Research Topics
Species | Klaus SeppiSummaryAffiliation: Innsbruck Medical University Country: Austria Publications
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Detail Information
Publications
Topography of cerebral monoamine transporter availability in families with SCA2 mutations: a voxel-wise [123I]beta-CIT SPECT analysisChristoph Scherfler
Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Eur J Nucl Med Mol Imaging 33:1084-90. 2006..To this end, nine patients were studied with [(123)I]beta-CIT SPECT...
MRI for the differential diagnosis of neurodegenerative parkinsonism in clinical practiceKlaus Seppi
Department of Neurology, Medical University Innsbruck, Austria
Parkinsonism Relat Disord 13:S400-5. 2007..Given that olfactory deficits may be a premotor marker of the disease, such methods may eventually evolve into an early screening tool for PD...- The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's diseaseKlaus Seppi
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
Mov Disord 26:S42-80. 2011..Several interventions and indications still lack good quality evidence, and these gaps offer an opportunity for ongoing research. © 2011 Movement Disorder Society... - Brain magnetic resonance imaging techniques in the diagnosis of parkinsonian syndromesKlaus Seppi
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Neuroimaging Clin N Am 20:29-55. 2010.... - Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's diseaseChristoph Scherfler
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Brain 128:1605-12. 2005..We suggest that the quantification of midbrain DAT signal should be included in the routine clinical analysis of [123I]beta-CIT SPECT in patients with uncertain parkinsonism... - Cortical atrophy in the cerebellar variant of multiple system atrophy: a voxel-based morphometry studyChristian Brenneis
Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Mov Disord 21:159-65. 2006..We observed a volume loss shared by both disorders comprising the cerebellum, vermis, pons, mesencephalon, orbitofrontal, mid-frontal, and temporomesial cortex of both hemispheres as well as the left insular cortex... - Progression of putaminal degeneration in multiple system atrophy: a serial diffusion MR studyKlaus Seppi
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Neuroimage 31:240-5. 2006.... - Red flags for multiple system atrophyMartin Köllensperger
Section for Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
Mov Disord 23:1093-9. 2008..9 (+/-7.0) months earlier than with the Consensus criteria alone. We propose a combination of two out of six red flag categories as additional diagnostic criteria for probable MSA-P... - Restless legs syndrome in Parkinson's diseaseCecilia M Peralta
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Mov Disord 24:2076-80. 2009..7 years). The majority (n = 17, 61%) who scored positive for RLS reported that the urge to move the legs and unpleasant sensations were associated with wearing off, raising the possibility of RLS mimics in fluctuating patients with PD... - Diffusion-weighted imaging in Huntington's diseaseKlaus Seppi
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Mov Disord 21:1043-7. 2006..Diffusion-weighted imaging appears to be a promising surrogate marker for disease severity in HD. Sensitivity to change remains to be established longitudinally... - Topography of putaminal degeneration in multiple system atrophy: a diffusion magnetic resonance studyKlaus Seppi
Department of Neurology, Innsbruck Medical University, Austria
Mov Disord 21:847-52. 2006..Our study demonstrates prominent involvement of the posterior putamen in early disease stages of MSA-P in vivo by assessing putaminal diffusivity with the help of DWI... - A novel computer-assisted image analysis of [123I]β-CIT SPECT images improves the diagnostic accuracy of parkinsonian disordersGeorg Goebel
Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schöpfstrasse 41 2, A 6020, Innsbruck, Austria
Eur J Nucl Med Mol Imaging 38:702-10. 2011.... - Topography of dopamine transporter availability in progressive supranuclear palsy: a voxelwise [123I]beta-CIT SPECT analysisKlaus Seppi
Department of Neurology, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
Arch Neurol 63:1154-60. 2006..Most previous SPECT studies have adopted region-of-interest methods for analysis, which are subjective and operator dependent... - Differentiation of SCA2 from MSA-C using proton magnetic resonance spectroscopic imagingSylvia M Boesch
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
J Magn Reson Imaging 25:564-9. 2007..To assess and compare biochemical and volumetric features of the cerebellum in patients with spinocerebellar ataxia type 2 (SCA2) and patients with the cerebellar variant of multiple system atrophy (MSA-C)... - Left hemispheric predominance of nigrostriatal dysfunction in Parkinson's diseaseChristoph Scherfler
Department of Neurology, Innsbruck, Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
Brain 135:3348-54. 2012.... - Voxel-wise analysis of diffusion weighted imaging reveals disruption of the olfactory tract in Parkinson's diseaseChristoph Scherfler
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Brain 129:538-42. 2006..Whether DWI can be used as a marker to identify individuals at risk to develop this disease remains to be shown... - Voxel based morphometry reveals specific gray matter changes in primary dystoniaKarl Egger
Department of Radiology, Innsbruck Medical University, Austria
Mov Disord 22:1538-42. 2007..This is the first study using VBM in patients with different types of primary dystonia, showing a common pattern of gray matter changes... - Progression of brain atrophy in multiple system atrophy. A longitudinal VBM studyChristian Brenneis
Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
J Neurol 254:191-6. 2007..The UPDRS-III score was not significantly correlated with any brain region. Our data suggest that cortical atrophy is prominent in MSA-P and early degeneration of the basal ganglia drives late onset cortical atrophy... - White and gray matter abnormalities in idiopathic rapid eye movement sleep behavior disorder: a diffusion-tensor imaging and voxel-based morphometry studyChristoph Scherfler
Department of Neurology, Innsbruck Medical University, Austria
Ann Neurol 69:400-7. 2011.... - Diffusion weighted imaging best discriminates PD from MSA-P: A comparison with tilt table testing and heart MIBG scintigraphyMartin Köllensperger
Clinical Department of Neurology, Innsbruck Medical University, Austria
Mov Disord 22:1771-6. 2007..6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA-P... - Presentation, diagnosis, and management of multiple system atrophy in Europe: final analysis of the European multiple system atrophy registryMartin Köllensperger
Clinical Department of Neurology, Innsbruck Medical University, Austria
Mov Disord 25:2604-12. 2010..The observed differences in diagnostic and therapeutic management including lack of therapy for dysautonomia emphasize the need for future guidelines in these areas... - Progression of multiple system atrophy (MSA): a prospective natural history study by the European MSA Study Group (EMSA SG)Felix Geser
Clinical Department of Neurology, Innsbruck Medical University, Austria
Mov Disord 21:179-86. 2006..Our data contribute to the ongoing validation process of UMSARS, and they facilitate the planning and implementation of future neuroprotective intervention trials... - Significance of MRI in diagnosis and differential diagnosis of Parkinson's diseasePhilipp Mahlknecht
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Neurodegener Dis 7:300-18. 2010..This article aims to review research findings on the value of MRI techniques in the differential diagnosis of neurodegenerative parkinsonian disorders... - Progression of dopamine transporter decline in patients with the Parkinson variant of multiple system atrophy: a voxel-based analysis of [123I]β-CIT SPECTMichael Nocker
Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Eur J Nucl Med Mol Imaging 39:1012-20. 2012.... - Levodopa-induced sleepiness in the Parkinson variant of multiple system atrophyKlaus Seppi
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Mov Disord 21:1281-3. 2006..These findings suggest greater potential of levodopa to induce sleepiness in MSA compared with PD, which may be related to differences in basal ganglia and brainstem pathology between the two disorders... - Comparison of diffusion-weighted imaging and [123I]IBZM-SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson's diseaseKlaus Seppi
Department of Neurology, University of Innsbruck, Innsbruck, Austria
Mov Disord 19:1438-45. 2004..Striatal rADCs had a significant higher overall predictive accuracy than D2R binding with IBZM. In summary, our data suggest that DWI may be more accurate compared to IBZM-SPECT in the differential diagnosis of MSA-P versus PD... - Diagnostic accuracy of the magnetic resonance Parkinsonism index and the midbrain-to-pontine area ratio to differentiate progressive supranuclear palsy from Parkinson's disease and the Parkinson variant of multiple system atrophyAnna Hussl
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Mov Disord 25:2444-9. 2010..6%) compared with the MRPI (77.3%). Both the m/p-ratio and the MRPI may assist the clinical differential diagnosis in neurodegenerative parkinsonism... - Progression of parkinsonism in multiple system atrophyKlaus Seppi
Department of Neurology, University Hospital, Innsbruck, Austria
J Neurol 252:91-6. 2005..Furthermore, motor progression appeared to be accelerated during the early disease stages.Our data allow sample size calculations that may be helpful for the planning of future therapeutic trials... - Is transcranial sonography useful to distinguish scans without evidence of dopaminergic deficit patients from Parkinson's disease?Heike Stockner
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
Mov Disord 27:1182-5. 2012..The aim of this study was to investigate the prevalence of midbrain hyperechogenicity in patients with suspected parkinsonism and scans without evidence of dopaminergic deficit (SWEDD), in comparison to PD patients... 
White and gray matter abnormalities in narcolepsy with cataplexyChristoph Scherfler
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Sleep 35:345-51. 2012....- Abnormal responses to repetitive transcranial magnetic stimulation in multiple system atrophyWolfgang N Löscher
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Mov Disord 22:174-8. 2007..We suggest that these abnormalities reflect the motor cortex pathology found in MSA-P... - Long-term antidyskinetic efficacy of amantadine in Parkinson's diseaseElisabeth Wolf
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
Mov Disord 25:1357-63. 2010..2 (95% CI, 2.1-4.4) to follow-up 3.6 (95% CI, 2.3-4.8) in patients staying on amantadine. These findings argue for long-term antidyskinetic efficacy of amantadine in PD patients with LID's... - Prevalence of movement disorders in men and women aged 50-89 years (Bruneck Study cohort): a population-based studyGregor K Wenning
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
Lancet Neurol 4:815-20. 2005..A fifth of all movement disorders were diagnosed to be probably drug-induced. INTERPRETATION: There is a high prevalence of and substantial under-recognition and under-treatment of movement disorders in the general community... - The Unified Multiple System Atrophy Rating Scale: intrarater reliabilityFlorian Krismer
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Mov Disord 27:1683-5. 2012..In the present study, the intrarater agreement of the motor examination part of the UMSARS was determined... - The natural history of multiple system atrophy: a prospective European cohort studyGregor K Wenning
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Lancet Neurol 12:264-74. 2013..Here we present the final analysis of a prospective multicentre study by the European MSA Study Group to investigate the natural history of MSA... - Auditory startle response in cervical dystoniaJörg Müller
Department of Neurology, University Hospital Innsbruck, Innsbruck, Austria
Mov Disord 18:1522-6. 2003..Reduced ASR probability and magnitude as well as prolonged EMG activity after the proper startle response corroborate and extend previous findings on brainstem dysfunction in CD... - Potential of advanced MR imaging techniques in the differential diagnosis of parkinsonismAnna Hotter
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Mov Disord 24:S711-20. 2009..This article aims to review recent research findings on the role of advanced MRI techniques in the differential diagnosis of neurodegenerative parkinsonian disorders... - Mortality in Parkinson's disease: a 20-year follow-up studyAnja Diem-Zangerl
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Mov Disord 24:819-25. 2009.... - Voxel-based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophyChristian Brenneis
Department of Neurology, University Hospital, Innsbruck, Austria
Mov Disord 18:1132-8. 2003..Further studies are required to determine clinical and/or subclinical correlates of cortical atrophy in MSA-P... - Midbrain hyperechogenicity in idiopathic REM sleep behavior disorderHeike Stockner
Department of Neurology, Medical University Innsbruck, Innsbruck 6020, Austria
Mov Disord 24:1906-9. 2009..The prospective follow-up of this iRBD cohort is needed to establish if those with midbrain hyperechogenicity will go on to develop clinically defined PD or not... - Role and clinical utility of pramipexole extended release in the treatment of early Parkinson's diseaseEva Maria Hametner
Department of Neurology, Innsbruck Medical University, Austria
Clin Interv Aging 7:83-8. 2012.... - Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndromeChristoph Schmidauer
Department of Neurology, Innsbruck Medical University, Austria
Ann Neurol 58:630-4. 2005..These findings lend further support to nigral iron deficiency as a pathogenetic factor in RLS... - Orthostatic hypotension is differentially associated with the cerebellar versus the parkinsonian variant of multiple system atrophy: a comparative studyGregor Karl Wenning
Autonomic Unit, Division of Clinical Neurobiology, Department of Neurology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
Cerebellum 11:223-6. 2012..Differences in brainstem pathology are likely to account for the tight association of MSA-C and OH. A simple standing test should be obligatory in the work-up of patients with sporadic late-onset ataxias... - Parkinson's disease and arithmetics: the role of executive functionsLaura Zamarian
Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
J Neurol Sci 248:124-30. 2006..The study contributes to better understanding the specific cognitive deficits in early PD and the neurocognitive architecture of arithmetic processing... - Computerized tremor analysis of valproate-induced tremor: a comparative study of controlled-release versus conventional valproateMartina Rinnerthaler
Department of Neurology, Innsbruck Medical University, Austria
Epilepsia 46:320-3. 2005..These results suggest that CR-VPA may cause less tremorigenic activity as compared with standard VPA. The mechanisms underlying this difference are unclear but may include greater peak-trough variation with VPA than with CR-VPA... - Abnormalities of dopaminergic neurotransmission in SCA2: a combined 123I-betaCIT and 123I-IBZM SPECT studySylvia M Boesch
Department of Neurology, University of Innsbruck, Austria
Mov Disord 19:1320-5. 2004..Both slowness of limb movements as well as dystonia in the ataxic SCA2 phenotype may reflect dysfunction not only at cerebellar but also at basal ganglia level... - Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)Gregor K Wenning
Department of Neurology, University of Innsbruck, Austria
Mov Disord 19:1391-402. 2004..Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients... - Drug safety evaluation of rotigotineFabienne Stephanie Sprenger
Medical University Innsbruck, Department of Neurology, Anichstrasse 35, 6020 Innsbruck, Austria
Expert Opin Drug Saf 11:503-12. 2012..In addition, transdermal delivery is associated with local skin reactions, which are usually mild but may lead to a treatment discontinuation in a minority of patients... - Pramipexole extended release in Parkinson's diseaseEva Maria Hametner
Department of Neurology, Innsbruck Medical University, Anichstraße 35, A 6020 Innsbruck, Austria
Expert Rev Neurother 11:1229-34. 2011..Pramipexole ER is well tolerated, with a similar adverse event profile to pramipexole IR. The aim of this article is to provide a short review of the most relevant pharmacological and clinical data on pramipexole ER... - Basal forebrain atrophy is a distinctive pattern in dementia with Lewy bodiesChristian Brenneis
Department of Neurology, University Hospital of Innsbruck, Anichstr 35, 6020 Innsbruck, Austria
Neuroreport 15:1711-4. 2004..Atrophy of insular cortex was found in both patient groups... - An open trial of levetiracetam for segmental and generalized dystoniaSascha Hering
Department of Neurology, Medical University Innsbruck, Austria
Mov Disord 22:1649-51. 2007..At 4-week follow-up, none of the patients showed improvement of dystonia, mild side-effects were observed in 3 patients... - Valvular heart disease in Parkinson's disease vs. controls: An echocardiographic studyCecilia Peralta
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Mov Disord 21:1109-13. 2006..These results highlight the need for further prospective studies of the prevalence and underlying mechanisms of cardiac valvulopathy in PD patients treated with different dopamine agonists... - An antibody microarray analysis of serum cytokines in neurodegenerative Parkinsonian syndromesPhilipp Mahlknecht
Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Proteome Sci 10:71. 2012..abstract:.. - Exaggerated auditory startle responses in multiple system atrophy: a comparative study of parkinson and cerebellar subtypesMarkus Kofler
Department of Neurology, Hospital Hochzirl, Anna Dengel Haus, A 6170 Zirl, Austria
Clin Neurophysiol 114:541-7. 2003.... - Increased daytime sleepiness in Parkinson's disease: a questionnaire surveyBirgit Hogl
Department of Neurology, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
Mov Disord 18:319-23. 2003..Increased daytime sleepiness is more frequent in patients with PD than in elderly controls. Similar to controls, increased daytime sleepiness in PD patients is correlated with heavy snoring... - An update on conventional and advanced magnetic resonance imaging techniques in the differential diagnosis of neurodegenerative parkinsonismKlaus Seppi
Department of Neurology, Medical University Innsbruck, Austria
Curr Opin Neurol 18:370-5. 2005..The aim of this article is to review the recent literature on the role of conventional and advanced MRI techniques in the differential diagnosis of neurodegenerative parkinsonian disorders... - Video-EEG monitoring: safety and adverse events in 507 consecutive patientsJudith Dobesberger
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Epilepsia 52:443-52. 2011..The aim of this study was to analyze safety and adverse events (AEs) during video-EEG monitoring... - Soluble receptor activator of nuclear factor-kappa B ligand and risk for cardiovascular diseaseStefan Kiechl
Department of Neurology, Innsbruck Medical University, Anichstr 35, A 6020 Innsbruck, Austria
Circulation 116:385-91. 2007.... - A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson diseaseAlexander Zimprich
Department of Neurology, Medizinische Universität Wien, Vienna, Austria
Am J Hum Genet 89:168-75. 2011..VPS35 is a component of the retromer complex and mediates retrograde transport between endosomes and the trans-Golgi network, and it has recently been found to be involved in Alzheimer disease... - Urinary albumin excretion is independently associated with carotid and femoral artery atherosclerosis in the general populationMartin Furtner
Department of Neurology, Innsbruck Medical University Clinic, Anichstrasse 35, A-6020 Innsbruck, Austria
Eur Heart J 26:279-87. 2005..The novel aspects of our study are its focus on various vascular territories and representivity of the general healthy population... - Freezing of gait in postmortem-confirmed atypical parkinsonismJörg Müller
Department of Neurology, University Hospital Innsbruck, Austria
Mov Disord 17:1041-5. 2002..Whether FoG and urinary incontinence share similar neuropathological substrates remains to be determined by future studies...