Felix Eckstein

Summary

Affiliation: Institute of Anatomy and Musculoskeletal Research
Country: Austria

Publications

  1. ncbi Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University PMU, A 5020 Salzburg, Austria
    NMR Biomed 19:822-54. 2006
  2. ncbi Proposal for a nomenclature for magnetic resonance imaging based measures of articular cartilage in osteoarthritis
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 14:974-83. 2006
  3. ncbi Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA)
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private University, Salzburg, Austria
    Magn Reson Med 58:402-6. 2007
  4. ncbi Recent advances in osteoarthritis imaging--the osteoarthritis initiative
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Strubergasse 21, A 5020, Salzburg, Austria
    Nat Rev Rheumatol 8:622-30. 2012
  5. ncbi How do short-term rates of femorotibial cartilage change compare to long-term changes? Four year follow-up data from the osteoarthritis initiative
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 20:1250-7. 2012
  6. ncbi Rates of change and sensitivity to change in cartilage morphology in healthy knees and in knees with mild, moderate, and end-stage radiographic osteoarthritis: results from 831 participants from the Osteoarthritis Initiative
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Arthritis Care Res (Hoboken) 63:311-9. 2011
  7. ncbi The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC, USA
    BMC Musculoskelet Disord 10:93. 2009
  8. ncbi Minimum joint space width and tibial cartilage morphology in the knees of healthy individuals: a cross-sectional study
    Karen A Beattie
    Dept of Medicine, McMaster University, Hamilton, ON, Canada
    BMC Musculoskelet Disord 9:119. 2008
  9. ncbi Two year longitudinal change and test-retest-precision of knee cartilage morphology in a pilot study for the osteoarthritis initiative
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University PMU, Salzburg, Austria
    Osteoarthritis Cartilage 15:1326-32. 2007
  10. ncbi Sex differences of human trabecular bone microstructure in aging are site-dependent
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    J Bone Miner Res 22:817-24. 2007

Detail Information

Publications101 found, 100 shown here

  1. ncbi Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University PMU, A 5020 Salzburg, Austria
    NMR Biomed 19:822-54. 2006
    ....
  2. ncbi Proposal for a nomenclature for magnetic resonance imaging based measures of articular cartilage in osteoarthritis
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 14:974-83. 2006
    ....
  3. ncbi Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA)
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private University, Salzburg, Austria
    Magn Reson Med 58:402-6. 2007
    ..pre-Gd-DTPA differences. Accurate morphological measurements of cartilage can be obtained after Gd-DTPA injection, allowing compositional and morphological imaging to be combined into one session...
  4. ncbi Recent advances in osteoarthritis imaging--the osteoarthritis initiative
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Strubergasse 21, A 5020, Salzburg, Austria
    Nat Rev Rheumatol 8:622-30. 2012
    ....
  5. ncbi How do short-term rates of femorotibial cartilage change compare to long-term changes? Four year follow-up data from the osteoarthritis initiative
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 20:1250-7. 2012
    ..To compare unbiased estimates of short- vs long-term cartilage loss in osteoarthritic knees...
  6. ncbi Rates of change and sensitivity to change in cartilage morphology in healthy knees and in knees with mild, moderate, and end-stage radiographic osteoarthritis: results from 831 participants from the Osteoarthritis Initiative
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Arthritis Care Res (Hoboken) 63:311-9. 2011
    ..To study the longitudinal rate of (and sensitivity to) change of knee cartilage thickness across defined stages of radiographic osteoarthritis (OA), specifically healthy knees and knees with end-stage radiographic OA...
  7. ncbi The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC, USA
    BMC Musculoskelet Disord 10:93. 2009
    ..This article describes the intervention, the empirical evidence to support it, and test-retest reliability data...
  8. ncbi Minimum joint space width and tibial cartilage morphology in the knees of healthy individuals: a cross-sectional study
    Karen A Beattie
    Dept of Medicine, McMaster University, Hamilton, ON, Canada
    BMC Musculoskelet Disord 9:119. 2008
    ..Thus, the purpose of this pilot study is to estimate reference values of medial joint space width and cartilage morphometry in healthy individuals of all ages using standard radiography and peripheral magnetic resonance imaging...
  9. ncbi Two year longitudinal change and test-retest-precision of knee cartilage morphology in a pilot study for the osteoarthritis initiative
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University PMU, Salzburg, Austria
    Osteoarthritis Cartilage 15:1326-32. 2007
    ..In this pilot study for the osteoarthritis (OA) initiative we compare their test-retest-precision and sensitivity to longitudinal change...
  10. ncbi Sex differences of human trabecular bone microstructure in aging are site-dependent
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    J Bone Miner Res 22:817-24. 2007
    ..Significant sex differences are observed at the distal radius, femoral neck, and femoral trochanter, but not at the iliac crest, calcaneus, and lumbar vertebral body. Correlations in BV/TV between sites ranged from r = 0.13 to 0.56...
  11. ncbi Impact of coil design on the contrast-to-noise ratio, precision, and consistency of quantitative cartilage morphometry at 3 Tesla: a pilot study for the osteoarthritis initiative
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, and Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, USA
    Magn Reson Med 57:448-54. 2007
    ..The higher CNR of the PA coil did not translate directly into improved precision of cartilage measurement; however, summing up cartilage plates within the medial and lateral compartment reduced precision errors...
  12. ncbi Greater rates of cartilage loss in painful knees than in pain-free knees after adjustment for radiographic disease stage: data from the osteoarthritis initiative
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Arthritis Rheum 63:2257-67. 2011
    ..To investigate whether rates of cartilage loss differ in knees with frequent baseline pain versus those without pain, after adjustment for radiographic osteoarthritis (OA) stage...
  13. ncbi Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T
    Felix Eckstein
    Paracelsus Private Medical University, Salzburg, Austria
    Arthritis Rheum 52:3132-6. 2005
    ..5T. The aim of this study was to evaluate the precision of quantitative MRI assessments of human cartilage morphology at 3.0T and to correlate the measurements at 3.0T with validated measurements at 1.5T...
  14. ncbi Reference values and Z-scores for subregional femorotibial cartilage thickness--results from a large population-based sample (Framingham) and comparison with the non-exposed Osteoarthritis Initiative reference cohort
    F Eckstein
    Paracelsus Medical University and Chondrometrics GmbH, Salzburg, Austria
    Osteoarthritis Cartilage 18:1275-83. 2010
    ..To establish sex-specific (subregional) reference values of cartilage thickness and potential maximal Z-scores in the femorotibial joint...
  15. ncbi Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis
    F Eckstein
    Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria
    Ann Rheum Dis 70:1223-30. 2011
    ..To examine the relationship of baseline clinical, radiographic, molecular and MRI measures with structural progression (subregional MRI-based femorotibial cartilage loss) in knee osteoarthritis (OA)...
  16. ncbi Magnetic resonance imaging (MRI) of articular cartilage in knee osteoarthritis (OA): morphological assessment
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University, Salzburg, Austria and Chondrometrics GmbH, Ainring, Germany
    Osteoarthritis Cartilage 14:A46-75. 2006
    ....
  17. ncbi Imaging of knee osteoarthritis: data beyond the beauty
    Felix Eckstein
    aInstitute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Curr Opin Rheumatol 19:435-43. 2007
    ..With the first image data of the Osteoarthritis Initiative now becoming publicly available, this article reviews recent developments in quantitative imaging of osteoarthritis...
  18. ncbi Double echo steady state magnetic resonance imaging of knee articular cartilage at 3 Tesla: a pilot study for the Osteoarthritis Initiative
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University, Strubergasse 21, A5020 Salzburg, Austria
    Ann Rheum Dis 65:433-41. 2006
    ..Quantitative magnetic resonance imaging (qMRI) may provide valuable measures of cartilage morphology in osteoarthritis (OA) but has been confined to sequences with relatively long acquisition times at 1.5 Tesla (T)...
  19. ncbi Relationship of compartment-specific structural knee status at baseline with change in cartilage morphology: a prospective observational study using data from the osteoarthritis initiative
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, A5020 Salzburg, Austria
    Arthritis Res Ther 11:R90. 2009
    ....
  20. ncbi Longitudinal quantitative MR imaging of cartilage morphology in the presence of gadopentetate dimeglumine (Gd-DTPA)
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Magn Reson Med 61:975-80. 2009
    ....
  21. ncbi Magnetic resonance imaging-based cartilage loss in painful contralateral knees with and without radiographic joint space narrowing: Data from the Osteoarthritis Initiative
    Felix Eckstein
    Paracelsus Medical University, Salzburg, Austria, and Chondrometrics, Ainring, Germany
    Arthritis Rheum 61:1218-25. 2009
    ....
  22. ncbi Medial-to-lateral ratio of tibiofemoral subchondral bone area is adapted to alignment and mechanical load
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Calcif Tissue Int 84:186-94. 2009
    ..Tibiofemoral subchondral bone surface areas are shown to be functionally adapted to the medial-to-lateral load distribution. The longitudinal findings indicate that this adaptational process may continue to take place at advanced age...
  23. ncbi Patterns of femorotibial cartilage loss in knees with neutral, varus, and valgus alignment
    Felix Eckstein
    Paracelsus Medical University, Salzburg, Austria
    Arthritis Rheum 59:1563-70. 2008
    ..We investigated the pattern of cartilage loss in neutral, varus, and valgus knees...
  24. ncbi Determinants and heterogeneity of mechanical competence throughout the thoracolumbar spine of elderly women and men
    Felix Eckstein
    Department of Diagnostic Radiology, TU, Munchen, Germany
    Bone 35:364-74. 2004
    ..However, total density predicts functional segment failure stress with higher accuracy than (sub)cortical or trabecular density and is thus recommended for predicting fracture strength clinically...
  25. ncbi Magnitude and regional distribution of cartilage loss associated with grades of joint space narrowing in radiographic osteoarthritis--data from the Osteoarthritis Initiative (OAI)
    F Eckstein
    Institute of Anatomy, PMU Salzburg, Austria
    Osteoarthritis Cartilage 18:760-8. 2010
    ....
  26. ncbi One year change of knee cartilage morphology in the first release of participants from the Osteoarthritis Initiative progression subcohort: association with sex, body mass index, symptoms and radiographic osteoarthritis status
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, PMU, Salzburg, Austria
    Ann Rheum Dis 68:674-9. 2009
    ..Here cartilage loss using 3 Tesla (3 T) MRI is analysed over 1 year in a subset of the OAI, together with its association with various risk factors...
  27. ncbi Correlation and sex differences between ankle and knee cartilage morphology determined by quantitative magnetic resonance imaging
    F Eckstein
    Institute of Anatomy, Paracelsus Medizinische Privatuniversitat, A5020 Salzburg, Austria
    Ann Rheum Dis 63:1490-5. 2004
    ....
  28. ncbi Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multicentre clinical trial
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, PMU, Strubergasse 21, A5020 Salzburg Austria
    Ann Rheum Dis 67:1683-8. 2008
    ..0 Tesla (T) are more reproducible (precise) than those at 1.5 T. Precision errors and stability in multicentre studies with imaging equipment from various vendors have, however, not yet been evaluated...
  29. ncbi Femorotibial subchondral bone area and regional cartilage thickness: a cross-sectional description in healthy reference cases and various radiographic stages of osteoarthritis in 1,003 knees from the Osteoarthritis Initiative
    Richard B Frobell
    Paracelsus Medical University, Salzburg, Austria
    Arthritis Care Res (Hoboken) 62:1612-23. 2010
    ..To identify structural differences in total subchondral bone area (tAB) and cartilage thickness between healthy reference knees and knees with radiographic osteoarthritis (OA)...
  30. ncbi A three-dimensional quantitative method to measure meniscus shape, position, and signal intensity using MR images: a pilot study and preliminary results in knee osteoarthritis
    Wolfgang Wirth
    Paracelsus Medical University, Salzburg, Austria
    Magn Reson Med 63:1162-71. 2010
    ..These results need to be confirmed in larger cohorts, preferably under weight-bearing conditions...
  31. ncbi Spatial patterns of cartilage loss in the medial femoral condyle in osteoarthritic knees: data from the Osteoarthritis Initiative
    Wolfgang Wirth
    Chondrometrics GmbH, Ainring, Germany
    Magn Reson Med 63:574-81. 2010
    ..32) but was minimally affected by medial-lateral trimming. In conclusion, the greatest sensitivity to change was achieved when analyzing the posterior aspect of the central, weight-bearing MF...
  32. ncbi Trabecular bone structure of the distal radius, the calcaneus, and the spine: which site predicts fracture status of the spine best?
    Thomas M Link
    Department of Diagnostic Radiology, Technische Universitaet Muenchen, Munich, Germany
    Invest Radiol 39:487-97. 2004
    ....
  33. ncbi Improved performance of hip DXA using a novel region of interest in the upper part of the femoral neck: in vitro study using bone strength as a standard of reference
    Holger F Boehm
    Department of Diagnostic Radiology, LMU Muenchen, Germany
    J Clin Densitom 8:488-94. 2005
    ..Only a weak association was observed between failure load and FNAL...
  34. ncbi Reproducibility and side differences of mechanical tests for determining the structural strength of the proximal femur
    Felix Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat, Munchen, Germany
    J Bone Miner Res 19:379-85. 2004
    ..Based on side differences in femoral failure loads in 55 pairs of femora, we estimated the upper limit of the precision error to be 15% for the side impact test, whereas the intersubject variability was >40%...
  35. ncbi Femoro-tibial cartilage metrics from coronal MR image data: Technique, test-retest reproducibility, and findings in osteoarthritis
    Christian Glaser
    Institute for Clinical Radiology, Klinikum der Ludwig Maximilians Universität München, Munchen, Germany
    Magn Reson Med 50:1229-36. 2003
    ..The technique proposed overcomes some of the problems associated with sagittal scans and thus shows high promise for reliable assessment of femoro-tibial cartilage loss in OA...
  36. ncbi Longitudinal in vivo effects of growth hormone overexpression on bone in transgenic mice
    Felix Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat, Munchen, Germany
    J Bone Miner Res 19:802-10. 2004
    ..We observed substantially increased BMC in GH transgenic mice and a significant reduction in serum osteocalcin. GH effects on bone were strongly dependent on gender and developmental stage...
  37. ncbi Three-dimensional analysis and visualization of regional MR signal intensity distribution of articular cartilage
    Jan Hohe
    Musculoskeletal Research Group, Institute of Anatomy, , , Pettenkoferstr. 11, D-80336, , Germany
    Med Eng Phys 24:219-27. 2002
    ..In conjunction with suitable MR protocols, this post-processing technique has potential to allow for detection and quantification of early degenerative processes in cartilage, before macro-morphological lesions occur...
  38. ncbi In vivo measures of cartilage deformation: patterns in healthy and osteoarthritic female knees using 3T MR imaging
    Sebastian Cotofana
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Strubergasse 21, A5020, Salzburg, Austria
    Eur Radiol 21:1127-35. 2011
    ..To explore and to compare the magnitude and spatial pattern of in vivo femorotibial cartilage deformation in healthy and in osteoarthritic (OA) knees...
  39. ncbi Correlation of knee-joint cartilage morphology with muscle cross-sectional areas vs. anthropometric variables
    Martin Hudelmaier
    Muskuloskeletal Research Group, Anatomische Anstalt, LMU Munchen, Munchen, Germany
    Anat Rec A Discov Mol Cell Evol Biol 270:175-84. 2003
    ..The significant decrease in cartilage volume and thickness with age is not associated with a proportional decrease in MCSAs...
  40. ncbi Precision and accuracy of peripheral quantitative computed tomography (pQCT) in the mouse skeleton compared with histology and microcomputed tomography (microCT)
    Corina Schmidt
    Musculoskeletal Research Group, Institute of Anatomy, , , Germany
    J Bone Miner Res 18:1486-96. 2003
    ..The potential advantage of pQCT is that it provides a large set of parameters on bone properties and that it can be used in vivo, extending the available methodological repertoire for genetic studies...
  41. ncbi Cartilage thickening in early radiographic knee osteoarthritis: A within-person, between-knee comparison
    Sebastian Cotofana
    Paracelsus Medical University, Salzburg, Austria Chondrometrics, Ainring, Germany
    Arthritis Care Res (Hoboken) 64:1681-90. 2012
    ..Based on previous results, the external weight-bearing medial femoral condyle (ecMF) and external weight-bearing lateral femoral condyle (ecLF) subregions were selected as primary end points...
  42. ncbi Revision 1 size and position of the healthy meniscus, and its correlation with sex, height, weight, and bone area- a cross-sectional study
    Katja Bloecker
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University Salzburg, Austria
    BMC Musculoskelet Disord 12:248. 2011
    ..Meniscus extrusion or hypertrophy may occur in knee osteoarthritis (OA). However, currently no data are available on the position and size of the meniscus in asymptomatic men and women with normal meniscus integrity...
  43. ncbi Interobserver reproducibility of quantitative meniscus analysis using coronal multiplanar DESS and IWTSE MR imaging
    Kristina Siorpaes
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Magn Reson Med 67:1419-26. 2012
    ..Quantitative meniscus measures from double echo steady state and intermediately-weighted turbo spin-echo were highly correlated (r = 0.71 to 0.99 for the medial meniscus)...
  44. ncbi Bone strength at clinically relevant sites displays substantial heterogeneity and is best predicted from site-specific bone densitometry
    Felix Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, , Munich, Germany
    J Bone Miner Res 17:162-71. 2002
    ..These data suggest that mechanical competence in the elderly is governed by strong regional variation, and that its loss in osteoporosis may not represent a strictly systemic process...
  45. ncbi Strength prediction of the distal radius by bone densitometry--evaluation using biomechanical tests
    Felix Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 11, 80336 Munchen, Germany
    Ann Biomed Eng 32:487-503. 2004
    ..The most accurate prediction of distal radius fractures, however, appears to be (patient-specific) microstructural finite element modeling...
  46. ncbi Knee cartilage morphologic characteristics and muscle status of professional weight lifters and sprinters: a magnetic resonance imaging study
    Christian Gratzke
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Am J Sports Med 35:1346-53. 2007
    ..Whereas muscle and bone mass have been shown to strongly depend on mechanical stimulation (loading history), this relationship has not been established for articular cartilage...
  47. ncbi Regional analysis of femorotibial cartilage loss in a subsample from the Osteoarthritis Initiative progression subcohort
    W Wirth
    Chondrometrics GmbH, Ainring, Germany
    Osteoarthritis Cartilage 17:291-7. 2009
    ..Here we analyze regional femorotibial (FT) cartilage thickness changes over 1 year using 3 Tesla MRI. Specifically, we tested whether changes in central subregions exceed those in the total cartilage plates...
  48. ncbi Relationship of 3D meniscal morphology and position with knee pain in subjects with knee osteoarthritis: a pilot study
    Andrea Wenger
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University PMU, Strubergasse 21, A5020 Salzburg, Austria
    Eur Radiol 22:211-20. 2012
    ..To explore whether quantitative, three-dimensional measurements of meniscal position and size are associated with knee pain using a within-person, between-knee study design...
  49. ncbi Quantitative MR imaging of cartilage and trabecular bone in osteoarthritis
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Strubergasse 21, A5020 Salzburg, Austria
    Radiol Clin North Am 47:655-73. 2009
    ....
  50. ncbi The role of fabric in the quasi-static compressive mechanical properties of human trabecular bone from various anatomical locations
    Maiko Matsuura
    Institute of Anatomy, Ludwig Maximillians University Munich, Pettenkoferstrasse 11, 80336 Munich, Germany
    Biomech Model Mechanobiol 7:27-42. 2008
    ....
  51. ncbi Functional adaptation of human joints to mechanical stimuli
    F Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 11, 80336 Munchen, Germany
    Osteoarthritis Cartilage 10:44-50. 2002
    ..This study tests the hypothesis that functional adaptation occurs in human joints, and that substantial differences in joint 'loading history' explain the phenotypic variability observed in human cartilage morphology...
  52. ncbi Can geometry-based parameters from pQCT and material parameters from quantitative ultrasound (QUS) improve the prediction of radial bone strength over that by bone mass (DXA)?
    M Hudelmaier
    Musculoskeletal Research Group, Institute of Anatomy, LMU Munchen, Pettenkoferstrasse 11, 80336, Munich, Germany
    Osteoporos Int 15:375-81. 2004
    ..pQCT and QUS parameters provided no significant improvement versus DXA alone. Measurement of bone mass by DXA or pQCT thus appears to be sufficient as a surrogate of mechanical strength and fracture risk of the distal radius...
  53. ncbi Measuring cartilage morphology with quantitative magnetic resonance imaging
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University Salzburg, Salzburg, Austria
    Semin Musculoskelet Radiol 8:329-53. 2004
    ..This renders these techniques powerful and promising tools for cartilage and osteoarthritis research...
  54. ncbi Quantitative cartilage imaging of the human hind foot: precision and inter-subject variability
    Dina Al-Ali
    Musculoskeletal Research Group, Institute of Anatomy, , , Germany
    J Orthop Res 20:249-56. 2002
    ....
  55. ncbi Correlation between single-slice muscle anatomical cross-sectional area and muscle volume in thigh extensors, flexors and adductors of perimenopausal women
    S Cotofana
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University, Strubergasse 21, 5020 Salzburg, Austria
    Eur J Appl Physiol 110:91-7. 2010
    ....
  56. ncbi Presence, location, type and size of denuded areas of subchondral bone in the knee as a function of radiographic stage of OA - data from the OA initiative
    R B Frobell
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 18:668-76. 2010
    ..To assess the presence, location, type and size of denuded areas of subchondral bone (dAB) in the femorotibial joint, measured quantitatively with 3T MRI, in a large subset of OAI participants...
  57. ncbi In vivo cartilage deformation after different types of activity and its dependence on physical training status
    F Eckstein
    Institut für Anatomie und Muskuloskelettale Forschung, Paracelsus Medizinische Privatuniversitat, Strubergasse 21, A 5020 Salzburg, Austria
    Ann Rheum Dis 64:291-5. 2005
    ..Knowledge of the deformational behaviour of articular cartilage in vivo is required to understand the pathogenesis of osteoarthritis and the mechanical target environment of prospective cartilage transplant recipients...
  58. ncbi A technique for 3D in vivo quantification of proton density and magnetization transfer coefficients of knee joint cartilage
    J Hohe
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 11, D 80336 MUnchen, Germany
    Osteoarthritis Cartilage 8:426-33. 2000
    ..To develop an MR-based method for the in vivo evaluation of the structural composition of articular cartilage...
  59. ncbi Sensitivity to change of cartilage morphometry using coronal FLASH, sagittal DESS, and coronal MPR DESS protocols--comparative data from the Osteoarthritis Initiative (OAI)
    W Wirth
    Chondrometrics GmbH, Ainring, Germany
    Osteoarthritis Cartilage 18:547-54. 2010
    ..We therefore directly compared the sensitivity to cartilage thickness changes and the correlation of these protocols longitudinally...
  60. ncbi Gender differences in trabecular bone architecture of the distal radius assessed with magnetic resonance imaging and implications for mechanical competence
    Martin Hudelmaier
    Institute of Anatomy and Muskuloskeletal Research, Paracelsus Medical Private University, Strubergasse 21, 5020 Salzburg, Austria
    Osteoporos Int 16:1124-33. 2005
    ..These findings imply that it should be of clinical interest to monitor both bone mass and trabecular microstructure for predicting osteoporotic fracture risk...
  61. ncbi Effects of joint unloading and reloading on human cartilage morphology and function, muscle cross-sectional areas, and bone density - a quantitative case report
    M Hudelmaier
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical Private University, Salzburg, Austria
    J Musculoskelet Neuronal Interact 6:284-90. 2006
    ..These preliminary results indicate that human cartilage macro-morphology may be less adaptive to variations of the mechanical loading than muscle and bone...
  62. ncbi Comparison of 1-year vs 2-year change in regional cartilage thickness in osteoarthritis results from 346 participants from the Osteoarthritis Initiative
    W Wirth
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 19:74-83. 2011
    ..To compare femorotibial cartilage thickness changes over a 2- vs a 1-year observation period in knees with radiographic knee osteoarthritis (OA)...
  63. ncbi Femorotibial cartilage morphology: reproducibility of different metrics and femoral regions, and sensitivity to change in disease
    M Hudelmaier
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Cells Tissues Organs 192:340-50. 2010
    ..35). The long femoral cartilage ROI provided more reproducible measurements than the short one. VCtAB and ThCtAB.Me may be preferable metrics in longitudinal studies of articular cartilage adaptation or OA...
  64. ncbi The effects of exercise on human articular cartilage
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University PMU, Salzburg, Austria
    J Anat 208:491-512. 2006
    ..Potential reasons for the inability of cartilage to adapt to mechanical stimuli include a lack of evolutionary pressure and a decoupling of mechanical competence and tissue mass...
  65. ncbi Surface size, curvature analysis, and assessment of knee joint incongruity with MRI in vivo
    Jan Hohe
    Musculoskeletal Research Group, Institute of Anatomy, , , Germany
    Magn Reson Med 47:554-61. 2002
    ..7 m(-1)) and lowest in the medial femorotibial joint (28.6 m(-1)). This technique will permit identification of the specific role of surface size, curvature, and incongruity as potential risk factors for osteoarthritis...
  66. ncbi Noninvasive study of human cartilage structure by MRI
    Felix Eckstein
    Institute of Anatomy, Paracelsus Medical Private University, Salzburg, Austria
    Methods Mol Med 101:191-217. 2004
    ....
  67. ncbi Long-term and resegmentation precision of quantitative cartilage MR imaging (qMRI)
    F Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 11, D 80336 MUnchen, Germany
    Osteoarthritis Cartilage 10:922-8. 2002
    ..The aim of this study was to analyse the long term and resegmentation precision of quantitative cartilage analysis with magnetic resonance imaging (qMRI) in vivo, and to relate precision errors to the estimated cartilage loss in OA...
  68. ncbi Effects of exercise intervention on knee morphology in middle-aged women: a longitudinal analysis using magnetic resonance imaging
    S Cotofana
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria sebastian cotofana pmu ac at
    Cells Tissues Organs 192:64-72. 2010
    ....
  69. ncbi Quantitative relationships of normal cartilage volumes of the human knee joint--assessment by magnetic resonance imaging
    F Eckstein
    Anatomische Anstalt, Ludwig Maximilians Universitat, Munchen, Germany
    Anat Embryol (Berl) 197:383-90. 1998
    ..The study shows that a wide variation of cartilage volumes exists in the knee joints of normal adults. To reduce the variability between individuals, the cartilage volumes may be normalised to the head of the tibial diameter...
  70. ncbi Mechanical strength of the thoracolumbar spine in the elderly: prediction from in situ dual-energy X-ray absorptiometry, quantitative computed tomography (QCT), upper and lower limb peripheral QCT, and quantitative ultrasound
    E M Lochmüller
    Frauenklinik Innenstadt, Ludwig Maximilians Universität LMU, Munchen, Germany
    Bone 31:77-84. 2002
    ..These experimental results advocate site-specific assessment of vertebral strength by either spinal DXA or QCT...
  71. ncbi Effect of gradient and section orientation on quantitative analysis of knee joint cartilage
    F Eckstein
    Institute of Anatomy, Ludwig Maximilians Universitat, Munchen, Germany
    J Magn Reson Imaging 11:161-7. 2000
    ..Whereas no significant systematic deviation between magnetic resonance imaging (MRI) and CT arthrography was recorded in the patella, there was a 10%-15% underestimation of tibial cartilage thickness in MRI...
  72. ncbi Mechanical strength of the proximal femur as predicted from geometric and densitometric bone properties at the lower limb versus the distal radius
    E M Lochmüller
    Universitätsfrauenklinik Innenstadt der Ludwig Maximilians Universität München, Munchen, Germany
    Bone 30:207-16. 2002
    ..those at the distal radius...
  73. ncbi Comparison between different implementations of the 3D FLASH sequence for knee cartilage quantification
    Martin Hudelmaier
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    MAGMA 25:305-12. 2012
    ..To compare several sequence implementations of the 3D FLASH sequence in the context of quantitative cartilage imaging...
  74. ncbi Effect of exercise intervention on thigh muscle volume and anatomical cross-sectional areas--quantitative assessment using MRI
    Martin Hudelmaier
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Magn Reson Med 64:1713-20. 2010
    ..The study shows that MRI can be used to monitor location-specific effects of exercise intervention on muscle cross-sectional areas, with the proximal aspect of the thigh muscles being most responsive...
  75. ncbi Correlation of thoracic and lumbar vertebral failure loads with in situ vs. ex situ dual energy X-ray absorptiometry
    D Burklein
    Frauenklinik der Ludwig Maximilians Universität München, Innenstadt, Maistr 11, D 80337, Munchen, Germany
    J Biomech 34:579-87. 2001
    ..Because of the high incidence of fractures in the thoracic spine, these findings suggest that, clinically, lateral DXA involves no relevant advantage over anterior-posterior measurements of the lumbar spine...
  76. ncbi Technical considerations for microstructural analysis of human trabecular bone from specimens excised from various skeletal sites
    E Nagele
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 11, D 80336 MUnchen, Germany
    Calcif Tissue Int 75:15-22. 2004
    ....
  77. ncbi Side differences of knee joint cartilage volume, thickness, and surface area, and correlation with lower limb dominance--an MRI-based study
    F Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 11, 80336 Munchen, Germany
    Osteoarthritis Cartilage 10:914-21. 2002
    ..To test the hypotheses that absolute side differences in knee joint cartilage morphology are substantially smaller than intersubject variability, and that systematic side differences are determined by (force) dominance of the lower limbs...
  78. ncbi Determination of 3D cartilage thickness data from MR imaging: computational method and reproducibility in the living
    T Stammberger
    Institut fur Radiologische Diagnostik, Klinikum Grosshadern, Munchen, Germany
    Magn Reson Med 41:529-36. 1999
    ..1-7.9%, and that of the thickness distribution 2.3-6.1%. The method presented allows for noninvasive analysis of 3D cartilage thickness from MR images in biomechanical and clinical investigations...
  79. ncbi Quantitative cartilage imaging in knee osteoarthritis
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Struberga β e 21, 5020 Salzburg, Austria
    Arthritis 2011:475684. 2011
    ....
  80. ncbi Patellar cartilage deformation in vivo after static versus dynamic loading
    F Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 11, D 80336, Munchen, Germany
    J Biomech 33:819-25. 2000
    ....
  81. ncbi Interindividual variability and correlation among morphological parameters of knee joint cartilage plates: analysis with three-dimensional MR imaging
    F Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat, Pettenkoferstr 11, Munich, D 80336, Germany
    Osteoarthritis Cartilage 9:101-11. 2001
    ....
  82. ncbi Quantitative analysis of incongruity, contact areas and cartilage thickness in the human hip joint
    F Eckstein
    Anatomische Anstalt der Ludwig Maximilians Universität, Munchen, Germany
    Acta Anat (Basel) 158:192-204. 1997
    ....
  83. ncbi Body composition, bone mass and microstructural analysis in GH-transgenic mice reveals that skeletal changes are specific to bone compartment and gender
    F Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 11, Germany
    Growth Horm IGF Res 12:116-25. 2002
    ..05). The results show that chronic GH excess affects trabecular bone in a gender-specific manner and that bone changes depend on the compartment investigated...
  84. ncbi Multislice computed tomography of the distal radius metaphysis: relationship of cortical bone structure with gender, age, osteoporotic status, and mechanical competence
    Harald M Bonel
    Institute for Clinical Radiology, , , Germany
    J Clin Densitom 7:169-82. 2004
    ..Further efforts are required to improve spatial resolution for determining metaphyseal cortical properties clinically...
  85. ncbi Quantitative assessment of cartilage status in osteoarthritis by quantitative magnetic resonance imaging: technical validation for use in analysis of cartilage volume and further morphologic parameters
    Heiko Graichen
    University of Frankfurt, Frankfurt, Germany
    Arthritis Rheum 50:811-6. 2004
    ..These parameters may be advantageous over determination of cartilage volume alone when diagnosing OA, exploring its progression, or testing responsiveness to new therapies...
  86. ncbi Inhomogeneous cartilage properties enhance superficial interstitial fluid support and frictional properties, but do not provide a homogeneous state of stress
    Ramaswamy Krishnan
    Columbia University, Department of Mechanical Engineering, 500 West 120th Street, 220 SW Mudd, MC4703, New York, NY 10027, USA
    J Biomech Eng 125:569-77. 2003
    ..Interstitial fluid pressurization, but not a homogeneous elastic stress distribution, appears thus to be a prerequisite for the functional and morphological integrity of the cartilage...
  87. ncbi Insulin-like growth factor-binding protein-2 (IGFBP-2) overexpression negatively regulates bone size and mass, but not density, in the absence and presence of growth hormone/IGF-I excess in transgenic mice
    Felix Eckstein
    Forschungsgruppe Muskuloskelettales System, Anatomische Anstalt, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 11, 80336 Munchen, Germany
    Anat Embryol (Berl) 206:139-48. 2002
    ..Interestingly, elevated IGFBP-2 levels did not lead to a decrease in bone density, suggesting that IGFBP-2 negatively affects bone size and mineral content, but not bone maintenance in adult mice...
  88. ncbi Radius bone strength in bending, compression, and falling and its correlation with clinical densitometry at multiple sites
    Eva Maria Lochmüller
    Frauenklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Germany
    J Bone Miner Res 17:1629-38. 2002
    ..Therefore, the noninvasive diagnosis of loss of strength at the distal radius should rely on site-specific measurements with DXA or pQCT and may be the earliest chance to detect individuals at risk of osteoporotic fracture...
  89. ncbi Trabecular bone structure obtained from multislice spiral computed tomography of the calcaneus predicts osteoporotic vertebral deformities
    Priyesh V Patel
    Chicago Medical School, North Chicago, IL, USA
    J Comput Assist Tomogr 29:246-53. 2005
    ....
  90. ncbi Proximal femur specimens: automated 3D trabecular bone mineral density analysis at multidetector CT--correlation with biomechanical strength measurement
    Markus B Huber
    Musculoskeletal and Quantitative Imaging Research, Department of Radiology, University of California, San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94107, USA
    Radiology 247:472-81. 2008
    ....
  91. ncbi A technique for regional analysis of femorotibial cartilage thickness based on quantitative magnetic resonance imaging
    Wolfgang Wirth
    Chondrometrics GmbH, Ulrichshöglerstr 23, 83404 Ainring, Germany
    IEEE Trans Med Imaging 27:737-44. 2008
    ..In longitudinal studies, this technique may substantially enhance the ability of quantitative MRI to monitor structural changes in osteoarthritis at narrow time intervals...
  92. ncbi Relationship of meniscal damage, meniscal extrusion, malalignment, and joint laxity to subsequent cartilage loss in osteoarthritic knees
    Leena Sharma
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 58:1716-26. 2008
    ..The aim of this study was to test whether meniscal damage, meniscal extrusion, malalignment, and laxity each predicted tibiofemoral cartilage loss after controlling for the other factors...
  93. ncbi Imaging in osteoarthritis
    Ali Guermazi
    Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, Third Floor, Boston, MA 02118, USA
    Rheum Dis Clin North Am 34:645-87. 2008
    ..The other modalities discussed in this article are valuable additional techniques indicated on a case-by-case basis...
  94. ncbi Fuzzy logic structure analysis of trabecular bone of the calcaneus to estimate proximal femur fracture load and discriminate subjects with and without vertebral fractures using high-resolution magnetic resonance imaging at 1.5 T and 3 T
    Priyesh V Patel
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    Calcif Tissue Int 81:294-304. 2007
    ..Local femoral measurements are still needed to estimate femoral bone strength. Overall, parameters obtained at 3.0 T performed better than those at 1.5 T...
  95. ncbi Quantitative image analysis: software systems in drug development trials
    Felix Eckstein
    Drug Discov Today 8:922-3. 2003
  96. ncbi Influence of adducting and abducting muscle forces on the subacromial space width
    Stefan Hinterwimmer
    Research Group for Kinematics and Biomechanics, Department of Orthopedic Surgery, University of Frankfurt, Germany
    Med Sci Sports Exerc 35:2055-9. 2003
    ....
  97. ncbi Association of geometric factors and failure load level with the distribution of cervical vs. trochanteric hip fractures
    Pasi Pulkkinen
    Department of Medical Technology, Faculty of Medicine, University of Oulu, Finland
    J Bone Miner Res 21:895-901. 2006
    ..The best predictor of fracture type across all failure loads and in both sexes was the neck-shaft angle...
  98. ncbi Quantitative imaging of musculoskeletal tissue
    Peter Augat
    Biomechanics Laboratory, Trauma Center Murnau, 82418 Murnau, Germany
    Annu Rev Biomed Eng 10:369-90. 2008
    ..Key areas of musculoskeletal disease where quantitative imaging is currently employed are osteoporosis and arthritis...
  99. ncbi Trabecular bone structure of the calcaneus: comparison of MR imaging at 3.0 and 1.5 T with micro-CT as the standard of reference
    Catherine M Phan
    Department of Radiology, University of California, San Francisco, 400 Parnassus Ave, A 367, Box 0628, San Francisco, CA 94143-0628, USA
    Radiology 239:488-96. 2006
    ..0 T provided a better measure of the trabecular bone structure than did MR imaging at 1.5 T. There was a trend for better differentiation of donors with from those without osteoporotic vertebral fractures at 3.0 T than at 1.5 T...
  100. ncbi Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element
    Roberto L de Souza
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK
    Bone 37:810-8. 2005
    ....
  101. ncbi Can novel clinical densitometric techniques replace or improve DXA in predicting bone strength in osteoporosis at the hip and other skeletal sites?
    Eva Maria Lochmüller
    Universitatsfrauenklinik, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Bone Miner Res 18:906-12. 2003
    ....