Gregor K Wenning

Summary

Affiliation: Innsbruck Medical University
Country: Austria

Publications

  1. doi request reprint Multiple system atrophy
    Gregor K Wenning
    Division of Clinical Neurobiology, Department of Neurology, Medical University, Innsbruck, Austria Electronic address
    Handb Clin Neurol 117:229-41. 2013
  2. pmc An antibody microarray analysis of serum cytokines in neurodegenerative Parkinsonian syndromes
    Philipp Mahlknecht
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Proteome Sci 10:71. 2012
  3. pmc The natural history of multiple system atrophy: a prospective European cohort study
    Gregor K Wenning
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Lancet Neurol 12:264-74. 2013
  4. doi request reprint Orthostatic hypotension is differentially associated with the cerebellar versus the parkinsonian variant of multiple system atrophy: a comparative study
    Gregor Karl Wenning
    Autonomic Unit, Division of Clinical Neurobiology, Department of Neurology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Cerebellum 11:223-6. 2012
  5. doi request reprint Recent developments in multiple system atrophy
    Gregor K Wenning
    Section of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 256:1791-808. 2009
  6. doi request reprint New insights into atypical parkinsonism
    Gregor K Wenning
    Department of Neurology, Medical University, Innsbruck, Austria
    Curr Opin Neurol 24:331-8. 2011
  7. doi request reprint Milestones in atypical and secondary Parkinsonisms
    Gregor K Wenning
    Division of Clinical Neurobiology, Department of Neurology, Medical University, Innsbruck, Austria
    Mov Disord 26:1083-95. 2011
  8. doi request reprint Multiple system atrophy: a primary oligodendrogliopathy
    Gregor K Wenning
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Ann Neurol 64:239-46. 2008
  9. ncbi request reprint Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 128:1605-12. 2005
  10. ncbi request reprint Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy
    Nadia Stefanova
    Clinical Neurobiology Unit, Neurodegeneration Research Laboratory, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:2196-203. 2007

Detail Information

Publications100

  1. doi request reprint Multiple system atrophy
    Gregor K Wenning
    Division of Clinical Neurobiology, Department of Neurology, Medical University, Innsbruck, Austria Electronic address
    Handb Clin Neurol 117:229-41. 2013
    ..Here we review key aspects of MSA integrating important insights from rapidly emerging fields such as genetics, diagnostic work-up including imaging, and translational therapies aimed at disease modification. ..
  2. pmc An antibody microarray analysis of serum cytokines in neurodegenerative Parkinsonian syndromes
    Philipp Mahlknecht
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Proteome Sci 10:71. 2012
    ..abstract:..
  3. pmc The natural history of multiple system atrophy: a prospective European cohort study
    Gregor K Wenning
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Lancet Neurol 12:264-74. 2013
    ..Here we present the final analysis of a prospective multicentre study by the European MSA Study Group to investigate the natural history of MSA...
  4. doi request reprint Orthostatic hypotension is differentially associated with the cerebellar versus the parkinsonian variant of multiple system atrophy: a comparative study
    Gregor Karl Wenning
    Autonomic Unit, Division of Clinical Neurobiology, Department of Neurology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Cerebellum 11:223-6. 2012
    ..Differences in brainstem pathology are likely to account for the tight association of MSA-C and OH. A simple standing test should be obligatory in the work-up of patients with sporadic late-onset ataxias...
  5. doi request reprint Recent developments in multiple system atrophy
    Gregor K Wenning
    Section of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 256:1791-808. 2009
    ..An outline of the rationale for managing symptomatic deterioration in MSA is provided together with a summary of novel experimental therapeutic approaches to decrease disease progression...
  6. doi request reprint New insights into atypical parkinsonism
    Gregor K Wenning
    Department of Neurology, Medical University, Innsbruck, Austria
    Curr Opin Neurol 24:331-8. 2011
    ..Based on literature published in 2010, we here review recent advances in the APD field...
  7. doi request reprint Milestones in atypical and secondary Parkinsonisms
    Gregor K Wenning
    Division of Clinical Neurobiology, Department of Neurology, Medical University, Innsbruck, Austria
    Mov Disord 26:1083-95. 2011
    ..Early-investigation-assisted clinical diagnosis has become more crucial than ever because disease-modifying therapies will hopefully become available within this decade...
  8. doi request reprint Multiple system atrophy: a primary oligodendrogliopathy
    Gregor K Wenning
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Ann Neurol 64:239-46. 2008
    ..Although these syndromes vary in their respective cause of oligodendrogliopathy, they have in common myelin disruption that is often followed by axonal dysfunction...
  9. ncbi request reprint Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 128:1605-12. 2005
    ..We suggest that the quantification of midbrain DAT signal should be included in the routine clinical analysis of [123I]beta-CIT SPECT in patients with uncertain parkinsonism...
  10. ncbi request reprint Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy
    Nadia Stefanova
    Clinical Neurobiology Unit, Neurodegeneration Research Laboratory, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:2196-203. 2007
    ....
  11. ncbi request reprint Progression of putaminal degeneration in multiple system atrophy: a serial diffusion MR study
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neuroimage 31:240-5. 2006
    ....
  12. ncbi request reprint Cortical atrophy in the cerebellar variant of multiple system atrophy: a voxel-based morphometry study
    Christian Brenneis
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:159-65. 2006
    ..We observed a volume loss shared by both disorders comprising the cerebellum, vermis, pons, mesencephalon, orbitofrontal, mid-frontal, and temporomesial cortex of both hemispheres as well as the left insular cortex...
  13. doi request reprint Striatal transplantation in a rodent model of multiple system atrophy: effects on L-Dopa response
    Martin Köllensperger
    Section for Clinical Neurobiology, Innsbruck Medical University, Innsbruck, Austria
    J Neurosci Res 87:1679-85. 2009
    ..Therefore, striatal transplantation should be further defined preclinically as a possible therapeutic option for patients with MSA-P and a failing L-Dopa response...
  14. ncbi request reprint Diffusion-weighted imaging in Huntington's disease
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:1043-7. 2006
    ..Diffusion-weighted imaging appears to be a promising surrogate marker for disease severity in HD. Sensitivity to change remains to be established longitudinally...
  15. doi request reprint Red flags for multiple system atrophy
    Martin Köllensperger
    Section for Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 23:1093-9. 2008
    ..9 (+/-7.0) months earlier than with the Consensus criteria alone. We propose a combination of two out of six red flag categories as additional diagnostic criteria for probable MSA-P...
  16. doi request reprint Rasagiline is neuroprotective in a transgenic model of multiple system atrophy
    Nadia Stefanova
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Exp Neurol 210:421-7. 2008
    ..5 mg/kg rasagiline. The results of the study indicate that rasagiline confers neuroprotection in a transgenic mouse model of MSA and may therefore be considered a promising disease-modifying candidate for human MSA...
  17. doi request reprint Restless legs syndrome in Parkinson's disease
    Cecilia M Peralta
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 24:2076-80. 2009
    ..7 years). The majority (n = 17, 61%) who scored positive for RLS reported that the urge to move the legs and unpleasant sensations were associated with wearing off, raising the possibility of RLS mimics in fluctuating patients with PD...
  18. ncbi request reprint Evaluation of [123I]IBZM pinhole SPECT for the detection of striatal dopamine D2 receptor availability in rats
    Christoph Scherfler
    Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria
    Neuroimage 24:822-31. 2005
    ..SPECT-MRI-based estimation of regional [123I]IBZM uptake provides a cost effective and widely available in vivo imaging technique for assessing striatal integrity in animal studies...
  19. ncbi request reprint Topography of cerebral monoamine transporter availability in families with SCA2 mutations: a voxel-wise [123I]beta-CIT SPECT analysis
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 33:1084-90. 2006
    ..To this end, nine patients were studied with [(123)I]beta-CIT SPECT...
  20. ncbi request reprint Loss of dopaminergic responsiveness in a double lesion rat model of the Parkinson variant of multiple system atrophy
    Martin Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 22:353-8. 2007
    ..593; P = 0.01) in the stepping test. These findings contribute further to the behavioral characterization of the double lesion rat model of MSA, improving its value in the evaluation of future neurorestorative strategies...
  21. doi request reprint Erythropoietin is neuroprotective in a transgenic mouse model of multiple system atrophy
    Martin Köllensperger
    Division of Clinical Neurobiology, Department of Neurology, Medical University, Innsbruck, Austria
    Mov Disord 26:507-15. 2011
    ..This effect is associated with improved motor function. Further studies are warranted to develop erythropoietin as a potential interventional therapy in multiple system atrophy...
  22. doi request reprint Behavioral and histological analysis of a partial double-lesion model of parkinson-variant multiple system atrophy
    Christine Kaindlstorfer
    Neurological Research Laboratory, University Hospital, Innsbruck, Austria
    J Neurosci Res 90:1284-95. 2012
    ..In summary, we have established the behavioral deficit profile of a partial double-lesion rat model mimicking the early stage of MSA-P...
  23. ncbi request reprint Failure of caspase inhibition in the double-lesion rat model of striatonigral degeneration (multiple system atrophy)
    Laura Mantoan
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria
    Acta Neuropathol 109:191-7. 2005
    ....
  24. ncbi request reprint Diffusion weighted imaging best discriminates PD from MSA-P: A comparison with tilt table testing and heart MIBG scintigraphy
    Martin Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 22:1771-6. 2007
    ..6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA-P...
  25. doi request reprint The Unified Multiple System Atrophy Rating Scale: intrarater reliability
    Florian Krismer
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 27:1683-5. 2012
    ..In the present study, the intrarater agreement of the motor examination part of the UMSARS was determined...
  26. pmc Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy
    Nadia Stefanova
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35 A 6020, Innsbruck, Austria
    Am J Pathol 166:869-76. 2005
    ..Our results indicate that combined mitochondrial inhibition and overexpression of oligodendroglial alpha-SYN generates a novel model of MSA that may be useful for evaluating both pathogenesis and treatment strategies...
  27. ncbi request reprint Topography of dopamine transporter availability in progressive supranuclear palsy: a voxelwise [123I]beta-CIT SPECT analysis
    Klaus Seppi
    Department of Neurology, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Arch Neurol 63:1154-60. 2006
    ..Most previous SPECT studies have adopted region-of-interest methods for analysis, which are subjective and operator dependent...
  28. ncbi request reprint Voxel-wise analysis of diffusion weighted imaging reveals disruption of the olfactory tract in Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 129:538-42. 2006
    ..Whether DWI can be used as a marker to identify individuals at risk to develop this disease remains to be shown...
  29. ncbi request reprint Topography of putaminal degeneration in multiple system atrophy: a diffusion magnetic resonance study
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 21:847-52. 2006
    ..Our study demonstrates prominent involvement of the posterior putamen in early disease stages of MSA-P in vivo by assessing putaminal diffusivity with the help of DWI...
  30. ncbi request reprint Abnormal responses to repetitive transcranial magnetic stimulation in multiple system atrophy
    Wolfgang N Löscher
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:174-8. 2007
    ..We suggest that these abnormalities reflect the motor cortex pathology found in MSA-P...
  31. ncbi request reprint Progression of parkinsonism in multiple system atrophy
    Klaus Seppi
    Department of Neurology, University Hospital, Innsbruck, Austria
    J Neurol 252:91-6. 2005
    ..However, it may also be subject to considerable variation. Prospective natural history studies using validated rating scales are required to accurately determine the progression of parkinsonism in MSA...
  32. doi request reprint Presentation, diagnosis, and management of multiple system atrophy in Europe: final analysis of the European multiple system atrophy registry
    Martin Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 25:2604-12. 2010
    ..The observed differences in diagnostic and therapeutic management including lack of therapy for dysautonomia emphasize the need for future guidelines in these areas...
  33. pmc Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
    Lisa Fellner
    Division of Neurobiology, Innsbruck Medical University, Austria
    Glia 61:349-60. 2013
    ..Our data provide novel insights into the mechanisms of α-synuclein-induced microglial and astroglial activation which may have an impact on understanding the pathogenesis of ASP...
  34. doi request reprint Left hemispheric predominance of nigrostriatal dysfunction in Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck, Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Brain 135:3348-54. 2012
    ....
  35. ncbi request reprint How to diagnose dementia with Lewy bodies: state of the art
    Felix Geser
    Clinical Department of Neurology, Medical University Innsbruck, Austria
    Mov Disord 20:S11-20. 2005
    ..We review the present state of the best practice in the clinical diagnosis of DLB. Future modifications of diagnostic criteria would ideally include the full range of clinical presentations that can be associated with LB disease...
  36. ncbi request reprint In vitro models of multiple system atrophy
    Nadia Stefanova
    Neurological Research Laboratory, Department of Neurology, University Hospital of Innsbruck, Austria
    Mov Disord 20:S53-6. 2005
    ..With this simplified system, we have demonstrated that alpha-synuclein significantly affects the survival of glia and its vulnerability to environmental stress, which might represent a major step in the pathogenesis of MSA...
  37. ncbi request reprint Restless legs syndrome and motor activity during sleep in spinocerebellar ataxia type 6
    Sylvia M Boesch
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Sleep Med 7:529-32. 2006
    ..We investigated the frequency of restless legs syndrome (RLS) and sleep disturbance in spinocerebellar ataxia type 6 (SCA6)...
  38. ncbi request reprint Voxel based morphometry reveals specific gray matter changes in primary dystonia
    Karl Egger
    Department of Radiology, Innsbruck Medical University, Austria
    Mov Disord 22:1538-42. 2007
    ..This is the first study using VBM in patients with different types of primary dystonia, showing a common pattern of gray matter changes...
  39. ncbi request reprint Evidence for dopaminergic re-innervation by embryonic allografts in an optimized rat model of the Parkinsonian variant of multiple system atrophy
    Zoe Puschban
    Experimental Neurodegeneration Laboratory, Department of Neurology, University Hospital Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Brain Res Bull 68:54-8. 2005
    ..e. early stage disease with limited striatal dysfunction...
  40. doi request reprint A novel computer-assisted image analysis of [123I]β-CIT SPECT images improves the diagnostic accuracy of parkinsonian disorders
    Georg Goebel
    Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schöpfstrasse 41 2, A 6020, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 38:702-10. 2011
    ....
  41. doi request reprint Striatal transplantation for multiple system atrophy--are grafts affected by alpha-synucleinopathy?
    Nadia Stefanova
    Department of Clinical Neurobiology, Innsbruck Medical University, Innsbruck, Austria
    Exp Neurol 219:368-71. 2009
    ..Our data suggest that the presence of MSA-like alpha-synuclein oligodendrogliopathy and related to it pro-inflammatory microenvironment may compromise the connectivity and neurorestorative outcome of striatal grafts...
  42. ncbi request reprint Progression of brain atrophy in multiple system atrophy. A longitudinal VBM study
    Christian Brenneis
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 254:191-6. 2007
    ..The UPDRS-III score was not significantly correlated with any brain region. Our data suggest that cortical atrophy is prominent in MSA-P and early degeneration of the basal ganglia drives late onset cortical atrophy...
  43. ncbi request reprint Differentiation of SCA2 from MSA-C using proton magnetic resonance spectroscopic imaging
    Sylvia M Boesch
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    J Magn Reson Imaging 25:564-9. 2007
    ..To assess and compare biochemical and volumetric features of the cerebellum in patients with spinocerebellar ataxia type 2 (SCA2) and patients with the cerebellar variant of multiple system atrophy (MSA-C)...
  44. ncbi request reprint Progression of multiple system atrophy (MSA): a prospective natural history study by the European MSA Study Group (EMSA SG)
    Felix Geser
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 21:179-86. 2006
    ..Our data contribute to the ongoing validation process of UMSARS, and they facilitate the planning and implementation of future neuroprotective intervention trials...
  45. pmc Cell fate analysis of embryonic ventral mesencephalic grafts in the 6-OHDA model of Parkinson's disease
    Sonya Carvalho Neto
    Division of Neurobiology, Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    PLoS ONE 7:e50178. 2012
    ..The molecular signature of VM grafts and its functional relevance should be further explored in future studies aimed at the optimization of DAergic cell therapy approaches in PD...
  46. ncbi request reprint Levodopa-induced sleepiness in the Parkinson variant of multiple system atrophy
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:1281-3. 2006
    ..These findings suggest greater potential of levodopa to induce sleepiness in MSA compared with PD, which may be related to differences in basal ganglia and brainstem pathology between the two disorders...
  47. pmc Intact olfaction in a mouse model of multiple system atrophy
    Florian Krismer
    Division of Neurobiology, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    PLoS ONE 8:e64625. 2013
    ..Consistent with these observations, recent experimental studies demonstrated olfactory deficits in transgenic Parkinson's disease mouse models, but corresponding data are lacking for MSA models...
  48. pmc Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy
    Nadia Stefanova
    Division of Neurobiology, Innsbruck Medical University, Innsbruck, Austria
    Acta Neuropathol 124:51-65. 2012
    ..In summary, we provide new evidence supporting a primary role of proteolytic failure and suggesting a neurodegenerative pathomechanism related to disturbed oligodendroglial/myelin trophic support in the pathogenesis of MSA...
  49. doi request reprint Progression of dopamine transporter decline in patients with the Parkinson variant of multiple system atrophy: a voxel-based analysis of [123I]β-CIT SPECT
    Michael Nocker
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 39:1012-20. 2012
    ....
  50. pmc Targeted overexpression of human alpha-synuclein in oligodendroglia induces lesions linked to MSA-like progressive autonomic failure
    Sylvia Stemberger
    Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Exp Neurol 224:459-64. 2010
    ....
  51. ncbi request reprint Midbrain sonography in patients with essential tremor
    Heike Stockner
    Department of Neurology, Medical University Innsbruck, Austria
    Mov Disord 22:414-7. 2007
    ..These findings might correspond to an increased risk of ET patients to develop PD. Long-term follow-up will show if those with hyperechogenic SN develop PD, while these without will not...
  52. ncbi request reprint Voxel-based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy
    Christian Brenneis
    Department of Neurology, University Hospital, Innsbruck, Austria
    Mov Disord 18:1132-8. 2003
    ..Further studies are required to determine clinical and/or subclinical correlates of cortical atrophy in MSA-P...
  53. pmc Oligodendroglial alpha-synucleinopathy and MSA-like cardiovascular autonomic failure: experimental evidence
    Daniela Kuzdas
    Division of Neurobiology, Department of Neurology and Neurosurgery, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Exp Neurol 247:531-6. 2013
    ....
  54. ncbi request reprint Freezing of gait in postmortem-confirmed atypical parkinsonism
    Jörg Müller
    Department of Neurology, University Hospital Innsbruck, Austria
    Mov Disord 17:1041-5. 2002
    ..Whether FoG and urinary incontinence share similar neuropathological substrates remains to be determined by future studies...
  55. pmc Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons
    Nadia Stefanova
    Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Am J Pathol 179:954-63. 2011
    ..The study supports TLR4 signaling as innate neuroprotective mechanism acting through clearance of α-synuclein...
  56. ncbi request reprint Prevalence of movement disorders in men and women aged 50-89 years (Bruneck Study cohort): a population-based study
    Gregor K Wenning
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Lancet Neurol 4:815-20. 2005
    ..We sought to assess the prevalence of all common categories of movement disorders in a population, accounting for sex differences and age trends...
  57. ncbi request reprint Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)
    Gregor K Wenning
    Department of Neurology, University of Innsbruck, Austria
    Mov Disord 19:1391-402. 2004
    ..Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients...
  58. ncbi request reprint Disturbance of rapid eye movement sleep in spinocerebellar ataxia type 2
    Sylvia M Boesch
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:1751-4. 2006
    ..Abnormal motor control during sleep with periodic leg movements and REM sleep without atonia occurs frequently in SCA2. This finding may reflect a dysfunction of dopaminergic and/or brainstem and cerebellar outflow pathways...
  59. ncbi request reprint Comparison of diffusion-weighted imaging and [123I]IBZM-SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson's disease
    Klaus Seppi
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    Mov Disord 19:1438-45. 2004
    ..Striatal rADCs had a significant higher overall predictive accuracy than D2R binding with IBZM. In summary, our data suggest that DWI may be more accurate compared to IBZM-SPECT in the differential diagnosis of MSA-P versus PD...
  60. ncbi request reprint Failure of neuronal protection by inhibition of glial activation in a rat model of striatonigral degeneration
    Nadia Stefanova
    Neurodegeneration Research Laboratory, Innsbruck MSA Study Group, Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    J Neurosci Res 78:87-91. 2004
    ..We conclude that despite its astrocytic and microglial suppression, minocycline failed to attenuate lesion-induced neuronal damage in the SND rat model...
  61. ncbi request reprint Therapeutic strategies in multiple system atrophy
    Gregor K Wenning
    Innsbruck Medical University, Clinical Department of Neurology, Austria
    Mov Disord 20:S67-76. 2005
    ..Because no drug treatment consistently benefits patients with this disease in the long-term, palliative therapies are all the more important. Novel symptomatic and neuroprotective therapies are urgently required...
  62. ncbi request reprint Auditory startle response in cervical dystonia
    Jörg Müller
    Department of Neurology, University Hospital Innsbruck, Innsbruck, Austria
    Mov Disord 18:1522-6. 2003
    ..Reduced ASR probability and magnitude as well as prolonged EMG activity after the proper startle response corroborate and extend previous findings on brainstem dysfunction in CD...
  63. doi request reprint Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model
    Nadia Stefanova
    Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Anichstr 35, 6020 Innsbruck, Austria
    Neurotox Res 21:393-404. 2012
    ..This study suggests that MPO inhibition may represent a novel candidate treatment strategy against MSA-like neurodegeneration acting through its anti-inflammatory and anti-oxidative properties...
  64. ncbi request reprint Animal models of multiple system atrophy
    Nadia Stefanova
    Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria
    Trends Neurosci 28:501-6. 2005
    ..Here, the currently available MSA animal models will be reviewed and leads for future research will be identified...
  65. ncbi request reprint Abnormalities of dopaminergic neurotransmission in SCA2: a combined 123I-betaCIT and 123I-IBZM SPECT study
    Sylvia M Boesch
    Department of Neurology, University of Innsbruck, Austria
    Mov Disord 19:1320-5. 2004
    ..Both slowness of limb movements as well as dystonia in the ataxic SCA2 phenotype may reflect dysfunction not only at cerebellar but also at basal ganglia level...
  66. pmc Mesenchymal stem cells in a transgenic mouse model of multiple system atrophy: immunomodulation and neuroprotection
    Sylvia Stemberger
    Divison of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    PLoS ONE 6:e19808. 2011
    ..In this study we investigated the efficacy of intravenously applied MSCs in terms of behavioural improvement, neuroprotection and modulation of neuroinflammation in the (PLP)-αsynuclein (αSYN) MSA model...
  67. doi request reprint Investigation of autonomic function in idiopathic REM sleep behavior disorder
    Birgit Frauscher
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 259:1056-61. 2012
    ..Follow-up studies are needed to determine whether iRBD patients with dysfunction on several autonomic domains are at particular risk for developing one of these diseases...
  68. ncbi request reprint Multiple system atrophy: an update
    Gregor K Wenning
    Department of Neurology, University Hospital, Innsbruck, Austria
    Mov Disord 18:S34-42. 2003
    ..Several research groups have been formed in Europe (EMSA-SG, NNIPPS) and United States (NAMSA-SG), providing a framework for coordinated trial activity in MSA...
  69. doi request reprint Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts
    Lisa Fellner
    Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
    Acta Neuropathol 121:675-93. 2011
    ..Finally, major therapeutic strategies targeting glial pathology in α-synucleinopathies as well as current pitfalls for disease-modification in clinical trials are discussed...
  70. doi request reprint Assessing disease progression with MRI in atypical parkinsonian disorders
    Martin Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 24:S699-702. 2009
    ..The article reviews the current state of the art focusing on three atypical parkinsonian disorders: multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and dementia with Lewy bodies (DLB)...
  71. doi request reprint Mortality in Parkinson's disease: a 20-year follow-up study
    Anja Diem-Zangerl
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 24:819-25. 2009
    ....
  72. ncbi request reprint The role of alpha-synuclein in the pathogenesis of multiple system atrophy
    Gregor K Wenning
    Department of Neurology, University of Innsbruck, School of Medicine, Anichstrasse 35, 6020, Innsbruck, Austria
    Acta Neuropathol 109:129-40. 2005
    ..Transgenic MSA mouse models are now available to determine these aspects of cellular disturbance experimentally...
  73. pmc Genetic players in multiple system atrophy: unfolding the nature of the beast
    Sylvia Stemberger
    Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neurobiol Aging 32:1924.e5-14. 2011
    ..In this review, we discuss the emerging evidence in favor of genetic players in MSA...
  74. ncbi request reprint Valvular heart disease in Parkinson's disease vs. controls: An echocardiographic study
    Cecilia Peralta
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:1109-13. 2006
    ..These results highlight the need for further prospective studies of the prevalence and underlying mechanisms of cardiac valvulopathy in PD patients treated with different dopamine agonists...
  75. ncbi request reprint Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome
    Christoph Schmidauer
    Department of Neurology, Innsbruck Medical University, Austria
    Ann Neurol 58:630-4. 2005
    ..These findings lend further support to nigral iron deficiency as a pathogenetic factor in RLS...
  76. ncbi request reprint Social stigmatization in patients with cranial and cervical dystonia
    Martina Rinnerthaler
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Mov Disord 21:1636-40. 2006
    ..CCD patients are subject to serious prejudice and enacted stigmatization. There is a need for informing the public about the nature and symptoms of this disorder and a need to support patients to cope with stigmatization...
  77. ncbi request reprint An open trial of levetiracetam for segmental and generalized dystonia
    Sascha Hering
    Department of Neurology, Medical University Innsbruck, Austria
    Mov Disord 22:1649-51. 2007
    ..At 4-week follow-up, none of the patients showed improvement of dystonia, mild side-effects were observed in 3 patients...
  78. ncbi request reprint The role of alpha-synuclein and tau in neurodegenerative movement disorders
    Gregor K Wenning
    Department of Neurology, Medical University, Innsbruck, Austria
    Curr Opin Neurol 18:357-62. 2005
  79. ncbi request reprint Basal forebrain atrophy is a distinctive pattern in dementia with Lewy bodies
    Christian Brenneis
    Department of Neurology, University Hospital of Innsbruck, Anichstr 35, 6020 Innsbruck, Austria
    Neuroreport 15:1711-4. 2004
    ..Atrophy of insular cortex was found in both patient groups...
  80. ncbi request reprint Homocysteine and serum markers of immune activation in primary dystonia
    Ulf J Muller
    University Hospital of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Mov Disord 20:1663-7. 2005
    ..HCY is a neuronal excitotoxic amino acid and hyperhomocysteinemia is considered an independent vascular risk factor. Further studies are required to define the background of hyperhomocysteinemia in primary dystonia...
  81. ncbi request reprint Tumor necrosis factor-alpha-induced cell death in U373 cells overexpressing alpha-synuclein
    Nadia Stefanova
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    J Neurosci Res 73:334-40. 2003
    ..We conclude that alpha-synuclein overexpression significantly increases the vulnerability of U373 cells to apoptosis through TNF-alpha-mediated pathways...
  82. ncbi request reprint Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy)
    Nadia Stefanova
    Department of Neurology, University Hospital of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Acta Neuropathol 106:157-66. 2003
    ..This suggests that complex integrative mechanisms are likely to regulate the vulnerability of the striatum and SNc to cell death in SND/MSA-P...
  83. ncbi request reprint Huntington's disease: present treatments and future therapeutic modalities
    Raphael M Bonelli
    University Clinic of Psychiatry, Karl Franzens University Graz, Graz University Clinic of Neurology, University of Innsbruck, Innsbruck, Austria
    Int Clin Psychopharmacol 19:51-62. 2004
    ..Finally, some cellular mechanisms are discussed in this paper because they are essential for future neuroprotective modalities, such as minocycline, unsaturated fatty acids or riluzole...
  84. ncbi request reprint Atrophy pattern in SCA2 determined by voxel-based morphometry
    Christian Brenneis
    Department of Neurology, University Hospital of Innsbruck, Innsbruck, Australia
    Neuroreport 14:1799-802. 2003
    ..Two mechanisms could contribute to the observed cortical atrophy. It could be either the result of primary supratentorial degeneration as part of the disease process and/or secondary atrophy due to cerebellar deafferentation...
  85. ncbi request reprint Placebo-controlled trial of amantadine in multiple-system atrophy
    Gregor K Wenning
    Department of Neurology, Innsbruck Medical University, Austria
    Clin Neuropharmacol 28:225-7. 2005
    ..Reports on the open-label use of amantadine in MSA suggest variable antiparkinsonian efficacy. The authors therefore conducted a double-blind, placebo-controlled crossover trial of amantadine in MSA patients...
  86. ncbi request reprint Multiple system atrophy
    Gregor K Wenning
    Department of Neurology, University Hospital, A 6020 Innsbruck, Austria
    Lancet Neurol 3:93-103. 2004
    ..Symptomatic therapeutic strategies are still limited; however, several candidate neuroprotective agents have entered phase II and phase III clinical trials...
  87. ncbi request reprint Trace of diffusion tensor differentiates the Parkinson variant of multiple system atrophy and Parkinson's disease
    Michael F H Schocke
    Department of Radiology, University of Innsbruck, Austria
    Neuroimage 21:1443-51. 2004
    ..Because rADCs in one direction are dependent on the slice orientation relative to the directions of fiber tracts, Trace(D) imaging appears to be more accurate in the separation of MSA-P from PD...
  88. ncbi request reprint Grading of neuropathology in multiple system atrophy: proposal for a novel scale
    Kurt A Jellinger
    Institute of Clinical Neurobiology, Vienna, Austria
    Mov Disord 20:S29-36. 2005
    ....
  89. ncbi request reprint Olivopontocerebellar atrophy: toward a better nosological definition
    Jose Berciano
    Service of Neurology, University Hospital Marques de Valdecilla, University of Cantabria, Santander, Spain
    Mov Disord 21:1607-13. 2006
    ..Our review suggests that the label "OPCA" is useful to designate a clinicopathological syndrome that has a variety of etiologies carrying a poor prognosis, particularly if associated with autonomic failure as occurs in MSA...
  90. ncbi request reprint Lewy bodies in patients presenting clinically with Alzheimer disease
    Kurt A Jellinger
    Institute of Clinical Neurobiology, Vienna, Austria
    J Alzheimers Dis 4:327-8. 2002
  91. ncbi request reprint Application of the International Cooperative Ataxia Scale rating in multiple system atrophy
    Francois Tison
    Federation de Neurologie, Epidémiologie et Biostatistiques Centre Hospitalo Universitaire de Bordeaux, Bordeaux, France
    Mov Disord 17:1248-54. 2002
    ..The ICARS appears a useful tool to extract and rate the severity of cerebellar signs in MSA; however, it is clearly contaminated by parkinsonian features...
  92. ncbi request reprint Movement Disorders Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders
    Irene Litvan
    Movement Disorder Program, University of Louisville, KY 40205, USA
    Mov Disord 18:467-86. 2003
    ..In each of these areas, diagnosis continues to rest on clinical findings and the judicious use of ancillary studies...
  93. ncbi request reprint Survival in multiple system atrophy
    Anette Schrag
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
    Mov Disord 23:294-6. 2008
    ..49, 95% CI 0.97-2.31, P = 0.07). Except for rediagnosis as PD, no predictive factors for better survival could be identified. These data confirm the relatively poor prognosis of MSA of less than 9 years on average...
  94. ncbi request reprint Disproportionate antecollis: a warning sign for multiple system atrophy
    Felix Geser
    Mov Disord 22:1986; author reply 1986-7. 2007
  95. ncbi request reprint Genetic analysis of candidate genes modifying the age-at-onset in Huntington's disease
    Silke Metzger
    Department of Medical Genetics, University of Tubingen, Calwerstrasse 7, 72076, Tubingen, Germany
    Hum Genet 120:285-92. 2006
    ..Although some of the factors have been defined as genetic modifier factors in previous studies, none of the genes encoding GRIK2, TBP, BDNF and ZDHHC17 could be identified as a genetic modifier for HD...
  96. ncbi request reprint The Lewis family revisited: no evidence for autosomal dominant multiple system atrophy
    Jose Berciano
    Department of Neurology, University Hospital Marqués de Valdecilla UC, Santander, Spain
    Parkinsonism Relat Disord 11:363-5. 2005
    ..There remains no conclusive evidence to support the notion of hereditary MSA...
  97. ncbi request reprint Health-related quality of life in multiple system atrophy
    Anette Schrag
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
    Mov Disord 21:809-15. 2006
    ....
  98. ncbi request reprint The 'risus sardonicus' of multiple system atrophy
    Gregor K Wenning
    Mov Disord 18:1211. 2003
  99. ncbi request reprint The S18Y polymorphism in the UCHL1 gene is a genetic modifier in Huntington's disease
    Silke Metzger
    Department of Medical Genetics, University of Tubingen, Calwerstrasse 7, 72076 Tubingen, Germany
    Neurogenetics 7:27-30. 2006
    ..In this group, the allelic variation on locus S18Y is responsible for 1.1% of the variance in the HD age-at-onset, and the rare Y allele is associated with younger-aged cases...
  100. ncbi request reprint Parkinsonism in multiple system atrophy: natural history, severity (UPDRS-III), and disability assessment compared with Parkinson's disease
    Francois Tison
    Federation de Neurologie, Epidémiologie et Biostatistiques Centre Hospitalo Universitaire de Bordeaux, Bordeaux, France
    Mov Disord 17:701-9. 2002
    ..It also indicates that the UPDRS-III provides a useful severity measure of parkinsonism in MSA, albeit contaminated by additional cerebellar dysfunction...