Herbert Tilg

Summary

Affiliation: Innsbruck Medical University
Country: Austria

Publications

  1. doi Malnutrition and microbiota--a new relationship?
    Herbert Tilg
    Department of Internal Medicine I, Gastroenterology, Endocrinology and Metabolism, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Nat Rev Gastroenterol Hepatol 10:261-2. 2013
  2. ncbi Adiponectin: key player in the adipose tissue-liver crosstalk
    A R Moschen
    Christian Doppler Research Laboratory for Gut Inflammation, Innsbruck Medical University, Innsbruck, Austria
    Curr Med Chem 19:5467-73. 2012
  3. ncbi Inflammatory bowel diseases: meeting of the European Crohn's Colitis Organization, 1-3 March 2007, Innsbruck, Austria
    Herbert Tilg
    Medical University Innsbruck, Department of Medicine, Anichstrasse 35, 6020 Innsbruck, Austria
    Expert Opin Ther Targets 11:853-6. 2007
  4. ncbi Mode of function of biological anti-TNF agents in the treatment of inflammatory bowel diseases
    Herbert Tilg
    Medical University Innsbruck, Department of Medicine, Division of Gastroenterology and Hepatology, Innsbruck, Austria
    Expert Opin Biol Ther 7:1051-9. 2007
  5. ncbi [Use of infliximab in ulcerative colitis]
    H Tilg
    Die Institutsangaben sind am Ende des Beitrags gelistet
    Z Gastroenterol 45:907-11. 2007
  6. pmc Inflammatory mechanisms in the regulation of insulin resistance
    Herbert Tilg
    Department of Gastroenterology and Hepatology, Innsbruck Medical University, Innsbruck, Austria
    Mol Med 14:222-31. 2008
  7. doi Insulin resistance, inflammation, and non-alcoholic fatty liver disease
    Herbert Tilg
    Department of Medicine, Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Austria
    Trends Endocrinol Metab 19:371-9. 2008
  8. doi Short bowel syndrome: searching for the proper diet
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation, Clinical Division of Gastroenterology and Hepatology, Medical University Innsbruck, Innsbruck, Austria
    Eur J Gastroenterol Hepatol 20:1061-3. 2008
  9. doi Suppression of interleukin-17 by type I interferons: a contributing factor in virus-induced immunosuppression?
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation and Department of Gastroenterology and Hepatology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur Cytokine Netw 20:1-6. 2009
  10. doi The role of cytokines in non-alcoholic fatty liver disease
    Herbert Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Innsbruck, Austria
    Dig Dis 28:179-85. 2010

Detail Information

Publications91

  1. doi Malnutrition and microbiota--a new relationship?
    Herbert Tilg
    Department of Internal Medicine I, Gastroenterology, Endocrinology and Metabolism, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Nat Rev Gastroenterol Hepatol 10:261-2. 2013
    ..The condition was transmissible into gnotobiotic mice by combining stool transplantation and region-specific diet. In addition, antibiotics reduce mortality in children with kwashiorkor...
  2. ncbi Adiponectin: key player in the adipose tissue-liver crosstalk
    A R Moschen
    Christian Doppler Research Laboratory for Gut Inflammation, Innsbruck Medical University, Innsbruck, Austria
    Curr Med Chem 19:5467-73. 2012
    ..Targeting adiponectin could evolve as a major treatment concept especially for fatty liver diseases in the future...
  3. ncbi Inflammatory bowel diseases: meeting of the European Crohn's Colitis Organization, 1-3 March 2007, Innsbruck, Austria
    Herbert Tilg
    Medical University Innsbruck, Department of Medicine, Anichstrasse 35, 6020 Innsbruck, Austria
    Expert Opin Ther Targets 11:853-6. 2007
    ..The European Crohn's Colitis Organization recently held its second annual meeting in Innsbruck, Austria dealing with both new basic and clinical developments in the field...
  4. ncbi Mode of function of biological anti-TNF agents in the treatment of inflammatory bowel diseases
    Herbert Tilg
    Medical University Innsbruck, Department of Medicine, Division of Gastroenterology and Hepatology, Innsbruck, Austria
    Expert Opin Biol Ther 7:1051-9. 2007
    ..Therefore, the capacity to induce apoptosis and neutralisation of TNF alone are insufficient to explain clinical efficacy of anti-TNF agents in human inflammatory bowel diseases...
  5. ncbi [Use of infliximab in ulcerative colitis]
    H Tilg
    Die Institutsangaben sind am Ende des Beitrags gelistet
    Z Gastroenterol 45:907-11. 2007
    ..Experienced gastroenterologists should be involved in the decision making for such a therapy to balance thoroughly the benefit/risk ratio for our patients...
  6. pmc Inflammatory mechanisms in the regulation of insulin resistance
    Herbert Tilg
    Department of Gastroenterology and Hepatology, Innsbruck Medical University, Innsbruck, Austria
    Mol Med 14:222-31. 2008
    ....
  7. doi Insulin resistance, inflammation, and non-alcoholic fatty liver disease
    Herbert Tilg
    Department of Medicine, Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Austria
    Trends Endocrinol Metab 19:371-9. 2008
    ..This review highlights new aspects in development of liver steatosis and the relevance of various cytokines and adipocytokines in NAFLD...
  8. doi Short bowel syndrome: searching for the proper diet
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation, Clinical Division of Gastroenterology and Hepatology, Medical University Innsbruck, Innsbruck, Austria
    Eur J Gastroenterol Hepatol 20:1061-3. 2008
    ..Supplementary nonprocessed cereals may be beneficial in a certain subgroup of patients. With the recent developments in medical therapy, a balanced diet may allow many patients to become nutritionally autonomous...
  9. doi Suppression of interleukin-17 by type I interferons: a contributing factor in virus-induced immunosuppression?
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation and Department of Gastroenterology and Hepatology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur Cytokine Netw 20:1-6. 2009
    ..Therefore, suppression of IL-17, as well as many other well-defined interactions of type I IFNs with the cytokine cascade, may contribute to virus-induced immunosuppression making the host vulnerable to bacterial and fungal attacks...
  10. doi The role of cytokines in non-alcoholic fatty liver disease
    Herbert Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Innsbruck, Austria
    Dig Dis 28:179-85. 2010
    ..Therefore, the balance between pro- and anti-inflammatory acting cytokines/adipocytokines appears to play a key role in hepatic and systemic insulin action, and they are supposed to have important functions in the development of NAFLD...
  11. pmc Gut microbiome, obesity, and metabolic dysfunction
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Innsbruck, Austria
    J Clin Invest 121:2126-32. 2011
    ..As most findings in this field of research are based on mouse studies, the relevance to human biology requires further investigation...
  12. ncbi Vedolizumab, a humanized mAb against the α4β7 integrin for the potential treatment of ulcerative colitis and Crohn's disease
    Herbert Tilg
    Innsbruck Medical University, Christian Doppler Research Laboratory for Gut Inflammation, Anichstrasse 35, 6020 Innsbruck, Austria
    Curr Opin Investig Drugs 11:1295-304. 2010
    ....
  13. doi Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Innsbruck, Austria
    Hepatology 52:1836-46. 2010
    ..Endoplasmic reticulum stress and related signaling networks, (adipo)cytokines, and innate immunity are emerging as central pathways that regulate key features of NASH...
  14. doi Gut, inflammation and osteoporosis: basic and clinical concepts
    H Tilg
    Christian Doppler Research Laboratory for Gut Inflammation and Division of Gastroenterology and Hepatology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Gut 57:684-94. 2008
    ....
  15. doi Obesity, metabolic syndrome, and microbiota: multiple interactions
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Austria
    J Clin Gastroenterol 44:S16-8. 2010
    ..Importantly, transmission of the microbiota from these mice to healthy mice results in features of the metabolic syndrome. Available data suggest that the microbiota might play a role in the development of metabolic syndrome and obesity...
  16. ncbi Weight loss: cornerstone in the treatment of non-alcoholic fatty liver disease
    H Tilg
    Christian Doppler Research Laboratory for Gut Inflammation, Innsbruck Medical University, Austria
    Minerva Gastroenterol Dietol 56:159-67. 2010
    ..Therefore, new weight-loss inducing agents are eagerly awaited to increase the percentage of obese people to benefit from weight reduction...
  17. doi Update on nonalcoholic fatty liver disease: genes involved in nonalcoholic fatty liver disease and associated inflammation
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation, Innsbruck Medical University, Innsbruck, Austria
    Curr Opin Clin Nutr Metab Care 13:391-6. 2010
    ..Advanced age, extensive overweight and a number of features of the metabolic syndrome are associated with NAFLD severity. The cause of NAFLD is considered multifactorial with a substantial genetic component...
  18. doi Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression
    Alexander R Moschen
    Christian Doppler Research Laboratory for Gut Inflammation and Department of Internal Medicine II, Medical University Innsbruck, 6020 Innsbruck, Austria
    Gut 59:1259-64. 2010
    ..Mouse studies suggest a key role of adipose tissue-derived IL-6 in hepatic insulin resistance via modification of liver suppressor of cytokine signalling 3 (SOCS-3) expression...
  19. doi Effects of weight loss induced by bariatric surgery on hepatic adipocytokine expression
    Alexander R Moschen
    Christian Doppler Research Laboratory for Gut Inflammation, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Hepatol 51:765-77. 2009
    ..Whereas adiponectin has mainly anti-inflammatory functions, leptin, resistin and pre-B cell enhancing factor (PBEF)/Nampt/visfatin are considered as mainly pro-inflammatory mediators regulating metabolic and immune processes...
  20. ncbi The RANKL/OPG system and bone mineral density in patients with chronic liver disease
    Alexander R Moschen
    Division of Gastroenterology and Hepatology, Department of Medicine, Innsbruck Medical University, Innsbruck, Austria
    J Hepatol 43:973-83. 2005
    ..This study investigated the activation state of the RANKL/OPG system and its association with bone loss in CLD...
  21. doi A-FABP--a biomarker associated with the metabolic syndrome and/or an indicator of weight change?
    Julia Engl
    Clinical Division of General Internal Medicine, Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    Obesity (Silver Spring) 16:1838-42. 2008
    ..The aim of these studies was to investigate changes of A-FABP during profound weight loss induced by laparoscopic adjustable gastric banding (LAGB)...
  22. pmc Adipose and liver expression of interleukin (IL)-1 family members in morbid obesity and effects of weight loss
    Alexander R Moschen
    Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Innsbruck, Austria
    Mol Med 17:840-5. 2011
    ..Excessive weight loss changes the adipose and liver expression profile of IL-1F members toward a more antiinflammatory direction...
  23. ncbi Up-regulation of the anti-inflammatory adipokine adiponectin in acute liver failure in mice
    Anna Maria Wolf
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    J Hepatol 44:537-43. 2006
    ..However, there is only scarce knowledge on the functional role and regulation of endogenous adiponectin in non-fat tissues such as the liver under conditions of acute inflammation...
  24. doi Effect of weight loss on serum pigment epithelium-derived factor levels
    Alexander Tschoner
    Department of Internal Medicine I, Medical University Innsbruck, Innsbruck, Austria
    Eur J Clin Invest 41:937-42. 2011
    ..To further elucidate the relationship between pigment epithelium-derived factor and metabolic perturbations characteristic of obesity, we examined the effect of pronounced weight loss on serum levels of pigment epithelium-derived factor...
  25. pmc The kinase inhibitor imatinib mesylate inhibits TNF-{alpha} production in vitro and prevents TNF-dependent acute hepatic inflammation
    Anna Maria Wolf
    Department of Gastroenterology and Hepatology, Innsbruck Medical University, 6020 Innsbruck, Austria
    Proc Natl Acad Sci U S A 102:13622-7. 2005
    ..These findings suggest a potent antiinflammatory role of imatinib by modulation of TNF-alpha production in monocytes/macrophages. This observation might be of therapeutic value for the treatment of TNF-mediated diseases...
  26. doi Pre-B cell colony enhancing factor/NAMPT/visfatin and its role in inflammation-related bone disease
    Alexander R Moschen
    Christian Doppler Research Laboratory for Gut Inflammation and Department of Internal Medicine II Gastroenterology and Hepatology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Mutat Res 690:95-101. 2010
    ..This is the first report demonstrating a potential role for this important cytokine/enzyme in inflammation-related bone disease...
  27. ncbi Visfatin, an adipocytokine with proinflammatory and immunomodulating properties
    Alexander R Moschen
    Department of Medicine, Christian Doppler Research Laboratory for Gut Inflammation and Clinical Division of Gastroenterology and Hepatology, Innsbruck Medical University, Innsbruck, Austria
    J Immunol 178:1748-58. 2007
    ..Macrophages, dendritic cells, and colonic epithelial cells might be additional sources of visfatin as determined by confocal microscopy. Visfatin can be considered a new proinflammatory adipocytokine...
  28. doi Influence of visceral obesity and liver fat on vascular structure and function in obese subjects
    Wolfgang Sturm
    Department of Internal Medicine 1, Innsbruck Medical University, Innsbruck, Austria
    Obesity (Silver Spring) 17:1783-8. 2009
    ..Measurement of visceral fat diameter by ultrasound is a novel and simple method to identify subjects with an increased risk for atherosclerosis within an obese population...
  29. ncbi The effect of zoledronic acid on the function and differentiation of myeloid cells
    Anna Maria Wolf
    Laboratory of Tumorimmunology, Department of Hematology and Oncology, Innsbruck Medical University, Anichstr 35, 6020 Innsbruck, Austria
    Haematologica 91:1165-71. 2006
    ..e. osteoclasts and monocytes). The latter represent the major source of dendritic cells (DC). Thus, we determined the immunomodulatory properties of zoledronic acid (ZA), a member of the latest generation of bisphosphonates...
  30. ncbi Elevated systemic levels of free interleukin-18 (IL-18) in patients with Crohn's disease
    Othmar Ludwiczek
    University Hospital Innsbruck, Department of Medicine, Division of Gastroenterology and Hepatology, Innsbruck, Austria
    Eur Cytokine Netw 16:27-33. 2005
    ....
  31. ncbi Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease
    Anna Maria Wolf
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Internal Medicine, Innsbruck, Austria
    Clin Immunol 113:47-55. 2004
    ..In summary, high local expression of IDO may represent an anti-inflammatory mechanism tempting to counterbalance the tissue-damaging effects of activated T-cells infiltrating the colonic mucosa in IBD...
  32. ncbi Increased expression of CCL20 in human inflammatory bowel disease
    Arthur Kaser
    Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Innsbruck, Austria
    J Clin Immunol 24:74-85. 2004
    ..Furthermore, abundant numbers of Langerin(+) immature dendritic cells were identified in the subepithelial space of IBD specimens. CCL20 might regulate the attraction of T lymphocytes and dendritic cells in IBD...
  33. doi Nutrition in pathophysiology and treatment of nonalcoholic fatty liver disease
    Alexander R Moschen
    Department of Medicine, Christian Doppler Research Laboratory for Gut Inflammation, Innsbruck Medical University, Innsbruck, Austria
    Curr Opin Clin Nutr Metab Care 11:620-5. 2008
    ..Currently, it is not clear which type of diet preferentially results in this common disease...
  34. ncbi Telomere length of in vivo expanded CD4(+)CD25 (+) regulatory T-cells is preserved in cancer patients
    Dominik Wolf
    Department of Hematology and Oncology, Innsbruck Medical University, Anichstr 35, 6020 Innsbruck, Austria
    Cancer Immunol Immunother 55:1198-208. 2006
    ..It remains unclear whether this is due to redistribution or active proliferation. The latter would require the upregulation of telomerase activity, whose regulation also remains unknown for Treg...
  35. ncbi How to modulate inflammatory cytokines in liver diseases
    Herbert Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, Innsbruck Medical University, Austria
    Liver Int 26:1029-39. 2006
    ..Interference with cytokine pathways and/or administration of anti-inflammatory cytokines will be of major interest in the future therapy of many liver diseases...
  36. doi Inflammation, cytokines and insulin resistance: a clinical perspective
    Verena Wieser
    Department of Medicine I, Gastroenterology, Endocrinology and Metabolism and Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Arch Immunol Ther Exp (Warsz) 61:119-25. 2013
    ..Although we still have missing links in the understanding of insulin resistance, certain inflammatory pathways have also evolved in humans as central players...
  37. ncbi Effects of pronounced weight loss on adiponectin oligomer composition and metabolic parameters
    Julia Engl
    Department of Internal Medicine, Clinical Division of General Internal Medicine, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Obesity (Silver Spring) 15:1172-8. 2007
    ..The aim of the study was to investigate changes of adiponectin isoforms during profound weight loss and its relation to anthropomorphometric and metabolic parameters...
  38. doi Role of adiponectin and PBEF/visfatin as regulators of inflammation: involvement in obesity-associated diseases
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation, Department of Medicine, Innsbruck Medical University, 6020 Innsbruck, Austria
    Clin Sci (Lond) 114:275-88. 2008
    ..Understanding this new exciting world of adipocytokines will be of importance in the development of novel therapies for obesity-associated diseases...
  39. ncbi Neurokinin-1 receptor interacts with PrP(106-126)-induced dendritic cell migration and maturation
    Nicole C Kaneider
    Division of General Internal Medicine, Department of Internal Medicine, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Neuroimmunol 158:153-8. 2005
    ..Other neuropeptides arrest chemotaxis. Data support a priming role of the neuropeptide substance P in PrP(106-126)-induced migration of DCs involving neurokinin-1-receptors...
  40. doi Interferon-alpha controls IL-17 expression in vitro and in vivo
    Alexander R Moschen
    Christian Doppler Research Laboratory for Gut Inflammation and Clinical Division of Gastroenterology and Hepatology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Immunobiology 213:779-87. 2008
    ..Our data suggest that IFNalpha down-regulates IL-17 expression and Th17 differentiation in vitro and in vivo. As a corollary, these effects might play a role in the mode of action of type I IFNs in the treatment of various diseases...
  41. ncbi Inflammatory bowel diseases: highlights from the United European Gastroenterology Week 2008
    Arthur Kaser
    Innsbruck Medical University, Department of Gastroenterology and Hepatology, Christian Doppler Research Laboratory for Gut Inflammation, Innsbruck, Austria
    Expert Opin Ther Targets 13:259-63. 2009
    ..Inflammatory bowel disease remains at the forefront of research in gastroenterology and recent findings will result in new treatment strategies...
  42. doi A key role for Pre-B cell colony-enhancing factor in experimental hepatitis
    Alexander R Moschen
    Christian Doppler Research Laboratory for Gut Inflammation, Department of Internal Medicine II, Gastroenterology and Hepatology, Medical University Innsbruck, Innsbruck, Austria
    Hepatology 54:675-86. 2011
    ..In primary murine Kupffer cells, FK866 suppressed LPS-induced interleukin (IL)-6 production, whereas incubation with recombinant PBEF resulted in increased IL-6 release...
  43. ncbi Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes
    Anna M Wolf
    Department of Gastroenterology and Hepatology, Medical University of Innsbruck, Innsbruck, Austria
    Biochem Biophys Res Commun 323:630-5. 2004
    ..This might represent a fundamental link between over-nutrition and an impaired inflammatory immune response...
  44. doi Influence of significant weight loss on serum matrix metalloproteinase (MMP)-7 levels
    Claudia Ress
    Department of Medicine I, Medical University Innsbruck, Innsbruck, Austria
    Eur Cytokine Netw 21:65-70. 2010
    ..MMPs and TIMPs are thought to play a major role in extensive reorganization of the adipose tissue in obesity...
  45. ncbi Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver
    Gernot Zollner
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Graz, Austria
    Am J Physiol Gastrointest Liver Physiol 289:G798-805. 2005
    ....
  46. doi Interleukin-32: a new proinflammatory cytokine involved in hepatitis C virus-related liver inflammation and fibrosis
    Alexander R Moschen
    Christian Doppler Research Laboratory for Gut Inflammation, Innsbruck Medical University, Innsbruck, Austria
    Hepatology 53:1819-29. 2011
    ..5 cells resulted in a significant (11-fold) induction of IL-32 mRNA expression. However, modulation of IL-32 in Huh-7.5 cells by overexpression or silencing did not influence HCV virus replication as determined by luciferase assays...
  47. ncbi Plasma levels of interleukin-18 and interleukin-18 binding protein are elevated in patients with chronic liver disease
    Othmar Ludwiczek
    University Hospital Innsbruck, Department of Medicine, Division of Gastroenterology and Hepatology, Innsbruck, Austria
    J Clin Immunol 22:331-7. 2002
    ..Plasma levels of IL-18 and its antagonist, IL-18BP, are elevated in CLD and correlate with severity of disease. IL-18BP may not be sufficient to counteract the overwhelming proinflammatory response in end stage liver disease...
  48. ncbi Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis
    Herbert Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    J Hepatol 38:419-25. 2003
    ..Severe alcoholic hepatitis (AH) is associated with high mortality. Tumor necrosis factor-alpha (TNFalpha) has been demonstrated to play an important role in its pathophysiology...
  49. ncbi Interleukin-18 attracts plasmacytoid dendritic cells (DC2s) and promotes Th1 induction by DC2s through IL-18 receptor expression
    Arthur Kaser
    Department of Medicine, University Hospital Innsbruck, Anichstr 35, 6020 Innsbruck, Austria
    Blood 103:648-55. 2004
    ..IL-18 might have a profound role during the initiation phase of an immune response by recruiting pre-DC2s and modulating the function of DC2s...
  50. doi Adipocytokines and hepatocellular carcinoma
    Verena Wieser
    Christian Doppler Research Laboratory for Gut Inflammation, Innsbruck Medical University, Austria
    Dig Dis 30:508-13. 2012
    ..In conclusion, adipocytokines are increasingly recognized as pleiotropic molecules involved in the pathophysiology of HCC, which might lead to therapeutic approaches targeting these mediators...
  51. ncbi Novel therapeutic targets in the treatment of IBD
    Arthur Kaser
    Medical University Innsbruck, Division of Gastroenterology and Hepatology, Innsbruck, Austria
    Expert Opin Ther Targets 12:553-63. 2008
    ..Advances in mucosal immunology have revealed a broad set of new therapeutic targets to resolve inflammation and symptoms in patients with inflammatory bowel diseases (IBD)...
  52. ncbi Antitumour necrosis factor therapy in Crohn's disease
    Herbert Tilg
    Department of Medicine, University Hospital Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Expert Opin Biol Ther 2:715-21. 2002
    ..These new cytokine-targeting approaches have changed clinical medicine in the field of inflammatory disorders...
  53. ncbi Knockdown of PgP resensitizes leukemic cells to proteasome inhibitors
    Holger Rumpold
    Laboratory of Molecular Genetics, Department of Hematology and Oncology, Medical University Innsbruck, Innsbruck, Austria
    Biochem Biophys Res Commun 361:549-54. 2007
    ..Our report provides evidence that MLN273 and, to a lesser degree, Bortezomib are both MDR-1-substrates, which might be relevant for drug-resistance in cancer...
  54. ncbi Adipocytokines: mediators linking adipose tissue, inflammation and immunity
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation and Department of Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Nat Rev Immunol 6:772-83. 2006
    ..Understanding this rapidly growing family of mainly adipocyte-derived mediators might be of importance in the development of new therapies for obesity-associated diseases...
  55. ncbi Pre-B cell colony enhancing factor/NAMPT/visfatin in inflammation and obesity-related disorders
    Alexander R Moschen
    Christian Doppler Research Laboratory for Gut Inflammation and Department of Medicine II, Gastroenterology and Hepatology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Curr Pharm Des 16:1913-20. 2010
    ..Many of the biological functions of this "cytokine-enzyme" have been characterized in the last years, however, its definite role in various metabolic, inflammatory and malignant diseases has yet to be defined...
  56. doi Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus
    Stefan Kiechl
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Nat Med 19:358-63. 2013
    ..Overall, this study provides evidence for a role of RANKL signaling in the pathogenesis of T2DM. If so, translation to the clinic may be feasible given current pharmacological strategies to lower RANKL activity to treat osteoporosis...
  57. ncbi Endotoxin and its binding proteins in chronic liver disease: the effect of transjugular intrahepatic portosystemic shunting
    Arthur Kaser
    Division of Gastroenterology and Hepatology, Department of Medicine, University Hospital Innsbruck, Austria
    Liver 22:380-7. 2002
    ..Endotoxin action might be modified by binding to soluble CD14 (sCD14) and lipopolysaccharide-binding protein (LBP), both of which have not yet been sufficiently studied in CLD...
  58. ncbi Role of IL-10 for induction of anemia during inflammation
    Herbert Tilg
    Division of Gastroenterology and Hepatology, Department of Medicine, University Hospital Innsbruck, Innsbruck, Austria
    J Immunol 169:2204-9. 2002
    ....
  59. ncbi Treatment strategies in nonalcoholic fatty liver disease
    Herbert Tilg
    Department of Medicine, Academic Teaching Hospital Hall, Tyrol, Austria
    Nat Clin Pract Gastroenterol Hepatol 2:148-55. 2005
    ....
  60. ncbi Adiponectin: a key fat-derived molecule regulating inflammation
    Herbert Tilg
    Division of Gastroenterology and Hepatology, Department of Medicine, University Hospital Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Expert Opin Ther Targets 9:245-51. 2005
    ..Therefore, either adiponectin itself or its inducing agents, such as thiazolidinediones, might be of key therapeutic interest in the near future far beyond diseases being associated with insulin resistance...
  61. ncbi CD4+CD25+ regulatory T cells inhibit experimental anti-glomerular basement membrane glomerulonephritis in mice
    Dominik Wolf
    Clinical Division of Hematology and Oncology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Am Soc Nephrol 16:1360-70. 2005
    ..This report provides first evidence that Treg are potent suppressors of anti-GBM GN. Treg therefore might be of therapeutic value for the treatment of severe GN in humans...
  62. ncbi Anti-inflammatory effects of hepatocyte growth factor: induction of interleukin-1 receptor antagonist
    Clemens Molnar
    Clinical Division of General Internal Medicine, Clinical Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur Cytokine Netw 15:303-11. 2004
    ....
  63. ncbi Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance
    Herbert Tilg
    Department of Medicine, Christian Doppler Laboratory for Gut Inflammation and Clinical Division of Gastroenterology and Hepatology, Innsbruck Medical University, Innsbruck, Austria
    Gastroenterology 131:934-45. 2006
  64. ncbi The kinase inhibitor imatinib--an immunosuppressive drug?
    D Wolf
    Laboratory for Tumorimmunology, Tyrolean Cancer Center, Innsbruck Medical University, Austria
    Curr Cancer Drug Targets 7:251-8. 2007
    ..Thus, Imatinib exerts potent immuno-modulatory effects in vitro and in vivo, which will be discussed together with their clinical relevance in detail throughout this review...
  65. ncbi Circulating adiponectin reflects severity of liver disease but not insulin sensitivity in liver cirrhosis
    S Kaser
    Clinical Division of General Internal Medicine, Department of Medicine, Medical University Innsbruck, Austria
    J Intern Med 258:274-80. 2005
    ..The adipocytokine adiponectin has been proposed to play important roles in the regulation of energy homeostasis, insulin sensitivity and shows anti-inflammatory properties...
  66. ncbi "Metabolic aspects" in inflammatory bowel diseases
    Arthur Kaser
    Department of Medicine II Gastroenterology and Hepatology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Curr Drug Deliv 9:326-32. 2012
    ..Metabolic aspects have evolved as of key importance in experimental colitis and human IBD, and certain adipocytokines, autophagy, and ER stress might reflect the central players...
  67. pmc Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-κB-inducible immune pathways
    Manfred Nairz
    Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Innsbruck Medical University, 6020 Innsbruck, Austria
    Immunity 34:61-74. 2011
    ..These immune-modulatory effects of EPO may be of therapeutic relevance in infectious and inflammatory diseases...
  68. ncbi Type I interferons and their therapeutic role in Th2-regulated inflammatory disorders
    Herbert Tilg
    Departmetn of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Austria
    Expert Opin Biol Ther 4:469-81. 2004
    ..These newly identified immunoregulatory and anti-inflammatory functions of type I IFNs may be of importance in the treatment of various chronic inflammatory disorders...
  69. ncbi Splanchnic blood flow determination in patients with suspected chronic intestinal ischaemia
    Herbert Tilg
    Department of Medicine, University Hospital Innsbruck, Austria
    Eur J Gastroenterol Hepatol 14:1169-71. 2002
    ..However, further studies are needed in the use of this experimental technique in the workup of these patients...
  70. ncbi Interferon-alpha suppresses leptin levels: studies in interferon-alpha treated patients with hepatitis C virus infection and murine adipocytes
    Susanne Kaser
    Department of Medicine, University of Innsbruck, Anichstra e 35, 6020 Innsbruck, Austria
    Eur Cytokine Netw 13:225-9. 2002
    ..We therefore hypothesize that loss of weight and appetite in interferon-alpha-treated patients with chronic hepatitis C might not be due to an elevation of leptin resulting in signals of increased energy stores in the brain...
  71. pmc The RANKL/OPG system is activated in inflammatory bowel disease and relates to the state of bone loss
    A R Moschen
    Department of Medicine, University Hospital Innsbruck, Anichstr 35, 6020 Innsbruck, Austria
    Gut 54:479-87. 2005
    ..Recent data from a mouse model of colitis suggest that the receptor activator of nuclear factor kappa B (RANKL)/osteoprotegerin (OPG) system may be responsible for bone loss...
  72. ncbi Infliximab in severe steroid-refractory ulcerative colitis: a pilot study
    A Kaser
    Division of Gastroenterology and Hepatology, Department of Medicine, University Hospital Innsbruck, Austria
    Wien Klin Wochenschr 113:930-3. 2001
    ..Apoptotic cells in the mucosa were reduced on day 7. Our data point toward a novel efficacious treatment option in severe steroid-refractory UC and raise the need for controlled trials...
  73. doi Effect of pronounced weight loss on visceral fat, liver steatosis and adiponectin isoforms
    J Engl
    Department of Internal Medicine, Clinical Division of General Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    Eur J Clin Invest 38:238-44. 2008
    ....
  74. ncbi Management strategies in alcoholic liver disease
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation and Department of Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Nat Clin Pract Gastroenterol Hepatol 4:24-34. 2007
    ..Independent of the stage of disease, abstinence from alcohol is the cornerstone of management. New treatment modalities for these diseases are eagerly awaited...
  75. ncbi Cheilitis granulomatosa and Melkersson-Rosenthal syndrome: evaluation of gastrointestinal involvement and therapeutic regimens in a series of 14 patients
    G Ratzinger
    Department of Dermatology and Venereology, Medical University, Innsbruck, Austria
    J Eur Acad Dermatol Venereol 21:1065-70. 2007
    ..Furthermore, because of their unknown aetiology, treatment is difficult, and evaluation of response is hampered by the natural tendency to spontaneous resolution and recurrence...
  76. pmc Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease
    O Ludwiczek
    Department of Medicine, University Hospital Innsbruck, Innsbruck, Austria
    Clin Exp Immunol 138:323-9. 2004
    ....
  77. pmc A randomised placebo controlled trial of pegylated interferon alpha in active ulcerative colitis
    H Tilg
    Department of Gastroenterology and Hepatology and Biostatistics, University Hospital Innsbruck, Austria
    Gut 52:1728-33. 2003
    ..We evaluated the safety of pegylated interferon alpha (PegIFN) and its role in induction of remission in patients with active ulcerative colitis, in a multicentre placebo controlled trial...
  78. ncbi Plasma levels of soluble CD40 ligand are elevated in inflammatory bowel diseases
    O Ludwiczek
    University Hospital Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Int J Colorectal Dis 18:142-7. 2003
    ..A soluble form of CD40L (sCD40L) exists in the circulation. This study investigated whether plasma levels of sCD40L are higher in patients with IBD than in healthy controls...
  79. doi Effect of bariatric surgery on circulating chemerin levels
    C Ress
    Department of Medicine I, Medical University Innsbruck, 6020 Innsbruck, Austria
    Eur J Clin Invest 40:277-80. 2010
    ..We set out to investigate the effect of pronounced weight loss on circulating chemerin levels, a chemoattractant protein that also influences adipose cell function by paracrine and autocrine mechanisms...
  80. ncbi Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis
    A Kaser
    Divisions of Gastroenterology and Hepatology and of General Internal Medicine, The Department of Medicine, University Hospital Innsbruck, Austria
    Blood 98:2720-5. 2001
    ..This regulatory pathway might be of relevance for the understanding of reactive thrombocytosis...
  81. ncbi IL-6 and APPs: anti-inflammatory and immunosuppressive mediators
    H Tilg
    Dept of Medicine, University Hospital Innsbruck, Austria
    Immunol Today 18:428-32. 1997
    ..Recent data suggest that interleukin 6 (IL-6) and IL-6-regulated APPs are anti-inflammatory and immuno-suppressive, and may negatively regulate the acute phase response...
  82. pmc Adiponectin and its receptors in non-alcoholic steatohepatitis
    S Kaser
    University Hospital Innsbruck, Department of Medicine, Division of General Internal Medicine, Anichstrasse 35, 6020 Innsbruck, Austria
    Gut 54:117-21. 2005
    ..Adiponectin, an adipocyte derived polypeptide, has been shown to alleviate steatosis and inflammation in mice with non-alcoholic fatty liver disease...
  83. pmc Diet and relapsing ulcerative colitis: take off the meat?
    H Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Gut 53:1399-401. 2004
  84. ncbi Interleukin-16 supports the migration of Langerhans cells, partly in a CD4-independent way
    P Stoitzner
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    J Invest Dermatol 116:641-9. 2001
    ..Taken together, it seems likely that locally secreted interleukin-16 might serve to enhance the migration of cutaneous dendritic cells and optimize the response to foreign antigen encountering the skin...
  85. pmc Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma
    H Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Austria
    Gut 50:191-5. 2002
    ..Interleukin 10 (IL-10) exerts anti-inflammatory actions by counteracting many biological effects of interferon gamma (IFN-gamma)...
  86. pmc Predicting mortality by the Glasgow alcoholic hepatitis score: the long awaited progress?
    H Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Gut 54:1057-9. 2005
    ..The new Glasgow alcoholic hepatitis score may represent a substantial improvement in clinical phenotyping and could catalyse the development of new treatments in severe alcoholic hepatitis...
  87. pmc XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    Arthur Kaser
    Division of Gastroenterology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Cell 134:743-56. 2008
    ..Hence, intestinal inflammation can originate solely from XBP1 abnormalities in IECs, thus linking cell-specific ER stress to the induction of organ-specific inflammation...
  88. ncbi Austrian infliximab experience in Crohn's disease: a nationwide cooperative study with long-term follow-up
    Heimo H Wenzl
    Department of Internal Medicine, Karl Franzens University Graz, Austria
    Eur J Gastroenterol Hepatol 16:767-73. 2004
    ..To determine the nationwide experience with infliximab for the treatment of Crohn's disease in Austria...
  89. ncbi Adiponectin and its receptors in patients with chronic hepatitis C
    Julie R Jonsson
    School of Medicine, Southern Division, University of Queensland, Brisbane, Australia
    J Hepatol 43:929-36. 2005
    ..In patients with non-alcoholic steatohepatitis, lower levels of adiponectin were associated with higher grades of hepatic steatosis and necroinflammatory activity, suggesting a pathophysiological role for this adipokine in liver disease...
  90. ncbi Infliximab and alcoholic hepatitis
    Rajeshwar P Mookerjee
    Hepatology 40:499-500; author reply 500-1. 2004
  91. ncbi Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction
    Michelle M Richardson
    School of Medicine, Southern Clinical Division, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Gastroenterology 133:80-90. 2007
    ..We propose that activation of this pathway, with increased cell injury in NASH, also induces a periportal ductular reaction (DR) that could produce a profibrogenic stimulus...