David A Keays
Breuss M, Fritz T, Gstrein T, Chan K, Ushakova L, Yu N, et al
. Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis. Development. 2016;143:1126-33 pubmed publisher
..This work sheds light on the functional repertoire of Tubb5, reveals that the E401K mutation acts by a complex mechanism, and demonstrates that the cellular pathology driving TUBB5-associated microcephaly is cell death. ..
Breuss M, Hansen A, Landler L, Keays D. Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition. Behav Brain Res. 2017;323:47-55 pubmed publisher
..This study provides insight into the behavioral consequences of tubulin gene mutations. ..
Breuss M, Leca I, Gstrein T, Hansen A, Keays D. Tubulins and brain development - The origins of functional specification. Mol Cell Neurosci. 2017;84:58-67 pubmed publisher
..We remind the reader that tubulins are not just loading controls for your average Western blot. ..