F Eckstein

Summary

Affiliation: Institute of Anatomy and Musculoskeletal Research
Country: Austria

Publications

  1. pmc The effects of exercise on human articular cartilage
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University PMU, Salzburg, Austria
    J Anat 208:491-512. 2006
  2. pmc Comparison of 1-year vs 2-year change in regional cartilage thickness in osteoarthritis results from 346 participants from the Osteoarthritis Initiative
    W Wirth
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 19:74-83. 2011
  3. pmc Two year longitudinal change and test-retest-precision of knee cartilage morphology in a pilot study for the osteoarthritis initiative
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University PMU, Salzburg, Austria
    Osteoarthritis Cartilage 15:1326-32. 2007
  4. doi request reprint Effects of exercise intervention on knee morphology in middle-aged women: a longitudinal analysis using magnetic resonance imaging
    S Cotofana
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria sebastian cotofana pmu ac at
    Cells Tissues Organs 192:64-72. 2010
  5. doi request reprint Tibial coverage, meniscus position, size and damage in knees discordant for joint space narrowing - data from the Osteoarthritis Initiative
    K Bloecker
    Institute for Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 21:419-27. 2013
  6. pmc How do short-term rates of femorotibial cartilage change compare to long-term changes? Four year follow-up data from the osteoarthritis initiative
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 20:1250-7. 2012
  7. pmc Baseline and longitudinal change in isometric muscle strength prior to radiographic progression in osteoarthritic and pre-osteoarthritic knees--data from the Osteoarthritis Initiative
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, A5020 Salzburg, Austria
    Osteoarthritis Cartilage 21:682-90. 2013
  8. doi request reprint Relationship between knee pain and the presence, location, size and phenotype of femorotibial denuded areas of subchondral bone as visualized by MRI
    S Cotofana
    Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 21:1214-22. 2013
  9. doi request reprint Femorotibial cartilage morphology: reproducibility of different metrics and femoral regions, and sensitivity to change in disease
    M Hudelmaier
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Cells Tissues Organs 192:340-50. 2010
  10. pmc Reference values and Z-scores for subregional femorotibial cartilage thickness--results from a large population-based sample (Framingham) and comparison with the non-exposed Osteoarthritis Initiative reference cohort
    F Eckstein
    Paracelsus Medical University and Chondrometrics GmbH, Salzburg, Austria
    Osteoarthritis Cartilage 18:1275-83. 2010

Detail Information

Publications70

  1. pmc The effects of exercise on human articular cartilage
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University PMU, Salzburg, Austria
    J Anat 208:491-512. 2006
    ..Potential reasons for the inability of cartilage to adapt to mechanical stimuli include a lack of evolutionary pressure and a decoupling of mechanical competence and tissue mass...
  2. pmc Comparison of 1-year vs 2-year change in regional cartilage thickness in osteoarthritis results from 346 participants from the Osteoarthritis Initiative
    W Wirth
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 19:74-83. 2011
    ..To compare femorotibial cartilage thickness changes over a 2- vs a 1-year observation period in knees with radiographic knee osteoarthritis (OA)...
  3. pmc Two year longitudinal change and test-retest-precision of knee cartilage morphology in a pilot study for the osteoarthritis initiative
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University PMU, Salzburg, Austria
    Osteoarthritis Cartilage 15:1326-32. 2007
    ..In this pilot study for the osteoarthritis (OA) initiative we compare their test-retest-precision and sensitivity to longitudinal change...
  4. doi request reprint Effects of exercise intervention on knee morphology in middle-aged women: a longitudinal analysis using magnetic resonance imaging
    S Cotofana
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria sebastian cotofana pmu ac at
    Cells Tissues Organs 192:64-72. 2010
    ....
  5. doi request reprint Tibial coverage, meniscus position, size and damage in knees discordant for joint space narrowing - data from the Osteoarthritis Initiative
    K Bloecker
    Institute for Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 21:419-27. 2013
    ..We therefore compared quantitative and semi-quantitative measures of meniscus position and morphology in individuals with bilateral painful knees discordant on medial joint space narrowing (mJSN)...
  6. pmc How do short-term rates of femorotibial cartilage change compare to long-term changes? Four year follow-up data from the osteoarthritis initiative
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 20:1250-7. 2012
    ..To compare unbiased estimates of short- vs long-term cartilage loss in osteoarthritic knees...
  7. pmc Baseline and longitudinal change in isometric muscle strength prior to radiographic progression in osteoarthritic and pre-osteoarthritic knees--data from the Osteoarthritis Initiative
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, A5020 Salzburg, Austria
    Osteoarthritis Cartilage 21:682-90. 2013
    ....
  8. doi request reprint Relationship between knee pain and the presence, location, size and phenotype of femorotibial denuded areas of subchondral bone as visualized by MRI
    S Cotofana
    Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 21:1214-22. 2013
    ..A relation between pain and denuded areas of subchondral bone (dABs) has been suggested and this study explores this relationship further by relating the presence, phenotype, location and size of dABs to different measures of knee pain...
  9. doi request reprint Femorotibial cartilage morphology: reproducibility of different metrics and femoral regions, and sensitivity to change in disease
    M Hudelmaier
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Cells Tissues Organs 192:340-50. 2010
    ..35). The long femoral cartilage ROI provided more reproducible measurements than the short one. VCtAB and ThCtAB.Me may be preferable metrics in longitudinal studies of articular cartilage adaptation or OA...
  10. pmc Reference values and Z-scores for subregional femorotibial cartilage thickness--results from a large population-based sample (Framingham) and comparison with the non-exposed Osteoarthritis Initiative reference cohort
    F Eckstein
    Paracelsus Medical University and Chondrometrics GmbH, Salzburg, Austria
    Osteoarthritis Cartilage 18:1275-83. 2010
    ..To establish sex-specific (subregional) reference values of cartilage thickness and potential maximal Z-scores in the femorotibial joint...
  11. pmc Side differences of thigh muscle cross-sectional areas and maximal isometric muscle force in bilateral knees with the same radiographic disease stage, but unilateral frequent pain - data from the osteoarthritis initiative
    M Sattler
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 20:532-40. 2012
    ....
  12. pmc One year change of knee cartilage morphology in the first release of participants from the Osteoarthritis Initiative progression subcohort: association with sex, body mass index, symptoms and radiographic osteoarthritis status
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, PMU, Salzburg, Austria
    Ann Rheum Dis 68:674-9. 2009
    ..Here cartilage loss using 3 Tesla (3 T) MRI is analysed over 1 year in a subset of the OAI, together with its association with various risk factors...
  13. doi request reprint Lateral and medial joint space narrowing predict subsequent cartilage loss in the narrowed, but not in the non-narrowed femorotibial compartment - data from the Osteoarthritis Initiative
    W Wirth
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria Chondrometrics GmbH, Ainring, Germany Electronic address
    Osteoarthritis Cartilage 22:63-70. 2014
    ..To determine the predictive value of unicompartimental joint space narrowing (JSN) for MRI-based cartilage thickness loss in the narrowed and the non-narrowed femorotibial compartment...
  14. pmc Direct comparison of fixed flexion, radiography and MRI in knee osteoarthritis: responsiveness data from the Osteoarthritis Initiative
    W Wirth
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 21:117-25. 2013
    ..We directly compare the responsiveness of magnetic resonance imaging (MRI)-based cartilage thickness and JSW measures from fixed-flexion radiography (FFR) and explore the correlation of region-matched changes between both methods...
  15. pmc Presence, location, type and size of denuded areas of subchondral bone in the knee as a function of radiographic stage of OA - data from the OA initiative
    R B Frobell
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 18:668-76. 2010
    ..To assess the presence, location, type and size of denuded areas of subchondral bone (dAB) in the femorotibial joint, measured quantitatively with 3T MRI, in a large subset of OAI participants...
  16. ncbi request reprint Effects of joint unloading and reloading on human cartilage morphology and function, muscle cross-sectional areas, and bone density - a quantitative case report
    M Hudelmaier
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical Private University, Salzburg, Austria
    J Musculoskelet Neuronal Interact 6:284-90. 2006
    ..These preliminary results indicate that human cartilage macro-morphology may be less adaptive to variations of the mechanical loading than muscle and bone...
  17. ncbi request reprint Proposal for a nomenclature for magnetic resonance imaging based measures of articular cartilage in osteoarthritis
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University, Salzburg, Austria
    Osteoarthritis Cartilage 14:974-83. 2006
    ....
  18. doi request reprint Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis
    F Eckstein
    Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria
    Ann Rheum Dis 70:1223-30. 2011
    ..To examine the relationship of baseline clinical, radiographic, molecular and MRI measures with structural progression (subregional MRI-based femorotibial cartilage loss) in knee osteoarthritis (OA)...
  19. pmc Correlation and sex differences between ankle and knee cartilage morphology determined by quantitative magnetic resonance imaging
    F Eckstein
    Institute of Anatomy, Paracelsus Medizinische Privatuniversitat, A5020 Salzburg, Austria
    Ann Rheum Dis 63:1490-5. 2004
    ....
  20. ncbi request reprint Gender differences in trabecular bone architecture of the distal radius assessed with magnetic resonance imaging and implications for mechanical competence
    Martin Hudelmaier
    Institute of Anatomy and Muskuloskeletal Research, Paracelsus Medical Private University, Strubergasse 21, 5020 Salzburg, Austria
    Osteoporos Int 16:1124-33. 2005
    ..These findings imply that it should be of clinical interest to monitor both bone mass and trabecular microstructure for predicting osteoporotic fracture risk...
  21. doi request reprint Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multicentre clinical trial
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, PMU, Strubergasse 21, A5020 Salzburg Austria
    Ann Rheum Dis 67:1683-8. 2008
    ..0 Tesla (T) are more reproducible (precise) than those at 1.5 T. Precision errors and stability in multicentre studies with imaging equipment from various vendors have, however, not yet been evaluated...
  22. pmc Magnitude and regional distribution of cartilage loss associated with grades of joint space narrowing in radiographic osteoarthritis--data from the Osteoarthritis Initiative (OAI)
    F Eckstein
    Institute of Anatomy, PMU Salzburg, Austria
    Osteoarthritis Cartilage 18:760-8. 2010
    ....
  23. pmc Sensitivity to change of cartilage morphometry using coronal FLASH, sagittal DESS, and coronal MPR DESS protocols--comparative data from the Osteoarthritis Initiative (OAI)
    W Wirth
    Chondrometrics GmbH, Ainring, Germany
    Osteoarthritis Cartilage 18:547-54. 2010
    ..We therefore directly compared the sensitivity to cartilage thickness changes and the correlation of these protocols longitudinally...
  24. pmc Morphometric differences between the medial and lateral meniscus in healthy men - a three-dimensional analysis using magnetic resonance imaging
    K Bloecker
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    Cells Tissues Organs 195:353-64. 2012
    ..001) than the medial one. Also, the LM displayed less (physiological) extrusion than the medial one. These data may guide strategies for meniscal tissue engineering and transplantation aiming to restore normal joint conditions...
  25. doi request reprint Correlation between single-slice muscle anatomical cross-sectional area and muscle volume in thigh extensors, flexors and adductors of perimenopausal women
    S Cotofana
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University, Strubergasse 21, 5020 Salzburg, Austria
    Eur J Appl Physiol 110:91-7. 2010
    ....
  26. ncbi request reprint Magnetic resonance imaging (MRI) of articular cartilage in knee osteoarthritis (OA): morphological assessment
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University, Salzburg, Austria and Chondrometrics GmbH, Ainring, Germany
    Osteoarthritis Cartilage 14:A46-75. 2006
    ....
  27. pmc Double echo steady state magnetic resonance imaging of knee articular cartilage at 3 Tesla: a pilot study for the Osteoarthritis Initiative
    F Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University, Strubergasse 21, A5020 Salzburg, Austria
    Ann Rheum Dis 65:433-41. 2006
    ..Quantitative magnetic resonance imaging (qMRI) may provide valuable measures of cartilage morphology in osteoarthritis (OA) but has been confined to sequences with relatively long acquisition times at 1.5 Tesla (T)...
  28. ncbi request reprint MRI protocols for whole-organ assessment of the knee in osteoarthritis
    C G Peterfy
    Synarc Inc, San Francisco, CA 94105, USA
    Osteoarthritis Cartilage 14:A95-111. 2006
    ..The discussion reviews the selection and qualification of imaging sites for clinical trials, designing imaging protocols for whole-organ assessment of OA, and key considerations in image quality (IQ) control and data management...
  29. ncbi request reprint Experimental hip fracture load can be predicted from plain radiography by combined analysis of trabecular bone structure and bone geometry
    P Pulkkinen
    Deparment of Medical Technology, Faculty of Medicine, University of Oulu, P O Box 5000, 90014 Oulu, Finland
    Osteoporos Int 19:547-58. 2008
    ..The study showed that combined analysis of trabecular bone structure and geometry predicts in vitro failure load with similar accuracy as DXA...
  30. ncbi request reprint Accuracy and test-retest precision of quantitative cartilage morphology on a 1.0 T peripheral magnetic resonance imaging system
    D Inglis
    McMaster University, Hamilton, ON, Canada
    Osteoarthritis Cartilage 15:110-5. 2007
    ..5 T whole-body equipment. Here we examine the reproducibility and accuracy of qMRI at 1.0 T by direct comparison with previously validated technology...
  31. ncbi request reprint [Parametric biomedical imaging--what defines the quality of quantitative radiological approaches?]
    C C Gluer
    Medizinische Physik, Klinik für Diagnostische Radiologie, Universitatsklinikum Schleswig Holstein, Kiel
    Rofo 178:1187-201. 2006
    ....
  32. ncbi request reprint Women have thinner cartilage and smaller joint surfaces than men after adjustment for body height and weight
    I G Otterness
    Division of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA
    Osteoarthritis Cartilage 15:666-72. 2007
    ..Here we examine the hypothesis that women have smaller joint surfaces than men, independent of weight and height, and thus encounter higher articular pressures that might contribute to the higher incidence of OA in the female knee...
  33. pmc Premorbid knee osteoarthritis is not characterised by diffuse thinness: the Framingham Osteoarthritis Study
    D J Hunter
    Boston University School of Medicine, Boston, MA, USA
    Ann Rheum Dis 67:1545-9. 2008
    ....
  34. ncbi request reprint Allometric relationships between knee cartilage volume, thickness, surface area and body dimensions
    I G Otterness
    Division of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA
    Osteoarthritis Cartilage 16:34-40. 2008
    ..To determine if anthropometric factors obtainable on routine examination can be used to estimate premorbid knee total subchondral bone area (tAB), cartilage surface area (AC), cartilage thickness (ThC), and cartilage volume (VC)...
  35. ncbi request reprint Structural analysis of trabecular bone of the proximal femur using multislice computed tomography: a comparison with dual X-ray absorptiometry for predicting biomechanical strength in vitro
    J S Bauer
    Musculoskeletal and Quantitative Imaging Research, Department of Radiology, University of California, San Francisco, CA, USA
    Calcif Tissue Int 78:78-89. 2006
    ..Male donors had larger femora even after adjustment for body size and height, but no differences in trabecular structure were found between males and females...
  36. ncbi request reprint Quantitative image analysis of the cartilage in Virtual Reality
    K H Englmeier
    GSF National Research Center for Environment and Health, Institute for Medical Informatics and Health System Research, Ingolstaedter Landstr 1, 85764 Neuherberg, Germany
    Stud Health Technol Inform 85:141-3. 2002
    ..In biomechanics, the thickness distribution serves to analyse the functional adaptation or the compression of the cartilage under loading and may be used for numerical simulation of load transmission in the joint...
  37. ncbi request reprint Mechanical strength of the thoracolumbar spine in the elderly: prediction from in situ dual-energy X-ray absorptiometry, quantitative computed tomography (QCT), upper and lower limb peripheral QCT, and quantitative ultrasound
    E M Lochmüller
    Frauenklinik Innenstadt, Ludwig Maximilians Universität LMU, Munchen, Germany
    Bone 31:77-84. 2002
    ..These experimental results advocate site-specific assessment of vertebral strength by either spinal DXA or QCT...
  38. ncbi request reprint Age-related changes in the morphology and deformational behavior of knee joint cartilage
    M Hudelmaier
    , Munich, Germany
    Arthritis Rheum 44:2556-61. 2001
    ..We show that under in vivo loading conditions, elderly subjects display a lower level of cartilage deformation than do healthy young subjects...
  39. ncbi request reprint Mechanical strength of the proximal femur as predicted from geometric and densitometric bone properties at the lower limb versus the distal radius
    E M Lochmüller
    Universitätsfrauenklinik Innenstadt der Ludwig Maximilians Universität München, Munchen, Germany
    Bone 30:207-16. 2002
    ..those at the distal radius...
  40. ncbi request reprint Can geometry-based parameters from pQCT and material parameters from quantitative ultrasound (QUS) improve the prediction of radial bone strength over that by bone mass (DXA)?
    M Hudelmaier
    Musculoskeletal Research Group, Institute of Anatomy, LMU Munchen, Pettenkoferstrasse 11, 80336, Munich, Germany
    Osteoporos Int 15:375-81. 2004
    ..pQCT and QUS parameters provided no significant improvement versus DXA alone. Measurement of bone mass by DXA or pQCT thus appears to be sufficient as a surrogate of mechanical strength and fracture risk of the distal radius...
  41. ncbi request reprint Functional adaptation of human joints to mechanical stimuli
    F Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 11, 80336 Munchen, Germany
    Osteoarthritis Cartilage 10:44-50. 2002
    ..This study tests the hypothesis that functional adaptation occurs in human joints, and that substantial differences in joint 'loading history' explain the phenotypic variability observed in human cartilage morphology...
  42. ncbi request reprint Trabecular bone tissue strains in the healthy and osteoporotic human femur
    B van Rietbergen
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    J Bone Miner Res 18:1781-8. 2003
    ..We made microfinite element models of a healthy and osteoporotic human femur and found that tissue-level strains in the osteoporotic femoral head were 70% higher on average and less uniformly distributed than those in the healthy one...
  43. ncbi request reprint Long-term and resegmentation precision of quantitative cartilage MR imaging (qMRI)
    F Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 11, D 80336 MUnchen, Germany
    Osteoarthritis Cartilage 10:922-8. 2002
    ..The aim of this study was to analyse the long term and resegmentation precision of quantitative cartilage analysis with magnetic resonance imaging (qMRI) in vivo, and to relate precision errors to the estimated cartilage loss in OA...
  44. ncbi request reprint Side differences of knee joint cartilage volume, thickness, and surface area, and correlation with lower limb dominance--an MRI-based study
    F Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 11, 80336 Munchen, Germany
    Osteoarthritis Cartilage 10:914-21. 2002
    ..To test the hypotheses that absolute side differences in knee joint cartilage morphology are substantially smaller than intersubject variability, and that systematic side differences are determined by (force) dominance of the lower limbs...
  45. ncbi request reprint [Quantitative cartilage analysis with magnetic resonance tomography (qMRI)--a new era in arthrosis diagnosis?]
    F Eckstein
    Forschungsgruppe Muskuloskelettales System Anatomische Anstalt Ludwig Maximilians Universität München Pettenkoferstr 11, 80336 Munchen, Germany
    Z Rheumatol 61:250-9. 2002
    ..It addition, we present approaches for quantitative analyses of structural/biochemical parameters and for the deformational behavior of cartilage in vivo...
  46. ncbi request reprint Femoro-tibial and menisco-tibial translation patterns in patients with unilateral anterior cruciate ligament deficiency--a potential cause of secondary meniscal tears
    R von Eisenhart-Rothe
    Research Group for Kinematics and Biomechanics, Department of Orthopedic Surgery, University of Frankfurt, Marienburgstr 2, 60528 Frankfurt, Germany
    J Orthop Res 22:275-82. 2004
    ..To analyze menisco-tibial and femoro-tibial translation patterns in healthy and ACL-deficient knees in different knee flexion angles under muscle activity...
  47. ncbi request reprint Technical considerations for microstructural analysis of human trabecular bone from specimens excised from various skeletal sites
    E Nagele
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 11, D 80336 MUnchen, Germany
    Calcif Tissue Int 75:15-22. 2004
    ....
  48. ncbi request reprint [Multislice-CT for structure analysis of trabecular bone - a comparison with micro-CT and biomechanical strength]
    J S Bauer
    Institut für Röntgendiagnostik der Technischen Universität München
    Rofo 176:709-18. 2004
    ..The purpose of this study was to investigate, if the higher spatial resolution of the MS-CT has advantages for structural analyses in the assessment of osteoporosis...
  49. pmc Femorotibial and patellar cartilage loss in patients prior to total knee arthroplasty, heterogeneity, and correlation with alignment of the knee
    R von Eisenhart-Rothe
    Department of Orthopaedics, University of Frankfurt, Germany
    Ann Rheum Dis 65:69-73. 2006
    ..To analyse tibial, femoral, and patellar cartilage loss in patients prior to total knee arthroplasty (TKA), and its correlation with alignment of the knee...
  50. pmc In vivo cartilage deformation after different types of activity and its dependence on physical training status
    F Eckstein
    Institut für Anatomie und Muskuloskelettale Forschung, Paracelsus Medizinische Privatuniversitat, Strubergasse 21, A 5020 Salzburg, Austria
    Ann Rheum Dis 64:291-5. 2005
    ..Knowledge of the deformational behaviour of articular cartilage in vivo is required to understand the pathogenesis of osteoarthritis and the mechanical target environment of prospective cartilage transplant recipients...
  51. ncbi request reprint Knee cartilage of spinal cord-injured patients displays progressive thinning in the absence of normal joint loading and movement
    B Vanwanseele
    Swiss Federal Institute of Technology, Zurich, Switzerland, Catholic University Leuven, Leuven, Belgium
    Arthritis Rheum 46:2073-8. 2002
    ..However, the findings have been inconsistent and it is unclear whether such changes also take place in humans. This study tested the hypothesis that progressive thinning of knee joint cartilage is observed after spinal cord injury...
  52. pmc Accuracy of quantitative magnetic resonance imaging in the detection of ex vivo focal cartilage defects
    H Graichen
    Research Group for Kinematics and Biomechanics, Orthopedic Department, University of Frankfurt, Marienburgstr 2, 60528 Frankfurt, Germany
    Ann Rheum Dis 64:1120-5. 2005
    ..No established, non-invasive diagnostic procedure for quantifying focal cartilage defects is currently available...
  53. ncbi request reprint Use of novel interactive input devices for segmentation of articular cartilage from magnetic resonance images
    E J McWalter
    Department of Mechanical Engineering, University of British Columbia, Vancouver, Canada
    Osteoarthritis Cartilage 13:48-53. 2005
    ..To study the effect of new interactive computer input devices on cartilage segmentation in terms of time, consistency between input devices, and precision in quantitative magnetic resonance imaging (qMRI)...
  54. ncbi request reprint Gender differences in knee joint cartilage thickness, volume and articular surface areas: assessment with quantitative three-dimensional MR imaging
    S C Faber
    Department of Clinical Radiology, Klinikum, University of Munich, Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    Skeletal Radiol 30:144-50. 2001
    ..Differences in cartilage volume are primarily due to differences in joint surface areas (epiphyseal bone size), not to differences in cartilage thickness...
  55. ncbi request reprint Image-based micro-finite-element modeling for improved distal radius strength diagnosis: moving from bench to bedside
    W Pistoia
    Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology ETH, Moussonstrasse 18, CH 8044 Zurich, Switzerland
    J Clin Densitom 7:153-60. 2004
    ..48, p < 0.001) and microstructural parameters (R2 = 0.47, p < 0.001). Hence, even when only a small region is modeled, micro-FE analysis provides an improved prediction of radius strength...
  56. ncbi request reprint Correlation of thoracic and lumbar vertebral failure loads with in situ vs. ex situ dual energy X-ray absorptiometry
    D Burklein
    Frauenklinik der Ludwig Maximilians Universität München, Innenstadt, Maistr 11, D 80337, Munchen, Germany
    J Biomech 34:579-87. 2001
    ..Because of the high incidence of fractures in the thoracic spine, these findings suggest that, clinically, lateral DXA involves no relevant advantage over anterior-posterior measurements of the lumbar spine...
  57. ncbi request reprint Body composition, bone mass and microstructural analysis in GH-transgenic mice reveals that skeletal changes are specific to bone compartment and gender
    F Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 11, Germany
    Growth Horm IGF Res 12:116-25. 2002
    ..05). The results show that chronic GH excess affects trabecular bone in a gender-specific manner and that bone changes depend on the compartment investigated...
  58. ncbi request reprint Effect of fixation, soft-tissues, and scan projection on bone mineral measurements with dual energy X-ray absorptiometry (DXA)
    E M Lochmüller
    Frauenklinik der Ludwig Maximilians Universität München, Innenstadt, Maistr 11, D 80337 München, Germany
    Calcif Tissue Int 68:140-5. 2001
    ..There were large deviations from linearity between in situ AP and ex situ lateral spinal scans with r2 values of 0.63 and 0.73 for BMD and BMC (SEE% = 52% and 27% relative to the vertebral body), respectively...
  59. ncbi request reprint Magnetic resonance imaging-based assessment of cartilage loss in severe osteoarthritis: accuracy, precision, and diagnostic value
    R Burgkart
    , , Germany
    Arthritis Rheum 44:2072-7. 2001
    ..CONCLUSION: Noninvasive quantitative MRI-based analysis of cartilage morphometry in severe OA is accurate, precise, and displays high potential diagnostic value...
  60. ncbi request reprint Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images
    W Pistoia
    Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology ETH, Zurich, Switzerland
    Bone 30:842-8. 2002
    ..001). We conclude that application of the techniques investigated here can lead to a better prediction of the bone failure load for bone in vivo than is possible from DXA measurements, structural parameters, or a combination thereof...
  61. ncbi request reprint Impact of bone density on distal radius fracture patterns and comparison between five different fracture classifications
    C A Lill
    AO Research Institute, Davos, Switzerland
    J Orthop Trauma 17:271-8. 2003
    ..To investigate the impact of bone mineral density (BMD) and bone geometry on failure loads and fracture patterns of the distal radius and to compare 5 different fracture classifications...
  62. ncbi request reprint Effect of abducting and adducting muscle activity on glenohumeral translation, scapular kinematics and subacromial space width in vivo
    H Graichen
    Research Group for Kinematics and Biomechanics, Department of Orthopedic Surgery, University of Frankfurt, Marienburgstr 2, 60528 Frankfurt, Germany
    J Biomech 38:755-60. 2005
    ..This effect may be employed for conservative treatment of the impingement syndrome...
  63. ncbi request reprint Cartilage atrophy in the knees of patients after seven weeks of partial load bearing
    S Hinterwimmer
    Ludwig Maximilians Universitat Munchen, Munich, Germany
    Arthritis Rheum 50:2516-20. 2004
    ..We used a post-ankle fracture model to explore whether changes in cartilage morphology occur in the knee under conditions of partial load bearing...
  64. ncbi request reprint In vivo precision of quantitative shoulder cartilage measurements, and changes after spinal cord injury
    B Vanwanseele
    Laboratory for Biomechanics, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Magn Reson Med 51:1026-30. 2004
    ..It was demonstrated that, in contrast to the knee, the articular cartilage morphology of the humeral head changes very little (i.e., there is no significant increase or decrease in thickness) after spinal cord injury (SCI)...
  65. ncbi request reprint The osteoporotic vertebral structure is well adapted to the loads of daily life, but not to infrequent "error" loads
    J Homminga
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Bone 34:510-6. 2004
    ..If future clinical imaging techniques would enable such high-resolution images to be obtained in vivo, the combination of microCT and microFEA would produce a powerful tool to diagnose osteoporosis...
  66. ncbi request reprint Does thoracic or lumbar spine bone architecture predict vertebral failure strength more accurately than density?
    E M Lochmüller
    Department of Gynecology I, LMU Munich, Munich, Germany
    Osteoporos Int 19:537-45. 2008
    ..Microstructural parameters at the locations examined provided only marginal additional information to quantitative computed tomography in predicting experimental failure strength...
  67. ncbi request reprint Longitudinal analysis of cartilage atrophy in the knees of patients with spinal cord injury
    B Vanwanseele
    Swiss Federal Institute of Technology, Zurich, Switzerland
    Arthritis Rheum 48:3377-81. 2003
    ..The aim of this study was to perform a longitudinal analysis of cartilage atrophy in all knee compartments, including the femoral condyles, in SCI patients over 12 months...
  68. ncbi request reprint Feasibility of T and Z scores from magnetic resonance imaging data for quantification of cartilage loss in osteoarthritis
    R Burgkart
    Technische Universitat Munchen, Munich, Germany
    Arthritis Rheum 48:2829-35. 2003
    ..We tested the feasibility of using T and Z scores derived from quantitative cartilage imaging with magnetic resonance imaging (MRI) for the diagnosis of osteoarthritis (OA)...
  69. ncbi request reprint Validation of cartilage volume and thickness measurements in the human shoulder with quantitative magnetic resonance imaging
    H Graichen
    Research Group for Kinematics and Biomechanics, Department of Orthopedic Surgery, University of Frankfurt, Marienburgstrasse 2, 60528, Frankfurt, Germany
    Osteoarthritis Cartilage 11:475-82. 2003
    ..To validate quantitative magnetic resonance imaging (qMRI) for the assessment of cartilage volume and thickness in thin and curved cartilage layers, such as the shoulder...
  70. ncbi request reprint Detection of osteoporotic vertebral fractures using multidetector CT
    J S Bauer
    Department of Radiology, University of California of San Francisco, CA, USA
    Osteoporos Int 17:608-15. 2006
    ....