echocardiogr 25:1041-9. 2012
  3. doi request reprint Left ventricular long-axis function: reference values of the mitral annular plane systolic excursion in 558 healthy children and calculation of z-score values
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Austria
    Am Heart J 164:125-31. 2012
  4. doi request reprint Systolic right ventricular function in children and young adults with pulmonary artery hypertension secondary to congenital heart disease and tetralogy of Fallot: tricuspid annular plane systolic excursion (TAPSE) and magnetic resonance imaging data
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Auenbruggerplatz 34 2, Graz, Austria
    Congenit Heart Dis 7:250-8. 2012
  5. doi request reprint Tricuspid annular plane systolic excursion and right ventricular ejection fraction in pediatric and adolescent patients with tetralogy of Fallot, patients with atrial septal defect, and age-matched normal subjects
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Auenbruggerplatz 30, 8036, Graz, Austria
    Clin Res Cardiol 100:67-75. 2011
  6. doi request reprint Systolic right ventricular function in pediatric and adolescent patients with tetralogy of Fallot: echocardiography versus magnetic resonance imaging
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University, Graz, Austria
    J Am Soc Echocardiogr 24:45-52. 2011
  7. doi request reprint Systolic right ventricular function in preterm and term neonates: reference values of the tricuspid annular plane systolic excursion (TAPSE) in 258 patients and calculation of Z-score values
    Martin Koestenberger
    Division of Pediatric Cardiology, Medical University Graz, Graz, Austria
    Neonatology 100:85-92. 2011
  8. doi request reprint Reference values of tricuspid annular peak systolic velocity in healthy pediatric patients, calculation of z score, and comparison to tricuspid annular plane systolic excursion
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University, Graz, Austria
    Am J Cardiol 109:116-21. 2012
  9. ncbi request reprint Additive effects of anticoagulants: recombinant human activated protein C and heparin or melagatran, in tissue factor-activated umbilical-cord plasma
    Martin Koestenberger
    Department of Pediatrics, and The Ludwig Boltzmann Research, Institute for Pediatric Haemostasis and Thrombosis, Medizinische Universitat Graz, Auenbruggerplatz 30, 8036 Graz, Austria
    Thromb Haemost 94:69-74. 2005
  10. doi request reprint Effects of nadroparin, enoxaparin, and unfractionated heparin on endogenous formation of factor Xa and IIa and on thrombelastometry profiles in cord versus adult blood
    Gerhard Cvirn
    Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria
    Neonatology 100:23-31. 2011

Collaborators

Detail Information

Publications46

  1. doi request reprint Right ventricular performance in preterm and term neonates: reference values of the tricuspid annular peak systolic velocity measured by tissue Doppler imaging
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Graz, Austria
    Neonatology 103:281-6. 2013
    ..Objective: We determined growth and birth weight-related changes of S' to establish reference values in preterm and term neonates...
  2. doi request reprint Tricuspid annular peak systolic velocity (S') in children and young adults with pulmonary artery hypertension secondary to congenital heart diseases, and in those with repaired tetralogy of Fallot: echocardiography and MRI data
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Auenbruggerplatz 34 2, Graz, Austria
    J Am Soc Echocardiogr 25:1041-9. 2012
    ....
  3. doi request reprint Left ventricular long-axis function: reference values of the mitral annular plane systolic excursion in 558 healthy children and calculation of z-score values
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Austria
    Am Heart J 164:125-31. 2012
    ..The aim of this study was to evaluate MAPSE values in a healthy pediatric population and to propose reference values...
  4. doi request reprint Systolic right ventricular function in children and young adults with pulmonary artery hypertension secondary to congenital heart disease and tetralogy of Fallot: tricuspid annular plane systolic excursion (TAPSE) and magnetic resonance imaging data
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Auenbruggerplatz 34 2, Graz, Austria
    Congenit Heart Dis 7:250-8. 2012
    ....
  5. doi request reprint Tricuspid annular plane systolic excursion and right ventricular ejection fraction in pediatric and adolescent patients with tetralogy of Fallot, patients with atrial septal defect, and age-matched normal subjects
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Auenbruggerplatz 30, 8036, Graz, Austria
    Clin Res Cardiol 100:67-75. 2011
    ..The tricuspid annular plane systolic excursion (TAPSE) values were measured and compared with RV ejection fraction (EF)...
  6. doi request reprint Systolic right ventricular function in pediatric and adolescent patients with tetralogy of Fallot: echocardiography versus magnetic resonance imaging
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University, Graz, Austria
    J Am Soc Echocardiogr 24:45-52. 2011
    ....
  7. doi request reprint Systolic right ventricular function in preterm and term neonates: reference values of the tricuspid annular plane systolic excursion (TAPSE) in 258 patients and calculation of Z-score values
    Martin Koestenberger
    Division of Pediatric Cardiology, Medical University Graz, Graz, Austria
    Neonatology 100:85-92. 2011
    ..The tricuspid annular plane systolic excursion (TAPSE) is an echocardiographic measurement to assess right ventricular systolic function in adults and children...
  8. doi request reprint Reference values of tricuspid annular peak systolic velocity in healthy pediatric patients, calculation of z score, and comparison to tricuspid annular plane systolic excursion
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University, Graz, Austria
    Am J Cardiol 109:116-21. 2012
    ..In conclusion, the z scores of the TAPSV values were calculated, and percentile charts were established to serve as reference data for patients with congenital heart disease...
  9. ncbi request reprint Additive effects of anticoagulants: recombinant human activated protein C and heparin or melagatran, in tissue factor-activated umbilical-cord plasma
    Martin Koestenberger
    Department of Pediatrics, and The Ludwig Boltzmann Research, Institute for Pediatric Haemostasis and Thrombosis, Medizinische Universitat Graz, Auenbruggerplatz 30, 8036 Graz, Austria
    Thromb Haemost 94:69-74. 2005
    ..Hence, combining rhAPC with melagatran might be a valuable therapeutic option in patients with severe sepsis...
  10. doi request reprint Effects of nadroparin, enoxaparin, and unfractionated heparin on endogenous formation of factor Xa and IIa and on thrombelastometry profiles in cord versus adult blood
    Gerhard Cvirn
    Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria
    Neonatology 100:23-31. 2011
    ..To date, only few pharmacokinetic studies on low-molecular-weight heparins (LMWHs) in neonates exist not allowing to formally assess pharmacodynamics of LMWHs in neonates...
  11. doi request reprint Collagen/endogenous thrombin-induced platelet aggregation in cord versus adult whole blood
    Gerhard Cvirn
    Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria
    Neonatology 95:187-92. 2009
    ..In previous studies, neonatal platelets have been shown to be hypoaggregable to various agonists when compared with adult platelets...
  12. ncbi request reprint Recombinant human activated protein C, heparin and melagatran in umbilical cord versus adult plasma
    Martin Koestenberger
    Department of Paediatrics, Ludwig Boltzmann Research Institute for Paediatric Haemostasis and Thrombosis, Medical University of Graz, Auenbruggerplatz 30, A 8036 Graz, Austria
    Acta Paediatr 94:884-9. 2005
    ..rhAPC is a promising candidate treatment to improve the outcome of severe sepsis in neonates and adults; the DTI melagatran represents a potential advance in antithrombotic therapy...
  13. ncbi request reprint Drotrecogin alfa (activated, Xigris) in combination with heparin or melagatran: an in vitro investigation
    Martin Koestenberger
    Ludwig Boltzmann Research Institute for Pediatric Hemostasis and Thrombosis, Medical University of Graz, Auenbruggerplatz 30, A 8036 Graz, Austria
    J Thromb Thrombolysis 18:5-10. 2004
    ....
  14. ncbi request reprint The respective and combined anticoagulant effects of recombinant human activated protein C, melagatran and heparins using CAT
    Christina Cimenti
    Ludwig Boltzmann Research Institute for Pediatric Hemostasis and Thrombosis at the Department of Pediatrics, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria
    Thromb Res 119:361-7. 2007
    ..Combinations of anticoagulants might be beneficial in some patients with sepsis, but most anticoagulants require specific clotting assays for monitoring. Thrombin generation assay, however, is a global function test of hemostasis...
  15. ncbi request reprint Anticoagulant action of melagatran: a comparison between neonates and adults using calibrated automated thrombography (CAT)
    Gerhard Cvirn
    Institute of Physiological Chemistry, Center of Physiological Medicine, Medical University of Graz, Harrachgasse 21 II, 8010, Graz, Austria
    Eur J Pediatr 166:427-31. 2007
    ..adult plasma. We conclude that our results suggest a higher ability of melagatran to suppress thrombin formation in cord vs. adult plasma. Thus, lower amounts of melagatran might be required in neonates undergoing antithrombotic therapy...
  16. ncbi request reprint Anticoagulant action of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, in umbilical cord and adult plasma: an in vitro examination
    Martin Koestenberger
    Department of Pediatrics, Karl Franzens University of Graz, Auenbruggerplatz, A 8036 Graz, Austria
    Thromb Res 115:135-42. 2005
    ..As a consequence, administration of melagatran is of special interest in neonates, who have physiologically low levels of AT...
  17. ncbi request reprint Thrombin generation determined by calibrated automated thrombography (CAT) in pediatric patients with congenital heart disease
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Auenbruggerplatz 30, A 8036 Graz, Austria
    Thromb Res 122:13-9. 2008
    ..The possible suitability to determine the coagulation status of these patients was investigated...
  18. doi request reprint Cardiac catheterization: haemostatic changes in pediatric versus adult patients
    Gerd Hoerl
    Institute of Physiological Chemistry, Medical University of Graz, Harrachgasse 21 II, Graz, Austria
    J Thromb Thrombolysis 32:372-7. 2011
    ..Thus, our results indicate that children might be at a higher risk for either thrombotic complications or post-operative bleeding events than adults...
  19. doi request reprint Clot strength: a comparison between cord and adult blood by means of thrombelastometry
    Gerhard Cvirn
    Institute of Physiological Chemistry, Department of Pediatrics, Medical University of Graz, Graz, Austria
    J Pediatr Hematol Oncol 30:210-3. 2008
    ..To evaluate the clot strength in cord versus adult blood...
  20. doi request reprint Effects of a single bout of walking exercise on blood coagulation parameters in obese women
    Manfred Lamprecht
    Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria
    J Appl Physiol (1985) 115:57-63. 2013
    ....
  21. ncbi request reprint Drotrecogin alfa activated (recombinant human activated protein C) in combination with heparin or melagatran: effects on prothrombin time and activated partial thromboplastin time
    Martin Koestenberger
    Ludwig Boltzmann Research Institute for Pediatric Hemostasis and Thrombosis, Medical University of Graz, Graz, Austria
    Blood Coagul Fibrinolysis 15:693-7. 2004
    ....
  22. ncbi request reprint Collagen/endogenous thrombin-induced platelet aggregation in whole blood samples
    Gerhard Cvirn
    Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria
    Blood Coagul Fibrinolysis 18:585-8. 2007
    ..min). In conclusion, endogenously generated thrombin is a potent platelet agonist in whole blood, and a combination of collagen and endogenous thrombin synergistically shortens the lag time until the onset of platelet aggregation...
  23. doi request reprint Right ventricular function in infants, children and adolescents: reference values of the tricuspid annular plane systolic excursion (TAPSE) in 640 healthy patients and calculation of z score values
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Auenbruggerplatz 30, Graz, Austria
    J Am Soc Echocardiogr 22:715-9. 2009
    ..The aim of this study was to determine growth-related changes in TAPSE to establish references values...
  24. ncbi request reprint Effects of melagatran on activated partial thromboplastin time and on ecarin clotting time in cord versus adult plasma
    Martin Koestenberger
    Department of Paediatrics, Medical University Graz, Graz, Austria
    Blood Coagul Fibrinolysis 17:677-80. 2006
    ..When the sensitive indicator ECT is used, results suggest that lower amounts of melagatran might be required in neonates than in adults. This has to be scrutinized in future clinical studies...
  25. ncbi request reprint High availability of intravascular tissue factor in neonates
    Gerhard Cvirn
    Institute of Physiological Chemistry, Department of Pediatrics, Medical University of Graz, Austria
    J Pediatr Hematol Oncol 29:279-83. 2007
    ..We suggest that the high levels of intravascular TF present in neonates (prior and after LPS-stimulation) might help to explain the clinically observed efficient clotting of cord blood despite low levels of procoagulatory factors...
  26. doi request reprint Longitudinal systolic ventricular interaction in pediatric and young adult patients with TOF: a cardiac magnetic resonance and M-mode echocardiographic study
    Martin Koestenberger
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Auenbruggerplatz 34 2, 8036, Graz, Austria
    Int J Cardiovasc Imaging 29:1707-15. 2013
    ..e. MAPSE) is a sufficient surrogate for estimation of LVEF. Therefore determination of the MAPSE is a helpful additional tool for LV systolic function assessment late after TOF repair...
  27. pmc Coagulation changes during presyncope and recovery
    Gerhard Cvirn
    Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria
    PLoS ONE 7:e42221. 2012
    ..g. those with coronary heart disease, atherosclerosis or hypertensives)...
  28. doi request reprint Pediatric patients with congenital heart disease: thrombin generation measured by calibrated automated thrombography
    Andrea Rosenkranz
    Department of Pediatrics, Austria cInstitute of Physiological Chemistry, Centre of Physiological Medicine, Medical University Graz, Graz, Austria
    Blood Coagul Fibrinolysis 19:389-93. 2008
    ....
  29. ncbi request reprint PFA-100 closure times in preoperative screening in 500 pediatric patients
    Birgit Roschitz
    Department of Pediatrics, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria
    Thromb Haemost 98:243-7. 2007
    ....
  30. ncbi request reprint An evaluation of the procoagulant action of recombinant activated factor VII in cord whole blood versus adult whole blood using thromboelastography
    Martin Koestenberger
    Department of Pediatrics, Medical University Graz, Graz, Austria
    Blood Coagul Fibrinolysis 16:613-7. 2005
    ....
  31. ncbi request reprint Effects of beta2-glycoprotein-I on platelet aggregation in cord versus adult whole blood
    Gerhard Cvirn
    Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria
    Platelets 18:24-8. 2007
    ..This mechanism might help to explain the clinically observed well-functioning hemostasis in neonates...
  32. doi request reprint Effects of nadroparin, enoxaparin, and unfractionated heparin on endogenous factor Xa and IIa formation and on thrombelastometry profiles
    Gerhard Cvirn
    Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria
    Blood Coagul Fibrinolysis 20:71-7. 2009
    ..Under our experimental conditions, the anticoagulant efficacy of nadroparin was comparable with that of enoxaparin but markedly lower than that of unfractionated heparin...
  33. doi request reprint Hemodiafiltration in infants with complications during peritoneal dialysis
    Siegfried Rodl
    Pediatric Intensive Care Unit, Department of Pediatrics, Medical University of Graz, Graz, Austria
    Artif Organs 36:590-3. 2012
    ..In case of PD complications, iHDF may be an appropriate bridge to achieve long-term survival until kidney transplantation...
  34. ncbi request reprint Combined effects of melagatran and eptifibatide on platelet aggregation inhibition but not thrombin generation inhibition
    Martin Koestenberger
    Department of Pediatrics, Ludwig Boltzmann Research Institute for Pediatric Haemostasis and Thrombosis and Institute of Medical Chemistry and Pregl Laboratory, University of Graz, Austria
    Blood Coagul Fibrinolysis 15:131-7. 2004
    ..The present study demonstrates the additive effect of melagatran and eptifibatide on platelet aggregation inhibition and on prolongation of the lag phase until the onset of platelet aggregation...
  35. doi request reprint A left-to-right shunt via the ductus arteriosus is associated with increased regional cerebral oxygen saturation during neonatal transition
    Berndt Urlesberger
    Research Unit for Cerebral Development and Oximetry, Division of Neonatology, Medical University of Graz, Graz, Austria
    Neonatology 103:259-63. 2013
    ..Objectives: The study was designed to investigate the influence of a left-to-right shunt via the ductus arteriosus (DA) on regional oxygen saturation (rSO2) of the brain and peripheral tissue during postnatal transition...
  36. ncbi request reprint Femoral vein access by contrast-guided puncture in cardiac catheterization in patients under one year of age
    Albrecht Beitzke
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University of Graz, Graz, Austria
    Pediatr Cardiol 30:768-70. 2009
    ....
  37. ncbi request reprint Myocardial infarction in an adolescent: anomalous origin of the left main coronary artery from the right coronary sinus in association with combined prothrombotic defects
    Martin Koestenberger
    Department of Pediatrics, Medical University Graz, Auenbruggerplatz 30, A 8036 Graz, Austria
    Pediatrics 120:e424-7. 2007
    ..He is now taking the anticoagulant warfarin. Combined prothrombotic defects in combination with additional risk factors such as coronary anomalies can lead to myocardial infarction even in children and adolescents...
  38. pmc Near-infrared spectroscopy for objectifying cerebral effects of laser acupuncture in term and preterm neonates
    Wolfgang Raith
    Division of Neonatology, Department of Paediatrics, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria Research Group for Paediatric Traditional Chinese Medicine, TCM Research Centre Graz Acupuncture Research, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria
    Evid Based Complement Alternat Med 2013:346852. 2013
    ..However, there was a significant decrease in rcSO2 (P = 0.003) within postintervention period, accompanied by a significant increase in cFTOE (P = 0.010) in postintervention period...
  39. doi request reprint Continuous renal replacement therapy with Prismaflex HF20 disposable set in children from 4 to 15 kg
    Siegfried Rodl
    Department of Paediatrics, Pediatric Intensive Care Unit, Medical University of Graz, Graz, Austria
    ASAIO J 57:451-5. 2011
    ..It can be used in CVVHDF or hemodialysis mode. Treatments were well tolerated in all patients, and flow rate adaptability to infants' needs was very acceptable, and the usage of this device was easy and safe...
  40. ncbi request reprint Heparinase-modified thrombelastometry: inactivation of heparin in plasma samples
    Gerhard Cvirn
    Institute of Physiological Chemistry, Medical University of Graz, Austria
    Clin Lab 56:585-9. 2010
    ..The aim of our study was to examine the heparin neutralizing capability of the HEPTEM assay in plasma samples...
  41. ncbi request reprint First experience with the Prismaflex HF 20 set in four infants
    Siegfried Rodl
    Department of Pediatrics, Pediatric Intensive Care Unit, Medical University of Graz, Graz Austria
    Int J Artif Organs 34:10-5. 2011
    ..We present our initial experience with the newly developed Prismaflex HF20 disposable set used on the Prismaflex device in infants with renal failure...
  42. doi request reprint Dislocation of a non-functional transvenous ventricular pacemaker lead in a child 6 years following abandonment
    Bert Nagel
    Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Auenbruggerplatz 30, A 8036 Graz, Austria
    Europace 12:1652-4. 2010
    ..This case report describes for the first time a late dislocation of an abandoned transvenous ventricular pacemaker (PM) lead in a child. Further management of this complication and the importance for follow-up of PM leads are discussed...
  43. doi request reprint Transcatheter closure of an atrial septal defect in a newborn with aortic stenosis
    Albrecht Beitzke
    Department of Paediatrics, Division of Pediatric Cardiology, University of Graz, Graz, Austria
    Acta Paediatr 98:582-3. 2009
    ..The small left ventricle of the newborn with signs of fibroelastosis showed good function but a reduced compliance and caused a large left to right shunt at atrial level...
  44. ncbi request reprint Signs of thrombin generation in pediatric cardiac catheterization with unfractionated heparin bolus or subcutaneous low molecular weight heparin for antithrombotic cover
    Birgit Roschitz
    Ludwig Boltzmann Research Institute for Pediatric Thrombosis and Hemostasis, Division of Pediatric Cardiology, Graz, Austria
    Thromb Res 111:335-41. 2003
    ....
  45. ncbi request reprint Combined effects of eptifibatide and anticoagulants: differences between LMWH and UH or rH in thrombin generation inhibition but not in platelet aggregation inhibition
    Martin Koestenberger
    Department of Pediatrics, University of Graz, Austria
    Thromb Haemost 88:1012-9. 2002
    ..Our results support the notion that combination of eptifibatide and anticoagulants might be beneficial in atherosclerotic disease to palliate the thrombogenic potency of ruptured atherosclerotic plaques...
  46. ncbi request reprint Alpha 2-macroglobulin enhances prothrombin activation and thrombin potential by inhibiting the anticoagulant protein C/protein S system in cord and adult plasma
    Gerhard Cvirn
    Ludwig Boltzmann Research Institute for Pediatric Hemostasis and Thrombosis, Graz, Austria
    Thromb Res 105:433-9. 2002
    ..Therefore, elevated levels of a2-M might restrict the up-regulation of the APC/PS pathway...