Siegfried Kasper

Summary

Country: Austria

Publications

  1. ncbi request reprint Efficacy and safety of aripiprazole vs. haloperidol for long-term maintenance treatment following acute relapse of schizophrenia
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Vienna, Austria
    Int J Neuropsychopharmacol 6:325-37. 2003
  2. doi request reprint Light-dependent alteration of serotonin-1A receptor binding in cortical and subcortical limbic regions in the human brain
    Christoph Spindelegger
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    World J Biol Psychiatry 13:413-22. 2012
  3. ncbi request reprint Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study
    Nikolas Klein
    Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Psychopharmacology (Berl) 191:333-9. 2007
  4. doi request reprint Interaction between serotonin 5-HT2A receptor gene and dopamine transporter (DAT1) gene polymorphisms influences personality trait of persistence in Austrian Caucasians
    Alexandra Schosser
    Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University Vienna, Vienna, Austria
    World J Biol Psychiatry 11:417-24. 2010
  5. doi request reprint Cortisol plasma levels in social anxiety disorder patients correlate with serotonin-1A receptor binding in limbic brain regions
    Rupert Lanzenberger
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int J Neuropsychopharmacol 13:1129-43. 2010
  6. doi request reprint Area-specific modulation of neural activation comparing escitalopram and citalopram revealed by pharmaco-fMRI: a randomized cross-over study
    Christian Windischberger
    MR Center of Excellence, Center for Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria
    Neuroimage 49:1161-70. 2010
  7. doi request reprint Differences in the dynamics of serotonin reuptake transporter occupancy may explain superior clinical efficacy of escitalopram versus citalopram
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int Clin Psychopharmacol 24:119-25. 2009
  8. ncbi request reprint Striatal D(2) receptor occupancy in bipolar patients treated with olanzapine
    Trawat Attarbaschi
    Department of General Psychiatry, Medical University Vienna, Vienna, Austria
    Eur Neuropsychopharmacol 17:102-7. 2007
  9. doi request reprint Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder
    Andreas Hahn
    Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University of Vienna, Vienna, Austria
    Neuroimage 56:881-9. 2011
  10. ncbi request reprint The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635
    Patrycja Stein
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Eur J Nucl Med Mol Imaging 35:2159-68. 2008

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Efficacy and safety of aripiprazole vs. haloperidol for long-term maintenance treatment following acute relapse of schizophrenia
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Vienna, Austria
    Int J Neuropsychopharmacol 6:325-37. 2003
    ..001). In summary, aripiprazole demonstrated efficacy equivalent or superior to haloperidol with associated benefits for safety and tolerability. Aripiprazole represents a promising new option for the long-term treatment of schizophrenia...
  2. doi request reprint Light-dependent alteration of serotonin-1A receptor binding in cortical and subcortical limbic regions in the human brain
    Christoph Spindelegger
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    World J Biol Psychiatry 13:413-22. 2012
    ..Higher serotonin transporter availability in healthy human subjects in times of lesser light exposure and lower serotonin levels have been shown in winter...
  3. ncbi request reprint Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study
    Nikolas Klein
    Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Psychopharmacology (Berl) 191:333-9. 2007
    ..In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioligand [(123)I]ADAM and single photon emission computed tomography (SPECT)...
  4. doi request reprint Interaction between serotonin 5-HT2A receptor gene and dopamine transporter (DAT1) gene polymorphisms influences personality trait of persistence in Austrian Caucasians
    Alexandra Schosser
    Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University Vienna, Vienna, Austria
    World J Biol Psychiatry 11:417-24. 2010
    ..004; homo-/heterozygous gene variants: P=0.0004). We conclude that an interaction between DAT1 and 5HT2A genes might influence the temperamental personality trait persistence...
  5. doi request reprint Cortisol plasma levels in social anxiety disorder patients correlate with serotonin-1A receptor binding in limbic brain regions
    Rupert Lanzenberger
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int J Neuropsychopharmacol 13:1129-43. 2010
    ..Dysregulation of the cortisol level might increase the vulnerability for mood disorders by altering limbic 5-HT1A receptors...
  6. doi request reprint Area-specific modulation of neural activation comparing escitalopram and citalopram revealed by pharmaco-fMRI: a randomized cross-over study
    Christian Windischberger
    MR Center of Excellence, Center for Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria
    Neuroimage 49:1161-70. 2010
    ..We believe that reduced reactivity in the medial frontal gyrus found for escitalopram compared to citalopram administration might explain the response differences between study drugs as demonstrated in previous clinical trials...
  7. doi request reprint Differences in the dynamics of serotonin reuptake transporter occupancy may explain superior clinical efficacy of escitalopram versus citalopram
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int Clin Psychopharmacol 24:119-25. 2009
    ....
  8. ncbi request reprint Striatal D(2) receptor occupancy in bipolar patients treated with olanzapine
    Trawat Attarbaschi
    Department of General Psychiatry, Medical University Vienna, Vienna, Austria
    Eur Neuropsychopharmacol 17:102-7. 2007
    ..Although we did not find an increased vulnerability for acute EPS in bipolar patients receiving olanzapine at clinical relevant doses, this needs to be replicated with larger sample sizes...
  9. doi request reprint Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder
    Andreas Hahn
    Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University of Vienna, Vienna, Austria
    Neuroimage 56:881-9. 2011
    ....
  10. ncbi request reprint The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635
    Patrycja Stein
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Eur J Nucl Med Mol Imaging 35:2159-68. 2008
    ..The present positron emission tomography (PET) study investigated the influence of sex on the major inhibitory serotonergic receptor subtype, the serotonin-1A (5-HT(1A)) receptor...
  11. doi request reprint Therapeutic effects of escitalopram and reboxetine in seasonal affective disorder: a pooled analysis
    Edda Pjrek
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    J Psychiatr Res 43:792-7. 2009
    ..Reboxetine displayed a faster onset of action, but was associated with more pronounced side effects. Further studies comparing SSRI and NARI in SAD are warranted...
  12. ncbi request reprint Seasonality of birth in seasonal affective disorder
    Edda Pjrek
    Department of General Psychiatry, Medical University of Vienna, Austria
    J Clin Psychiatry 65:1389-93. 2004
    ..The aim of this investigation was to examine seasonal differences in the frequency of birth in a clinical sample of patients with seasonal affective disorder (SAD)...
  13. ncbi request reprint Serotonin transporter promoter gene polymorphic region (5-HTTLPR) and personality in female patients with seasonal affective disorder and in healthy controls
    Nikolaus Thierry
    Department of General Psychiatry, Waehringer Guertel 18 20, University of Vienna, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 14:53-8. 2004
    ..The s allele was associated with lower Self-Directedness scores in SAD patients, whereas there were no significant differences in TCI dimensions between patients and controls in carriers of the long allele...
  14. ncbi request reprint A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study
    Nicole Praschak-Rieder
    Department of General Psychiatry, Medical University of Vienna, Austria
    J Psychiatr Res 39:561-7. 2005
    ....
  15. ncbi request reprint Actigraphy in patients with seasonal affective disorder and healthy control subjects treated with light therapy
    Dietmar Winkler
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Biol Psychiatry 58:331-6. 2005
    ..The purpose of this study was to investigate if bright light therapy (BLT) is able to reverse these disturbances...
  16. ncbi request reprint Enhanced serotonin transporter function during depression in seasonal affective disorder
    Matthaus Willeit
    Department of Biological Psychiatry, Medical University of Vienna, Vienna, Austria
    Neuropsychopharmacology 33:1503-13. 2008
    ..5-HTTLPR was not associated with any of the 5-HTT parameters. In sum, we conclude that the 5-HTT is in a hyperfunctional state during depression in SAD and normalizes after light therapy and in natural summer remission...
  17. ncbi request reprint Effects of olanzapine and ziprasidone on glucose tolerance in healthy volunteers
    Julia Sacher
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Neuropsychopharmacology 33:1633-41. 2008
    ..Our finding is suggestive that not all atypical antipsychotics cause acute direct effects on glucose disposal and that accurate determination of side effect profile should be performed when choosing an atypical antipsychotic...
  18. doi request reprint Bright-light therapy in the treatment of mood disorders
    Gerald Pail
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Neuropsychobiology 64:152-62. 2011
    ..In the third part, the mode of action, application, efficacy, tolerability and safety of BLT in SAD and other mood disorders are explored...
  19. ncbi request reprint Typical neuroleptics vs. atypical antipsychotics in the treatment of acute mania in a natural setting
    Martin Letmaier
    Department of General Psychiatry, Medical University of Vienna, Austria
    Int J Neuropsychopharmacol 9:529-37. 2006
    ....
  20. doi request reprint Efficacy and safety of silexan, a new, orally administered lavender oil preparation, in subthreshold anxiety disorder - evidence from clinical trials
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Wien Med Wochenschr 160:547-56. 2010
    ..4 ± 7.1 and 12.0 ± 7.2 points at week 6 and by between 11.8 ± 7.7 and 16.0 ± 8.3 points at week 10. In GAD silexan and lorazepam showed comparable HAMA total score reductions (90% CI for mean value difference: -2.3; 2.8 points)...
  21. doi request reprint The impact of Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk-a European multicentre study on treatment-resistant major depressive disorder
    Peter Hofer
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Eur Arch Psychiatry Clin Neurosci 263:385-91. 2013
    ....
  22. ncbi request reprint Reduced serotonin-1A receptor binding in social anxiety disorder
    Rupert R Lanzenberger
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Biol Psychiatry 61:1081-9. 2007
    ..The objective of this study was to investigate 5-HT1A receptor binding potential (BP) in social anxiety disorder (SAD)...
  23. ncbi request reprint Anger attacks in seasonal affective disorder
    Dietmar Winkler
    Department of General Psychiatry, Medical University of Vienna, Austria
    Int J Neuropsychopharmacol 9:215-9. 2006
    ..021) and obtained lower global seasonality scores than SAD patients without anger attacks (p=0.001). Anger attacks are experienced as particularly intense in SAD patients and seem to contribute considerably to their symptomatology...
  24. ncbi request reprint Quetiapine is effective against anxiety and depressive symptoms in long-term treatment of patients with schizophrenia
    Siegfried Kasper
    Medical University of Vienna, Department of General Psychiatry, Vienna, Austria
    Depress Anxiety 20:44-7. 2004
    ..13 (-1.23, -1.04) and after 156 weeks, it was -1.33 (-1.78, -0.87). Therefore, the efficacy of quetiapine for the treatment of anxiety and depressive symptoms is maintained in long-term treatment...
  25. ncbi request reprint Escitalopram in a working population: results from an observational study of 2378 outpatients in Austria
    Dietmar Winkler
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Hum Psychopharmacol 22:245-51. 2007
    ..The aim of this observational study was to evaluate the effectiveness of escitalopram in a naturalistic sample of employed people with mood and anxiety disorders...
  26. ncbi request reprint Agomelatine in the treatment of seasonal affective disorder
    Edda Pjrek
    Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Psychopharmacology (Berl) 190:575-9. 2007
    ..Previous studies showed that agomelatine is able to restore disrupted circadian rhythms, which were implicated in the pathophysiology of seasonal affective disorder (SAD)...
  27. ncbi request reprint Bright light therapy in seasonal affective disorder--does it suffice?
    Edda Pjrek
    Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 14:347-51. 2004
    ..Opposed to treatment guidelines, patients with several depressive episodes did not receive antidepressant maintenance medication or mood stabilizers more often than patients with only a few episodes...
  28. ncbi request reprint Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29
    Alexandra Schosser
    Department of General Psychiatry, University Hospital for Psychiatry, Medical University Vienna, Austria
    Eur Neuropsychopharmacol 17:501-5. 2007
    ..1r3. A NPL score Z(all) of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs)...
  29. ncbi request reprint Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder
    Dietmar Winkler
    Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Eur Neuropsychopharmacol 13:129-34. 2003
    ..Due to methodological limitations our results need to be replicated in controlled double-blind randomized clinical trials...
  30. ncbi request reprint Better tolerability of St. John's wort extract WS 5570 compared to treatment with SSRIs: a reanalysis of data from controlled clinical trials in acute major depression
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int Clin Psychopharmacol 25:204-13. 2010
    ..In conclusion, WS 5570 exhibits substantially lower incidence rates of adverse events than paroxetine and other SSRIs...
  31. ncbi request reprint Escitalopram in the long-term treatment of major depressive disorder in elderly patients
    Siegfried Kasper
    Medical University of Vienna, Vienna, Austria
    Neuropsychobiology 54:152-9. 2006
    ..The secondary aim was to examine response to treatment, as measured by change in the Montgomery-Asberg Depression Rating Scale (MADRS) total score from study entry to each visit, using observed cases...
  32. ncbi request reprint Validation of a simplified definition of anger attacks
    Dietmar Winkler
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Psychother Psychosom 75:103-6. 2006
    ..Assessment normally requires the use of specific instruments. The aim of this study was the validation of a simplified definition for anger attacks...
  33. doi request reprint Beyond the monoaminergic hypothesis: agomelatine, a new antidepressant with an innovative mechanism of action
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    World J Biol Psychiatry 10:117-26. 2009
    ..Collectively, its efficacy, together with its excellent tolerability, makes agomelatine an especially promising antidepressant for the near future...
  34. doi request reprint No association of the neuropeptide Y (Leu7Pro) and ghrelin gene (Arg51Gln, Leu72Met, Gln90Leu) single nucleotide polymorphisms with eating disorders
    Jochen Kindler
    Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University Vienna, Vienna, Austria
    Nord J Psychiatry 65:203-7. 2011
    ..Genetic factors likely contribute to the biological vulnerability of eating disorders...
  35. ncbi request reprint Effect of intravenous magnesium sulphate in reducing irritability and restlessness in pure and polysubstance opiate detoxification
    Angela Naderi-Heiden
    Department of General Psychiatry, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Psychiatry Res 135:53-63. 2005
    ..Despite promising pilot studies, the administration of Mg did not enable a dose reduction of tranquilizing medication (chlormethiazole) in pure and polysubstance opiate detoxification...
  36. doi request reprint Sex-specific predictors of criminal recidivism in a representative sample of incarcerated youth
    Belinda Plattner
    Universitätsklinik für Psychiatrie des Kindes und Jugendalters, Medizinische Universität Wien, Vienna, Austria
    Compr Psychiatry 50:400-7. 2009
    ..The objective of the study was to identify sex-specific psychopathologic predictors of criminal recidivism among a representative sample of incarcerated youths...
  37. doi request reprint Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects
    A Veronica Witte
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Hum Brain Mapp 30:2558-70. 2009
    ..The present study aimed to elucidate potential interactions between human aggression, the inhibitory serotonergic 5-HT(1A) receptor, and sex hormones...
  38. doi request reprint Actigraphic measurements in opioid detoxification with methadone or buprenorphine
    Edda Pjrek
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    J Clin Psychopharmacol 32:75-82. 2012
    ..Opioid tapering with methadone or buprenorphine leads to characteristic changes of the rest-activity cycle, but further study is required to validate these results...
  39. ncbi request reprint Onset of action of escitalopram compared with other antidepressants: results of a pooled analysis
    Siegfried Kasper
    Department of General Psychiatry, Medical University of Vienna, Austria
    Int Clin Psychopharmacol 21:105-10. 2006
    ....
  40. ncbi request reprint Anger attacks in depression--evidence for a male depressive syndrome
    Dietmar Winkler
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Psychother Psychosom 74:303-7. 2005
    ..It has been proposed that aggression and especially anger attacks play an important role in the symptomatology of depression. Furthermore, it has been hypothesized that these symptoms are more prevalent in males than in females...
  41. doi request reprint Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, placebo controlled trial
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int Clin Psychopharmacol 25:277-87. 2010
    ..Lavandula oil preparation silexan is both efficacious and safe for the relief of anxiety disorder not otherwise specified. It has a clinically meaningful anxiolytic effect and alleviates anxiety related disturbed sleep...
  42. ncbi request reprint Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects
    A Veronica Witte
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Hum Brain Mapp 31:339. 2010
    ..The article to which this erratum refers was published in Hum Brain Mapp 2008, DOI: . (c) 2009 Wiley-Liss, Inc...
  43. ncbi request reprint Guided self-help versus cognitive-behavioral group therapy in the treatment of bulimia nervosa
    Ursula Bailer
    Department of General Psychiatry, University Hospital of Psychiatry, Medical University of Vienna, Vienna, Austria
    Int J Eat Disord 35:522-37. 2004
    ..The aim of the current study was to evaluate whether guided self-help was effective in the short and long term in the treatment of bulimia nervosa...
  44. ncbi request reprint Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacology
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    World J Biol Psychiatry 3:133-46. 2002
    ..Our data provide insight into the pathophysiology of neuropsychiatric disorders and may guide future psychopharmacological drug developments...
  45. ncbi request reprint Gender differences in the psychopathology of depressed inpatients
    Dietmar Winkler
    Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Eur Arch Psychiatry Clin Neurosci 254:209-14. 2004
    ..These differences may influence diagnostic practice and gender specific treatment of depression...
  46. doi request reprint Psychosocial background in incarcerated adolescents from Austria, Turkey and former Yugoslavia
    Susanne Monika Bauer
    Department of Psychiatry and Psychotherapy, Medical University of Vienna MUW, Vienna, Austria
    Psychiatry Res 185:193-9. 2011
    ..Family systems, even if substantially dysfunctional, seem to be perceived as more stable by migrant youth than by Austrian youth...
  47. ncbi request reprint On the application of light therapy in German-speaking countries
    Reinhard Fischer
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Eur Arch Psychiatry Clin Neurosci 262:501-5. 2012
    ..Further efforts on the propagation of LT should therefore be undertaken, with the same rigorous studies as for pharmacotherapy...
  48. doi request reprint A highly parallelized framework for computationally intensive MR data analysis
    Roland N Boubela
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
    MAGMA 25:313-20. 2012
    ..The goal of this study was to develop a comprehensive magnetic resonance (MR) data analysis framework for handling very large datasets with user-friendly tools for parallelization and to provide an example implementation...
  49. doi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of eating disorders
    Martin Aigner
    Department of Psychiatry and Psychotherapy, Medical University Vienna MUW, Vienna, Austria
    World J Biol Psychiatry 12:400-43. 2011
    ..In this review recommendations for the pharmacological treatment of eating disorders (anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED)) are presented, based on the available literature...
  50. ncbi request reprint Possible linkage of schizophrenia and bipolar affective disorder to chromosome 3q29; a follow-up
    Alexandra Schosser
    Department of General Psychiatry, University Hospital for Psychiatry, A 1090 Vienna, Austria
    J Psychiatr Res 38:357-64. 2004
    ..The results of our follow-up study support our previous linkage finding of schizophrenia and bipolar affective disorder to chromosome 3q29...
  51. doi request reprint The European post-marketing observational sertindole study: an investigation of the safety of antipsychotic drug treatment
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Eur Arch Psychiatry Clin Neurosci 260:59-68. 2010
    ..Although CIs remained large, this post-marketing study does not provide any evidence against the use of sertindole under normal conditions. Sertindole was well tolerated and posed no significant safety problems...
  52. doi request reprint Polymorphisms of the 5-HT2A receptor gene and clinical response to olanzapine in paranoid schizophrenia
    Luiza Olajossy-Hilkesberger
    Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Neuropsychobiology 64:202-10. 2011
    ..The aim of the study was to investigate whether the 5-HT2A receptor gene's polymorphisms (His452Tyr and T102C) have an influence on the response to olanzapine in patients with schizophrenia...
  53. ncbi request reprint Efficacy of pregabalin and venlafaxine-XR in generalized anxiety disorder: results of a double-blind, placebo-controlled 8-week trial
    Siegfried Kasper
    Department of General Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int Clin Psychopharmacol 24:87-96. 2009
    ..1%) and PBO (7.8%), but higher for VXR (20.0%; P < 0.05). In conclusion, PGB was a safe and effective treatment of GAD, with a significantly earlier onset of anxiolytic activity than VXR...
  54. doi request reprint Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression
    Siegfried Kasper
    Department of General Psychiatry, Medical University of Wien, MUV, Austria
    Eur Neuropsychopharmacol 20:747-65. 2010
    ..In this review, WS 5572, LI 160, WS 5570 and ZE 117 Hypericum extracts have been shown to be significantly more effective than placebo with at least similar efficacy and better tolerability compared to standard antidepressant drugs...
  55. doi request reprint Longitudinal analysis of the suicidal behaviour risk in short-term placebo-controlled studies of mirtazapine in major depressive disorder
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    World J Biol Psychiatry 11:36-44. 2010
    ..To examine suicidal behaviour risk in the short-term placebo-controlled studies of mirtazapine in Major Depressive Disorder (MDD)...
  56. doi request reprint An orally administered lavandula oil preparation (Silexan) for anxiety disorder and related conditions: an evidence based review
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int J Psychiatry Clin Pract 17:15-22. 2013
    ..Silexan is a lavender oil preparation in gelatine capsules containing 80 mg. We reviewed the clinical trials investigating the anxiolytic efficacy and tolerability of Silexan as well as its safety and potential for drug interactions...
  57. doi request reprint Testosterone in the brain: neuroimaging findings and the potential role for neuropsychopharmacology
    Peter Hofer
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Eur Neuropsychopharmacol 23:79-88. 2013
    ..An antidepressant effect of testosterone can be implicitly explained by its effects on the limbic system--especially amygdala, a major target in the treatment of depression--solidly demonstrated by a large body of neuroimaging findings...
  58. doi request reprint Cerebral serotonin transporter asymmetry in females, males and male-to-female transsexuals measured by PET in vivo
    Georg S Kranz
    Functional, Molecular and Translational Neuroimaging Lab, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18 20, 1090, Vienna, Austria
    Brain Struct Funct 219:171-83. 2014
    ..The absence of serotonin transporter asymmetry in the midcingulate in MtF transsexuals may be attributed to an absence of brain masculinization in this region. ..
  59. pmc RESCALE: Voxel-specific task-fMRI scaling using resting state fluctuation amplitude
    Klaudius Kalcher
    MR Centre of Excellence, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
    Neuroimage 70:80-8. 2013
    ..0% in the visual cortex and 12.7% in the left motor cortex. The RESCALE method as proposed herein can be easily applied to all task-based fMRI group studies provided that resting-state data for the same subject group is also acquired...
  60. ncbi request reprint Therapy of treatment resistant depression: focus on the management of TRD with atypical antipsychotics
    Nikolas Klein
    Department of General Psychiatry, Medical University of Vienna, A 1090 Vienna, Austria
    CNS Spectr 9:823-32. 2004
    ..This review especially focuses on the augmentation of the antidepressant therapy with atypical antipsychotics...
  61. ncbi request reprint Maintenance of long-term efficacy and safety of quetiapine in the open-label treatment of schizophrenia
    Siegfried Kasper
    Department of General Psychiatry, Medical University Vienna, Vienna, Austria
    Int Clin Psychopharmacol 19:281-9. 2004
    ..In conclusion, quetiapine may be a suitable therapy in the long-term treatment of schizophrenia...
  62. ncbi request reprint White matter hyperintensities and chronicity of depression
    Angela Heiden
    Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Psychiatr Res 39:285-93. 2005
    ..A prospective study was undertaken to investigate the association between extent of WMHs and clinical outcome in elderly depressed patients...
  63. ncbi request reprint Atypical antipsychotics in mood disorders
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Vienna, Austria
    Int Clin Psychopharmacol 17:S1-10. 2002
    ....
  64. ncbi request reprint Is dopamine neurotransmission altered in prodromal schizophrenia? A review of the evidence
    Martin Bauer
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Curr Pharm Des 18:1568-79. 2012
    ....
  65. doi request reprint Clinical data in early intervention
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Int Psychogeriatr 24:S41-5. 2012
    ....
  66. ncbi request reprint Escitalopram in the treatment of depressed elderly patients
    Siegfried Kasper
    Dept of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Am J Geriatr Psychiatry 13:884-91. 2005
    ..The authors examined the efficacy and tolerability of escitalopram and fluoxetine versus placebo in the treatment of elderly patients with major depressive disorder (MDD)...
  67. ncbi request reprint Recurrent brief depression revisited
    Lukas Pezawas
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Int Rev Psychiatry 17:63-70. 2005
    ..Obviously future treatment studies without the limitations of previous studies are clearly required for RBD. Results of ongoing studies will soon provide the first data on the biological underpinnings of RBD...
  68. pmc Superior efficacy of St John's wort extract WS 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]
    Siegfried Kasper
    Department of General Psychiatry, Vienna Medical University, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    BMC Med 4:14. 2006
    ..The aim of the current study was to assess the antidepressant efficacy and safety of Hypericum perforatum (St. John's wort) extract WS 5570 at doses of 600 mg/day in a single dose and 1200 mg/day in two doses...
  69. ncbi request reprint Relationship between power spectra of the awake EEG and psychomotor activity patterns measured by short-term actigraphy
    Dietmar Winkler
    Department of General Psychiatry, University Hospital for Psychiatry, Vienna, Austria
    Neuropsychobiology 48:176-81. 2003
    ..Our results, while preliminary, suggest that short-term actigraphy may be apt to reflect central nervous system arousal...
  70. ncbi request reprint European College of Neuropsychopharmacology - 16th Congress. 20-24 September 2003, Prague, Czech Republic
    Dietmar Winkler
    University Hospital for Psychiatry, Vienna, Austria
    IDrugs 6:1020-3. 2003
  71. ncbi request reprint C825T polymorphism in the G protein beta3-subunit gene is associated with seasonal affective disorder
    Matthaus Willeit
    Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria
    Biol Psychiatry 54:682-6. 2003
    ....
  72. ncbi request reprint Tardive Dyskinesia: analysis of outpatients with schizophrenia from Africa and the Middle East, Asia, Central and Eastern Europe, and Latin America
    Siegfried Kasper
    Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Schizophr Res 81:139-43. 2006
    ..This study provides new data in a non-Western population with a unique regional geography comparison...
  73. ncbi request reprint Dopaminergic deficit and the role of amisulpride in the treatment of schizophrenia
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Vienna, Austria
    Int Clin Psychopharmacol 17:S19-26. 2002
    ....
  74. ncbi request reprint Escitalopram in the treatment of social anxiety disorder: randomised, placebo-controlled, flexible-dosage study
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Br J Psychiatry 186:222-6. 2005
    ..Selective serotonin reuptake inhibitors are effective in the treatment of social anxiety disorder and are currently regarded as the pharmacotherapy of choice...
  75. ncbi request reprint Effects of tryptophan depletion and catecholamine depletion on immune parameters in patients with seasonal affective disorder in remission with light therapy
    Jürgen Stastny
    Department of General Psychiatry, University of Vienna, Vienna, Austria
    Biol Psychiatry 53:332-7. 2003
    ....
  76. ncbi request reprint A longitudinal view of triggers and thresholds of suicidal behavior in depression
    Lukas Pezawas
    Department of General Psychiatry, University of Vienna, Austria
    J Clin Psychiatry 63:866-73. 2002
    ..RBD and MDD diagnoses were based on DSM-IV criteria. Furthermore, the goal of this study was to determine if impulsivity as an underlying factor could explain high suicide attempt rates in CD...
  77. ncbi request reprint Striatal dopamine-2 receptor occupancy as measured with [123I]iodobenzamide and SPECT predicted the occurrence of EPS in patients treated with atypical antipsychotics and haloperidol
    Johannes Tauscher
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Psychopharmacology (Berl) 162:42-9. 2002
    ..Extrapyramidal symptoms (EPS) are common with conventional antipsychotics. Clozapine and other novel antipsychotic substances with lower in vitro affinity for dopamine-2 (D(2)) receptors have a lower propensity to induce EPS...
  78. ncbi request reprint Issues in the treatment of bipolar disorder
    Siegfried Kasper
    Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Eur Neuropsychopharmacol 13:S37-42. 2003
    ..Therefore, successful treatment and prevention of bipolar depression remains an essential treatment goal...
  79. ncbi request reprint Genome scan for susceptibility loci for schizophrenia and bipolar disorder
    Ursula Bailer
    Department of General Psychiatry, University Hospital for Psychiatry, Vienna, Austria
    Biol Psychiatry 52:40-52. 2002
    ..The objective of our analyses was to search for vulnerability loci for the two disorders...
  80. ncbi request reprint Quetiapine in the treatment of borderline personality disorder
    Eva Hilger
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    World J Biol Psychiatry 4:42-4. 2003
    ..Thus, there is a clear need for further controlled studies to evaluate pharmacological treatment options for this disorder...
  81. ncbi request reprint Treatment challenges in the acute hospital setting
    Siegfried Kasper
    World J Biol Psychiatry 6:210-1. 2005
  82. ncbi request reprint Optimisation of long-term treatment in schizophrenia: treating the true spectrum of symptoms
    Siegfried Kasper
    Department of Psychiatry, Medical University of Vienna, Austria
    Eur Neuropsychopharmacol 16:S135-41. 2006
    ....
  83. ncbi request reprint Effectiveness, tolerability, and safety of ziprasidone in patients with schizophrenia or schizoaffective disorder: results of a multi-centre observational trial
    Duerten Kudla
    Centre for Psychosocial Medicine, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur Psychiatry 22:195-202. 2007
    ..Secondary objectives included quality of life, subjective well-being, tolerability, and safety...
  84. ncbi request reprint Do we need another atypical antipsychotic?
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wein, Austria
    Eur Neuropsychopharmacol 18:S146-52. 2008
    ..The propensity of sertindole to cause anticholinergic effects, which can be particularly troublesome, is small and, more recently, there have been suggestions that sertindole may have beneficial effects on cognition...
  85. ncbi request reprint Efficacy of agomelatine, a MT1/MT2 receptor agonist with 5-HT2C antagonistic properties, in major depressive disorder
    Jean Pierre Olie
    Sainte Anne Hospital, University Department of Psychiatry, Paris, France
    Int J Neuropsychopharmacol 10:661-73. 2007
    ....
  86. ncbi request reprint Serum lipid levels in seasonal affective disorder
    Edda Pjrek
    Dept of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Eur Arch Psychiatry Clin Neurosci 257:197-202. 2007
    ..56 +/- 0.96 mmol/l; p = 0.126). The results of this study support the idea that low cholesterol levels may be of pathogenetic importance in SAD. Further study in larger clinical samples is warranted to clarify our findings...
  87. ncbi request reprint A placebo-controlled study of sertraline in the treatment of outpatients with seasonal affective disorder
    Adam Moscovitch
    Canadian Sleep Institute, Unit 300, 295 Midpark Way, South East, Calgary, Alberta, T2X 2A8, Canada
    Psychopharmacology (Berl) 171:390-7. 2004
    ..The disorder is commonly responsive to light therapy, but antidepressant drug efficacy has not been definitely established. Serotonin selective re-uptake inhibitors are potentially efficacious treatments for SAD...
  88. ncbi request reprint [Transcranial magnetic stimulation (TMS)--from diagnostic procedure to therapy]
    Sylvia Quiner
    Universitätsklinik für Neuropsychiatrie des Kindes und Jugendalters, Wien
    Wien Klin Wochenschr 114:181-6. 2002
    ....
  89. ncbi request reprint [Electroconvulsive therapy as maintenance therapy and for prevention of recurrence in psychiatric disorders and Parkinson disease]
    Matthaus Willeit
    Klinische Abteilung für Allgemeine Psychiatrie, Universitätsklinik für Psychiatrie Wien, Wien, Osterreich
    Wien Klin Wochenschr 115:281-90. 2003
    ..First-line evidence data on incidence, dimensions and outcome of cognitive side effects under maintenance electroconvulsive therapy is still warranted...
  90. ncbi request reprint Severe depression and antidepressants: focus on a pooled analysis of placebo-controlled studies on agomelatine
    Stuart A Montgomery
    Imperial College School of Medicine, University of London, London, UK
    Int Clin Psychopharmacol 22:283-91. 2007
    ..06 rising to 4.45 points on the Hamilton Depression Rating Scale. In conclusion, agomelatine is effective in treating severe depression...
  91. ncbi request reprint Clinical factors associated with treatment resistance in major depressive disorder: results from a European multicenter study
    Daniel Souery
    Department of Psychiatry, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Clin Psychiatry 68:1062-70. 2007
    ....
  92. ncbi request reprint Partial response and nonresponse to antidepressant therapy: current approaches and treatment options
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
    J Clin Psychiatry 63:826-37. 2002
    ....
  93. ncbi request reprint The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders, Part II: Treatment of Mania
    Heinz Grunze
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 4:5-13. 2003
    ..Key words: bipolar disorder, mania, acute treatment, evidence-based guidelines, pharmacotherapy, antipsychotics, mood stabiliser, electroconvulsive therapy...
  94. ncbi request reprint A meta-analysis of clinical trials comparing reboxetine, a norepinephrine reuptake inhibitor, with selective serotonin reuptake inhibitors for the treatment of major depressive disorder
    George I Papakostas
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, WAC 812 Boston, MA 02114, USA
    Eur Neuropsychopharmacol 18:122-7. 2008
    ..These results suggest that the NRI reboxetine and the SSRIs differ with respect to their side-effect profile and overall tolerability but not their efficacy in treating MDD...
  95. ncbi request reprint Season of birth in siblings of patients with seasonal affective disorder. A test of the parental conception habits hypothesis
    Edda Pjrek
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Eur Arch Psychiatry Clin Neurosci 257:378-82. 2007
    ..Further research could be conducted in non-seasonal depression as there is still a lack of studies on seasonality of birth in affective disorders...
  96. ncbi request reprint Broadening the treatment indication: is the term antipsychotic still justified?
    Siegfried Kasper
    World J Biol Psychiatry 4:144-5. 2003
  97. ncbi request reprint Case report: intestinal atonia as an unusual symptom of malignant catatonia responsive to electroconvulsive therapy
    Rainer Marco Kaufmann
    Schizophr Res 84:178-9. 2006
  98. ncbi request reprint Addressing the limitations of the CATIE study
    Siegfried Kasper
    World J Biol Psychiatry 7:126-7. 2006
  99. ncbi request reprint Efficacy and safety of pregabalin in the treatment of generalized anxiety disorder: a 6-week, multicenter, randomized, double-blind, placebo-controlled comparison of pregabalin and venlafaxine
    Stuart A Montgomery
    Imperial College School of Medicine, London, UK
    J Clin Psychiatry 67:771-82. 2006
    ..The current study compared the efficacy and safety of pregabalin and venlafaxine in patients diagnosed with moderate to severe GAD...
  100. ncbi request reprint Escitalopram in the treatment of social anxiety disorder: analysis of efficacy for different clinical subgroups and symptom dimensions
    Dan J Stein
    MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    Depress Anxiety 20:175-81. 2004
    ..A six-factor model of social anxiety symptoms is supported by the distinctive association between these symptom dimensions and different areas of disability, but did not predict differential response to escitalopram...
  101. ncbi request reprint A review of the evidence for carbamazepine and oxcarbazepine in the treatment of bipolar disorder
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch at Galveston, TX 77555 0188, USA
    Int J Neuropsychopharmacol 7:507-22. 2004
    ..This review presents a balanced selection of the key studies on carbamazepine and oxcarbazepine in bipolar disorder...