Gilbert Spizzo

Summary

Affiliation: Innsbruck Medical University
Country: Austria

Publications

  1. pmc Effects of EpCAM overexpression on human breast cancer cell lines
    Johanna M Gostner
    Laboratory for Experimental Oncology, Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria
    BMC Cancer 11:45. 2011
  2. pmc EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis
    Gilbert Spizzo
    Laboratory for Experimental Oncology Tyrolean Cancer Research Institute, Innsbruck Medical University, Innsbruck, Austria
    J Clin Pathol 64:415-20. 2011
  3. ncbi request reprint TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity
    Dominic Fong
    Department of Hematology and Oncology, Innsbruck Medical University, Innsbruck, Austria
    Mod Pathol 21:186-91. 2008
  4. pmc EpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growth
    Agnieszka Martowicz
    Laboratory of Experimental Oncology, Tyrolean Cancer Research Institute, Innsbruck, Austria
    Mol Cancer 12:56. 2013
  5. ncbi request reprint STAT1 activation in squamous cell cancer of the oral cavity: a potential predictive marker of response to adjuvant chemotherapy
    Klaus Laimer
    Division of Maxillofacial Surgery, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Cancer 110:326-33. 2007
  6. ncbi request reprint EpCAM expression in squamous cell carcinoma of the oral cavity: frequency and relationship to clinicopathologic features
    Klaus Laimer
    Department of Craniomaxillofacial and Oral Surgery, Innsbruck Medical University, Anichstrasse 35 A 6020 Innsbruck, Austria
    Oral Oncol 44:72-7. 2008
  7. doi request reprint Prognostic significance of 14-3-3sigma expression in oral squamous cell carcinoma (OSCC)
    Klaus Laimer
    Division of Maxillofacial Surgery, Innsbruck Medical University, Austria
    Oral Oncol 45:127-34. 2009
  8. ncbi request reprint High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer
    Gilbert Spizzo
    Division of Haematology and Oncology, University of Innsbruck, Innsbruck, Austria
    Breast Cancer Res Treat 86:207-13. 2004
  9. pmc Expression of EpCAM(MF) and EpCAM(MT) variants in human carcinomas
    Dominic Fong
    Tyrolean Cancer Research Institute, Innsbruck, Austria
    J Clin Pathol 67:408-14. 2014
  10. doi request reprint Low expression of junctional adhesion molecule A is associated with metastasis and poor survival in pancreatic cancer
    Dominic Fong
    Division of Hematology and Oncology, Medical University Innsbruck, Innsbruck, Austria
    Ann Surg Oncol 19:4330-6. 2012

Collaborators

Detail Information

Publications21

  1. pmc Effects of EpCAM overexpression on human breast cancer cell lines
    Johanna M Gostner
    Laboratory for Experimental Oncology, Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria
    BMC Cancer 11:45. 2011
    ..The use of EpCAM-specific monoclonal antibodies is a promising treatment approach in these patients...
  2. pmc EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis
    Gilbert Spizzo
    Laboratory for Experimental Oncology Tyrolean Cancer Research Institute, Innsbruck Medical University, Innsbruck, Austria
    J Clin Pathol 64:415-20. 2011
    ..However, no consensus exists on how and when to evaluate EpCAM expression in patients with cancer...
  3. ncbi request reprint TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity
    Dominic Fong
    Department of Hematology and Oncology, Innsbruck Medical University, Innsbruck, Austria
    Mod Pathol 21:186-91. 2008
    ..TROP2 overexpression was detectable in 58% of the tumor samples, indicating it to be a potential novel therapeutic target in squamous cell carcinoma of the oral cavity...
  4. pmc EpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growth
    Agnieszka Martowicz
    Laboratory of Experimental Oncology, Tyrolean Cancer Research Institute, Innsbruck, Austria
    Mol Cancer 12:56. 2013
    ..Therefore, we analyzed effects of transient adenoviral overexpression of EpCAM on proliferation, migration and differentiation of primary human mammary epithelial cells (HMECs)...
  5. ncbi request reprint STAT1 activation in squamous cell cancer of the oral cavity: a potential predictive marker of response to adjuvant chemotherapy
    Klaus Laimer
    Division of Maxillofacial Surgery, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Cancer 110:326-33. 2007
    ..This retrospective study was designed to investigate the predictive and/or prognostic value of STAT1 activation in squamous cell carcinoma of the oral cavity...
  6. ncbi request reprint EpCAM expression in squamous cell carcinoma of the oral cavity: frequency and relationship to clinicopathologic features
    Klaus Laimer
    Department of Craniomaxillofacial and Oral Surgery, Innsbruck Medical University, Anichstrasse 35 A 6020 Innsbruck, Austria
    Oral Oncol 44:72-7. 2008
    ..Taken together, these data suggest that EpCAM might become an attractive treatment target in a subgroup of patients with OSCC...
  7. doi request reprint Prognostic significance of 14-3-3sigma expression in oral squamous cell carcinoma (OSCC)
    Klaus Laimer
    Division of Maxillofacial Surgery, Innsbruck Medical University, Austria
    Oral Oncol 45:127-34. 2009
    ..Pending validation targeting 14-3-3sigma might also be a new opportunity to improve therapy...
  8. ncbi request reprint High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer
    Gilbert Spizzo
    Division of Haematology and Oncology, University of Innsbruck, Innsbruck, Austria
    Breast Cancer Res Treat 86:207-13. 2004
    ....
  9. pmc Expression of EpCAM(MF) and EpCAM(MT) variants in human carcinomas
    Dominic Fong
    Tyrolean Cancer Research Institute, Innsbruck, Austria
    J Clin Pathol 67:408-14. 2014
    ....
  10. doi request reprint Low expression of junctional adhesion molecule A is associated with metastasis and poor survival in pancreatic cancer
    Dominic Fong
    Division of Hematology and Oncology, Medical University Innsbruck, Innsbruck, Austria
    Ann Surg Oncol 19:4330-6. 2012
    ..The junctional adhesion molecule A (JAM-A) is a type I transmembrane glycoprotein, which recently has been shown to affect the prognosis of several human malignancies...
  11. ncbi request reprint Methylation status of the Ep-CAM promoter region in human breast cancer cell lines and breast cancer tissue
    Gilbert Spizzo
    Division of Haematology and Oncology, Innsbruck Medical University, Innsbruck, Austria
    Cancer Lett 246:253-61. 2007
    ..Taken together, these data suggest that methylation of the Ep-CAM promoter is not a crucial mechanism for regulation of Ep-CAM expression in breast cancer. Thus, most important regulatory mechanisms have to be supposed in vivo...
  12. doi request reprint Loss of membranous expression of the intracellular domain of EpCAM is a frequent event and predicts poor survival in patients with pancreatic cancer
    Dominic Fong
    Tyrolean Cancer Research Institute, Laboratory for Experimental Oncology, Innsbruck, Austria Department of Internal Medicine V, Hematology and Oncology, Medical University Innsbruck, Innsbruck, Austria Department of Hematology and Oncology, Franz Tappeiner Hospital, Merano, Italy Oncotyrol Center for Personalized Cancer Medicine, Innsbruck, Austria
    Histopathology 64:683-92. 2014
    ..Antibodies to target EpCAM are usually directed against its ectodomain (EpEX), but do not detect the intracellular domain (EpICD). The aim of this study was to compare membranous EpEX versus EpICD expression by immunohistochemistry...
  13. ncbi request reprint High EGFR expression predicts poor prognosis in patients with squamous cell carcinoma of the oral cavity and oropharynx: a TMA-based immunohistochemical analysis
    Klaus Laimer
    Division of Maxillofacial Surgery, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Oral Oncol 43:193-8. 2007
    ..The EGFR antigen represents an attractive target for targeted therapies with monoclonal antibodies or specific tyrosine-kinase inhibitors in these patients...
  14. ncbi request reprint Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer
    Gilbert Spizzo
    Division of Hematology and Oncology, Innsbruck Medical University, Austria
    Gynecol Oncol 103:483-8. 2006
    ..To identify a potential molecular target and prognostic/predictive factor for EOC, we investigated in a retrospective study the prognostic value of Ep-CAM overexpression in EOC...
  15. doi request reprint Hodgkin lymphoma in Tyrol-a population-based study
    Dominic Fong
    Department of Hematology and Oncology, Innsbruck Medical University, Austria
    Ann Hematol 88:449-56. 2009
    ..Furthermore, 3% of HL patients had an antecedent malignant hematological disease before occurrence of HL...
  16. pmc Phenotype-dependent effects of EpCAM expression on growth and invasion of human breast cancer cell lines
    Agnieszka Martowicz
    Laboratory of Experimental Oncology, Tyrolean Cancer Research Institute, Innsbruck, Austria
    BMC Cancer 12:501. 2012
    ..This study analyzes the effects of EpCAM on breast cancer cell lines with epithelial or mesenchymal phenotype...
  17. ncbi request reprint Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival
    Meri Varga
    Division of Hematology and Oncology, University of Innsbruck, Innsbruck, Austria
    Clin Cancer Res 10:3131-6. 2004
    ..This retrospective study was designed to investigate the prognostic significance of epithelial cell adhesion molecule (Ep-CAM) overexpression in human gallbladder carcinoma...
  18. ncbi request reprint Prognostic significance of Ep-CAM AND Her-2/neu overexpression in invasive breast cancer
    Gilbert Spizzo
    Division of Hematology and Oncology, University of Innsbruck, Innsbruck, Austria
    Int J Cancer 98:883-8. 2002
    ..Determination of these tumor markers should help in assigning breast cancer patients to 1 of 3 distinct risk categories...
  19. ncbi request reprint Hodgkin's disease variant of Richter's syndrome in chronic lymphocytic leukaemia patients previously treated with fludarabine
    Dominic Fong
    Division of Haematology and Oncology, Innsbruck Medical University, Innsbruck, Austria
    Br J Haematol 129:199-205. 2005
    ..The majority present with B-symptoms and CLL treatment-resistant lymphadenopathy, are of the MC type, clonally related to CLL and might be triggered by an EBV infection...
  20. ncbi request reprint 14-3-3sigma expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients
    Alexander Perathoner
    Tyrolean Cancer Research Institute, Innsbruck, Austria
    Clin Cancer Res 11:3274-9. 2005
    ..In this study, we examined the expression of 14-3-3sigma and evaluated its clinical significance in colorectal carcinoma...
  21. pmc Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury
    Christian M Kähler
    Department of Internal Medicine, Division of General Internal Medicine, Pneumology Centre, Innsbruck Medical University, Austria
    Respir Res 8:50. 2007
    ..Homing of ex vivo generated bone marrow-derived EPC into the injured lung has not been investigated so far. We therefore tested the hypothesis whether homing of EPC in damaged lung tissue occurs after intravenous administration...