Affiliation: Institute of Anatomy and Musculoskeletal Research
Michael J, Marschallinger J, Aigner L. The leukotriene signaling pathway: a druggable target in Alzheimer's disease. Drug Discov Today. 2018;: pubmed publisher
..Here, we review the current literature on the leukotriene signaling pathway as a target for drug development in AD. ..
Unger M, Schernthaner P, Marschallinger J, Mrowetz H, Aigner L. Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice. J Neuroinflammation. 2018;15:274 pubmed publisher
..Investigating the role of peripheral immune cells, their interaction with microglia, and understanding the link between innate and adaptive immune responses in the brain might be a future directive in treating AD pathology. ..
Unger M, Marschallinger J, Kaindl J, Klein B, Johnson M, Khundakar A, et al
. Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-? plaques: A potential role in shaping plaque pathology?. Alzheimers Dement. 2018;14:1022-1037 pubmed publisher
..Peculiarly, the DCX+/ionized calcium-binding adapter molecule 1+ microglia and DCX+/CD8+ T-cells were closely attached, suggesting that these two cell types are tightly interacting and that this interaction might shape plaque pathology. ..
Marschallinger J, Sah A, Schmuckermair C, Unger M, Rotheneichner P, Kharitonova M, et al
. The L-type calcium channel Cav1.3 is required for proper hippocampal neurogenesis and cognitive functions. Cell Calcium. 2015;58:606-16 pubmed publisher
..Thus, modulation of LTCC activities may have a crucial impact on neurogenic responses and cognition, which should be considered for future therapeutic administration of LTCCs modulators. ..
Unger M, Marschallinger J, Kaindl J, HÃ¶fling C, Rossner S, Heneka M, et al
. Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer's Disease. Mol Neurobiol. 2016;53:5796-806 pubmed publisher
..In summary, changes in neurogenesis are evident already before plaque deposition and might contribute to well-known early hippocampal dysfunctions in prodromal AD such as hippocampal overactivity. ..
Marschallinger J, Krampert M, Couillard Despres S, Heuchel R, Bogdahn U, Aigner L. Age-dependent and differential effects of Smad7?Ex1 on neural progenitor cell proliferation and on neurogenesis. Exp Gerontol. 2014;57:149-54 pubmed publisher